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The debilitating symptoms of Parkinson's disease, including the hallmark slowness of movement, termed bradykinesia, were described more than 100 years ago. Despite significant advances in elucidating the genetic, molecular and neurobiological changes in Parkinson's disease, it remains conceptually unclear exactly why patients with Parkinson's disease move slowly. To address this, we summarize behavioural observations of movement slowness in Parkinson's disease and discuss these findings in a behavioural framework of optimal control. In this framework, agents optimize the time it takes to gather and harvest rewards by adapting their movement vigour according to the reward that is at stake and the effort that needs to be expended. Thus, slow movements can be favourable when the reward is deemed unappealing or the movement very costly. While reduced reward sensitivity, which makes patients less inclined to work for reward, has been reported in Parkinson's disease, this appears to be related mainly to motivational deficits (apathy) rather than bradykinesia. Increased effort sensitivity has been proposed to underlie movement slowness in Parkinson's disease. However, careful behavioural observations of bradykinesia are inconsistent with abnormal computations of effort costs due to accuracy constraints or movement energetic expenditure. These inconsistencies can be resolved when considering that a general disability to switch between stable and dynamic movement states can contribute to an abnormal composite effort cost related to movement in Parkinson's disease. This can account for paradoxical observations such as the abnormally slow relaxation of isometric contractions or difficulties in halting a movement in Parkinson's disease, both of which increase movement energy expenditure. A sound understanding of the abnormal behavioural computations mediating motor impairment in Parkinson's disease will be vital for linking them to their underlying neural dynamics in distributed brain networks and for grounding future experimental studies in well-defined behavioural frameworks. [ABSTRACT FROM AUTHOR]

A growing number of supernovae (SNe) are now known to exhibit evidence for significant interaction with a dense, pre-existing, circumstellar medium (CSM). SNe Ibn comprise one such class that can be characterized by both rapidly evolving light curves and persistent narrow He  i lines. The origin of such a dense CSM in these systems remains a pressing question, specifically concerning the progenitor system and mass-loss mechanism. In this paper, we present multiwavelength data of the Type Ibn SN 2020nxt, including HST /STIS ultraviolet spectra. We fit the data with recently updated CMFGEN models designed to handle configurations for SNe Ibn. The UV coverage yields strong constraints on the energetics and, when combined with the CMFGEN models, offer new insight on potential progenitor systems. We find the most successful model is a ≲4 M⊙ helium star that lost its |$\sim 1\, {\rm M}_\odot$| He-rich envelope in the years preceding core collapse. We also consider viable alternatives, such as a He white dwarf merger. Ultimately, we conclude at least some SNe Ibn do not arise from single, massive (>30 M⊙) Wolf–Rayet-like stars. [ABSTRACT FROM AUTHOR]

Meteor showers and their outbursts are the dominant source of meteoroid impact risk to spacecraft on short time-scales. Meteor shower prediction models depend on historical observations to produce accurate forecasts. However, the current lack of quality and persistent world-wide monitoring at optical meteoroid sizes has left some recent major outbursts poorly observed. A novel method of computing meteor shower flux is developed and applied to Global Meteor Network data. The method is verified against previously published observations of the Perseids and the Geminids. The complete mathematical and algorithmic details of computing meteor shower fluxes from video observations are described. As an example application of our approach, the flux measurements of the 2021 Perseid outburst, the 2020–2022 Quadrantids, and 2020–2021 Geminids are presented. The flux of the 2021 Perseids reached similar levels to the 1991–1994 and 2016 outbursts (ZHR ∼ 280). The flux of the Quadrantids shows high year-to-year variability in the core of the stream while the longer lasting background activity is less variable, consistent with an age difference between the two components. The Geminids show a double peak in flux near the time of peak. [ABSTRACT FROM AUTHOR]

Physical properties of ten millimetre-sized meteoroids from the Southern Delta Aquariids (SDA) shower are derived using optical observations from the Canadian Automated Meteor Observatory between 2020 and 2023. The meteors are found to ablate in two distinct erosion stages, the second stage showing a single, bright leading fragment. Our modelling interprets these observations as evidence for equal masses of compact grains embedded in a porous, low density matrix. The average bulk density of SDA meteors is found to be 1420 ± 100   |$\rm {kg \ m^{-3}}$|⁠ , with the compact component having a density of 2310 ± 160 |$\rm {kg \ m^{-3}}$| and the porous component a density of 700 ± 110   |$\rm {kg \ m^{-3}}$|⁠. The high bulk density of SDA meteors is comparable to densities found for the Quadrantid and Geminid showers, both of which also have low perihelion distances. This suggests that thermal desorption may play a significant role in the processing of meteoroids. [ABSTRACT FROM AUTHOR]

The Danish SEQUEL cohort is a study that aims to investigate the inequalities and late effects experienced by cancer survivors in Denmark. The cohort includes adult survivors of breast, prostate, lung, colon and rectum cancer, melanoma, and lymphoma. It provides comprehensive data on tumor characteristics, cancer treatment, educational level, income, cohabitation, comorbidity, and more. The study has found that cancer survivors, especially those with lower education levels, have a greater need for healthcare services and experience impaired functioning and severe symptoms. The data from the cohort is not publicly available, but researchers can contact the principal investigator for collaborative research projects. The study has been approved by the National Board of Health Data and has received funding from various organizations. [Extracted from the article]

We present photometric and spectroscopic observations and analysis of SN 2021bxu (ATLAS21dov), a low-luminosity, fast-evolving Type IIb supernova (SN). SN 2021bxu is unique, showing a large initial decline in brightness followed by a short plateau phase. With |$M_r = -15.93 \pm 0.16\, \mathrm{mag}$| during the plateau, it is at the lower end of the luminosity distribution of stripped-envelope supernovae (SE-SNe) and shows a distinct ∼10 d plateau not caused by H- or He-recombination. SN 2021bxu shows line velocities which are at least |$\sim 1500\, \mathrm{km\, s^{-1}}$| slower than typical SE-SNe. It is photometrically and spectroscopically similar to Type IIb SNe during the photospheric phases of evolution, with similarities to Ca-rich IIb SNe. We find that the bolometric light curve is best described by a composite model of shock interaction between the ejecta and an envelope of extended material, combined with a typical SN IIb powered by the radioactive decay of 56Ni. The best-fitting parameters for SN 2021bxu include a 56Ni mass of |$M_{\mathrm{Ni}} = 0.029^{+0.004}_{-0.005}\, \mathrm{{\rm M}_{\odot }}$|⁠ , an ejecta mass of |$M_{\mathrm{ej}} = 0.61^{+0.06}_{-0.05}\, \mathrm{{\rm M}_{\odot }}$|⁠ , and an ejecta kinetic energy of |$K_{\mathrm{ej}} = 8.8^{+1.1}_{-1.0} \times 10^{49}\, \mathrm{erg}$|⁠. From the fits to the properties of the extended material of Ca-rich IIb SNe we find a trend of decreasing envelope radius with increasing envelope mass. SN 2021bxu has M Ni on the low end compared to SE-SNe and Ca-rich SNe in the literature, demonstrating that SN 2021bxu-like events are rare explosions in extreme areas of parameter space. The progenitor of SN 2021bxu is likely a low-mass He star with an extended envelope. [ABSTRACT FROM AUTHOR]

Bioblitzes are a popular approach to engage people and collect biodiversity data. Despite this, few studies have actually evaluated the multiple outcomes of bioblitz activities. We used a systematic review, an analysis of data from more than 1000 bioblitzes, and a detailed analysis of one specific bioblitz to inform our inquiry. We evaluated five possible bioblitz outcomes, which were creating a species inventory, engaging people in biological recording, enhancing learning about nature, discovering a species new to an area, and promoting an organization. We conclude that bioblitzes are diverse but overall effective at their aims and have advantages over unstructured biodiversity recording. We demonstrate for the first time that bioblitzes increase the recording activity of the participants for several months after the event. In addition, we provide evidence that bioblitzes are effective at bringing people and organizations together to build communities of professionals and amateurs, critical for conserving and protecting biodiversity. [ABSTRACT FROM AUTHOR]

Aims Methylation of non-histone proteins is emerging as a central regulatory mechanism in health and disease. The methyltransferase SETD7 has shown to methylate and alter the function of a variety of proteins in vitro ; however, its function in the heart is poorly understood. The present study investigates the role of SETD7 in myocardial ischaemic injury. Methods and results Experiments were performed in neonatal rat ventricular myocytes (NRVMs), SETD7 knockout mice (SETD7−/−) undergoing myocardial ischaemia/reperfusion (I/R) injury, left ventricular (LV) myocardial samples from patients with ischaemic cardiomyopathy (ICM), and peripheral blood mononuclear cells (PBMCs) from patients with ST-elevation MI (STEMI). We show that SETD7 is activated upon energy deprivation in cultured NRVMs and methylates the Hippo pathway effector YAP, leading to its cytosolic retention and impaired transcription of antioxidant genes manganese superoxide dismutase (MnSOD) and catalase (CAT). Such impairment of antioxidant defence was associated with mitochondrial reactive oxygen species (mtROS), organelle swelling, and apoptosis. Selective pharmacological inhibition of SETD7 by (R) -PFI-2 restored YAP nuclear localization, thus preventing mtROS, mitochondrial damage, and apoptosis in NRVMs. In mice, genetic deletion of SETD7 attenuated myocardial I/R injury, mtROS, and LV dysfunction by restoring YAP-dependent transcription of MnSOD and CAT. Moreover, in cardiomyocytes isolated from I/R mice and ICM patients, (R) -PFI-2 prevented mtROS accumulation, while improving Ca2+-activated tension. Finally, SETD7 was up-regulated in PBMCs from STEMI patients and negatively correlated with MnSOD and CAT. Conclusion We show a methylation-dependent checkpoint regulating oxidative stress during myocardial ischaemia. SETD7 inhibition may represent a valid therapeutic strategy in this setting. [ABSTRACT FROM AUTHOR]

Early-time radiative signals from Type Ia supernovae (SNe Ia) can provide important constraints on the explosion mechanism and the progenitor system. We present observations and analysis of SN 2019np, a nearby SN Ia discovered within 1–2 days after the explosion. Follow-up observations were conducted in optical, ultraviolet, and near-infrared bands, covering the phases from ∼−16.7 d to ∼+ 367.8 d relative to its B -band peak luminosity. The photometric and spectral evolutions of SN 2019np resemble the average behaviour of normal SNe Ia. The absolute B -band peak magnitude and the post-peak decline rate are M max(B) = −19.52 ± 0.47 mag and Δ m 15(B) = 1.04 ± 0.04 mag, respectively. No Hydrogen line has been detected in the nebular-phase spectra of SN 2019np. Assuming that the 56Ni powering the light curve is centrally located, we find that the bolometric light curve of SN 2019np shows a flux excess up to 5.0 per cent in the early phase compared to the radiative diffusion model. Such an extra radiation perhaps suggests the presence of an additional energy source beyond the radioactive decay of central nickel. Comparing the observed colour evolution with that predicted by different models, such as interactions of SN ejecta with circumstellar matter (CSM)/companion star, a double-detonation explosion from a sub-Chandrasekhar mass white dwarf (WD) and surface 56Ni mixing, we propose that the nickel mixing is more favoured for SN 2019np. [ABSTRACT FROM AUTHOR]

Exaggerated local field potential bursts of activity at frequencies in the low beta band are a well-established phenomenon in the subthalamic nucleus of patients with Parkinson's disease. However, such activity is only moderately correlated with motor impairment. Here we test the hypothesis that beta bursts are just one of several dynamic states in the subthalamic nucleus local field potential in Parkinson's disease, and that together these different states predict motor impairment with high fidelity. Local field potentials were recorded in 32 patients (64 hemispheres) undergoing deep brain stimulation surgery targeting the subthalamic nucleus. Recordings were performed following overnight withdrawal of anti-parkinsonian medication, and after administration of levodopa. Local field potentials were analysed using hidden Markov modelling to identify transient spectral states with frequencies under 40 Hz. Findings in the low beta frequency band were similar to those previously reported; levodopa reduced occurrence rate and duration of low beta states, and the greater the reductions, the greater the improvement in motor impairment. However, additional local field potential states were distinguished in the theta, alpha and high beta bands, and these behaved in an opposite manner. They were increased in occurrence rate and duration by levodopa, and the greater the increases, the greater the improvement in motor impairment. In addition, levodopa favoured the transition of low beta states to other spectral states. When all local field potential states and corresponding features were considered in a multivariate model it was possible to predict 50% of the variance in patients' hemibody impairment OFF medication, and in the change in hemibody impairment following levodopa. This only improved slightly if signal amplitude or gamma band features were also included in the multivariate model. In addition, it compares with a prediction of only 16% of the variance when using beta bursts alone. We conclude that multiple spectral states in the subthalamic nucleus local field potential have a bearing on motor impairment, and that levodopa-induced shifts in the balance between these states can predict clinical change with high fidelity. This is important in suggesting that some states might be upregulated to improve parkinsonism and in suggesting how local field potential feedback can be made more informative in closed-loop deep brain stimulation systems. [ABSTRACT FROM AUTHOR]

The Global Meteor Network (GMN) utilizes highly sensitive low-cost CMOS video cameras which run open-source meteor detection software on Raspberry Pi computers. Currently, over 450 GMN cameras in 30 countries are deployed. The main goal of the network is to provide long-term characterization of the radiants, flux, and size distribution of annual meteor showers and outbursts in the optical meteor mass range. The rapid 24-h publication cycle the orbital data will enhance the public situational awareness of the near-Earth meteoroid environment. The GMN also aims to increase the number of instrumentally observed meteorite falls and the transparency of data reduction methods. A novel astrometry calibration method is presented which allows decoupling of the camera pointing from the distortion, and is used for frequent pointing calibrations through the night. Using wide-field cameras (88° × 48°) with a limiting stellar magnitude of +6.0 ± 0.5 at 25 frames per second, over 220 000 precise meteoroid orbits were collected since 2018 December until 2021 June. The median radiant precision of all computed trajectories is 0.47°, 0.32° for |$\sim 20{{\ \rm per\ cent}}$| of meteors which were observed from 4 + stations, a precision sufficient to measure physical dispersions of meteor showers. All non-daytime annual established meteor showers were observed during that time, including five outbursts. An analysis of a meteorite-dropping fireball is presented which showed visible wake, fragmentation details, and several discernible fragments. It had spatial trajectory fit errors of only ∼40 m, which translated into the estimated radiant and velocity errors of 3 arcmin and tens of meters per second. [ABSTRACT FROM AUTHOR]

Tracking wood formation in semiarid regions during the seasonal march of precipitation extremes has two important applications. It can provide (i) insight into the adaptive capacities of trees to drought and (ii) a basis for a richer interpretation of tree-ring data, assisting in a deeper understanding of past and current climate. In the southwestern USA, the anatomical signature of seasonally bimodal precipitation is the 'false ring'—a band of latewood-like cells in the earlywood. These occur when a particularly deep drought during the early growing season ends abruptly with timely, mid-growing season monsoonal rains. Such conditions presented in southern Arizona in 2014, enabling us to explore false-ring formation in ponderosa pine (Pinus ponderosa Lawson and C. Lawson) and Douglas-fir (Pseudotsuga menziesii Mirb. Franco) in mixed-conifer forest at 2573 m above sea level. We ask: what were the cell-by-cell timings and durations in the phases of wood cell development in 2014? How do these seasonal patterns relate to strongly fluctuating environmental conditions during the growing season? We took weekly microcores from March through November from six ponderosa pine and seven Douglas-fir trees at a well-instrumented flux tower site. Thin sections were prepared, and we counted cells in cambial, expansion, cell wall thickening and mature phases. For ponderosa pine trees forming a false ring, the first impact of intensifying seasonal drought was seen in the enlarging phase and then, almost a month later, in cambial activity. In this species, recovery from drought was associated with recovery first in cambial activity, followed by cell enlargement. This timing raised the possibility that cell division may be affected by atmospheric moisture increases before soil recharge. In both species, the last false-ring cells matured during the summer rainy season. Bimodal cambial activity coincident with moisture availability was observed in both species, whether or not they formed a false ring. This deeper knowledge of the precise timing of both developmental and environmental events should help define mechanistic connections among these factors in creating bimodal growth patterns. [ABSTRACT FROM AUTHOR]

We present optical and ultraviolet photometry, as well as optical spectra, for the type II supernova (SN) 2015bf. Our observations cover the phases from ∼2 to ∼200 d after explosion. The first spectrum is characterized by a blue continuum with a blackbody temperature of ∼24 000 K and flash-ionized emission lines. After about 1 week, the spectra of SN 2015bf evolve like those of a regular SN II. From the luminosity of the narrow emission component of H α, we deduce that the mass-loss rate is larger than |${\sim}3.7\times 10^{-3}\, {\rm M_\odot \, yr^{-1}}$|⁠. The disappearance of the flash features in the first week after explosion indicates that the circumstellar material is confined within ∼6 × 1014 cm. Thus, we suggest that the progenitor of SN 2015bf experienced violent mass loss shortly before the supernova explosion. The multiband light curves show that SN 2015bf has a high peak luminosity with an absolute visual magnitude MV  = −18.11 ± 0.08 mag and a fast post-peak decline with a V -band decay of 1.22 ± 0.09 mag within ∼50 d after maximum light. Moreover, the R -band tail luminosity of SN 2015bf is fainter than that of SNe II with similar peak by 1–2 mag, suggesting a small amount of 56Ni (⁠|${\sim}0.009\, {\rm M_\odot }$|⁠) synthesized during the explosion. Such a low nickel mass indicates that the progenitor of SN 2015bf could be a super-asymptotic-giant-branch star that collapsed owing to electron capture. [ABSTRACT FROM AUTHOR]