1. Long-Term Outcomes of Recipients of Liver Transplants from Living Donors Treated with a Very Low-Calorie Diet.
- Author
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Wozniak, Hannah, Naimimohasses, Sara, Goto, Toru, Sapisochin, Gonzalo, Sayed, Blayne, Ghanekar, Anand, Cattral, Mark, and Selzner, Nazia
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ORGAN donors , *WEIGHT loss , *FATTY liver , *PATIENTS , *TRANSPLANTATION of organs, tissues, etc. , *LOGISTIC regression analysis , *TREATMENT effectiveness , *RETROSPECTIVE studies , *MULTIVARIATE analysis , *COMPARATIVE studies , *REDUCING diets , *LIVER transplantation - Abstract
The increasing prevalence of steatotic liver disease (SLD) in potential living donors is concerning, as it limits donor's availability amid rising demand. OPTIFAST very low-calorie diet (VLCD), a meal replacement product, effectively reduces weight and hepatic steatosis before transplantation. However, data on the outcomes of recipients of VLCD-treated donors are lacking. We conducted a single-center, retrospective study on 199 living donor liver transplant recipients at Toronto General Hospital, Canada, between January 2015 and January 2020. We compared the 1-year posttransplant outcomes between recipients who received organs from donors treated with VLCD (N = 34) for either weight loss or steatosis reduction, with those who did not require treatment (N = 165). Our analysis revealed no statistically significant differences in the rates of postoperative complications (23% vs 32.4%, p = 0.3) or intensive care unit stays (70.9% vs 70.6%, p = 1) between recipients of non-VLCD and VLCD grafts. Following adjusted multivariate logistic regression, receipt of VLCD grafts was not associated with increased hospital length of stay. In addition, one-year mortality did not differ between the two groups (4.2% non-VLCD recipients vs 2.9% VLCD recipients, p = 0.6). OPTIFAST VLCD treatment for liver donors demonstrates positive and safe outcomes in recipients, expanding the pool of potential living donors for increased organ availability. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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