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Background: Primary pancreatic signet ring cell carcinoma (PSRCC), an extremely rare histologic variant of pancreatic cancer, has a poor prognosis. This study aimed to investigate the prognostic value of chemotherapy in PSRCC. Methods: Patients with PSRCC between 2000 and 2019 were identified using the Surveillance Epidemiology and End Results (SEER) database. The main outcomes in this study were cancer-specific survival (CSS) and overall survival (OS). The baseline characteristics of patients were compared using Pearson's Chi-square test. Kaplan-Meier analysis was used to generate the survival curves. Least absolute shrinkage and selection operator (LASSO), univariate and multivariate Cox regression models, and Random Survival Forest model were used to analyze the prognostic variables for OS and CSS. The variance inflation factors (VIFs) were used to analyze whether there was an overfitting problem. Results: A total of 588 patients were identified. Chemotherapy was an independent prognostic factor for OS and CSS, and significantly associated with OS (HR = 0.33, 95% CI = 0.27–0.40, P <0.001) and CSS (HR = 0.32, 95% CI = 0.26–0.39, P <0.001). Conclusions: Chemotherapy showed beneficial effects on OS and CSS in patients with PSRCC and should be recommended in clinical practice. [ABSTRACT FROM AUTHOR]

The Funding statement is incorrect. Reference 1 Li P, Qin X, Tao F, Huang K (2020) Maternal exposure to sulfonamides and adverse pregnancy outcomes: A systematic review and meta-analysis. The correct Funding statement is as follows: This work was supported by the National Natural Science Foundation of China (Grant 81872630 to KH); the Special Project Reproductive health, prevention, and control of major birth defects of National Key Research and Development Program (Grant 2016YFC1000204-2 to FT); and Sci-tech Basic Resources Research Program of China (Grant 2017FY101107 to KH). [Extracted from the article]