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Copyright of Revista Española de Cardiología (18855857) is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

• Brain-dedicated PET scanner detects Alzheimer's disease using the Centiloid scale. • The effectiveness of the Centiloid Scale requiring only PET images is demonstrated. • Centiloid Scale in a brain-dedicated PET can reduce the neurology burden on PET/CT. To evaluate whether the Centiloid Scale may be used to diagnose Alzheimer's Disease (AD) pathology effectively with the only use of amyloid PET imaging modality from a brain-dedicated PET scanner. This study included 26 patients with amyloid PET images with 3 different radiotracers. All patients were acquired both on a PET/CT and a brain-dedicated PET scanner (CareMiBrain, CMB), from which 4 different reconstructions were implemented. A new pipeline was proposed and used for the PET image analysis based on the original Centiloid Scale processing pipeline, but with only PET images. The Youden's Index was employed to calculate the optimal cutoffs for diagnosis and evaluated by the AUC, accuracy, precision, and recall metrics. The Centiloid Scale (CL) processing pipeline was validated with and without the use of MR images. The CL cutoffs for AD pathology diagnosis on the PET/CT and the 4 CMB reconstructions were 34.4 ± 2.2, 43.5 ± 3.5, 51.9 ± 12.5, 57.5 ± 6.8 and 41.8 ± 1.2 respectively. Overall, for these cutoffs all metrics obtained the maximum score. The Centiloid scale applied to PET images allows for AD pathology diagnosis. The CMB scanner can be used with the Centiloid scale to automatically assist in the diagnosis of AD pathology, relieving the large burden of neurodegenerative diseases on a traditional PET/CT. [ABSTRACT FROM AUTHOR]

Due to the climatic conditions in central-southern Chile, there are high heating energy consumption and PM2.5 emissions. Among the alternatives to mitigate it, the Chilean government has implemented subsidies to improve the housings envelope and to replace firewood stoves by pellet stoves and air-to-air heat pumps. Accordingly, for evaluating the effectivity of above-mentioned initiatives, this study proposes to identify the optimal solutions that minimize the energy demand, the environmental impacts, and the global costs, for social housing using different insulation materials and heating systems in four Chilean cities located in central-southern Chile. Results reveal pellet stoves with lower environmental impacts but higher global costs, while heat pumps offer an intermediate solution that can be enhanced with a greener electricity grid, but the global costs are still too high. Firewood stoves could be optimal solution depending on optimization weighting factors. The study emphasizes prioritizing housing envelope improvements in energy policies, followed by heating system enhancements. Although replacing firewood poses challenges due to costs, it is crucial for Chile's 2050 decarbonization goal. This research provides valuable insights into the complexities and potential solutions for transitioning away from firewood in Chilean social housing. • Woodstove replaced by pellet stove or heat pump reduce environmental impact by 34–45 %. • Heat pumps present global costs 34 %–88 % higher than wood stoves. • To improve the housing envelope is the first recommended public policy. • Public policies must simultaneously subsidy initial and operational cost. • Trade-off: global cost vs. environmental impacts determines optimal approach. [ABSTRACT FROM AUTHOR]