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We employ a sample of 135 873 RR Lyrae stars (RRLs) with precise photometric-metallicity and distance estimates from the newly calibrated P –ϕ31– R 21–[Fe/H] and Gaia G band P – R 21–[Fe/H] absolute magnitude–metallicity relations of Li et al. combined with available proper motions from Gaia EDR3, and 6955 systemic radial velocities from Gaia DR3 and other sources, in order to explore the chemistry and kinematics of the halo of the Milky Way (MW). This sample is ideally suited for characterization of the inner- and outer-halo populations of the stellar halo, free from the bias associated with spectroscopically selected probes, and for estimation of their relative contributions as a function of Galactocentric distance. The results of a Gaussian mixture model analysis of these contributions are broadly consistent with other observational studies of the halo, and with expectations from recent MW simulation studies. We apply the hdbscan clustering method to the specific energies and cylindrical actions (E , Jr, Jϕ, J z ), identifying 97 dynamically tagged groups (DTGs) of RRLs, and explore their associations with recognized substructures of the MW. The precise photometric-distance determinations (relative distance errors on the order of 5 per cent or better), and the resulting high-quality determination of dynamical parameters, yield highly statistically significant (low) dispersions of [Fe/H] for the stellar members of the DTGs compared to random draws from the full sample, indicating that they share common star-formation and chemical histories, influenced by their birth environments. [ABSTRACT FROM AUTHOR]

Candida auris is a widely distributed, highly lethal, multidrug-resistant fungal pathogen. It was first identified in 2009 when it was isolated from fluid drained from the external ear canal of a patient in Japan. Since then, it has caused infectious outbreaks in over 45 countries, with mortality rates approaching 60%. Drug resistance is common in this species, with a large proportion of isolates displaying fluconazole resistance and nearly half are resistant to two or more antifungal drugs. In this review, we describe the drug resistance mechanism of C. auris and potential small-molecule drugs for treating C. auris infection. Among these antifungal agents, rezafungin was approved by the US Food and Drug Administration (FDA) for the treatment of candidemia and invasive candidiasis on March 22, 2023. Ibrexafungerp and fosmanogepix have entered phase III clinical trials. [ABSTRACT FROM AUTHOR]

We use 3653 (2661 RRab, 992 RRc) RR Lyrae stars (RRLs) with 7D (3D position, 3D velocity, and metallicity) information selected from Sloan Digital Sky Survey, Large Sky Area Multi-Object Fiber Spectroscopic Telescope, and Gaia EDR3, and divide the sample into two Oosterhoff groups (Oo I and Oo II) according to their amplitude–period behaviour in the Bailey diagram. We present a comparative study of these two groups based on chemistry, kinematics, and dynamics. We find that Oo I RRLs are relatively more metal-rich, with predominately radially dominated orbits and large eccentricities, while Oo II RRLs are relatively more metal-poor, and have mildly radially dominated orbits. The Oosterhoff dichotomy of the Milky Way's halo is more apparent for the inner-halo region than for the outer-halo region. Additionally, we also search for this phenomenon in the haloes of the two largest satellite galaxies, the Large and Small Magellanic clouds, and compare over different bins in metallicity. We find that the Oosterhoff dichotomy is not immutable, and varies based on position in the Galaxy and from galaxy to galaxy. We conclude that the Oosterhoff dichotomy is the result of a combination of stellar and galactic evolution, and that it is much more complex than the dichotomy originally identified in Galactic globular clusters. [ABSTRACT FROM AUTHOR]

Based on a large spectroscopic sample of ∼4300 RR Lyrae stars with metallicity, systemic radial velocity, and distance measurements, we present a detailed analysis of the chemical and kinematic properties of the Galactic halo. Using this sample, the metallicity distribution function (MDF) as a function of r and the velocity anisotropy parameter β profiles (for different metallicity populations) are derived for the stellar halo. Both the chemical and kinematic results suggest that the Galactic halo is composed of two distinct parts, the inner halo and outer halo. The cutoff radius (∼30 kpc) is similar to the previous break radius found in the density distribution of the stellar halo. We find that the inner part is dominated by a metal-rich population with extremely radial anisotropy (β ∼ 0.9). These features are in accordance with those of ' Gaia -Enceladus-Sausage' (GES) and we attribute this inner halo component as being dominantly composed of stars deposited from this ancient merged satellite. We find that GES probably has a slightly negative metallicity gradient. The metal-poor populations in the inner halo are characterized as a long tail in MDF with an anisotropy of β ∼ 0.5, which is similar to that of the outer part. The MDF for the outer halo is very broad with several weak peaks and the value of β is around 0.5 for all metallicities. [ABSTRACT FROM AUTHOR]

Computed tomographic angiography revealed bilateral pulmonary artery (PA) dissection ( I Panel C i ) and pulmonary trunk aneurysm (6.5 cm; I Panel D i ), associated with a PDA (white arrow, I Panel E i ). PA aneurysm and dissection are very rare complications of pulmonary artery hypertension (PAH), mostly diagnosed at post-mortem examination. [Extracted from the article]