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Studies of geochemical proxies, such as carbonate δ18O and TEX 86 , show that the Earth's climate has changed significantly during the Cretaceous Period. However, knowledge about the sea surface temperature (SST) history of the eastern Tethys is limited. Based on the calcareous nannofossil record of the Nirang section, Tethys Himalayas, this paper attempts to establish the biostratigraphic framework and SST evolution of the Cretaceous Period in the southern Tibet. A total of 131 species were identified from the studied succession. Twelve bioevents were recognized, allowing for early Albian to the early Campanian (CC8 to CC18 biozones) in the section. Meanwhile, a disconformity within 81–71 Ma was also identified. The SST evolution was analysed by the calcareous nannofossils modified temperature index (mTI), and the results reveal that the long-term SST changes in the Tethys Himalayas of southern Tibet experienced progressive warming from the early Albian to the early Turonian and the warm interval persisted until the early Campanian. Short-term warming and cooling events, e.g., rapid warming in the early and late Albian, subsequent cooling in the latest Albian and peak warmth at the Cenomanian–Turonian transition, are also recorded in the study area. The SST history of the Albian-Cenomanian in the eastern Tethys can be well correlated to the western Tethys (central Italy). However, the compilation of TEX 86 data indicates substantial global cooling during the Coniacian to Campanian. This study suggests that the northward drift of the Indian continent towards the equator is likely to be responsible for the sustained warmth in the Tethys Himalayas from the middle Turonian to the early Campanian. • Calcareous nannofossil biozones of Albian-early Campanian in Tethys Himalaya of southern Tibet is defined. • Based on mTI of nannofossils, long term history of Cretaceous palaeoclimate of eastern Tethys is reconstructed. • The SST history in Tethys Himalaya is controlled by changes of global palaeotemperature and regional palaeolatitude. [ABSTRACT FROM AUTHOR]