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Your search keyword '"Yao, Hui"' showing total 134 results
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134 results on '"Yao, Hui"'

47. Palatal perforation caused by Alternaria alternata infection in an immunocompetent adolescent.

Author

Chen, Junjun, Yao, Hui, Yuan, Xiaoling, Yan, Lei, Tang, Guoyao, Yan, Kepeng, and Shen, Xuemin

Subjects
*ALTERNARIA alternata, *MYCOSES, *TEENAGERS, *MYCOBACTERIAL diseases, *BONE resorption, *MUCORMYCOSIS, *THRUSH (Mouth disease)
Abstract

• Invasive fungal infections are on the rise among immunocompromised populations. • Using whole-genome sequencing, we identified a novel etiology of palatal perforation. • This novel pathomycete of palatal perforation was found in an immunocompetent adolescent. • Multidisciplinary treatment helps the prompt diagnosis and specific treatment of invasive fungal infections. Opportunistic oral mucosal fungal infection caused by Alternaria alternata is extremely rare. Herein, we present a rare palatal perforation as a result of oral infection caused by A. alternata in an immunocompetent adolescent. An 18-year-old boy, who had previously been healthy, was admitted to our institution with persistent pain in the palate for the past 12 months. Upon impression of palatal bone resorption based on computed tomography imaging and chronic granulomatous inflammation based on biopsy (hematoxylin-eosin staining), the patient was examined for commonly relevant causes such as potential tumor and Mycobacterium tuberculosis infection. All test results were inconclusive. After a thorough diagnostic investigation, an unusual fungal infection, A. alternata infection, was confirmed by next-generation sequencing and biopsy (periodic acid-Schiff staining and immunofluorescence staining). The patient underwent surgical debridement and was subjected to voriconazole treatment postoperatively for over a period of 5 months. Thus, these findings highlight the importance of considering A. alternata as a potential pathogenic factor in an etiological palatal perforation. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Prenatal alcohol exposure enhanced alcohol preference and susceptibility to PTSD in a sex-dependent manner through the synaptic HCN1 channel.

Author

Yao, Hui, Wang, Changliang, and Xia, Zhixiu

Subjects
*PRENATAL alcohol exposure, *POST-traumatic stress disorder, *EXPOSURE therapy, *PRENATAL exposure delayed effects, *PREFRONTAL cortex, *ALCOHOL
Abstract

Prenatal alcohol exposure (PAE) adversely affects the neurobiological and behavioral functions of offspring. Increasing evidence indicates that alcohol-use disorders and post-traumatic stress disorder (PTSD) commonly co-occur. Enhanced function of hyperpolarization-activated gated channel 1 (HCN1) may be involved in the pathogenesis of PTSD. This study aimed to explore the effect of PAE on fear extinction, spontaneous recovery, alcohol preference, and function of HCN1 channels in offspring of both sexes. The PAE model was established with a 20 % (m/V) ethanol solution, and offspring were treated with 0.5, 1, and 2 μg/mL ZD7288 to block the HCN1 channel. Behavioral tests were used to detect the mental state and fear of extinction of the mice. Western blot was used to detect HCN1 expression in the synaptosomes. The BDNF/TrkB-pmTOR pathway was also examined. ZD7288 administration ameliorated PAE-induced impairment of fear extinction and depression-like behavior. ZD7288 administration also alleviated PAE-induced inhibition of the HCN1 channel in the prefrontal cortex (PFC) and the BDNF/TrkB-pmTOR pathway in the hippocampus of offspring. In addition, the therapeutic effect of ZD7288 in males was better than that in females. Overall, these results suggest that PAE enhances alcohol preference and susceptibility to PTSD through synaptic HCN1 channels in the PFC. In addition, ZD7288 may be a promising candidate for preventing alcohol-associated PTSD-like syndrome, particularly in males. The effects of ZD7288 were only studied in PAE animals and not in healthy animals. • PAE enhanced alcohol preference and susceptibility to PTSD in offspring mice. • HCN channel blocker ZD7288 attenuated PAE's effects on offspring. • PAE and ZD7288 affected offspring in a sex-dependent manner. [ABSTRACT FROM AUTHOR]

Published
2023
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