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Your search keyword '"Manfred T. Reetz"' showing total 1 results
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1. Rational enzyme design for enabling biocatalytic Baldwin cyclization and asymmetric synthesis of chiral heterocycles

Author

Jun-Kuan Li, Ge Qu, Xu Li, Yuchen Tian, Chengsen Cui, Fa-Guang Zhang, Wuyuan Zhang, Jun-An Ma, Manfred T. Reetz, and Zhoutong Sun

Subjects
Science
Abstract

Chiral heterocyclic compounds are privileged structures in medicinal chemistry. Here, the authors report an in silico strategy for the enzymatic synthesis of pharmaceutically significant chiral N- and O-heterocycles via Baldwin cyclization of hydroxy- and amino-substituted epoxides and oxetanes using epoxide hydrolase mutants.

Published
2022
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