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Keywords: sulfinate; sulfenylation; iodine; microwave heating; heterocycles; thiolation EN sulfinate sulfenylation iodine microwave heating heterocycles thiolation 1723 1726 4 08/18/23 20230901 NES 230901 Graph Organic sulfur compounds, especially thioethers, are prominent structural motifs in many bioactive natural products, pharmaceuticals, materials, and agrochemicals. [7] In 2018, the Song group developed a difunctionalization of an imidazopyridine by using a sodium sulfinate and iodine (Scheme 1)..[8] With the base and iodine, they obtained the sulfonylated product exclusively, whereas with iodine and a reducing agent (PPh SB 3 sb ), they obtained the sulfenylated product exclusively. However, the reaction of B 1a b with B 2a b in Et SB 2 sb O as a solvent under basic conditions at 100 °C for 20 hours gave the 3-phenylsulfonylated product B 4a b in only 50% conversion, along with 50% of the 3-iodo compound B 5 b (Table 1, entry 1). [Extracted from the article]

Aminoquinolinium salts, aminoquinazolinium salts, N, N '-bridging alkylation, amination, nucleophilic aromatic substitution An attempted I N i , I N i '-alkylation of two molecules of 4-chloro-6,7-dimethoxyquinoline ( B 2 b ) with a propyl bridge resulted in an inseparable mixture of the expected dimer B 26 b , the monosubstituted I N i -(3-halopropyl)quinolinium salts B 24 b and B 25 b , and the protonated 4-halo-6,7-dimethoxyquinolinium salt B 23 b , in addition to halogen-exchange products. Keywords: aminoquinolinium salts; aminoquinazolinium salts; N, N '-bridging alkylation; amination; nucleophilic aromatic substitution EN aminoquinolinium salts aminoquinazolinium salts N, N '-bridging alkylation amination nucleophilic aromatic substitution 1685 1688 4 08/18/23 20230901 NES 230901 Graph Most drugs available on the market, as well as pharmacologically active molecules in development, have heterocyclic pharmacophoric structures, often with quinoline or quinazoline nuclei. [Extracted from the article]

The first nucleophilic selenocyanation from selenium dioxide and malononitrile is described. This methodology produced a wide variety of selenocyanates from halides in moderate to excellent yields under mild conditions, highlighting the versatility and usefulness of this new source of nucleophilic selenocyanation. [ABSTRACT FROM AUTHOR]

A new method of deborylative selanylation using arylboronic acids and arylseleninic acids gave diaryl selenoethers and diarylselenoxide. The present approach requires only equimolar arylseleninic acid and led selectively to selenoethers or selenoxides depending on the solvent. The method is metal-free, base- or oxidant-free, efficient, and environmentally friendly. [ABSTRACT FROM AUTHOR]