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In this study, we demonstrate breakdown voltage at 1500 V of GaN on a QST power device. The high breakdown voltage and low current collapse performance can be attributed to the higher quality of GaN buffer layers grown on QST substrates. This is primarily due to the matched coefficient of thermal expansion (CTE) with GaN and the enhanced mechanical strength. Based on computer-aided design (TCAD) simulations, the strong electric-field-induced trap-assisted thermionic field emissions (TA-TFEs) in the GaN on QST could be eliminated in the GaN buffer. This demonstration showed the potential of GaN on QST, and promises well-controlled performance and reliability under high-power operation conditions. [ABSTRACT FROM AUTHOR]

Computer systems and applications generate large amounts of logs to measure and record information, which is vital to protect the systems from malicious attacks and useful for repairing faults, especially with the rapid development of distributed computing. Among various logs, the anomaly log is beneficial for operations and maintenance (O&M) personnel to locate faults and improve efficiency. In this paper, we utilize a large language model, ChatGPT, for the log parser task. We choose the BERT model, a self-supervised framework for log anomaly detection. BERT, an embedded transformer encoder, with a self-attention mechanism can better handle context-dependent tasks such as anomaly log detection. Meanwhile, it is based on the masked language model task and next sentence prediction task in the pretraining period to capture the normal log sequence pattern. The experimental results on two log datasets show that the BERT model combined with an LLM performed better than other classical models such as Deelog and Loganomaly. [ABSTRACT FROM AUTHOR]

Supercritical carbon dioxide (SCCO2) is a non-toxic and environmentally friendly fluid and has been used in polymerization reactions, processing, foaming, and plasticizing of polymers. Exploring the behavior and data of SCCO2 sorption and dissolution in polymers provides essential information for polymer applications. This study investigated the sorption and diffusion of SCCO2 into polyetherimide (PEI). The sorption and desorption processes of SCCO2 in PEI samples were measured in the temperature range from 40 to 60 °C, the pressure range from 20 to 40 MPa, and the sorption time from 0.25 to 52 h. This study used the ex situ gravimetric method under different operating conditions and applied the Fickian diffusion model to determine the mass diffusivity of SCCO2 during sorption and desorption processes into and out of PEI. The equilibrium mass gain fraction of SCCO2 into PEI was reported from 9.0 wt% (at 60 °C and 20 MPa) to 12.8 wt% (at 40 °C and 40 MPa). The sorption amount increased with the increasing SCCO2 pressure and decreased with the increasing SCCO2 temperature. This study showed the crossover phenomenon of equilibrium mass gain fraction isotherms with respect to SCCO2 density. Changes in the sorption mechanism in PEI were observed when the SCCO2 density was at approximately 840 kg/m3. This study qualitatively performed FTIR analysis during the SCCO2 desorption process. A CO2 antisymmetric stretching mode was observed near a wavenumber of 2340 cm−1. A comparison of loss modulus measurements of pure and SCCO2-treated PEI specimens showed the shifting of loss maxima. This result showed that the plasticization of PEI was achieved through the sorption process of SCCO2. [ABSTRACT FROM AUTHOR]

Bitter melon vine (an agricultural waste product with high fiber content) is difficult to treat and has caused problems in the environment. This research aims to produce biochar through low-temperature pyrolysis assisted by non-polluting steam explosion. The physical and chemical properties of the biochar were characterized using scanning electron microscopy (SEM) images, specific surface area measurements (BET), X-ray diffraction patters (XRD), elemental analysis (EA), and Fourier transform infrared spectroscopy (FTIR). Next, the adsorption mechanism of methylene blue (MB) on the steam-exploded bitter melon vine biochar pyrolyzed at 200 °C (qBC200) and the effects of adsorption time, pH, initial concentration, adsorption temperature, and adsorbent dosage on the adsorption effect were investigated. Steam explosion destroyed the dense structure of the plant, increased the number of oxygen-containing surface functional groups, and improved the adsorption performance of the material. Therefore, qBC200 more effectively adsorbed MB than untreated biochar, reaching a saturated adsorption capacity of 267.72 mg/g. The MB adsorption kinetics and isothermal adsorption process of qBC200 align with the pseudo-second-order kinetic model and Langmuir isothermal equation (monolayer adsorption), respectively. The thermodynamic results show that MB adsorbs via a spontaneous, entropy-increasing exothermic reaction. The adsorption mechanism involves electrostatic attraction, hydrogen bonding, and π–π interactions. The prepared biomass with high fiber content is a promising new material for wastewater treatment. [ABSTRACT FROM AUTHOR]

In current industries, sampling inspections of the quality of powders, such as superabsorbent polymers (SAPs) still are conducted via visual inspection. The size of samples and foreign matter are around 500 μm, making them difficult for humans to identify. An automatic foreign matter detection system for powder has been developed in the present study. The powder samples can be automatically delivered, distributed, and recycled, and images of them are captured through the hardware of the system, while the identification software of this system was developed based on diffusion adversarial representation learning (DARL). The background image is a foreign-matter-free powder image with an input image size of 1024 × 1024 × 3. Since DARL includes adversarial segmentation, a diffusion process, and synthetic image generation, the DARL model was trained using a diffusion block with the employment of a U-Net attention mechanism and a spatial-adaptation de-normalization (SPADE) layer through the adoption of a loss function from a vanilla generative adversarial network (GAN). This model was then compared with supervised models such as a fully convolutional network (FCN), U-Net, and DeepLABV3+, as well as with an unsupervised Otsu threshold segmentation. It should be noted that only 10% of the training samples were utilized for the DARL to learn and the intersection over union (IoU) of the DARL can reach up to 80.15%, which is much higher than the 59.00%, 53.47%, 49.39%, and 30.08% for the Otsu threshold segmentation, FCN, U-Net, and DeepLABV3+ models. Therefore, the performance of the model developed in the present study would not be degraded due to an insufficient number of samples containing foreign matter. In practical applications, there is no need to collect, label, and design features for a large number of foreign matter samples before using the developed system. [ABSTRACT FROM AUTHOR]

Sound source identification technology based on a microphone array has many application scenarios. The compressive beamforming method has attracted much attention due to its high accuracy and high-resolution performance. However, for the far-field measurement problem of large microphone arrays, existing methods based on fixed grids have the defect of basis mismatch. Due to the large number of grid points representing potential sound source locations, the identification accuracy of traditional grid adjustment methods also needs to be improved. To solve this problem, this paper proposes a sound source identification method based on adaptive grid splitting and refinement. First, the initial source locations are obtained through a sparse Bayesian learning framework. Then, higher-weight candidate grids are retained, and local regions near them are split and updated. During the iteration process, Green's function and the source strength obtained in the previous iteration are multiplied to get the sound pressure matrix. The robust principal component analysis model of the Gaussian mixture separates and replaces the sound pressure matrix with a low-rank matrix. The actual sound source locations are gradually approximated through the dynamically adjusted sound pressure low-rank matrix and optimized grid transfer matrix. The performance of the method is verified through numerical simulations. In addition, experiments on a standard aircraft model are conducted in a wind tunnel and speakers are installed on the model, proving that the proposed method can achieve fast, high-precision imaging of low-frequency sound sources in an extensive dynamic range at long distances. [ABSTRACT FROM AUTHOR]

Transition metal oxides (TMOs) are important anode materials in sodium-ion batteries (SIBs) due to their high theoretical capacities, abundant resources, and cost-effectiveness. However, issues such as the low conductivity and large volume variation of TMO bulk materials during the cycling process result in poor electrochemical performance. Nanosizing and compositing with carbon materials are two effective strategies to overcome these issues. In this study, spherical MnFe2O4@xC nanocomposites composed of MnFe2O4 inner cores and tunable carbon shell thicknesses were successfully prepared and utilized as anode materials for SIBs. It was found that the property of the carbon shell plays a crucial role in tuning the electrochemical performance of MnFe2O4@xC nanocomposites and an appropriate carbon shell thickness (content) leads to the optimal battery performance. Thus, compared to MnFe2O4@1C and MnFe2O4@8C, MnFe2O4@4C nanocomposite exhibits optimal electrochemical performance by releasing a reversible specific capacity of around 308 mAh·g−1 at 0.1 A·g−1 with 93% capacity retention after 100 cycles, 250 mAh·g−1 at 1.0 A g−1 with 73% capacity retention after 300 cycles in a half cell, and around 111 mAh·g−1 at 1.0 C when coupled with a Na3V2(PO4)3 (NVP) cathode in a full SIB cell. [ABSTRACT FROM AUTHOR]

In this paper, we propose a novel approach for solving two-dimensional time-fractional advection–diffusion equations, where the fractional derivative is described in the Caputo sense. The discrete scheme is constructed based on the barycentric rational interpolation collocation method and the Gauss–Legendre quadrature rule. We employ the barycentric rational interpolation collocation method to approximate the unknown function involved in the equation. Through theoretical analysis, we establish the convergence rate of the discrete scheme and show its remarkable accuracy. In addition, we give some numerical examples, to illustrate the proposed method. All the numerical results show the flexible application ability and reliability of the present method. [ABSTRACT FROM AUTHOR]

The advancement of artificial intelligence (AI) demands significant data and computational resources that have an adverse impact on the environment. To address this issue, a novel computing architecture that is both energy efficient and eco-friendly is urgently required. Edge computing has emerged as an increasingly popular solution to this problem. In this study, we explore the development history of edge computing and AI and analyze the potential of model quantization to link AI and edge computing. Our comparative analysis demonstrates that the quantization approach can effectively reduce the model's size and accelerate model inference while maintaining its functionality, thereby enabling its deployment on edge devices. This research serves as a valuable guide and reference for future advancements in edge AI. [ABSTRACT FROM AUTHOR]

This study aims to unveil correlations between wastewater microbiota and the catchment-specific population health risk, specifically alcohol abuse, with smoking and obesity as confounding factors. Our study highlights the importance of extracting human-associated microbial communities from wastewater metagenomes by excluding environmental microorganisms, due to their irrelevance to human health. After excluding environmental microbes, we observed strong associations of all three health risk factors, including alcohol abuse, smoking and obesity, with the human gut microbiome in wastewater. The linear discriminant analysis effect size (LEfSe) analysis showed Lactococcus_A, Leuconostoc, Aeromicrobium, Akkermansia, Weissella, Limosilactobacillus, Klebsiella_A, Desulfovibrio and Cloacibacillus as potential microbial biomarkers for alcoholism, after accounting for the confounding effects of smoking and obesity. Functional annotations of microorganisms linked with lower alcoholism rates are primarily related to energy metabolism and intercellular communication. Microorganisms associated with higher alcoholism rates are predominantly involved in immune regulation and cellular DNA architecture. This study highlights the need for a comprehensive exploration of different health risk factors together to identify potential associations between the wastewater microbiome and population lifestyle. [ABSTRACT FROM AUTHOR]

Path planning is one of the core issues in the autonomous navigation of an Unmanned Surface Vehicle (USV), as the accuracy of the results directly affects the safety of the USV. Hence, this paper proposes a USV path planning algorithm that integrates an improved Particle Swarm Optimisation (PSO) algorithm with a Dynamic Window Approach (DWA). Firstly, in order to advance the solution accuracy and convergence speed of the PSO algorithm, a nonlinear decreasing inertia weight and adaptive learning factors are introduced. Secondly, in order to solve the problem of long path and path non-smoothness, the fitness function of PSO is modified to consider both path length and path smoothness. Finally, the International Regulations for Preventing Collisions at Sea (COLREGS) are utilised to achieve dynamic obstacle avoidance while complying with maritime practices. Numerical cases verify that the path planned via the proposed algorithm is shorter and smoother, guaranteeing the safety of USV navigation while complying with the COLREGS. [ABSTRACT FROM AUTHOR]

Mastitis typically arises from bacterial invasion, where host cell apoptosis significantly contributes to the inflammatory response. Gram-positive bacteria predominantly utilize the virulence factor lipoteichoic acid (LTA), which frequently leads to chronic breast infections, thereby impacting dairy production and animal husbandry adversely. This study employed LTA to develop models of mastitis in cow mammary gland cells and mice. Transcriptomic analysis identified 120 mRNAs associated with endocytosis and apoptosis pathways that were enriched in the LTA-induced inflammation of the Mammary Alveolar Cells-large T antigen (MAC-T), with numerous differential proteins also concentrated in the endocytosis pathway. Notably, actin-related protein 2/3 complex subunit 3 (ARPC3), actin-related protein 2/3 complex subunit 4 (ARPC4), and the heat shock protein 70 (HSP70) are closely related. STRING analysis revealed interactions among ARPC3, ARPC4, and HSP70 with components of the apoptosis pathway. Histological and molecular biological assessments confirmed that ARPC3, ARPC4, and HSP70 were mainly localized to the cell membrane of mammary epithelial cells. ARPC3 and ARPC4 are implicated in the mechanisms of bacterial invasion and the initiation of inflammation. Compared to the control group, the expression levels of these proteins were markedly increased, alongside the significant upregulation of apoptosis-related factors. While HSP70 appears to inhibit apoptosis and alleviate inflammation, its upregulation presents novel research opportunities. In conclusion, we deduced the development mechanism of ARPC3, ARPC4, and HSP70 in breast inflammation, laying the foundation for further exploring the interaction mechanism between the actin-related protein 2/3 (ARP2/3) complex and HSP70. [ABSTRACT FROM AUTHOR]

The main active component of Polygonatum sibiricum (P. sibiricum) rhizome is Polygonatum sibiricum Polysaccharide (PsP) with antioxidant function. At present, only the mature rhizome of P. sibiricum is used to extract PsP, while the young rhizome of by-product is discarded directly as waste, resulting in significant wastage of P. sibiricum resources. We used ultrasound-assisted extraction-deep eutectic solvents (UAE-DESs) method to extract PsP of young and mature rhizomes, respectively. The extraction rate, structure composition and antioxidant ability of PsP between young and mature rhizomes were compared, so as to provide references for comprehensive utilization of P. sibiricum resources. The PsP extraction rate (33.88 ± 1.95%) of young rhizome was close to that (45.08 ± 1.92%) of mature rhizomes. The main component (PsP-2) of the PsP in young rhizome contained six kinds of monosaccharides, which belonged to acidic polysaccharides. The above characteristics of the PsP of young rhizome were similar to those of mature rhizome. The PsP of young rhizome also exhibited similar biological activity to that of the mature rhizome, which indicated even more advantages in DPPH free radical scavenging ability. The results of this study support the utility of the young rhizome, consequently helping to avoid unnecessary waste and provide reference for comprehensive utilization of P. sibiricum. [ABSTRACT FROM AUTHOR]

Research studies on the conservation genetics of endangered plants play a crucial role in establishing management plans for biodiversity conservation. Phoebe chekiangensis is a precious and scarce tree species resource in the East China region. To comprehend the origin, evolutionary history, geographical, and historical factors that has contributed to the current distribution pattern of Phoebe chekiangensis in the East China region, we conducted a phylogeographic analysis that utilized intergenic spacers of chloroplast DNA (cpDNA). We amplified and sequenced three spacer regions of cpDNA (psbC-trnS, trnL-Intro, and Ycf3) intergenic spacer regions of 306 individuals from 11 populations, encompassing the majority of its geographical range in China. Our analysis revealed a total of 11 haplotypes. The research findings show that the spacer regions of the cpDNA genetic diversity of Phoebe chekiangensis was Hd = 0.423, and the nucleotide diversity was Pi × 10−3 = 0.400. At the species level, the population differentiation index Fst = 0.25610 (p < 0.05), and the gene flow Nm = 0.73. The genetic variation between populations was 29.14%, while within populations, it was 70.86%, with the inter-population genetic variation much lower than the within-population variation. The divergence time between the genera Phoebe and Machilus was estimated to be approximately 37.87 mya (PP = 1; 95%HPD: 25.63–44.54 mya), and the crown group time of the genus Phoebe was estimated to be 21.30 mya (PP = 1; 95%HPD: 9.76–34.94 mya). The common ancestor of the 11 Phoebe chekiangensis haplotypes was 7.85 mya, while the H7, H8, and H10 haplotypes of Phoebe chekiangensis (northern region) differentiated relatively late, with a divergence time of 1.90 mya. Neutrality tests (NTs) and mismatch distribution analysis (MDA) suggest that the time frame for Phoebe chekiangensis to expand southwestward along Wuyishan was relatively short and its adaptability to the environment was low, thereby limiting the formation of new haplotypes. These results suggest that Phoebe chekiangensis exhibited greater adaptation to the northern subtropics than to the central subtropics, offering valuable insights for the conservation and utilization of germplasm resources. [ABSTRACT FROM AUTHOR]

To improve probiotics' survivability during gastrointestinal digestion and heat treatment, Lactobacillus plantarum was microencapsulated by spray-drying using Laminaria japonica polysaccharide/sodium caseinate/gelatin (LJP/SC/GE) composites. Thermogravimetry and differential scanning calorimetry results revealed that the denaturation of LJP/SC/GE microcapsules requires higher thermal energy than that of SC/GE microcapsules, and the addition of LJP may improve thermal stability. Zeta potential measurements indicated that, at low pH of the gastric fluid, the negatively charged LJP attracted the positively charged SC/GE, helping to maintain an intact microstructure without disintegration. The encapsulation efficiency of L. plantarum-loaded LJP/SC/GE microcapsules reached about 93.4%, and the survival rate was 46.9% in simulated gastric fluid (SGF) for 2 h and 96.0% in simulated intestinal fluid (SIF) for 2 h. In vitro release experiments showed that the LJP/SC/GE microcapsules could protect the viability of L. plantarum in SGF and release probiotics slowly in SIF. The cell survival of LJP/SC/GE microcapsules was significantly improved during the heat treatment compared to SC/GE microcapsules and free cells. LJP/SC/GE microcapsules can increase the survival of L. plantarum by maintaining the lactate dehydrogenase and Na+-K+-ATPase activity. Overall, this study demonstrates the great potential of LJP/SC/GE microcapsules to protect and deliver probiotics in food and pharmaceutical systems. [ABSTRACT FROM AUTHOR]

In addressing the challenges of non-standardization and limited annotation resources in Chinese marine domain texts, particularly with complex entities like long and nested entities in coral reef ecosystem-related texts, existing Named Entity Recognition (NER) methods often fail to capture deep semantic features, leading to inefficiencies and inaccuracies. This study introduces a deep learning model that integrates Bidirectional Encoder Representations from Transformers (BERT), Bidirectional Gated Recurrent Units (BiGRU), and Conditional Random Fields (CRF), enhanced by an attention mechanism, to improve the recognition of complex entity structures. The model utilizes BERT to capture context-relevant character vectors, employs BiGRU to extract global semantic features, incorporates an attention mechanism to focus on key information, and uses CRF to produce optimized label sequences. We constructed a specialized coral reef ecosystem corpus to evaluate the model's performance through a series of experiments. The results demonstrated that our model achieved an F1 score of 86.54%, significantly outperforming existing methods. The contributions of this research are threefold: (1) We designed an efficient named entity recognition framework for marine domain texts, improving the recognition of long and nested entities. (2) By introducing the attention mechanism, we enhanced the model's ability to recognize complex entity structures in coral reef ecosystem texts. (3) This work offers new tools and perspectives for marine domain knowledge graph construction and study, laying a foundation for future research. These advancements propel the development of marine domain text analysis technology and provide valuable references for related research fields. [ABSTRACT FROM AUTHOR]

Unidiameter Vertical Interpenetrating Cylindrical Surfaces (UVICS, also called T-pipe surfaces) are a type of typical complex surface that exists in facilities or equipment such as oil storage tanks and industrial pipelines. The shape and surface characteristics of a component undergoing spraying will have a significant impact on the spray flow field and the resulting coating film. In order to optimize the coating effects of complex surfaces, the Euler-Euler approach was utilized to model a spray film formation process that encompasses both a spray flow field model and a wall adhesion model. Subsequently, the influence of the geometric features, geometric dimensions, lateral air pressure of the spray gun, and spraying distance on the coating film characteristics of this kind of surface were systematically investigated. It is determined that the film thickness uniformity could be enhanced by decreasing the dimensions of the workpiece or increasing the lateral air pressure and spraying distance in an appropriate manner when spraying at the location with the most complex geometric features of UVICS. Furthermore, the optimal parameters under varying spraying conditions were identified. The experiments validated the accuracy of the numerical simulation results and demonstrated the feasibility of this simulation model. The study is of significant value in addressing the challenges associated with film formation during spraying on complex surfaces, developing a comprehensive theoretical framework for air spraying, and expanding the scope of applications for automatic spraying technology. [ABSTRACT FROM AUTHOR]

Neutron diffraction instruments offer a platform for materials science and engineering studies at extended temperature ranges far from ambient. As one of the widely used neutron sample environment types, cryogenic furnaces are usually bulky and complex, and they may need hours of beamtime overhead for installation, configuration, cooling, and sample change, etc. To reduce the overhead time and expedite experiments at the state-of-the-art high-flux neutron source, we developed a low-cost, miniature, and easy-to-use cryogenic environment (77–473 K) for in situ neutron diffraction. A travel-size mug serves for the environment where the samples sit inside. Immediate cooling and an isothermal dwell at 77 K are realized on the sample by direct contact with liquid N2 in the mug. The designed Al inserts serve as the holder of samples and heating elements, alleviate the thermal gradient, and clear neutron pathways. Both a single-sample continuous measurement and multi-sample high-throughput measurements are demonstrated in this environment. High-quality and refinable in situ neutron diffraction patterns are acquired on model materials. The results quantify the orthorhombic-to-cubic phase transformation process in LiMn2O4 and differentiate the anisotropic lattice thermal expansions and bond length evolutions between rhombohedral perovskite oxides with composition variation. [ABSTRACT FROM AUTHOR]

The objective of the pansharpening task is to integrate multispectral (MS) images with low spatial resolution (LR) and to integrate panchromatic (PAN) images with high spatial resolution (HR) to generate HRMS images. Recently, deep learning-based pansharpening methods have been widely studied. However, traditional deep learning methods lack transparency while deep unrolling methods have limited performance when using one implicit prior for HRMS images. To address this issue, we incorporate one implicit prior with a semi-implicit prior and propose a double prior deep unrolling network (DPDU-Net) for pansharpening. Specifically, we first formulate the objective function based on observation models of PAN and LRMS images and two priors of an HRMS image. In addition to the implicit prior in the image domain, we enforce the sparsity of the HRMS image in a certain multi-scale implicit space; thereby, the feature map can obtain better sparse representation ability. We optimize the proposed objective function via alternating iteration. Then, the iterative process is unrolled into an elaborate network, with each iteration corresponding to a stage of the network. We conduct both reduced-resolution and full-resolution experiments on two satellite datasets. Both visual comparisons and metric-based evaluations consistently demonstrate the superiority of the proposed DPDU-Net. [ABSTRACT FROM AUTHOR]

Five new diterpenes including four diterpenes with 1,2,3,4,4a,5,6,8a-octalin skeleton talaroacids A–D (1–4) and an isopimarane diterpenoid talaromarane A (5) were isolated from the mangrove endophytic fungus Talaromyces sp. JNQQJ-4. Their structures and absolute configurations were determined by analysis of high-resolution electrospray ionization mass spectroscopy (HRESIMS), 1D/2D Nuclear Magnetic Resonance (NMR) spectra, single-crystal X-ray diffraction, quantum chemical calculation, and electronic circular dichroism (ECD). Talaromarane A (5) contains a rare 2-oxabicyclo [3.2.1] octan moiety in isopimarane diterpenoids. In bioassays, compounds 1, 2, 4, and 5 displayed significant anti-inflammatory activities with the IC50 value from 4.59 to 21.60 μM. [ABSTRACT FROM AUTHOR]

Arc (also known as Arg3.1) is an activity-dependent immediate early gene product enriched in neuronal dendrites. Arc plays essential roles in long-term potentiation, long-term depression, and synaptic scaling. Although its mechanisms of action in these forms of synaptic plasticity are not completely well established, the activities of Arc include the remodeling of the actin cytoskeleton, the facilitation of AMPA receptor (AMPAR) endocytosis, and the regulation of the transcription of AMPAR subunits. In addition, Arc has sequence and structural similarity to retroviral Gag proteins and self-associates into virus-like particles that encapsulate mRNA and perhaps other cargo for intercellular transport. Each of these activities is likely to be influenced by Arc's reversible self-association into multiple oligomeric species. Here, we used mass photometry to show that Arc exists predominantly as monomers, dimers, and trimers at approximately 20 nM concentration in vitro. Fluorescence fluctuation spectroscopy revealed that Arc is almost exclusively present as low-order (monomer to tetramer) oligomers in the cytoplasm of living cells, over a 200 nM to 5 μM concentration range. We also confirmed that an α-helical segment in the N-terminal domain contains essential determinants of Arc's self-association. [ABSTRACT FROM AUTHOR]

According to our recent studies on hydrophobicity, this work is aimed at understanding the dependence of hydrophobic interactions on the shape of a solute's surface. It has been observed that dissolved solutes primarily affect the structure of interfacial water, which refers to the top layer of water at the interface between the solute and water. As solutes aggregate in a solution, hydrophobic interactions become closely related to the transition of water molecules from the interfacial region to the bulk water. It is inferred that hydrophobic interactions may depend on the shape of the solute surface. To enhance the strength of hydrophobic interactions, the solutes tend to aggregate, thereby minimizing their surface area-to-volume ratio. This also suggests that hydrophobic interactions may exhibit directional characteristics. Moreover, this phenomenon can be supported by calculated potential mean forces (PMFs) using molecular dynamics (MD) simulations, where different surfaces, such as convex, flat, or concave, are associated with a sphere. Furthermore, this concept can be extended to comprehend the molecular packing parameter, commonly utilized in studying the self-assembly behavior of amphiphilic molecules in aqueous solutions. [ABSTRACT FROM AUTHOR]

Cisplatin is a widely used antineoplastic drug for treating various types of cancers. However, it can cause severe side effects, such as bilateral and irreversible hearing loss, which significantly impacts quality of life. Ferroptosis, an iron-dependent form of programmed cell death, has been implicated in the pathogenesis of cisplatin-induced ototoxicity. Here, we investigated the effects of nuciferine, a natural active ingredient isolated from lotus species, on the ferroptosis of cochlear hair cells. Firstly, our results demonstrated that nuciferine can protect hair cells against RSL3-induced and cisplatin-induced damage. Secondly, nuciferine treatment reduced ferrous iron (Fe2+) overload in cochlear hair cells via inhibiting NCOA4-mediated ferritinophagy. Inhibition of ferritinophagy by knocking down Ncoa4 alleviated cisplatin-induced ototoxicity. Importantly, nuciferine treatment mitigated cochlear hair cell loss and damage to ribbon synapse, and improved mouse hearing function in an acute cisplatin-induced hearing loss model. Our findings highlight the role of NCOA4-mediated ferritinophagy in the pathogenesis of cisplatin-induced ototoxicity and provide evidence for nuciferine as a promising protective agent for treating cisplatin-induced hearing loss. [ABSTRACT FROM AUTHOR]

Copy number variation (CNV) serves as a significant source of genetic diversity in mammals and exerts substantial effects on various complex traits. Pingliang red cattle, an outstanding indigenous resource in China, possess remarkable breeding value attributed to their tender meat and superior marbling quality. However, the genetic mechanisms influencing carcass and meat quality traits in Pingliang red cattle are not well understood. We generated a comprehensive genome-wide CNV map for Pingliang red cattle using the GGP Bovine 100K SNP chip. A total of 755 copy number variable regions (CNVRs) spanning 81.03 Mb were identified, accounting for approximately 3.24% of the bovine autosomal genome. Among these, we discovered 270 potentially breed-specific CNVRs in Pingliang red cattle, including 143 gains, 73 losses, and 54 mixed events. Functional annotation analysis revealed significant associations between these specific CNVRs and important traits such as carcass and meat quality, reproduction, exterior traits, growth traits, and health traits. Additionally, our network and transcriptome analysis highlighted CACNA2D1, CYLD, UBXN2B, TG, NADK, and ITGA9 as promising candidate genes associated with carcass weight and intramuscular fat deposition. The current study presents a genome-wide CNV map in Pingliang red cattle, highlighting breed-specific CNVRs, and transcriptome findings provide valuable insights into the underlying genetic characteristics of Pingliang red cattle. These results offer potential avenues for enhancing meat quality through a targeted breeding program. [ABSTRACT FROM AUTHOR]

Fly ash was used as raw material to prepare zeolites through silicate gels, assisted by the hydrothermal method. The silicate gels could be effectively formed in a few minutes in a molten alkali environment. The zeolites could be prepared by using these silicate gels through the hydrothermal method, which realizes the transformation from useless materials to highly valuable materials. The obtained zeolites were applied to the removal of ammonium in water, achieving the highvalue utilization of fly ash. The synthesized zeolites were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectrum (EDS), thermogravimetric (TG), and Fourier transform infrared (FTIR) spectroscopy. The study on the adsorption and removal of ammonium in water shows that the adsorption of ammonium is more in line with pseudo first-order kinetics, and the adsorption mainly occurs in the first 20 min. The adsorption can reach equilibrium in 30 min, and the maximum adsorption capacity can reach 49.1 mg/g. The adsorption capacity of ammonium has the best performance at pH = 5. Furthermore, within a certain range, an increase in temperature is beneficial for the removal of ammonium. [ABSTRACT FROM AUTHOR]

TiO2-based catalysts with various surface heterostructures (0D, 1D, 2D, and 3D) have been widely researched owing to their cost-effectiveness, high stability, and environmentally friendly nature, and can be used for many applications in various fields, including hydrogen production and pollutant degradation. However, there are also many existing problems limiting their practical application, such as their large band gap and rapid electron–hole recombination rate. Owing to the abundance of recent achievements in materials science, we will summarize the recent structural engineering strategies which provide favorable photocatalytic activity enhancements, such as enhanced visible light absorption, stability, an increased charge–carrier separation rate and improved specific surface area. Among the various structural engineering methods in this review, we will introduce TiO2-based materials with different dimensional structures. Meanwhile, we also discuss recent achievements in synthesis methods and application of TiO2-based catalysts in various fields. We aim to display a comprehensive overview which can be a guide for the development of a new generation of TiO2-based catalysts according to their structural design for enhanced solar energy conversion. [ABSTRACT FROM AUTHOR]

NAC (NAM, ATAF1/2, and CUC2) transcription factors regulate plant growth and development and response to various stresses. However, there is still limited insight into the NAC family in Chimonanthus praecox. This study performed a genome-wide characterization of the NAC transcription factor family members in C. praecox. A total of 105 NAC family members were identified from the C. praecox genome. The phylogenetic tree categorized the CpNACs into nine groups and the accuracy of this classification was confirmed by the analysis results of conserved motifs, conserved domain, and gene structure. Cis-acting element analysis revealed that the promoters of CpNACs were abundant in elements responsive to various hormones and stresses, implying the functional diversity and complexity of CpNACs. Furthermore, we investigated the function of the CpNAC30. The expression level of CpNAC30 could be significantly induced by abiotic stress and the CpNAC30 was the highest expressed in mature leaves of C. praecox. Overexpression of CpNAC30 reduced salt stress tolerance of transgenic Arabidopsis. Nevertheless, the drought stress tolerance of transgenic plants was enhanced. This study lays a foundation for further understanding the function of CpNACs genes and provides insights for abiotic stress tolerance breeding of C. praecox and other woody plants. [ABSTRACT FROM AUTHOR]

Ambient particulate matter (PM) pollution is a leading environmental health threat worldwide. PM with an aerodynamic diameter ≤ 1.0 μm, also known as PM1, has been implicated in the morbidity and mortality of several cardiorespiratory and cerebrovascular diseases. However, previous studies have mostly focused on analyzing fine PM (PM2.5) associated with disease metrics, such as emergency department visits and mortality, rather than ultrafine PM, including PM1. This study aimed to evaluate the association between short-term PM1 exposure and hospital admissions (HAs) for all-cause diseases, chronic obstructive pulmonary disease (COPD), and respiratory infections (RIs), as well as the associated expenditures, using Beijing as a case study. Here, based on air pollution and hospital admission data in Beijing from 2015 to 2017, we performed a time-series analysis and meta-analysis. It was found that a 10 μg/m3 increase in the PM1 concentration significantly increased all-cause disease HAs by 0.07% (95% Confidence Interval (CI): [0, 0.14%]) in Beijing between 2015 and 2017, while the COPD and RI-related HAs were not significantly associated with short-term PM1 exposure. Meanwhile, we estimated the attributable number of HAs and hospital expenditures related to all-cause diseases. This study revealed that an average of 6644 (95% CI: [351, 12,917]) cases of HAs were attributable to ambient PM1, which was estimated to be associated with a 106 million CNY increase in hospital expenditure annually (95% CI: [5.6, 207]), accounting for 0.32% (95% CI: [0.02, 0.62%]) of the annual total expenses. The findings reported here highlight the underlying impact of ambient PM pollution on health risks and economic burden to society and indicate the need for further policy actions on public health. [ABSTRACT FROM AUTHOR]

In this research, we conducted 1 × 3 and 2 × 2 between-subject experiments to delve into the impacts of ESG assurance, the assurance presentation mode, and the depth of assured ESG indicators on the investment inclination of non-professional investors. Our empirical findings illuminated that non-professional investors exhibited a stronger inclination to invest in companies endorsed with ESG assurance compared to those lacking such endorsement. Furthermore, we observed that this inclination was heightened by presenting the ESG assurance report separately from the ESG report and by enriching the assured ESG indicators. Mediation analysis underscored that the influence of ESG assurance on the investment willingness of non-professional investors operated through its effect on their perception of companies' ESG performances. This study stands as a valuable addition to the literature on non-financial information disclosure, shedding light on the pivotal role of ESG assurance. [ABSTRACT FROM AUTHOR]

This study details the rational design and synthesis of Cu2ZnSnS4 (CZTS)-doped anatase (A) heterostructures, utilizing earth-abundant elements to enhance the efficiency of solar-driven water splitting. A one-step hydrothermal method was employed to fabricate a series of CZTS–A heterojunctions. As the concentration of titanium dioxide (TiO2) varied, the morphology of CZTS shifted from floral patterns to sheet-like structures. The resulting CZTS–A heterostructures underwent comprehensive characterization through photoelectrochemical response assessments, optical measurements, and electrochemical impedance spectroscopy analyses. Detailed photoelectrochemical (PEC) investigations demonstrated notable enhancements in photocurrent density and incident photon-to-electron conversion efficiency (IPCE). Compared to pure anatase electrodes, the optimized CZTS–A heterostructures exhibited a seven-fold increase in photocurrent density and reached a hydrogen production efficiency of 1.1%. Additionally, the maximum H2 production rate from these heterostructures was 11-times greater than that of pure anatase and 250-times higher than the original CZTS after 2 h of irradiation. These results underscore the enhanced PEC performance of CZTS–A heterostructures, highlighting their potential as highly efficient materials for solar water splitting. Integrating Cu2ZnSnS4 nanoparticles (NPs) within TiO2 (anatase) heterostructures implied new avenues for developing earth-abundant and cost-effective photocatalytic systems for renewable energy applications. [ABSTRACT FROM AUTHOR]

Background: Central metatarsal pressure is increased in patients with hallux valgus, but the pedographic outcomes after hallux valgus (HV) correction are inconclusive. No known literature has reported the pedographic outcomes after HV correction with Minimally Invasive Chevron and Akin Osteotomy (MICA). Methods: A prospective cohort of 31 feet from 25 patients with moderate-to-severe symptomatic HV but without metatarsalgia underwent MICA and was evaluated using radiographic parameters and pedographic measurements (Footscan®, RSscan International, Olen, Belgium). Data were collected preoperatively and 3 months after surgery. Results: The radiographic parameters of the hallux valgus angle, intermetatarsal angle, distal metatarsal articular angle, first metatarsal head lateral shape, and lateral sesamoid grade significantly improved after MICA. The corrected first metatarsal length was significantly shortened by 2.3 mm, with consistent second metatarsal protrusion distance, lateral Meary's angle, and calcaneal pitch angle. Max force, max pressure, cumulative force, and cumulative pressure on the central metatarsals did not show significant changes between pre- and post-operative measurements, while these parameters significantly decreased in the hallux and first metatarsal area. Conclusion: MICA effectively corrects radiographic parameters but does not reduce central metatarsal loading in patients with moderate-to-severe HV without metatarsalgia. [ABSTRACT FROM AUTHOR]

This paper presents an acoustic emission (AE) detection method for refined oil storage tanks which is aimed towards specialized places such as oil storage tanks with high explosion-proof requirements, such as cave oil tanks and buried oil tanks. The method utilizes an explosion-proof acoustic emission instrument to detect the floor of a refined oil storage tank. By calculating the time difference between the defective acoustic signal and the speed of acoustic wave transmission, a mathematical model is constructed to analyze the detected signals. An independent channel AE detection system is designed, which can store the collected data in a piece of independent explosion-proof equipment, and can analyze and process the data in a safe area after the detection, solving the problems of a short signal acquisition distance and the weak safety protection applied to traditional AE instruments. A location analysis of the AE sources is conducted on the bottom plate of the tank, evaluating its corrosion condition accurately. The consistency between the evaluation and subsequent open-tank tests confirms that using AE technology effectively captures corrosion signals from oil storage tanks' bottoms. The feasibility of carrying out online inspection under the condition of oil storage in vertical steel oil tanks was verified through a comparison with open inspections, which provided a guide for determining the inspection target and opening order of large-scale oil tanks. [ABSTRACT FROM AUTHOR]

The protection of ecological systems is currently a trending topic. Numerous countries have implemented various measures to safeguard ecosystems. Evaluating the effectiveness of regional ecological protection and cooperative conservation is of paramount importance. In this paper, Hainan Island, China, was taken as an example to construct an evaluation framework of the ecosystem change characteristics and conservation effects of different types of protected areas. In this way, the study evaluated the ecological status of important protected areas and the effects of collaborative management and control, and it discussed the changes in ecological status and protection effects. The results revealed the following. (1) Important protected areas occupy a large proportion of natural ecological space, reaching 76.33%, more than twice the proportion of ecological space on Hainan Island. In the past 20 years, the ecological space retention rate has increased by 0.57%. (2) The contribution of excellent-quality and good-quality ecosystems is the greatest, accounting for 82.65% of the whole island. In the past 20 years, the ec7osystem quality has improved in more than 80% of the areas. The proportion of excellent-quality and good-quality ecosystems is as high as 96.75% in these conservation areas, and their contribution to Hainan Island is 44.29%, while conservation areas only account for about 38%. (3) The ecosystem services of Hainan Island have improved and become stable in the past 20 years. The contribution of all types of protected areas to the ecosystem services of Hainan Island is more than 53.22%. In general, the ecological quality and service function has increased in Hainan Island, and the ecological space tends to be stable. Different types of protected areas have effectively protected various ecosystems on Hainan Island with different protection and management mechanisms. [ABSTRACT FROM AUTHOR]

Rayleigh damping is proportional to the combination of the structural mass matrix and stiffness matrix and is widely used in structural seismic analysis. The accuracy of seismic analysis of nuclear power structures directly depends on the value of the Rayleigh damping parameters. However, the stiffness component of Rayleigh damping is not included in the explicit integral, so the Rayleigh damping in the explicit and implicit integrals needs to be handled differently. LS-DYNA R11.1.0 software provides various calculation methods for the value of the Rayleigh damping parameter in the explicit integral. To investigate the influence of the value of the Rayleigh damping parameter in the explicit and implicit integrals on the results of the dynamic analysis of a nuclear power plant, the AP1000 nuclear island plant is taken as an example, and the explicit and implicit dynamic calculation are carried out respectively for the nuclear power plant, considering the soil–structure interaction. The results show that the Rayleigh damping parameter calculated by different methods in the explicit integral has a large influence on the results of seismic analysis of nuclear power plants. The mass component of Rayleigh damping in the explicit and implicit integrals takes the same value, and the stiffness component of Rayleigh damping in the explicit integrals is taken as the negative of the stiffness component in the implicit integrals. Thus, the results of the two dynamic analyses can be in good agreement. The results provide a reference for the application of Rayleigh damping in the explicit integral for the seismic analysis of nuclear power structures. [ABSTRACT FROM AUTHOR]

In the process of water displacing oil within mobile pipelines, it is common that the oil tends to accumulate at the elevated sections of inclined pipelines, leading to an issue of residual oil accumulation. In this paper, the mechanism of carrying accumulated oil out of the pipeline with water flow is discussed. Taking the residual oil layer in down-hill pipelines as a research object, a hydrodynamic model of the water-oil displacement process is established based on the theory of liquid–liquid two-phase flow and the application of the momentum transfer equation. It has been found that the use of this model can enhance the computational speed by 15% without affecting the accuracy of the calculations. Subsequently, the model is used to analyze the impact of different initial water-phase velocities, inclination angles, initial oil-phase heights, and pipeline diameters on the oil-carrying process of water flow. The results indicate that increasing the initial water-phase velocity, the angle of inclination, and the initial oil-phase height all enhance the fluctuation in the oil–water interface, making it easier for the oil phase to be carried away from the pipeline. Conversely, when all other parameters are held constant, an increase in the pipeline diameter tends to stabilize the oil–water interface, thereby making it more difficult for the residual oil to be carried away by the water flow. [ABSTRACT FROM AUTHOR]

Simple Summary: Information about the effect of curcumin supplementation on the cecum of Eimeria tenella-infected broilers is scarce. This study examined the effects of curcumin on the growth performance, antioxidant system, intestinal integrity, and microbiota structure of broilers infected with E. tenella. Thus, this study provided a reference for using curcumin as a healthy feed additive. This study was conducted to investigate the effects of dietary curcumin supplementation on growth performance, anticoccidial index, antioxidant capacity, intestinal inflammation, and cecum microbiota in broilers infected with Eimeria tenella. A total of 234 one-day-old broilers were categorized into three treatments, with six replicates per treatment containing 13 broilers each. The three treatments included the control group, Eimeria tenella group, and Eimeria tenella + curcumin (200 mg/kg) group. The feeding trial lasted for 42 days, during which the broilers were orally administered with 0.9% saline or 5 × 104 Eimeria tenella oocysts on day 14 of the study. On day 17 and day 21, one bird per replicate was selected for slaughtering. Results indicated an increased survival rate and anticoccidial index and improved productive performance in coccidia-infected broilers with curcumin supplementation. Furthermore, curcumin enhanced the serum antioxidant capacity in Eimeria tenella-infected broilers, evidenced by increased serum catalase activity (3d, 7d), as well as decreased malondialdehyde level (3d, 7d) and nitric oxide synthase activity (7d) (p < 0.05). Curcumin also improved intestinal inflammation and barrier function, evidenced by the downregulation of interleukin (IL)-1β (3d, 7d), TNF-alpha (TNF-α) (3d, 7d), and IL-2 (7d) and the up-regulated mRNA levels of claudin-1 (7d), zonula occludens (ZO-1; 3d, 7d), and occludin (3d, 7d) in the ceca of infected broilers (p < 0.05). Eimeria tenella infection significantly disrupted cecum microbial balance, but curcumin did not alleviate cecum microbial disorder in broilers infected with Eimeria tenella. Collectively, curcumin supplementation enhanced growth performance and anticoccidial index in Eimeria tenella-infected broilers via improving antioxidant ability and cecum inflammation without affecting cecum microbiota. [ABSTRACT FROM AUTHOR]

Lushan Yunwu tea (LSYWT) is a famous green tea in China. However, the effects of intercropping tea with flowering cherry on the overall aroma of tea have not been well understood. In this study, headspace solid-phase microextraction (HS-SPME) coupled with gas chromatography–mass spectrometry (GC–MS) was used for analysis. A total of 54 volatile compounds from eight chemical classes were identified in tea samples from both the intercropping and pure-tea-plantation groups. Principal component analysis (PCA), orthogonal partial least-squares discriminant analysis (OPLS-DA), and odor activity value (OAV) methods combined with sensory evaluation identified cis-jasmone, nonanal, and linalool as the key aroma compounds in the intercropping group. Benzaldehyde, α-farnesene, and methyl benzene were identified as the main volatile compounds in the flowering cherry using headspace solid-phase microextraction/gas chromatography–mass spectrometry (HS-SPME/GC–MS). These findings will enrich the research on tea aroma chemistry and offer new insights into the product development and quality improvement of LSYWT. [ABSTRACT FROM AUTHOR]

This study aimed to investigate the preventive effects of the total polyphenols from Nymphaea candida (NCTP) on LPS-induced septic acute lung injury (ALI) in mice and its mechanisms. NCTP could significantly ameliorate LPS-induced lung tissue pathological injury in mice as well as lung wet/dry ratio and MPO activities (p < 0.05). NCTP could significantly decrease the blood leukocyte, neutrophil, monocyte, basophil, and eosinophil amounts and LPS contents in ALI mice compared with the model group (p < 0.05), improving lymphocyte amounts (p < 0.05). Moreover, compared with the model group, NCTP could decrease lung tissue TNF-α, IL-6, and IL-1β levels (p < 0.05) and downregulate the protein expression of TLR4, MyD88, TRAF6, IKKβ, IκB-α, p-IκB-α, NF-κB p65, p-NF-κB p65, NLRP3, ASC, and Caspase1 in lung tissues (p < 0.05). Furthermore, NCTP could inhibit ileum histopathological injuries, restoring the ileum tight junctions by increasing the expression of ZO-1 and occludin. Simultaneously, NCTP could reverse the gut microbiota disorder, restore the diversity of gut microbiota, increase the relative abundance of Clostridiales and Lachnospiraceae, and enhance the content of SCFAs (acetic acid, propionic acid, and butyric acid) in feces. These results suggested that NCTP has preventive effects on septic ALI, and its mechanism is related to the regulation of gut microbiota, SCFA metabolism, and the TLR-4/NF-κB and NLRP3 pathways. [ABSTRACT FROM AUTHOR]

Recent advancements in computational performance and medical simulation technology have made significant strides, particularly in predictive diagnosis. This study focuses on the blood flow simulation reduced-order models, which provide swift and cost-effective solutions for complex vascular systems, positioning them as practical alternatives to 3D simulations in resource-limited medical settings. The paper introduces a visualization platform for patient-specific and image-based 1D–0D simulations. This platform covers the entire workflow, from modeling to dynamic 3D visualization of simulation results. Two case studies on, respectively, carotid stenosis and arterial remodeling demonstrate its utility in blood flow simulation applications. [ABSTRACT FROM AUTHOR]

Hemophilia A (HA) is a common X-linked recessive hereditary bleeding disorder. Coagulation factor VIII (FVIII) is insufficient in patients with HA due to the mutations in the F8 gene. The restoration of plasma levels of FVIII via both recombinant B-domain-deleted FVIII (BDD-FVIII) and B-domain-deleted F8 (BDDF8) transgenes was proven to be helpful. FVIII-Padua is a 23.4 kb tandem repeat mutation in the F8 associated with a high F8 gene expression and thrombogenesis. Here we screened a core enhancer element in FVIII-Padua for improving the F8 expression. In detail, we identified a 400 bp efficient enhancer element, C400, in FVIII-Padua for the first time. The core enhancer C400 extensively improved the transcription of BDDF8 driven by human elongation factor-1 alpha in HepG2, HeLa, HEK-293T and induced pluripotent stem cells (iPSCs) with different genetic backgrounds, as well as iPSCs-derived endothelial progenitor cells (iEPCs) and iPSCs-derived mesenchymal stem cells (iMSCs). The expression of FVIII protein was increased by C400, especially in iEPCs. Our research provides a novel molecular target to enhance expression of FVIII protein, which has scientific value and application prospects in both viral and nonviral HA gene therapy strategies. [ABSTRACT FROM AUTHOR]

The aim of this study was to investigate targets through which Gualou Xiebai Banxia decoction aids in treating myocardial infarction (MI) using network pharmacology in combination with molecular docking. The principal active ingredients of Gualou Xiebai Banxia decoction were identified from the TCMSP database using the criteria of drug-likeness ≥30% and oral bioavailability ≥0.18. Interactions and pathway enrichment were investigated using protein–protein interaction (PPI) networks and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, respectively. Active component structures were docked with those of potential protein targets using AutoDock molecular docking relative softwares. HIF1A was of particular interest as it was identified by the PPI network, GO and KEGG pathway enrichment analyses. In conclusion, the use of network pharmacology prediction and molecular docking assessments provides further information on the active components and mechanisms of action Gualou Xiebai Banxia decoction. [ABSTRACT FROM AUTHOR]

With the rapid growth and development of urban areas, the economy has often been prioritized at the expense of the environment and ecological systems. However, it is essential to delve deeper into the relationship between the economy and the ecological environment. Therefore, this study introduces a comprehensive evaluation system that encompasses economic, ecological, and environmental factors in the Beijing–Tianjin–Hebei urban agglomeration in China. The Criteria Importance Through Inter-criteria Correlation (CRITIC) method is utilized to determine the weights of various indicators, and coupling as well as coupling coordination models are employed to investigate the spatiotemporal trends and interrelationships of the three factors. The results indicate that the economic development index has displayed a consistent uptrend since 2000, with the economic development index from 2015–2020 increasing by approximately four times compared to 2000–2005. The ecological status index has also increased in the last five years, with a rise of about 0.05 from 2015–2020 compared to 2000–2005. The environmental status index has fluctuated but generally increased, with a rise of approximately 5.6 times from 2015–2020 compared to 2000–2005. The coupling degree of the Beijing–Tianjin–Hebei urban agglomeration is relatively high, with intense coupling from 2005–2020, and moderate coupling from 2000–2005. Furthermore, the coupling coordination has continuously improved from mild maladjustment to barely coordinated from 2000 to 2020, indicating the enhancement of the coupling coordination of the three factors. It is crucial to acknowledge that there exists spatial heterogeneity in both the coupling degree and coupling coordination degree. This heterogeneity stems from the uneven progress in economic development, ecological conditions, and environmental status across various cities. Additional endeavors are required to foster the harmonized advancement of these factors across the entire region. [ABSTRACT FROM AUTHOR]

In this work, a fluorescent complex [Zn(NTD)2(DTP)2(H2O)2]·(H2O)0.8 (Complex Zn), (H2NTD = 1,4-naphthalenedicarboxylic acid and DTP = 3,5-di(1,2,4-triazol-1-yl)pyridine) was synthesized. The fluorescent complex was characterized by single-crystal X-ray diffraction, powder X-ray diffraction, and thermogravimetric, elemental, infrared spectroscopy, and fluorescence analyses. In the fluorescence sensing tests, Complex Zn exhibited excellent fluorescence quenching efficiency towards Fe3+, MnO4−, Cr2O72−, nitrofurantoin, and imidacloprid in aqueous media. A mechanism investigation suggested that the fluorescence quenching caused by the quenchers toward the sensor was due to the inner filter effect and the fluorescence resonance energy transfer effect in the fluorescent sensing process. [ABSTRACT FROM AUTHOR]

The advancement of exosome studies has positioned engineered exosomes as crucial biomaterials for the development of advanced drug delivery systems. This study focuses on developing a hybrid exosome system by fusing mesenchymal stem cells (MSCs) exosomes with folate-targeted liposomes. The aim was to improve the drug loading capacity and target modification of exosome nanocarriers for delivering the first-line chemotherapy drug paclitaxel (PTX) and its effectiveness was assessed through cellular uptake studies to evaluate its ability to deliver drugs to tumor cells in vitro. Additionally, in vivo experiments were conducted using a CT26 tumor-bearing mouse model to assess the therapeutic efficacy of hybrid exosomes loaded with PTX (ELP). Cellular uptake studies demonstrated that ELP exhibited superior drug delivery capabilities to tumor cells in vitro. Moreover, in vivo experiments revealed that ELP significantly suppressed tumor growth in the CT26 tumor-bearing mouse model. Notably, for the first time, we examined the tumor microenvironment following intratumoral administration of ELP. We observed that ELP treatment activated CD4+ and CD8+ T cells, reduced the expression of M2 type tumor-associated macrophages (TAMs), polarized TAMs towards the M1 type, and decreased regulatory T cells (Tregs). Our research highlights the considerable therapeutic efficacy of ELP and its promising potential for future application in cancer therapy. The development of hybrid exosomes presents an innovative approach to enhance drug delivery and modulate the tumor microenvironment, offering exciting prospects for effective cancer treatment strategies. [ABSTRACT FROM AUTHOR]

This study was performed to investigate the effects of structural nonlinearity and large deformations on the aeroelastic loads of flexible wind turbine blades. First, a blade structural analysis model was established using the geometrically exact beam (GEB) theory. Subsequently, the blade element momentum (BEM) theory was corrected using the geometrically exact method leading to the development of a geometrically exact blade element momentum (GE-BEM) model. The results from the GE-BEM model indicated that flapwise deformations always reduce blade fatigue loads, while torsional deformations decrease fatigue loads under low wind speeds but increase them under high wind speeds. Finally, the linear Euler–Bernoulli beam and the GEB were compared to explore the influence of geometric nonlinearity on the blade aeroelastic loads, which revealed that the Euler beam model underestimates the blade loads. The simulations that used the GEB model produced torsional root twist fatigue loads that were 57.49% greater than those generated when the Euler beam model was used. Furthermore, the flapwise bending moment fatigue loads at the root were 8.24% greater than those obtained by the Euler beam model. The smallest discrepancy between the results of the two models was 7.26%, and it corresponded to the edgewise fatigue load. [ABSTRACT FROM AUTHOR]

A new kind of modified emulsified bitumen used to plug a microcrack was studied. The sizes of high-temperature emulsified bitumen were fit for the sizes of the microcrack, which were approved by the scanning electron microscope and laser particle size analyzer. Some tests have been designed to demonstrate that the polymer could be used to promote the softening point of modified asphalt, and the high-temperature emulsified bitumen has also shown an excellent performance in terms of static filtration, the viscous coefficient, and extreme pressure lubrication, as well as to inhibit ting shale expansion. The permeability recovery could reach 88.26%, which meets the specification requirements. The mud cake, which was formed by high-temperature emulsified bitumen as an additive, was thin, tough, and dense, which was proved by the scanning electron microscope. The process used to obtain this additive was simple, and the performance of the plugging microfracture was excellent, so this kind of plugging agent could have a better application future. [ABSTRACT FROM AUTHOR]

The use of renewable energy for food and vegetable production is a potential sustainable method to reduce fossil energy consumption. Chinese solar greenhouses (CSGs) are horticultural facility buildings in the northern hemisphere that use solar energy to produce off-season vegetables in winter. The north wall heat storage and release capacity of CSG has a significant impact on the indoor thermal–humidity environment. However, common traditional solar greenhouses commonly have problems such as insufficient heat storage and release, thick temperature stability zones inside the walls, and inability to dynamically regulate the entire greenhouse environment. Therefore, a novel active–passive heat storage wall system (APHSWS) incorporating phase change materials has been developed to promote the thermal performance of the CSG and its internal temperature of the thermal storage wall in this paper. Through experimental and simulation methods, the heat storage and release of the APHSWS and its impact on the greenhouse environment are investigated. The findings indicate that the APHSWS has increased the wall heat storage and release capacity, compared to the ordinary greenhouse without the APHSWS, in three typical weather conditions in winter (i.e., sunny, overcast, and cloudy); the average temperature of greenhouse with the APHSWS has increased in indoor air temperature, wall surface temperature, and soil surface temperatures of 1.58–6.06 °C, 2.71–6.58 °C, 0.91–6.39 °C, respectively; and during the experiment, the greenhouse with the APHSWS has a monthly average daily effective accumulated temperature of 1.39 times, 1.18 times, 0.60 times, and 0.20 times that of the ordinary greenhouse without the APHSWS from December to March of the next year, respectively. Under typical sunny conditions, the greenhouse wall heat storage capacity increased by 1.59–2.44 MJ/m2 and the heat release capacity increased by 0.97–1.17 MJ/m2. At the direction of wall thickness, the temperature at each point inside the wall with the APHSWS is always higher than that of ordinary wall without the APHSWS. In addition, the operating cost of the APHSWS in winter is analyzed. [ABSTRACT FROM AUTHOR]