68 results
Search Results
2. SARS-CoV-2, fertility and assisted reproduction.
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Ata, Baris, Vermeulen, Nathalie, Mocanu, Edgar, Gianaroli, Luca, Lundin, Kersti, Rautakallio-Hokkanen, Satu, Tapanainen, Juha S, and Veiga, Anna
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REPRODUCTIVE technology ,MEDICAL personnel ,HUMAN reproductive technology ,SARS-CoV-2 ,SEXUALLY transmitted diseases ,FERTILITY clinics ,MAYER-Rokitansky-Kuster-Hauser syndrome ,FLUID intelligence - Abstract
Background: In 2020, SARS-CoV-2 and the COVID-19 pandemic had a huge impact on the access to and provision of ART treatments. Gradually, knowledge of the virus and its transmission has become available, allowing ART activities to resume. Still, questions on the impact of the virus on human gametes and fertility remain.Objective and Rationale: This article summarizes published data, aiming to clarify the impact of SARS-CoV-2 and the COVID-19 disease on human fertility and assisted reproduction, as well as the impact of vaccination, and from this, provide answers to questions that are relevant for people contemplating pregnancy and for health care professionals.Search Methods: PUBMED/MEDLINE and the WHO COVID-19 database were searched from inception to 5 October 2022 with search terms focusing on 'SARS-CoV-2' and gametes, embryos, reproductive function, fertility and ART. Non-English studies and papers published prior to 2020 were excluded, as well as reviews and non-peer reviewed publications. Full papers were assessed for relevance and quality, where feasible.Outcomes: From the 148 papers included, the following observations were made. The SARS-CoV-2-binding proteins, angiotensin-converting enzyme 2 (ACE2) and type II transmembrane serine protease (TMPRSS2), are expressed in the testis, but co-expression remains to be proven. There is some evidence of SARS-CoV-2 RNA in the ejaculate of COVID-19 patients with severe disease, but not in those with mild/moderate disease. SARS-CoV-2 infection can impair spermatogenesis, but this seems to resolve after one spermatogenic cycle. Testosterone levels seem to be lower during and after COVID-19, but long-term data are lacking; disease severity may be associated with testosterone levels. COVID-19 cannot be considered a sexually transmitted disease. There is no co-expression of ACE2 and TMPRSS2 in the myometrium, uterus, ovaries or fallopian tubes. Oocytes seem to have the receptors and protease machinery to be susceptible to SARS-CoV-2 infection; however, viral RNA in oocytes has not been detected so far. Women contemplating pregnancy following COVID-19 may benefit from screening for thyroid dysfunction. There is a possible (transient) impact of COVID-19 on menstrual patterns. Embryos, and particularly late blastocysts, seem to have the machinery to be susceptible to SARS-CoV-2 infection. Most studies have not reported a significant impact of COVID-19 on ovarian reserve, ovarian function or follicular fluid parameters. Previous asymptomatic or mild SARS-CoV-2 infection in females does not seem to negatively affect laboratory and clinical outcomes of ART. There are no data on the minimum required interval, if any, between COVID-19 recovery and ART. There is no evidence of a negative effect of SARS-CoV-2 vaccination on semen parameters or spermatogenesis, ovarian function, ovarian reserve or folliculogenesis. A transient effect on the menstrual cycle has been documented. Despite concerns, cross reactivity between anti-SARS-CoV-2 spike protein antibodies and Syncytin-1, an essential protein in human implantation, is absent. There is no influence of mRNA SARS-CoV-2 vaccine on patients' performance during their immediate subsequent ART cycle. Pregnancy rates post-vaccination are similar to those in unvaccinated patients.Wider Implications: This review highlights existing knowledge on the impact of SARS-CoV-2 infection or COVID-19 on fertility and assisted reproduction, but also identifies gaps and offers suggestions for future research. The knowledge presented should help to provide evidence-based advice for practitioners and couples contemplating pregnancy alike, facilitating informed decision-making in an environment of significant emotional turmoil. [ABSTRACT FROM AUTHOR]- Published
- 2023
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3. Vaccination policy and mortality from COVID-19 in the European Union.
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Agostini, Eleonora, Bloise, Francesco, and Tancioni, Massimiliano
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VACCINATION policies ,COVID-19 ,MORTALITY ,MACHINE learning ,COVID-19 vaccines - Abstract
This paper estimates the dynamic effect of vaccination on mortality from COVID-19 using weekly data from 26 European Union countries during 2021. Our analysis relies on the double machine learning method to control for multiple confounders, including nonpharmaceutical interventions, climate variables, mobility factors, variants of concern, country- and week-specific shocks. In our baseline specification, we show that a 10 percentage point increase in cumulative doses per hundred inhabitants averts 5.08 COVID-19 deaths per million inhabitants at the eight-week horizon and 26.41 deaths in the eight-week time window considered. The average reduction in mortality in this window is close to 50%. Further estimates reveal that the effect of doses administered to adults aged 18–59 does not statistically differ from that of doses received by people aged 60 and over. Finally, vaccine-specific estimates document that mRNA-1273 (Moderna) and Vaxzevria (AstraZeneca) are more cost-effective in saving lives than Comirnaty (Pfizer), while we are unable to demonstrate any effect of Ad26.COV2.S (Johnson & Johnson). [ABSTRACT FROM AUTHOR]
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- 2024
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4. Taking Risks to Protect Others—Pediatric Vaccination and Moral Responsibility.
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Fahlquist, Jessica Nihlén
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RESPONSIBILITY ,RISK-taking behavior ,VACCINATION of children ,VACCINATION ,COVID-19 pandemic ,COVID-19 - Abstract
The COVID-19 pandemic during 2020–2022 raised ethical questions concerning the balance between individual autonomy and the protection of the population, vulnerable individuals and the healthcare system. Pediatric COVID-19 vaccination differs from, for example, measles vaccination in that children were not as severely affected. The main question concerning pediatric vaccination has been whether the autonomy of parents outweighs the protection of the population. When children are seen as mature enough to be granted autonomy, questions arise about whether they have the right to decline vaccination and who should make the decision when parents disagree with each other and/or the child. In this paper, I argue that children should be encouraged to not only take responsibility for themselves, but for others. The discussion of pediatric vaccination in cases where this kind of risk–benefit ratio exists extends beyond the 2020–2022 pandemic. The pandemic entailed a question that is crucial for the future of public health as a global problem, that is, to what extent children should be seen as responsible decision-makers who are capable of contributing to its management and potential solution. I conclude that society should encourage children to cultivate such responsibility, conceived as a virtue, in the context of public health. [ABSTRACT FROM AUTHOR]
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- 2023
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5. COVID-19 vaccination certificate (CVC) for ASEAN: the way forward?
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Corpuz, Jeff Clyde G
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COVID-19 ,COVID-19 vaccines ,CERTIFICATION ,COVID-19 pandemic - Abstract
The emergence of coronavirus disease-2019 (COVID-19) pandemic has stimulated governments to an extensive discussion on the necessity of COVID-19 vaccination certificate (CVC) to help monitor and manage the rollout of vaccinations and revive the economy. A recent correspondence highlighted the ethical issues concerning COVID-19 diagnostic test results and vaccination certificates. This paper highlights the potential benefits and harms of implementing CVC in the ASEAN region. [ABSTRACT FROM AUTHOR]
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- 2022
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6. New insights of antineutrophil cytoplasmic antibody-associated vasculitis from the perspective of COVID-19 vaccination.
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Yang, Yang, Xiong, Yi, and Xu, Gaosi
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COVID-19 vaccines , *COVID-19 , *ANTINEUTROPHIL cytoplasmic antibodies , *ADENOVIRUS diseases , *VASCULITIS , *COVID-19 pandemic - Abstract
Summary: The occurrence of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) has been reported since the coronavirus disease 2019 (COVID-19) vaccination, but whether there is a causal relationship or coincidence remains to be verified. We combined the term COVID-19 vaccination with each word of AAV to search for case reports and case series published in PubMed, EMBASE, and Web of Science databases before 13 March 2023. A total of 56 patients who developed AAV after COVID-19 vaccination were identified from 44 research centers. Of the 56 subjects, 43 (76.7%) were vaccinated with the mRNA vaccine, followed by the adenovirus vaccine (14.3%) and inactivated vaccine (9.0%) (P = 0.015). Compared with relapsed AAV, new-onset AAV patients had at least two other diseases previously (P < 0.001). Twenty-five (44.6%) patients presented symptoms after the first injection, and the medium onset time was 12 (1–77) days, while Twenty-eight (50.0%) patients developed symptoms after the second dose, and their medium period was 14 (1–60) days. Forty-four (78.5%) patients achieved remission after immunosuppressive agents, plasma exchange, and hemodialysis. One (1.8%) patient died from progressive respiratory failure and nine (16.1%) did not recover, leaving five patients permanently dependent on hemodialysis. Pathogenic ANCA may be activated by enhanced immune response and epitope spreading after COVID-19 vaccination and induced the occurrence of AAV, especially in genetically susceptible populations. The occurrence of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) has been reported since the coronavirus disease 2019 (COVID-19) vaccination, but whether there is a causal relationship or coincidence remains to be verified. This paper explores the occurrence of AAV, especially in genetically susceptible populations. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Disentangling the effect of measures, variants, and vaccines on SARS-CoV-2 infections in England: a dynamic intensity model.
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Boldea, Otilia, Cornea-Madeira, Adriana, and Madeira, João
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COVID-19 vaccines ,DYNAMIC models ,BOOSTER vaccines ,INFECTION ,VACCINATION ,HOSPITAL care of children - Abstract
In this paper, we estimate the path of daily SARS-CoV-2 infections in England from the beginning of the pandemic until the end of 2021. We employ a dynamic intensity model, where the mean intensity conditional on the past depends both on past intensity of infections and past realized infections. The model parameters are time-varying, and we employ a multiplicative specification along with logistic transition functions to disentangle the time-varying effects of nonpharmaceutical policy interventions, of different variants, and of protection (waning) of vaccines/boosters. Our model results indicate that earlier interventions and vaccinations are key to containing an infection wave. We consider several scenarios that account for more infectious variants and different protection levels of vaccines/boosters. These scenarios suggest that, as vaccine protection wanes, containing a new wave in infections and an associated increase in hospitalizations in the near future may require further booster campaigns and/or nonpharmaceutical interventions. [ABSTRACT FROM AUTHOR]
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- 2023
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8. Are we allowed to visit now? Concerns and issues surrounding vaccination and infection risks in UK care homes during COVID-19.
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Giebel, Clarissa, Hanna, Kerry, Cannon, Jacqueline, Marlow, Paul, Tetlow, Hilary, Mason, Stephen, Shenton, Justine, Rajagopal, Manoj, and Gabbay, Mark
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VISITING the sick ,COVID-19 ,COVID-19 vaccines ,HOME care services ,RESEARCH methodology ,INTERVIEWING ,QUALITATIVE research ,DEMENTIA ,THEMATIC analysis ,DATA analysis ,LONGITUDINAL method - Abstract
Background vaccination uptake in the UK and increased care home testing are likely affecting care home visitation. With scant scientific evidence to date, the aim of this longitudinal qualitative study was to explore the impact of both (vaccination and testing) on the conduct and experiences of care home visits. Methods family carers of care home residents with dementia and care home staff from across the UK took part in baseline (October/November 2020) and follow-up interviews (March 2021). Public advisers were involved in all elements of the research. Data were analysed using thematic analysis. Results across 62 baseline and follow-up interviews with family carers (n = 26; 11) and care home staff (n = 16; 9), five core themes were developed: delayed and inconsistent offers of face-to-face visits; procedures and facilitation of visits; variable uptake of the COVID-19 vaccine; misinformation, education and free choice; frustration and anger among family carers. The variable uptake in staff, compared to family carers, was a key factor seemingly influencing visitation, with a lack of clear guidance leading care homes to implement infection control measures and visitation rights differently. Conclusions we make five recommendations in this paper to enable improved care home visitation in the ongoing, and in future, pandemics. Visits need to be enabled and any changes to visiting rights must be used as a last resort, reviewed regularly in consultation with residents and carers and restored as soon as possible as a top priority, whilst more education needs to be provided surrounding vaccination for care home staff. [ABSTRACT FROM AUTHOR]
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- 2022
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9. Correspondence Harnessing strategic policy on COVID-19 vaccination rollout in the Philippines.
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Cardenas, Nicky C
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HEALTH policy ,VACCINATION ,STRATEGIC planning ,COVID-19 ,IMMUNIZATION ,HUMAN rights ,COVID-19 vaccines ,ATTITUDE (Psychology) ,PUBLIC health ,MEDICAL protocols ,GOVERNMENT agencies ,DECISION making ,GOVERNMENT aid - Abstract
The article discusses COVID-19 vaccination rollout strategies developed and disseminated the World Health Organization referencing recent correspondence of Cordero. Topics discussed include role of government in COVID-19 vaccines procurement and rollout which is to be proactive, transparent and efficient; analyzes the urgent need to harness the Philippine government's strategic policy-making; and efficient implementation of COVID-19 vaccination rollout in Philippines.
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- 2022
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10. Disparities in Coronavirus Disease 2019 Clinical Outcomes and Vaccination Coverage Among Migrants With Human Immunodeficiency Virus in the PISCIS Cohort: A Population-Based Propensity Score–Matched Analysis.
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Nomah, Daniel K, Díaz, Yesika, Bruguera, Andreu, Moreno-Fornés, Sergio, Aceiton, Jordi, Reyes-Urueña, Juliana, Llibre, Josep M, Falcó, Vicenç, Imaz, Arkaitz, Fanjul, Francisco Javier, Peraire, Joaquim, Deig, Elisabet, Domingo, Pere, Inciarte, Alexy, Casabona, Jordi, and Miró, José M
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SARS-CoV-2 ,COVID-19 ,HIV ,VACCINATION coverage ,CORONAVIRUS diseases - Abstract
Background Coronavirus disease 2019 (COVID-19) disproportionately affects migrants and ethnic minorities, including those with human immunodeficiency virus (HIV). Comprehensive studies are needed to understand the impact and risk factors. Methods Using data from the PISCIS cohort of people with HIV (PWH) in Catalonia, Spain, we investigated COVID-19 outcomes and vaccination coverage. Among 10 640 PWH we compared migrants and non-migrants assessing rates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing, diagnosis, and associated clinical outcomes through propensity score matching and multivariable Cox regression. Results The cohort (mean age, 43 years; 83.5% male) included 57.4% (3053) Latin American migrants. Migrants with HIV (MWH) had fewer SARS-CoV-2 tests (67.8% vs 72.1%, P <.0001) but similar COVID-19 diagnoses (29.2% vs 29.4%, P =.847) compared to Spanish natives. Migrants had lower complete vaccination (78.9% vs 85.1%, P <.0001) and booster doses (63.0% vs 65.5%, P =.027). COVID-19 hospitalizations (8.1% vs 5.1%, P <.0001) and intensive care unit (ICU) admissions (2.9% vs 1.2%, P <.0001) were higher among migrants, with similar hospitalization duration (5.5 vs 4.0 days, P =.098) and mortality (3 [0.2%] vs 6 [0.4%], P =.510). Age ≥40 years, CD4 counts <200 cells/μL, ≥2 comorbidities, and incomplete/nonreception of the SARS-CoV-2 vaccine increased the risk of severe COVID-19 among migrants. Conclusions MWH had lower rates of SARS-CoV-2 testing and vaccination coverage, although the rates of COVID-19 diagnosis were similar between migrants and non-migrants. Rates of COVID-19–associated hospitalizations and ICU admissions were higher among migrants in comparison with non-migrants, with similar hospitalization duration and mortality. These findings can inform policies to address disparities in future pandemic responses for MWH. [ABSTRACT FROM AUTHOR]
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- 2024
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11. 6.C. Oral presentations: COVID-19 vaccination readiness: How the population worldwide is reacting to the COVID-19 vaccines: a systematic review on hesitancy.
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Failla, G., Pantovic, A., Al-Ajlouni, Y., Ricciardi, W., and Cascini, F.
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VACCINATION ,COVID-19 ,COVID-19 vaccines ,ATTITUDE (Psychology) ,WORLD health ,CONFERENCES & conventions ,PUBLIC opinion - Abstract
Background: High rates of vaccination are worldwide required to establish a herd immunity stopping the current COVID-19 pandemic evolution. Vaccine hesitancy is a major barrier in achieving herd immunity across different populations. This study sought to conduct a systematic review of the current literature regarding attitudes and hesitancy to receiving COVID-19 vaccination worldwide. Methods: A systematic literature search was performed in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Multiple databases were searched, namely PubMed and Web of Science, on February 24th, 2021 using a set of developed keywords. Inclusion criteria included the study to be 1) conducted in English; 2) investigated attitudes, hesitancy, and/or barriers to COVID-19 vaccine acceptability among a given population; 3) utilized validated measurements techniques; 4) have the full text paper available and 5) be peer-reviewed prior to final publication. The Newcastle Ottawa (NOS) scale for cross sectional studies was used to assess the quality of the studies. Results: 73 studies were included in qualitative synthesis. Overall, vaccine acceptance rates ranged from 23.6% in Kuwait to 94.3% in Malaysia and Nepal. A variety of different factors contributed to increased hesitancy, some of which included having negative perception of vaccine efficacy, safety, convenience and price. Some of the consistent socio-demographic groups that were identified to be associated with increased hesitancy included: women, younger participants, less educated, with lower income, with no insurance, living in the rural area and self-identified as a racial/ethnic minority. Conclusions: Vaccine hesitancy rates against COVID-19 vaccine ranged widely among across different populations. Identifying the factors that interplay and result in high hesitancy rates among a population can allow formulating a directed intervention to increase their vaccination uptake rates. Key messages: • It is necessary to understand the factors that contribute to the COVID-19 vaccine hesitancy. • It is important to inform policy-makers and formulate direct intervention measures that will successfully handle the pandemic. [ABSTRACT FROM AUTHOR]
- Published
- 2021
12. Protection of COVID-19 Vaccination Against Hospitalization During the Era of Omicron BA.4 and BA.5 Predominance: A Nationwide Case–Control Study Based on the French National Health Data System.
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Semenzato, Laura, Botton, Jérémie, Vu, Stéphane Le, Jabagi, Marie-Joëlle, Cuenot, François, Drouin, Jérôme, Dray-Spira, Rosemary, Weill, Alain, and Zureik, Mahmoud
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SARS-CoV-2 ,SARS-CoV-2 Omicron variant ,COVID-19 ,COVID-19 vaccines ,CORONAVIRUS diseases ,BOOSTER vaccines - Abstract
Background Knowing the duration of effectiveness of coronavirus disease 2019 (COVID-19) booster doses is essential to providing decision-makers with scientific arguments about the frequency of subsequent injections. We estimated the level of protection against COVID-19-related hospitalizations (Omicron BA.4-BA.5) over time after vaccination, accounting for breakthrough infections. Methods In this nationwide case–control study, all cases of hospitalizations for COVID-19 identified in the comprehensive French National Health Data System between June 1, 2022, and October 15, 2022, were matched with up to 10 controls by year of birth, sex, department, and an individual COVID-19 hospitalization risk score. Conditional logistic regressions were used to estimate the level of protection against COVID-19-related hospitalizations conferred by primary and booster vaccination, accounting for history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Results A total of 38 839 cases were matched to 377 653 controls; 19.2% and 9.9% were unvaccinated, respectively, while 68.2% and 77.7% had received ≥1 booster dose. Protection provided by primary vaccination reached 45% (95% CI, 42%–47%). The incremental effectiveness of booster doses ranged from 69% (95% CI, 67%–71%; ≤2 months) to 22% (95% CI, 19%–25%; ≥6 months). Specifically, the second booster provided an additional protection compared with the first ranging from 61% (95% CI, 59%–64%; ≤2 months) to 7% (95% CI, 2%–13%; ≥4 months). Previous SARS-CoV-2 infection conferred a strong, long-lasting protection (51% ≥20 months). There was no incremental effectiveness of a second booster among individuals infected since the first booster. Conclusions In the era of Omicron BA.4 and BA.5 predominance, primary vaccination still conferred protection against COVID-19 hospitalization, while booster doses provided an additional time-limited protection. The second booster had no additional protection in case of infection since the first booster. [ABSTRACT FROM AUTHOR]
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- 2023
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13. Longitudinal proteomic investigation of COVID-19 vaccination.
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Wang, Yingrui, Zhu, Qianru, Sun, Rui, Yi, Xiao, Huang, Lingling, Hu, Yifan, Ge, Weigang, Gao, Huanhuan, Ye, Xinfu, Song, Yu, Shao, Li, Li, Yantao, Li, Jie, Guo, Tiannan, and Shi, Junping
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Although the development of COVID-19 vaccines has been a remarkable success, the heterogeneous individual antibody generation and decline over time are unknown and still hard to predict. In this study, blood samples were collected from 163 participants who next received two doses of an inactivated COVID-19 vaccine (CoronaVac
® ) at a 28-day interval. Using TMT-based proteomics, we identified 1,715 serum and 7,342 peripheral blood mononuclear cells (PBMCs) proteins. We proposed two sets of potential biomarkers (seven from serum, five from PBMCs) at baseline using machine learning, and predicted the individual seropositivity 57 days after vaccination (AUC = 0.87). Based on the four PBMC's potential biomarkers, we predicted the antibody persistence until 180 days after vaccination (AUC = 0.79). Our data highlighted characteristic hematological host responses, including altered lymphocyte migration regulation, neutrophil degranulation, and humoral immune response. This study proposed potential blood-derived protein biomarkers before vaccination for predicting heterogeneous antibody generation and decline after COVID-19 vaccination, shedding light on immunization mechanisms and individual booster shot planning. [ABSTRACT FROM AUTHOR]- Published
- 2023
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14. Can Geographically Targeted Vaccinations Be Ethically Justified? The Case of Norway During the COVID-19 Pandemic.
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Amdam, Håkon, Norheim, Ole Frithjof, Solberg, Carl Tollef, and Littmann, Jasper R
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COVID-19 pandemic ,VACCINATION ,PUBLIC opinion ,COVID-19 - Abstract
This article discusses the fairness of geographically targeted vaccinations (GTVs). During the initial period of local and global vaccine scarcity, health authorities had to enact priority-setting strategies for mass vaccination campaigns against COVID-19. These strategies have in common that priority setting was based on personal characteristics, such as age, health status or profession. However, in 2021, an alternative to this strategy was employed in some countries, particularly Norway. In these countries, vaccine allocation was also based on the epidemiological situations in different regions, and vaccines were assigned based on local incidence rates. The aim of this article is to describe and examine how a geographical allocation mechanism may work by considering Norway as a case study and discuss what ethical issues may arise in this type of priority setting. We explain three core concepts: priority setting, geographical priority setting and GTVs. With a particular focus on Norway, we discuss the potential effects of GTV, the public perception of such a strategy, and if GTV can be considered a fair strategy. We conclude that the most reasonable defence of GTV seems to be through a consequentialist account that values both total health outcomes and more equal outcomes. [ABSTRACT FROM AUTHOR]
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- 2023
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15. Vaccine hesitancy among health-care professionals in the era of COVID-19.
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Geva, Hagar Z Pikkel, Gershgoren, Harel, Nir, Dana, Khazen, Maram, and Rose, Adam J
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HEALTH facility employees ,VACCINATION ,HEALTH policy ,COVID-19 ,MASS media ,IMMUNIZATION ,COVID-19 vaccines ,ATTITUDE (Psychology) ,ATTITUDES of medical personnel ,PRACTICAL politics ,RESEARCH methodology ,INTERVIEWING ,UNCERTAINTY ,VACCINE effectiveness ,MEDICAL protocols ,CONCEPTUAL structures ,RISK perception ,PSYCHOSOCIAL factors ,VACCINE hesitancy ,INFORMATION resources ,DECISION making ,SOCIAL responsibility - Abstract
Health-care professionals (HCPs) are key trusted figures in addressing coronavirus disease 2019 (COVID-19) challenges. They are thought to influence others' health decisions by personal example. However, during the COVID-19 crisis, some HCPs hesitated to be vaccinated. We examined factors contributing to that decision. We performed 12 semi-structured interviews, between February and May 2021, with Israeli HCPs who had declined or delayed COVID-19 vaccination. Three coders conducted a combined top-down and bottom-up analysis. We identified four main themes shaping vaccine decision-making: (i) sources of information, (ii) perceptions of necessity and risks of the vaccine, (iii) individual versus collective responsibility and (iv) political climate and media influence. Participants were worried about long-term effectiveness and safety, and while many agreed that high-risk populations should be vaccinated, all considered themselves to be at low risk for serious disease. Some felt they should avoid taking a perceived risk (accepting a new vaccine) to protect society, although they felt pressured to do so. Vaccination campaign politization and the way the media approached the subject also contributed to mistrust and hesitancy to be vaccinated. These findings help us understand HCP beliefs and uncertainties about COVID-19 vaccinations. This study can help inform future campaigns targeted at HCPs to promote the acceptance of vaccines. [ABSTRACT FROM AUTHOR]
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- 2023
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16. fundamental Christian argument for vaccine promotion.
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Galang, Joseph Renus F and Galang, Justine Renus F
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IMMUNIZATION ,VACCINATION ,POPULATION health ,COVID-19 vaccines ,ATTITUDE (Psychology) ,ETHICS ,VACCINE hesitancy ,CHRISTIANITY - Abstract
A recent correspondence highlighted the need to change the COVID-19 vaccine narrative to combat vaccine hesitancy by stressing that vaccination is a moral act. The said article was in response to another correspondence which said that science and religion must work together for vaccine promotion. This article presents a fundamental Christian argument for vaccine promotion by saying that God may have provided an answer to the pandemic through the COVID-19 vaccine. [ABSTRACT FROM AUTHOR]
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- 2022
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17. Building vaccine confidence through public participation.
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Corpuz, Jeff Clyde G
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VACCINATION ,PATIENT participation ,CONFIDENCE ,IMMUNIZATION ,ATTITUDE (Psychology) ,COVID-19 vaccines ,MEDICAL protocols ,VACCINE hesitancy ,INTERPROFESSIONAL relations ,PUBLIC opinion ,TRUST - Abstract
A recently published correspondence proposed the involvement of private-owned companies in Coronavirus Disease 2019 (COVID-19) vaccination program. This article raises awareness that vaccine hesitancy could undermine the effectiveness of COVID-19 vaccination programs. This article proposes the idea of public participation: dialog-based approach, incentive-based (non-financial) approach and reminder-recall approach based on the World Health Organization guidelines. [ABSTRACT FROM AUTHOR]
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- 2022
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18. C-Reactive protein rise in rheumatology patients following COVID-19 vaccination.
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Gor, Shivani, Kim, Sung-Hee, Yein, Khin, Michael, Jessica, and Price, Elizabeth
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Objective The aim was to determine the proportion of patients with inflammatory arthritis who have a flare of their rheumatological disease within 4 weeks of receiving a coronavirus disease 2019 (COVID-19) vaccine, using CRP as a surrogate marker. Methods A retrospective review was conducted of notes for patients with inflammatory arthritis within 30 days of their COVID-19 vaccine. An electronic database (DAWN) was used to identify all patients who were currently on a DMARD or biologic therapy. This was then correlated with vaccine data from the National Immunisation and Vaccination System (NIVS) and CRP within 30 days of their vaccination. Results From the DAWN database, 1620 adults were identified (mean age 61 years, 64% female). Three types of vaccinations were administered: AstraZeneca (AZ), BioNTech-Pfizer or Moderna. Vaccine uptake was 1542 of 1620 (95.2% for the first dose), 1550 of 1620 (95.7% for the second dose) and 1437 of 1620 (88.7% for the third dose). One hundred and ninety-two of 1542 patients (12.5%) had a CRP rise of >10 mg/l within 30 days of their vaccine, which was higher than the baseline flare rate of 8.6% (P = 0.0004). Conclusion Patients with inflammatory arthritis and on DMARDs have a high uptake of COVID-19 vaccine (95%), which is greater than the national average. A CRP rise >10 mg/l within 30 days of vaccination was observed in ∼1 in 10 patients in our study population after all three doses. There might be a slight increase in disease flare in patients with inflammatory arthritis after COVID-19 vaccinations, and additional research is required to assess this association further. [ABSTRACT FROM AUTHOR]
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- 2023
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19. Should states restrict recipient choice amongst relevant and available COVID-19 vaccines?
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Cave, Emma and McMahon, Aisling
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CORONAVIRUS diseases ,VACCINATION ,INFORMED consent (Medical law) ,HUMAN rights ,PATIENTS ,CHOICE (Psychology) - Abstract
Several COVID-19 vaccinations have been authorised worldwide. Whilst some vaccines are contraindicated for certain age groups or health conditions, there are often multiple clinically suitable authorised vaccine brands available. Few states have allowed recipients to choose amongst them, though there are multiple reasons why choice would be valued. We consider the policy justifications for state controls on recipient choice amongst COVID-19 vaccine brands, focusing on European countries and drawing on the UK context as an example. We contrast justifications for not offering choice at the height of the early pandemic crisis, and as some states seek to de-escalate their response and transition towards living with COVID-19. We argue that in the latter context public expectations of choice between available vaccine brands and platforms may rise, but that several considerations may justify continued restrictions on choice. A key factor which states should continue to take into consideration is the global nature of the pandemic. Insofar as offering recipient choice at a national level might exacerbate global inequity in vaccine distribution, states retain a normative and legal justification for restricting choice amongst available and clinically suitable vaccine brands. [ABSTRACT FROM AUTHOR]
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- 2023
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20. Which vaccination strategy against COVID-19?
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Matteis, Alessandro De, Ceylan, Fethiye B Turkmen, and Urpis, Enrico
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SARS-CoV-2 ,VACCINATION ,VACCINE effectiveness ,COVID-19 - Abstract
Background Bottlenecks in the production and supply pipeline of vaccines against coronavirus disease 2019 have led some countries to consider the option of dose-sparing strategies (e.g. increasing the number of people who receive some vaccine by halving the dose or increasing the interval between doses). In this study we assess the contribution of vaccination strategies to reducing the mortality induced by severe acute respiratory syndrome coronavirus 2. Methods This study focuses on the evolution of the pandemic and related vaccination efforts in five countries that have adopted different vaccination strategies or have experienced a bottleneck in their vaccine supply. The analysis is conducted using an autoregressive time-series approach through a system of simultaneous equations. Results The outcome of the early months of the vaccination campaign in containing the number of deaths induced by the epidemic varies across our sample. Overall, our results highlight the effective role played by the vaccine in containing the death toll induced by the epidemic. We could not find evidence of reduced effectiveness of the second dose in the presence of an extended inter-dose interval. The effectiveness of the vaccination campaign results appears to be strongly affected by the stability of vaccine supply. Conclusions The vaccine is effective in containing the deaths caused by the virus, particularly when multiple doses have been administered. The stability of the vaccine pipeline plays a critical role in determining the effectiveness of the vaccination campaign. [ABSTRACT FROM AUTHOR]
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- 2023
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21. A Documentary History of the Immunity (or Vaccine) Passport: Health Certificates of Public Health, Personal Identity and Power from the Plague to the Coronavirus Pandemic.
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Kosciejew, Marc
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VACCINE passports ,VACCINATION ,IMMUNITY ,HISTORY of public health ,COVID-19 pandemic ,PLAGUE ,YELLOW fever ,CHOLERA - Abstract
The immunity (or vaccine) passport of the coronavirus pandemic, as a concept and object, is not unprecedented. This health and identity document features a history spanning over half-a-millennium and appearing across diverse geopolitical and sociocultural contexts. This article presents a documentary history of the immunity passport and its heterogeneous material instantiations, uses and effects across divergent historical settings. It illuminates how the immunity passport has helped shaped identities and public health, as well as impacted individual and institutional agency, during health crises. Four historical cases are explored, including the plagues ravaging the Renaissance Mediterranean region, the 1665 Great Plague of London, the yellow fever outbreaks in the antebellum slave-era southern USA and the chronic cholera conditions confronting colonial-era British India. Although disparate, these historical cases share the immunity passport as a non-pharmaceutical intervention into their respective health crises that played important roles in people's lives during these troubled times. [ABSTRACT FROM AUTHOR]
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- 2023
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22. Kidney transplantation during mass disasters—from COVID-19 to other catastrophes: a Consensus Statement by the DESCARTES Working Group and Ethics Committee of the ERA.
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Sever, Mehmet Sukru, Vanholder, Raymond, Oniscu, Gabriel, Abramowicz, Daniel, Biesen, Wim Van, Maggiore, Umberto, Watschinger, Bruno, Mariat, Christophe, Buturovic-Ponikvar, Jadranka, Crespo, Marta, Mjoen, Geir, Heering, Peter, Peruzzi, Licia, Gandolfini, Ilaria, Hellemans, Rachel, and Hilbrands, Luuk
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KIDNEY transplantation ,COVID-19 ,ETHICS committees ,DISASTERS ,CIVILIAN evacuation - Abstract
Mass disasters are characterized by a disparity between healthcare demand and supply, which hampers complex therapies like kidney transplantation. Considering the scarcity of publications on previous disasters, we reviewed transplantation practice during the recent coronavirus disease 2019 (COVID-19) pandemic, and dwelled upon this experience to guide transplantation strategies in the future pandemic and non-pandemic catastrophes. We strongly suggest continuing transplantation programs during mass disasters, if medical and logistic operational circumstances are appropriate. Postponing transplantations from living donors and referral of urgent cases to safe regions or hospitals are justified. Specific preventative measures in anticipated disasters (such as vaccination programs during pandemics or evacuation in case of hurricanes or wars) may be useful to minimize risks. Immunosuppressive therapies should consider stratifying risk status and avoiding heavy immune suppression in patients with a low probability of therapeutic success. Discharging patients at the earliest convenience is justified during pandemics, whereas delaying discharge is reasonable in other disasters, if infrastructural damage results in unhygienic living environments for the patients. In the outpatient setting, telemedicine is a useful approach to reduce the patient load to hospitals, to minimize the risk of nosocomial transmission in pandemics and the need for transport in destructive disasters. If it comes down to saving as many lives as possible, some ethical principles may vary in function of disaster circumstances, but elementary ethical rules are non-negotiable. Patient education is essential to minimize disaster-related complications and to allow for an efficient use of healthcare resources. [ABSTRACT FROM AUTHOR]
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- 2023
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23. Immunosuppressive treatments selectively affect the humoral and cellular response to SARS-CoV-2 in vaccinated patients with vasculitis.
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Monti, Sara, Fornara, Chiara, Delvino, Paolo, Bartoletti, Alice, Bergami, Federica, Comolli, Giuditta, Sammartino, Josè Camilla, Biglia, Alessandro, Cassione, Emanuele Bozzalla, Cassaniti, Irene, Baldanti, Fausto, Lilleri, Daniele, and Montecucco, Carlomaurizio
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GIANT cell arteritis diagnosis ,COVID-19 ,IMMUNIZATION ,IMMUNOGLOBULINS ,COVID-19 vaccines ,GIANT cell arteritis ,IMMUNOSUPPRESSION ,ANTIBODY formation ,MESSENGER RNA ,ENZYME-linked immunosorbent assay ,DESCRIPTIVE statistics ,RESEARCH funding ,CELLULAR immunity ,T cells - Abstract
Objectives To analyse humoral and cellular immune response to mRNA COVID-19 vaccines in patients with GCA. Methods Consecutive patients with a diagnosis of GCA receiving two doses of BNT162b2 vaccine were assessed at baseline and 3 weeks from the second vaccine dose. Healthy subjects (n = 51) were included as controls (HC). Humoral response was assessed with Spike-specific IgG antibody response (S-IgG) and neutralizing antibodies (NtAb). Specific T cell response was assessed by enzyme linked immunosorbent spot (ELISpot). Results Of 56 included patients with GCA, 44 were eligible after exclusion of previous evidence of COVID-19 and incomplete follow-up. A significant proportion of patients with GCA (91%) demonstrated antibody (S-IgG) response, but this was significantly lower than HCs (100%); P < 0.0001. Neutralizing activity was not detected in 16% of patients with GCA. Antibody titres (S-IgG and NtAb) were significantly lower compared with HCs. Humoral response (S-IgG and NtAb) was significantly hampered by treatment with MTX. Cellular response was lacking in 30% of patients with GCA (vs 0% in HCs; P < 0.0001). Cellular response was significantly influenced by the levels of baseline peripheral T-lymphocytes and by glucocorticoid treatment. Treatment with tocilizumab did not affect any level of the immune response elicited by vaccination. Conclusions Although patients with GCA apparently achieve a robust antibody seroconversion, there is a significant impairment of the neutralizing activity. MTX significantly reduced all levels of the humoral response. Up to one-third of patients do not develop a cellular immune protection in response to COVID-19 vaccination. [ABSTRACT FROM AUTHOR]
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- 2023
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24. Effectiveness of fourth dose of COVID-19 vaccine against the Omicron variant compared with no vaccination.
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Zeng, Jessie, Szanyi, Joshua, and Blakely, Tony
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SARS-CoV-2 Omicron variant ,COVID-19 vaccines ,VACCINATION ,COVID-19 ,VACCINE effectiveness - Abstract
However, third- and fourth-dose aVE estimates for comparable time points were not included, meaning it was impossible to determine whether the fourth dose returned people to the same or greater protection as a third dose for the equivalent time post-vaccination. We also account for the lack of data at comparable time periods by matching predicted third-dose aVE with reported fourth-dose rVE at an equivalent time (i.e. 3 weeks) since the last dose of vaccination. [Extracted from the article]
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- 2023
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25. Waning of first- and second-dose ChAdOx1 and BNT162b2 COVID-19 vaccinations: a pooled target trial study of 12.9 million individuals in England, Northern Ireland, Scotland and Wales.
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Kerr, Steven, Bedston, Stuart, Bradley, Declan T, Joy, Mark, Lowthian, Emily, Mulholland, Rachel M, Akbari, Ashley, Hobbs, F D Richard, Katikireddi, Srinivasa Vittal, Lusignan, Simon de, Rudan, Igor, Torabi, Fatemeh, Tsang, Ruby S M, Lyons, Ronan A, Robertson, Chris, Sheikh, Aziz, and de Lusignan, Simon
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COVID-19 vaccines ,VACCINE effectiveness ,COVID-19 ,VACCINATION - Abstract
Background: Several SARS-CoV-2 vaccines have been shown to provide protection against COVID-19 hospitalization and death. However, some evidence suggests that notable waning in effectiveness against these outcomes occurs within months of vaccination. We undertook a pooled analysis across the four nations of the UK to investigate waning in vaccine effectiveness (VE) and relative vaccine effectiveness (rVE) against severe COVID-19 outcomes.Methods: We carried out a target trial design for first/second doses of ChAdOx1(Oxford-AstraZeneca) and BNT162b2 (Pfizer-BioNTech) with a composite outcome of COVID-19 hospitalization or death over the period 8 December 2020 to 30 June 2021. Exposure groups were matched by age, local authority area and propensity for vaccination. We pooled event counts across the four UK nations.Results: For Doses 1 and 2 of ChAdOx1 and Dose 1 of BNT162b2, VE/rVE reached zero by approximately Days 60-80 and then went negative. By Day 70, VE/rVE was -25% (95% CI: -80 to 14) and 10% (95% CI: -32 to 39) for Doses 1 and 2 of ChAdOx1, respectively, and 42% (95% CI: 9 to 64) and 53% (95% CI: 26 to 70) for Doses 1 and 2 of BNT162b2, respectively. rVE for Dose 2 of BNT162b2 remained above zero throughout and reached 46% (95% CI: 13 to 67) after 98 days of follow-up.Conclusions: We found strong evidence of waning in VE/rVE for Doses 1 and 2 of ChAdOx1, as well as Dose 1 of BNT162b2. This evidence may be used to inform policies on timings of additional doses of vaccine. [ABSTRACT FROM AUTHOR]- Published
- 2023
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26. Vaccines alone are no silver bullets: a modeling study on the impact of efficient contact tracing on COVID-19 infection and transmission in Malaysia.
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Raja, Dhesi Baha, Taib, Nur Asheila Abdul, Teo, Alvin Kuo Jing, Jayaraj, Vivek Jason, and Ting, Choo-Yee
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CONTACT tracing ,INFECTIOUS disease transmission ,COVID-19 ,VACCINE effectiveness ,CORONAVIRUS diseases ,BULLETS - Abstract
Background The computer simulation presented in this study aimed to investigate the effect of contact tracing on coronavirus disease 2019 (COVID-19) transmission and infection in the context of rising vaccination rates. Methods This study proposed a deterministic, compartmental model with contact tracing and vaccination components. We defined contact tracing effectiveness as the proportion of contacts of a positive case that was successfully traced and the vaccination rate as the proportion of daily doses administered per population in Malaysia. Sensitivity analyses on the untraced and infectious populations were conducted. Results At a vaccination rate of 1.4%, contact tracing with an effectiveness of 70% could delay the peak of untraced asymptomatic cases by 17 d and reduce it by 70% compared with 30% contact tracing effectiveness. A similar trend was observed for symptomatic cases when a similar experiment setting was used. We also performed sensitivity analyses by using different combinations of contact tracing effectiveness and vaccination rates. In all scenarios, the effect of contact tracing on COVID-19 incidence persisted for both asymptomatic and symptomatic cases. Conclusions While vaccines are progressively rolled out, efficient contact tracing must be rapidly implemented concurrently to reach, find, test, isolate and support the affected populations to bring COVID-19 under control. [ABSTRACT FROM AUTHOR]
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- 2023
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27. Vaccination saves lives: a real-time study of patients with chronic diseases and severe COVID-19 infection.
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Mukherjee, A, Kumar, G, Turuk, A, Bhalla, A, Bingi, T C, Bhardwaj, P, Baruah, T D, Mukherjee, S, Talukdar, A, Ray, Y, John, M, Khambholja, J R, Patel, A H, Bhuniya, S, Joshi, R, Menon, G R, Sahu, D, Rao, V V, Bhargava, B, and Panda, S
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COVID-19 ,CHRONICALLY ill ,VACCINATION ,DATA collection platforms ,CORONAVIRUS diseases ,CHRONIC kidney failure ,COUGH - Abstract
Objectives This study aims to describe the demographic and clinical profile and ascertain the determinants of outcome among hospitalized coronavirus disease 2019 (COVID-19) adult patients enrolled in the National Clinical Registry for COVID-19 (NCRC). Methods NCRC is an on-going data collection platform operational in 42 hospitals across India. Data of hospitalized COVID-19 patients enrolled in NCRC between 1st September 2020 to 26th October 2021 were examined. Results Analysis of 29 509 hospitalized, adult COVID-19 patients [mean (SD) age: 51.1 (16.2) year; male: 18 752 (63.6%)] showed that 15 678 (53.1%) had at least one comorbidity. Among 25 715 (87.1%) symptomatic patients, fever was the commonest symptom (72.3%) followed by shortness of breath (48.9%) and dry cough (45.5%). In-hospital mortality was 14.5% (n = 3957). Adjusted odds of dying were significantly higher in age group ≥60 years, males, with diabetes, chronic kidney diseases, chronic liver disease, malignancy and tuberculosis, presenting with dyspnoea and neurological symptoms. WHO ordinal scale 4 or above at admission carried the highest odds of dying [5.6 (95% CI: 4.6–7.0)]. Patients receiving one [OR: 0.5 (95% CI: 0.4–0.7)] or two doses of anti-SARS CoV-2 vaccine [OR: 0.4 (95% CI: 0.3–0.7)] were protected from in-hospital mortality. Conclusions WHO ordinal scale at admission is the most important independent predictor for in-hospital death in COVID-19 patients. Anti-SARS-CoV2 vaccination provides significant protection against mortality. [ABSTRACT FROM AUTHOR]
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- 2023
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28. Postdischarge outcomes of COVID-19 patients from South Asia: a prospective study.
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Abeysuriya, Visula, Seneviratne, Suranjith L, Silva, Arjuna P De, Mowjood, Riaz, Mowjood, Shazli, Silva, Thushara de, Mel, Primesh de, Mel, Chandima de, Wijesinha, R S, Fernando, Amitha, Mel, Sanjay de, and Chandrasena, Lal
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COVID-19 ,CORONAVIRUS diseases ,MYOCARDIAL infarction ,RESPIRATORY infections ,LONGITUDINAL method ,SYMPTOMS - Abstract
Background Coronavirus disease 2019 (COVID-19) may cause clinical manifestations that last for weeks or months after hospital discharge. The manifestations are heterogeneous and vary in their frequency. Their multisystem nature requires a holistic approach to management. There are sparse data from the South Asian region on the outcomes of hospital-discharged COVID-19 patients. We assessed the posthospital discharge outcomes of a cohort of Sri Lankan COVID-19 patients and explored the factors that influenced these outcomes. Methods Data were prospectively collected from patients who were discharged following an admission to the Nawaloka Hospital, Sri Lanka with COVID-19 from March to June 2021. At discharge, their demographic, clinical and laboratory findings were recorded. The patients were categorised as having mild, moderate and severe COVID-19, based on the Sri Lanka Ministry of Health COVID-19 guidelines. Following discharge, information on health status, complications and outcomes was collected through clinic visits and preplanned telephone interviews. A validated (in Sri Lanka) version of the Short Form 36 health survey questionnaire (SF-36) was used to assess multi-item dimensions health status of the patients at 1, 2 and 3 mo postdischarge. Results We collected data on 203 patients (male, n=111 [54.7%]). The level of vaccination was significantly associated with disease severity (p<0.001). Early recovery was seen in the mild group compared with the moderate and severe groups. At 3 mo, on average 98% of mild and 90% of moderate/severe patients had recovered. Based on the SF-36, physical functioning dimensions, role limitation due to physical and emotional health, energy/ fatigue, emotional well-being, social functioning, pain and general health were significantly different in the moderate/severe vs mild COVID-19 groups at 1, 2 and 3 mo postdischarge (p<0.05). Twenty-three patients developed complications, of which the most common were myocardial infarction with heart failure (n=6/23; 26.1%), cerebrovascular accident (n=6/23; 26.1%) and respiratory tract infections (n=3/23; 13.01%) and there were six deaths. Conclusions In our cohort, receiving two doses of the COVID-19 vaccine was associated with reduced disease severity. Those with mild disease recovered faster than those with moderate/severe disease. At 3 mo posthospital discharge, >90% had recovered. [ABSTRACT FROM AUTHOR]
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- 2022
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29. Distributing a billion vaccines: COVAX successes, challenges, and opportunities.
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Budish, Eric, Kettler, Hannah, Kominers, Scott Duke, Osland, Erik, Prendergast, Canice, and Torkelson, Andrew A
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VACCINATION ,COVID-19 vaccines ,VACCINES ,COST effectiveness - Abstract
By January 2022, the COVAX international vaccine collaboration had allocated over a billion vaccines to over 140 countries. We describe and review the allocation process chosen, which reflected both an objective of equitably distributing vaccines across the world and the need to fund that mission. We show how vaccine supply limitations and constraints on some countries' absorptive capacity have affected overall allocative outcomes. We also discuss market design approaches that were considered but not implemented, including the use of an exchange mechanism to better match countries' vaccine allocations to their preferences, as well as a vaccine brokerage under which countries could sell excess vaccines to countries with ongoing need. Our analysis addresses some criticisms of COVAX, and offers suggestions for agencies organizing global vaccine cooperation for future pandemics. [ABSTRACT FROM AUTHOR]
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- 2022
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30. The attitude of fully vaccinated individuals towards COVID-19 vaccine booster dose: a transverse study from Jordan.
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Abuhammad, Sawsan, Alzoubi, Karem H, Khabour, Omar F, Hamaideh, Shaher, and El-zubi, Maryam K
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BOOSTER vaccines ,VACCINATION ,VACCINATION complications ,ATTITUDES toward illness ,COVID-19 vaccines ,DEMOGRAPHIC characteristics - Abstract
Objectives COVID-19 vaccines are efficient against serious infections, and those initiated by the various variants. Many high- and middle-income countries have decided to offer third-dose boosters to ensure their populations remain protected against novel COVID-19 variants before additional waves of COVID-19. This study aims to assess individuals' attitudes towards COVID-19 booster vaccination dose and to determine predictors of this attitude. Methods This study used a cross-sectional descriptive design. The inclusion criteria for participants were Jordanian adults who had been fully vaccinated against COVID-19. A quota sampling strategy based on the participant's, age and gender was used to ensure that the sample was broadly representative of the general population in Jordan. The instrument was distributed across popular social networking sites such as Facebook and WhatsApp. The study was conducted in October 2021. Key findings The response rate of this study was 63.5% (n = 952). The mean score of attitudes towards a booster dose of COVID-19 was 47.1 ± 8.2, indicating that about half of the sample was supportive to the booster dose. There were differences in the acceptability of a booster dose for COVID-19 according to the demographic and clinical characteristics of the participants. Individuals with high income (B = 0.210, P = 0.000), high educational level (B = −0.076, P = 0.026), those who have suffered vaccine side effects (B = −0.081, P = 0.013) and follow the news about COVID-19 (B = 0.076, P = 0.043) were more likely to accept the booster dose than the other groups. Conclusions Participants had mixed attitudes towards the booster dose with about half of the participants willing to take the booster. Some factors associated with such attitude were identified. The findings are useful in developing and implementing effective vaccination strategies that target people who are not ready to take a booster dose. [ABSTRACT FROM AUTHOR]
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- 2022
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31. Engaging Same-Day Peer Ambassadors to Increase Coronavirus Disease 2019 Vaccination Among People Experiencing Unsheltered Homelessness in Los Angeles County: A Hybrid Feasibility-Evaluation Study.
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Shover, Chelsea L, Rosen, Allison, Mata, José, Robie, Brooke, Alvarado, Julissa, Frederes, Ashley, Romero, Ruby, Beltran, Jacqueline, Bratcher, Anna, Chang, Alicia H, Choi, Kristen R, Garcia, Candelaria, Shoptaw, Steven, Guha, Priyanka, Richard, Lindsey, Sixx, Gunner, Baez, Angel, Coleman, Anthony, Harvell, Sarah, and Jackson, Shirnae
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Background: This study aimed to evaluate the feasibility and acceptability of engaging unhoused peer ambassadors (PAs) in coronavirus disease 2019 (COVID-19) vaccination efforts to reach people experiencing unsheltered homelessness in Los Angeles County.Methods: From August to December 2021, vaccinated PAs aged ≥18 years who could provide informed consent were recruited during vaccination events for same-day participation. Events were held at encampments, service providers (eg, housing agencies, food lines, and mobile showers), and roving locations around Los Angeles. PAs were asked to join outreach alongside community health workers and shared their experience getting vaccinated, receiving a $25 gift card for each hour they participated. Postevent surveys evaluated how many PAs enrolled and how long they participated. In October 2021, we added a preliminary effectiveness evaluation of how many additional vaccinations were attributable to PAs. Staff who enrolled the PAs estimated the number of additional people vaccinated because of talking with the PA.Results: A total of 117 PAs were enrolled at 103 events, participating for an average of 2 hours. At events with the effectiveness evaluation, 197 additional people were vaccinated over 167 PA hours ($21.19 gift card cost per additional person vaccinated), accounting for >25% of all vaccines given at these events.Discussion: Recruiting same-day unhoused PAs is a feasible, acceptable, and preliminarily effective technique to increase COVID-19 vaccination in unsheltered settings. The findings can inform delivery of other health services for people experiencing homelessness. [ABSTRACT FROM AUTHOR]- Published
- 2022
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32. Outcome and effect of vaccination in SARS-CoV-2 Omicron infection in hemodialysis patients: a cohort study.
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Ashby, Damien R, Caplin, Ben, Corbett, Richard W, Asgari, Elham, Kumar, Nicola, Sarnowski, Alexander, Hull, Richard, Makanjuola, David, Cole, Nicholas, Chen, Jian, Nyberg, Sofia, Forbes, Suzanne, McCafferty, Kieran, Zaman, Faryal, Cairns, Hugh, Sharpe, Claire, Bramham, Kate, Motallebzadeh, Reza, Anwari, Kashif, and Roper, Tayeba
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SARS-CoV-2 Omicron variant ,HEMODIALYSIS patients ,SARS-CoV-2 ,VACCINE effectiveness ,PROPORTIONAL hazards models - Abstract
Background Hemodialysis patients are at high risk of Covid-19, though vaccination has significant efficacy in preventing and reducing the severity of infection. Little information is available on disease severity and vaccine efficacy since the dissemination of the Omicron variant. Methods In a multi-center study, during a period of the epidemic driven by the Omicron variant, all hemodialysis patients positive for SARS-CoV-2 were identified. Outcomes were analyzed according to predictor variables including vaccination status. Risk of infection was analyzed using a Cox proportional hazards model. Results SARS-CoV-2 infection was identified in 1126 patients including 200 (18%) unvaccinated, 56 (5%) post first dose, 433 (38%) post second dose, and 437 (39%) at least 7 days beyond their third dose. The majority of patients had a mild course but 160 (14%) were hospitalized and 28 (2%) died. In regression models adjusted for age and comorbidity, two-dose vaccination was associated with a 39% (95%CI: 2%–62%) reduction in admissions, but third doses provided additional protection, with a 51% (95%CI: 25%–69%) further reduction in admissions. Among 1265 patients at risk at the start of the observation period, SARS-CoV-2 infection was observed in 211 (17%). Two-dose vaccination was associated with a 41% (95%CI: 3%–64%) reduction in the incidence of infection, with no clear additional effect provided by third doses. Conclusions These data demonstrate lower incidence of SARS-CoV-2 infection after vaccination in dialysis patients during an Omicron dominant period of the epidemic. Among those developing infection, severe illness was less common with prior vaccination, particularly after third vaccine doses. [ABSTRACT FROM AUTHOR]
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- 2022
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33. Vaccination as an Equaliser? Evaluating COVID-19 Vaccine Prioritisation and Compensation.
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Günther, Christian, Tonti, Lauren, and Domenici, Irene
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COVID-19 vaccines ,JURISDICTION ,SOCIAL determinants of health ,VACCINATION - Abstract
This article assesses the equity of COVID-19 vaccination programmes in three jurisdictions that have historically taken different approaches to the institutionalisation of equity considerations. The Sars-Cov-2 pandemic has thrown into sharp relief persistent societal inequalities and has added novel dimensions to these problems. Certain groups have proved particularly vulnerable, both in terms of infection risk and severity as well as the accompanying social fallout. Against this background the implementation of 'objective' vaccination programmes may seem like a great leveller, addressing the disparate risks that are tied to social determinants of health and the pandemic behemoth. However, implementing vaccination programmes in an equitable manner is itself essential for the realisation of such a vision. This article undertakes a comparative analysis of the English, Italian, and American jurisdictions and critically assesses two aspects of their vaccination frameworks: (i) the prioritisation of groups for vaccination and (ii) the nature of public compensation schemes for those who have suffered vaccine-related injuries. It examines whether and to what extent these measures address the inequalities raised by COVID-19 and the role of the law in this pursuit. [ABSTRACT FROM AUTHOR]
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- 2022
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34. Risk stratification through allergy history: single-centre experience of specialized COVID-19 vaccine clinic.
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Lyons, Daniel, Murray, Cliodhna, Hannigan, Siobhan, Sui, Jacklyn, Alamin, Salma, Conlon, Niall, Keogan, Mary, Khalib, Khairin, Fitzpatrick, Chris, O'B Hourihane, Jonathan, Carey, Michael, and Edgar, J David M
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URTICARIA ,COVID-19 vaccines ,FOOD allergy ,ALLERGIES ,VACCINE safety ,DRUG allergy - Abstract
Anaphylaxis is a rare side-effect of COVID-19 vaccines. To (a) provide direct advice and reassurance to certain persons with a history of anaphylaxis/complex allergy, in addition to that available in national guidelines, and (b) to provide a medically supervised vaccination, a specialist regional vaccine allergy clinic was established. The main objective was to determine if risk stratification through history can lead to safe COVID-19 vaccination for maximum population coverage. A focused history was taken to establish contraindications to giving COVID-19 vaccines. People who reported a high-risk allergy history were given a vaccine not containing the excipient thought to have directly caused previous anaphylaxis. All vaccines were monitored for 30 min after administration. A total of 206 people were vaccinated between 6 July 2021 and 31 August 2021; Comirnaty (Pfizer-BioNTech) (n = 34), and Janssen (n = 172). In total, 78% were women. Ninety-two people (45%) reported a high-risk allergy history. There were no cases of anaphylaxis. Three people developed urticaria and one of these also developed transient tachycardia. One vaccinee developed a pseudoseizure. Two of 208 people (<1%) referred during this time declined vaccination based on personal preference, despite the assessment of low clinical risk. In our experience, all vaccines with high-risk allergy histories were administered Pfizer BioNTech or Janssen Covid-19 vaccines uneventfully following screening based on allergy-focussed history. Our data support that drug allergy is not associated with a higher risk of vaccine-related anaphylaxis but may act to guide the administration of alternate vaccines to people with polyethylene glycol/polysorbate 80/trometamol allergies or anaphylaxis after the first dose. Individuals with complex allergy histories have experienced COVID-19 vaccine delay and there have been many reports of both immediate and delayed reactions to prior COVID-19 vaccination doses. The study demonstrates a successful strategy for vaccinating the majority of people with documented allergy history, showing those deemed high-risk can be vaccinated safely following screening based on an allergy-focussed history, without need for allergy investigation (e.g. skin prick testing) prior to vaccination. The results of this study act as reassurance of vaccine safety and can be used to guide future community vaccination management of persons reporting drug/food allergy history. [ABSTRACT FROM AUTHOR]
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- 2022
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35. role of religiosity in COVID-19 vaccine hesitancy.
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Garcia, Louiegi L and Yap, John Federick C
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VACCINATION ,HERD immunity ,ATTITUDE (Psychology) ,COVID-19 vaccines ,PSYCHOLOGY & religion - Abstract
With the surge of COVID-19 cases worldwide, it is essential that vaccination be prioritized to facilitate herd immunity. However, there is vaccine hesitancy reflected in religiosity. This correspondence aims to understand religiosity as a factor that plays a role in vaccination hesitancy. Medical and scientifically sound evidence is influenced by religious beliefs resulting in varied responses toward getting vaccinated such as vaccination hesitancy. [ABSTRACT FROM AUTHOR]
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- 2021
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36. Science, religion and state: a multidimensional perspective.
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Corpuz, Jeff Clyde G
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VACCINATION ,IMMUNIZATION ,COVID-19 ,COVID-19 vaccines ,ATTITUDE (Psychology) ,PUBLIC health ,MEDICAL protocols ,STATE health plans ,INTERPROFESSIONAL relations ,SCIENCE ,RELIGION ,HEALTH promotion - Abstract
The SARS-CoV-2 (COVID-19) does not discriminate; it affects everyone regardless of beliefs, gender, nationality, skin color, and social class. A recent correspondence published in the Journal of Public Health proposed the 'collaboration of science and religion in COVID-19 vaccine promotion.' The said article was in response to a previously published correspondence, which proposed a multi-sectoral approach on coronavirus disease 2019 (COVID-19) vaccination hesitancy. This article further adds that science, religion and state are not mutually exclusive with each other. What this article, therefore, proposes is a multidimensional relationship of science, religion and state to promote the COVID-19 vaccine and other science-based findings to combat the public fear of the public on vaccine and virus. [ABSTRACT FROM AUTHOR]
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- 2021
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37. Science and religion for COVID-19 vaccine promotion.
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Galang, Joseph Renus F
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VACCINATION ,OCCUPATIONAL roles ,IMMUNIZATION ,COVID-19 vaccines ,ATTITUDE (Psychology) ,PUBLIC health ,MEDICAL protocols ,PUBLIC opinion ,HEALTH promotion ,SCIENCE ,RELIGION ,CHURCH buildings ,TRUST - Abstract
A recent correspondence published in this journal proposed a multi-sectoral approach on the coronavirus disease 2019 (COVID-19) vaccination hesitancy, whereas another proposed that religious leaders play a role in gaining the public's trust in COVID-19 vaccine. This article raises awareness that though religious leaders play a huge role in promoting the COVID-19 vaccine, they are still bound by the findings of science. What this article, therefore, proposes is the collaboration of science and religion in COVID-19 vaccine promotion. [ABSTRACT FROM AUTHOR]
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- 2021
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38. Vaccine refusal/hesitancy—the ethical point of view.
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Gentil, João
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VACCINATION , *ATTITUDE (Psychology) , *COVID-19 vaccines , *SYSTEMATIC reviews , *CONFERENCES & conventions , *BIOETHICS - Abstract
Background In 2019, WHO classified vaccine hesitancy as one of the top 10 threats to global health. Vaccination is an area of excellence in nursing that has gained a new focus and has become a challenge in the provision of care and in the management field. Vaccine hesitation raises questions about mandatory vaccination, individual versus collective freedom that are highlighted in the current context due to the emergence of new vaccines. In this paper, we want to analyze and update knowledge about vaccines hesitancy from an ethical and bioethical perspective. Methods A combination of literature reviews on vaccine refusal/hesitancy, ethics and COVID-19 vaccine confidence, accessed on SciELO and PubMed databases and analysis of documents from General Directorate of Health and Ordem dos Enfermeiros (National Nurses Association). Results Vaccination programs aim is a collective protection. The desirable effects at individual level do not have the same ethical value at collective level, leading to cost-benefit imbalances. Moral conflicts between the individual and the collective, cost-benefit imbalances and the insufficiency of bioethics principles, lead us to the use of other moral values and principles, such as responsibility, solidarity and social justice, as a tool for ethical reflection problems related to COVID-19 vaccines. Conclusions There are no perfect solutions to ethical dilemmas and some optimal solutions could depend the context. In a pandemic situation, one of the most relevant ethical issues is the herd immunity since it leaves public health at risk. Equity and the principle of justice in vaccination campaign are shown daily in the nursing profession. [ABSTRACT FROM AUTHOR]
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- 2021
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39. Value choices in European COVID-19 vaccination schedules: how vaccination prioritization differs from other forms of priority setting.
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Wiśniowska, Karolina, Żuradzki, Tomasz, and Ciszewski, Wojciech
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COVID-19 vaccines ,MEDICAL ethics ,VACCINATION ,DEATH rate - Abstract
With the limited initial availability of COVID-19 vaccines in the first months of 2021, decision-makers had to determine the order in which different groups were prioritized. Our aim was to find out what normative approaches to the allocation of scarce preventive resources were embedded in the national COVID-19 vaccination schedules. We systematically reviewed and compared prioritization regulations in 27 members of the European Union, the United Kingdom, and Israel. We differentiated between two types of priority categories: groups that have increased infection fatality rate (IFR) compared to the average for the general population and groups chosen because their members experience increased risk of being infected (ROI). Our findings show a clear trend: all researched schedules prioritized criteria referring to IFR (being over 65 years old and coexisting health conditions) over the ROI criteria (eg occupation and housing conditions). This is surprising since, in the context of treatment, it is common and justifiable to adopt different allocation principles (eg introducing a saving more life-year approach or prioritizing younger patients). We discuss how utilitarian, prioritarian, and egalitarian principles can be applied to interpret normative differences between the allocation of curative and preventive interventions. [ABSTRACT FROM AUTHOR]
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- 2022
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40. ethico-legal assessment of intellectual property rights and their effect on COVID-19 vaccine distribution: an Australian case study.
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Scheibner, James, Nielsen, Jane, and Nicol, Dianne
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INTELLECTUAL property ,COVID-19 vaccines ,VALUATION of real property ,VACCINATION ,VACCINE manufacturing - Abstract
This article posits that Australia, as an affluent country with increasing capacity to manufacture vaccines, has an obligation to assist its regional (and global) counterparts in implementing vaccination programs that protect their populations. First, the article explores the capacity of high-income nations to meet their obligations, assist their neighbours and refrain from vaccine nationalism. This inquiry involves an analysis of the optimal ethical strategy for distributing vaccines globally, and the role that Australia might play in this distribution strategy. Secondly, the article examines the intellectual property landscape for vaccines in Australia, focusing on the patents that cover vaccine compositions and manufacturing techniques (recognizing the potential for know-how and access to materials as well as patents to affect manufacturing capacity). This article then discusses the strategies the Australian Government has at its disposal to counter potential intellectual property impediments whilst complying with existing obligations under the Agreement on Trade-related Aspects of Intellectual Property Rights (TRIPS), as an ethically appropriate response to the pandemic. This article also considers whether a so-called TRIPS waiver could provide better options and concludes that the challenge of compelling disclosure of know-how remains. [ABSTRACT FROM AUTHOR]
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- 2022
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41. COVID-19 vaccine hesitancy and acceptance: a comprehensive scoping review of global literature.
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Majid, Umair, Ahmad, Mobeen, Zain, Shahzadi, Akande, Adebisi, and Ikhlaq, Fahham
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VACCINATION ,CULTURE ,PSYCHOLOGY information storage & retrieval systems ,CINAHL database ,COVID-19 ,IMMUNIZATION ,MEDICAL information storage & retrieval systems ,ATTITUDE (Psychology) ,SYSTEMATIC reviews ,COVID-19 vaccines ,PRACTICAL politics ,MOTIVATION (Psychology) ,NEGOTIATION ,RISK perception ,VACCINE effectiveness ,VACCINE hesitancy ,COMMUNICATION ,LITERATURE reviews ,MISINFORMATION ,MEDLINE ,THEMATIC analysis ,TRUST ,SOCIAL responsibility ,PSYCHOSOCIAL factors - Abstract
As countries continue the third year of the pandemic, we believe that there has been unfair attention to COVID-19 vaccine efficacy and safety, while tacitly ignoring serious challenges with vaccine uptake, without which vaccination may not be effective against the spread of COVID-19. While several studies have been published on COVID-19 vaccine hesitancy, there remains a need to conduct a comprehensive global analysis of vaccine hesitancy. We conducted a scoping review of 60 studies published globally on vaccine hesitancy and acceptance. We conducted a qualitative analysis to identify motivators and barriers to vaccination across several cultural and demographic contexts. We found the following factors to be relevant in any discussion about addressing or minimizing vaccine hesitancy: risk perceptions, trust in health care systems, solidarity, previous experiences with vaccines, misinformation, concerns about vaccine side effects and political ideology. We combine our insights from this comprehensive review of global literature to offer an important and practical discussion about two strategies that have been used to improve vaccine uptake: (i) communication and education and (ii) vaccine rollout and logistics. [ABSTRACT FROM AUTHOR]
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- 2022
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42. Impact of COVID-19 and COVID-19 vaccination on high-risk patients with antiphospholipid syndrome: a nationwide survey.
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Pengo, Vittorio, Ross, Teresa Del, Tonello, Marta, Andreoli, Laura, Tincani, Angela, Gresele, Paolo, Silvestri, Elena, Simioni, Paolo, Campello, Elena, Hoxha, Ariela, Falanga, Anna, Ghirarduzzi, Angelo, Denas, Gentian, and collaborators, COVID-19 APS
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THROMBOSIS ,COVID-19 ,ANTIPHOSPHOLIPID syndrome ,COVID-19 vaccines ,SURVEYS ,QUESTIONNAIRES ,MEDICAL referrals ,DRUG side effects ,DISEASE risk factors ,SYMPTOMS - Abstract
Objectives Patients with APS and triple-positive for aPL are at high risk of recurrent events. As COVID-19 and COVID-19 vaccination may induce thrombotic complications, the objective of the study was to assess the course of COVID-19 and adverse events after vaccination in these patients. Methods This is a nationwide multicentre survey conducted in nine APS referral centres by means of a questionnaire. Included patients are thrombotic APS with triple-positive aPL confirmed 12 weeks apart. Reference specialist physicians used a four-graded scale of severity for COVID-19 [from 0 (asymptomatic) to 3 (hospitalization in intensive care unit)] and a six-graded scale for adverse reactions to vaccination [from 0 (transient local injection site sign/symptoms) to 5 (potentially life-threatening reactions)]. Outcomes were considered within a 30-day period. Results Out of 161 patients interviewed, 18 (11%) had COVID-19. All of them fully recovered without any progression to severe disease nor thromboembolic event. A total of 146 patients received the first (92%) and 129 (80%) the second dose of vaccine; side effects were minimal and, in most cases (83% after the first and 68% after the second vaccination) limited to a sore arm. Fifteen patients (9%) were unvaccinated. Most of them raised doubts on the need for vaccination, complained of poor safety and in general were reluctant about COVID-19 vaccination. Conclusion Patients with triple-positive thrombotic APS did not suffer from severe COVID-19 outcomes. Importantly, COVID-19 vaccination was well tolerated. These data may reassure patients and physicians and contribute to reducing hesitancy in unvaccinated patients. [ABSTRACT FROM AUTHOR]
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- 2022
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43. Expected Rates of Select Adverse Events After Immunization for Coronavirus Disease 2019 Vaccine Safety Monitoring.
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Abara, Winston E, Gee, Julianne, Delorey, Mark, Tun, Ye, Mu, Yi, Shay, David K, and Shimabukuro, Tom
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COVID-19 ,VACCINE safety ,IMMUNIZATION ,MEDICAL communication ,COVID-19 vaccines ,PERICARDITIS ,CORONAVIRUS diseases - Abstract
Using meta-analytic methods, we calculated expected rates of 20 potential adverse events of special interest (AESI) that would occur after coronavirus disease 2019 (COVID-19) vaccination within 1-, 7-, and 42-day intervals without causal associations. Based on these expected rates, if 10 000 000 persons are vaccinated, (1) 0.5, 3.7, and 22.5 Guillain-Barre syndrome cases, (2) 0.3, 2.4, and 14.3 myopericarditis cases, (3) and 236.5, 1655.5, and 9932.8 all-cause deaths would occur coincidentally within 1, 7, and 42 days postvaccination, respectively. Expected rates of potential AESI can contextualize events associated temporally with immunization, aid in safety signal detection, guide COVID-19 vaccine health communications, and inform COVID-19 vaccine benefit-risk assessments. [ABSTRACT FROM AUTHOR]
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- 2022
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44. Modelling the effect of COVID-19 mass vaccination on acute hospital admissions.
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Booton, Ross D, Powell, Anna L, Turner, Katy M E, and Wood, Richard M
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Background Managing high levels of acute COVID-19 bed occupancy can affect the quality of care provided to both affected patients and those requiring other hospital services. Mass vaccination has offered a route to reduce societal restrictions while protecting hospitals from being overwhelmed. Yet, early in the mass vaccination effort, the possible impact on future bed pressures remained subject to considerable uncertainty. Objective The aim of this study was to model the effect of vaccination on projections of acute and intensive care bed demand within a 1 million resident healthcare system located in South West England. Methods An age-structured epidemiological model of the susceptible–exposed–infectious–recovered type was fitted to local data up to the time of the study, in early March 2021. Model parameters and vaccination scenarios were calibrated through a system-wide multidisciplinary working group, comprising public health intelligence specialists, healthcare planners, epidemiologists and academics. Scenarios assumed incremental relaxations to societal restrictions according to the envisaged UK Government timeline, with all restrictions to be removed by 21 June 2021. Results Achieving 95% vaccine uptake in adults by 31 July 2021 would not avert the third wave in autumn 2021 but would produce a median peak bed requirement ∼6% (IQR: 1–24%) of that experienced during the second wave (January 2021). A 2-month delay in vaccine rollout would lead to significantly higher peak bed occupancy, at 66% (11–146%) of that of the second wave. If only 75% uptake was achieved (the amount typically associated with vaccination campaigns), then the second wave peak for acute and intensive care beds would be exceeded by 4% and 19%, respectively, an amount which would seriously pressure hospital capacity. Conclusion Modelling influenced decision-making among senior managers in setting COVID-19 bed capacity levels, as well as highlighting the importance of public health in promoting high vaccine uptake among the population. Forecast accuracy has since been supported by actual data collected following the analysis, with observed peak bed occupancy falling comfortably within the inter-quartile range of modelled projections. [ABSTRACT FROM AUTHOR]
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- 2022
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45. Vaccination Against COVID-19: A Longitudinal Trans-Theoretical Study to Determine Factors that Predict Intentions and Behavior.
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Shiloh, Shoshana, Peleg, Shira, and Nudelman, Gabriel
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Background: Despite the clear benefits of vaccination, their uptake against common infectious diseases is suboptimal. In December 2020, vaccines against COVID-19 became available.Purpose: To determine factors that predict who will take the COVID-19 vaccine based on a conceptual model.Methods: An online survey was administered twice: prior to public vaccination, and after vaccinations were available. Participants were 309 Israelis with initial data and 240 at follow-up. Baseline questionnaires measured intentions to be vaccinated and hypothesized predictors clustered in four categories: background, COVID-19, vaccination, and social factors. Self-reported vaccination uptake was measured at follow-up.Results: Sixty-two percent of the sample reported having been vaccinated. Intentions were strongly associated with vaccination uptake and mediated the effects of other predictors on behavior. Eighty-six percent of the variance in vaccination intentions was explained by attitudes toward COVID-19 vaccination, regret for having declined vaccination, trust in vaccination, vaccination barriers, past flu vaccination, perceived social norms, and COVID-19 representations.Conclusions: Beliefs related directly to the COVID-19 vaccine explained most of the variance in intentions to vaccinate, which in turn predicted vaccination uptake. [ABSTRACT FROM AUTHOR]- Published
- 2022
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46. Mandatory vaccination against COVID-19 for health and social care workers caring for older people.
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Gordon, Adam L, Achterberg, Wilco P, and Delden, Johannes J M van
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VACCINATION policies ,COVID-19 ,COVID-19 vaccines ,SOCIAL workers ,VACCINATION mandates ,INFECTIOUS disease transmission ,ELDER care - Abstract
The COVID-19 pandemic has particularly adversely affected older people with frailty and functional dependency. Essential regular contact with care staff has been evidenced as an important source of infection for this group. Vaccinating care staff can reduce the incidence, duration and severity of infection, preventing onward transmission to older people and minimising the harm associated with discontinuity caused by staff absence. Voluntary vaccination programmes for staff are more likely to be effective when associated with information and education, community engagement and financial incentives, but programmes using all of these approaches have failed to establish consistently high vaccination rates among care staff during the pandemic. Mandatory vaccination, proposed as a solution in some countries, can increase vaccination rates. It is only ethical if a vaccine is effective and cost-effective, the risk associated with vaccinating care workers is proportionate to the risk reduction achieved through vaccination, and where all efforts to encourage voluntary vaccination have been exhausted. Even when these conditions have been met, careful attention is required to ensure that the penalties associated with conscientious objection are proportionate and to ensure that implementation is equitable in a way that does not disadvantage particular groups of staff. [ABSTRACT FROM AUTHOR]
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- 2022
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47. Small but Significantly Greater Incidence of Inflammatory Heart Disease Identified After Vaccination for Severe Acute Respiratory Syndrome Coronavirus 2.
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Knowlton, Kirk U, Knight, Stacey, Muhlestein, Joseph B, Le, Viet T, Horne, Benjamin D, May, Heidi T, Stenehjem, Edward A, and Anderson, Jeffrey L
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SARS-CoV-2 ,CORONAVIRUS diseases ,HEART diseases ,COVID-19 ,CARDIAC patients - Abstract
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are being administered on an unprecedented scale. Assessing the risks of side effects is needed to aid clinicians in early detection and treatment. This study examined the risk of inflammatory heart disease, including pericarditis and myocarditis, after SARS-CoV-2 vaccination. Methods Intermountain Healthcare patients with inflammatory heart disease from December 15, 2020 to June 15, 2021, and with or without preceding SARS-CoV-2 vaccinations, were studied. Relative rates of inflammatory heart disease were examined for vaccinated patients compared to unvaccinated patients. Results Of 67 patients identified with inflammatory heart disease, 21 (31.3%) had a SARS-Cov-2 vaccination within the previous 60 days. Overall, 914 611 Intermountain Healthcare patients received a SARS-CoV-2 vaccine, resulting in an inflammatory heart disease rate of 2.30 per 100 000 vaccinated patients. The relative risk of inflammatory heart disease for the vaccinated patients compared to the unvaccinated patients was 2.05 times higher rate within the 30-day window (P = .01) and had a trend toward increase in the 60-day window (relative rate = 1.63; P = .07). All vaccinated patients with inflammatory heart disease were treated successfully with 1 death related to a pre-existing condition. Conclusions Although rare, the rate of inflammatory heart disease was greater in a SARS-CoV-2-vaccinated population than the unvaccinated population. This risk is eclipsed by the risk of contracting coronavirus disease 2019 and its associated, commonly severe outcomes. Nevertheless, clinicians and patients should be informed of this risk to facilitate earlier recognition and treatment. [ABSTRACT FROM AUTHOR]
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- 2022
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48. Mathematical Modeling to Inform Vaccination Strategies and Testing Approaches for Coronavirus Disease 2019 (COVID-19) in Nursing Homes.
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Kahn, Rebecca, Holmdahl, Inga, Reddy, Sujan, Jernigan, John, Mina, Michael J, and Slayton, Rachel B
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PREVENTION of infectious disease transmission ,VACCINATION ,COVID-19 ,COVID-19 vaccines ,NURSING care facilities ,MATHEMATICS ,PHARMACEUTICAL arithmetic ,VACCINE effectiveness ,COVID-19 testing - Abstract
Background Nursing home residents and staff were included in the first phase of coronavirus disease 2019 vaccination in the United States. Because the primary trial endpoint was vaccine efficacy (VE) against symptomatic disease, there are limited data on the extent to which vaccines protect against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the ability to infect others (infectiousness). Assumptions about VE against infection and infectiousness have implications for changes to infection prevention guidance for vaccinated populations, including testing strategies. Methods We use a stochastic agent-based Susceptible-Exposed-Infectious (Asymptomatic/Symptomatic)-Recovered model of a nursing home to simulate SARS-CoV-2 transmission. We model 3 scenarios, varying VE against infection, infectiousness, and symptoms, to understand the expected impact of vaccination in nursing homes, increasing staff vaccination coverage, and different screening testing strategies under each scenario. Results Increasing vaccination coverage in staff decreases total symptomatic cases in the nursing home (among staff and residents combined) in each VE scenario. In scenarios with 50% and 90% VE against infection and infectiousness, increasing staff coverage reduces symptomatic cases among residents. If vaccination only protects against symptoms, and asymptomatic cases remain infectious, increased staff coverage increases symptomatic cases among residents. However, this is outweighed by the reduction in symptomatic cases among staff. Higher frequency testing—more than once weekly—is needed to reduce total symptomatic cases if the vaccine has lower efficacy against infection and infectiousness, or only protects against symptoms. Conclusions Encouraging staff vaccination is not only important for protecting staff, but might also reduce symptomatic cases in residents if a vaccine confers at least some protection against infection or infectiousness. [ABSTRACT FROM AUTHOR]
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- 2022
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49. What factors promote vaccine hesitancy or acceptance during pandemics? A systematic review and thematic analysis.
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Truong, Judy, Bakshi, Simran, Wasim, Aghna, Ahmad, Mobeen, and Majid, Umair
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INFLUENZA prevention ,EBOLA virus disease prevention ,VACCINATION ,PSYCHOLOGY information storage & retrieval systems ,INFLUENZA vaccines ,DRUG efficacy ,MEDICAL information storage & retrieval systems ,COVID-19 ,VIRAL vaccines ,HEALTH services accessibility ,ATTITUDE (Psychology) ,SYSTEMATIC reviews ,COVID-19 vaccines ,MEDICAL care costs ,RISK assessment ,EPIDEMICS ,VACCINE hesitancy ,DESCRIPTIVE statistics ,MEDLINE ,THEMATIC analysis ,MISINFORMATION ,PATIENT safety ,PSYCHOLOGICAL factors - Abstract
Examine the factors that promote vaccine hesitancy or acceptance during pandemics, major epidemics and global outbreaks. A systematic review and thematic analysis of 28 studies on the Influenza A/H1N1 pandemic and the global spread of Ebola Virus Disease. We found seven major factors that promote vaccine hesitancy or acceptance: demographic factors influencing vaccination (ethnicity, age, sex, pregnancy, education, and employment), accessibility and cost, personal responsibility and risk perceptions, precautionary measures taken based on the decision to vaccinate, trust in health authorities and vaccines, the safety and efficacy of a new vaccine, and lack of information or vaccine misinformation. An understanding of participant experiences and perspectives toward vaccines from previous pandemics will greatly inform the development of strategies to address the present situation with the COVID-19 pandemic. We discuss the impact vaccine hesitancy might have for the introduction and effectiveness of a potential COVID-19 vaccine. In particular, we believe that skepticism toward vaccines can still exist when there are no vaccines available, which is contrary to contemporary conceptualizations of vaccine hesitancy. We recommend conducting further research assessing the relationship between the accessibility and cost of vaccines, and vaccine hesitancy. [ABSTRACT FROM AUTHOR]
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- 2022
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50. Post-COVID-19 vaccination inflammatory syndrome: A case report.
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Durucan, Ibrahim, Guner, Sabriye, Kilickiran Avci, Burcak, Unverengil, Gokcen, Melikoglu, Melike, and Ugurlu, Serdal
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HEART failure ,MYOSITIS ,COVID-19 pandemic ,HISTOCOMPATIBILITY class I antigens ,VACCINATION - Published
- 2023
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