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Your search keyword '"Jia, Shi-Kun"' showing total 1 results
Start Over Author "Jia, Shi-Kun" Publication Year Range Last 3 years Publisher elsevier b.v.
1 results on '"Jia, Shi-Kun"'

1. A base-mediated dearomatization [2 + 3] annulation of 2-nitrobenzofurans with 4-hydroxycoumarins: A simple and direct synthesis of dihydrofurobenzofuran-coumarins.

Author

Du, Si-Si, Zhou, Peng, Mei, Guang-Jian, Jia, Shi-Kun, Hua, Yuan-Zhao, and Wang, Min-Can

Subjects
*COUMARINS, *NUCLEOPHILIC substitution reactions, *ANNULATION, *SINGLE crystals, *CRYSTAL structure
Abstract

A simple base-mediated dearomatization [2 + 3] annulation of 2-nitrobenzofurans with 4-hydroxycoumarins has been reported. A series of polycyclic heterocycles bearing dihydrofurobenzofuran and coumarin blocks were synthesized via Michael/nucleophilic substitution cascade reaction in moderate to excellent yields. 2-Nitrobenzothiophene and 4-hydroxyquinolin-2-one are also tolerated in this protocol. The reaction can be carried out on a gram scale. The configuration of product is confirmed by X-ray single crystal structure analysis. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2023
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