1. How tumor stiffness alters immune cell behavior to escape destruction.
- Subjects
CYTOTOXIC T cells - Abstract
Immunotherapy is a type of cancer treatment that uses the body's immune system to fight cancer cells. However, some patients with certain types of tumors do not respond well to immunotherapy, and researchers believe that tumor-associated fibrosis may be a contributing factor. Tumor-associated fibrosis is the formation of a thick layer of fibrous collagen around the tumor, which acts as a barrier to immune cells that can attack the tumor. In a recent study focused on breast cancer, researchers found that immune cells called tumor-associated macrophages respond to the physical properties of fibrosis by producing substances that suppress the anti-tumor function of other immune cells. These findings highlight the importance of environmental factors, such as tissue stiffness and metabolic challenges, in regulating immune responses in cancer and may help in the development of new strategies to improve immunotherapy for cancer patients. [Extracted from the article]
- Published
- 2024