1. Dissecting autoimmune encephalitis through the lens of intrathecal B cells.
- Author
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Iversen, Rasmus and Sollid, Ludvig M.
- Subjects
- *
B cells , *T cells , *B cell receptors , *T cell receptors , *ENCEPHALITIS , *PLASMA cells , *REGULATORY T cells - Abstract
The article explores autoimmune encephalitis, a condition where the immune system attacks the brain. It emphasizes the role of B cells in the development of autoantibodies, which are responsible for the disease. The authors studied immune cells from patients with anti-LGI1 and anti-CASPR2 encephalitis and found an abundance of plasma cells that produce the autoantibodies. They also discuss the interaction between T cells and B cells in the activation and expansion of B cells. The article suggests that B cells may be activated outside of the central nervous system and cross the blood-brain barrier to produce autoantibodies. It mentions the potential for B cell-targeted therapies in treating autoimmune diseases, but the specific antigens recognized by T cells in autoimmune encephalitis remain unknown. [Extracted from the article]
- Published
- 2024
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