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The article aimed to show the fundamental possibility of constructing a computational digital twin of the acoustic tomograph within the framework of a unified physics–mathematical model based on the Navier–Stokes equations. The authors suggested that the size of the modeling area is quite small, sound waves are waves of "small" disturbance, and given that a person consists of more than 60% water, human organs can be modeled using a liquid model, taking into account their density. During numerical experiments, we obtained the pressure registered in the receivers that are located on the side walls of the tomograph. The differences in pressure values are shown depending on the configuration of inclusions in the mannequin imitating internal organs. The results show that the developed technology can be used to probe the human body in medical acoustic tomographs and determine the acoustic parameters of the human body to detect neoplasms. [ABSTRACT FROM AUTHOR]

In this paper, we consider the Gelfand–Levitan–Marchenko–Krein approach. It is used for solving a variety of inverse problems, like inverse scattering or inverse problems for wave-type equations in both spectral and dynamic formulations. The approach is based on a reduction of the problem to the set of integral equations. While it is used in a wide range of applications, one of the most famous parts of the approach is given via the inverse scattering method, which utilizes solving the inverse problem for integrating the nonlinear Schrodinger equation. In this work, we present a short historical review that reflects the development of the approach, provide the variations of the method for 1D and 2D problems and consider some aspects of numerical solutions of the corresponding integral equations. [ABSTRACT FROM AUTHOR]

This paper considers a model for the accumulation of mutations in a population of mice with a weakened function of polymerases responsible for correcting DNA copying errors during cell division. The model uses the results of the experiment published by Japanese scientists, which contain data on the accumulation of phenotypic differences in three isolated groups of laboratory mice. We have developed a model for the accumulation of negative mutations. Since the accumulation of phenotypic differences in each of the three groups of mice occurred in its own way, we assumed that these differences were associated with genotypic differences in the zeroth generation and set the inverse problem of determining the initial distribution of these differences. Additional information for solving the inverse problem was a set of experimental data on the number of mutant lines and the number of individuals in each group of mice. The results obtained confirmed our assumption. [ABSTRACT FROM AUTHOR]

We consider the coefficient inverse problem for the 2D acoustic equation. The problem is recovering the speed of sound in the medium (which depends only on the depth) and the density (function of both variables). We describe the method, based on the Gelfand–Levitan–Krein approach, which allows us to obtain both functions by solving two sets of integral equations. The main advantage of the proposed approach is that the method does not use the multiple solution of direct problems, and thus has quite low CPU time requirements. We also consider the variation of the method for the 1D case, where the variation of the wave equation is considered. We illustrate the results with numerical experiments in the 1D and 2D case and study the efficiency and stability of the approach. [ABSTRACT FROM AUTHOR]

A problem of modeling radiation patterns of wave sources in two-dimensional acoustic tomography is considered. Each source has its own radiation patterns, and their modeling will be used to improve the solvability of inverse problems of recovering the acoustic parameters of human soft tissues and come closer to building a digital twin of acoustic tomography. The problem is considered as a control problem of the right side for the velocities by spatial variables. Two statements are investigated—control by time or space functions. A numerical solution method is implemented. The results of numerical calculations are presented. [ABSTRACT FROM AUTHOR]

The work continues a series of articles devoted to the peculiarities of solving coefficient inverse problems for nonlinear singularly perturbed equations of the reaction-diffusion-advection-type with data on the position of the reaction front. In this paper, we place the emphasis on some problems of the numerical solving process. One of the approaches to solving inverse problems of the class under consideration is the use of methods of asymptotic analysis. These methods, under certain conditions, make it possible to construct the so-called reduced formulation of the inverse problem. Usually, a differential equation in this formulation has a lower dimension/order with respect to the differential equation, which is included in the full statement of the inverse problem. In this paper, we consider an example that leads to a reduced formulation of the problem, the solving of which is no less a time-consuming procedure in comparison with the numerical solving of the problem in the full statement. In particular, to obtain an approximate numerical solution, one has to use the methods of the numerical diagnostics of the solution's blow-up. Thus, it is demonstrated that the possibility of constructing a reduced formulation of the inverse problem does not guarantee its more efficient solving. Moreover, the possibility of constructing a reduced formulation of the problem does not guarantee the existence of an approximate solution that is qualitatively comparable to the true one. In previous works of the authors, it was shown that an acceptable approximate solution can be obtained only for sufficiently small values of the singular parameter included in the full statement of the problem. However, the question of how to proceed if the singular parameter is not small enough remains open. The work also gives an answer to this question. [ABSTRACT FROM AUTHOR]