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In this paper, recently developed set theoretical variants of the teaching-learning-based optimization (TLBO) algorithm and the shuffled shepherd optimization algorithm (SSOA) are employed for system reliability-based design optimization (SRBDO) of truss structures. The set theoretical variants are designed based on a simple framework in which the population of candidate solutions is divided into some number of smaller well-arranged sub-populations. In addition, the framework is applied to the Jaya algorithm, leading to a set-theoretical variant of the Jaya algorithm. So far, most of the reliability-based design optimization studies have focused on the reliability of single structural members. This is due to the fact that the optimization problems with system reliability-based constraints are computationally expensive to solve. This is especially the case of statically redundant structures, where the number of failure modes is so high that it is impractical to identify all of them. System-level reliability analysis of truss structures is carried out by the branch and bound method by which the stochastically dominant failure paths are identified within a reasonable time. At last, three numerical examples, including size optimization of truss structures, are presented to illustrate the effectiveness of the proposed SRBDO approach. The results indicate the efficiency and applicability of the set theoretical optimization algorithms to solve the SRBDO problems of truss structures. [ABSTRACT FROM AUTHOR]