1. Enantioselective synthesis of 3-(N-indolyl)quinolines containing axial and central chiralities.
- Author
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Yamanomoto, Ken, Yamamoto, Kota, Yoshida, Satoshi, Sato, Sota, and Akiyama, Takahiko
- Subjects
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CHIRALITY element , *BIOACTIVE compounds , *ACID catalysts , *ADDITION reactions , *INDOLE , *QUINOLINE - Abstract
Quinoline and indole are important core structures in biologically active compounds and materials. Atropisomeric biaryls consisting of quinoline and indole are a unique class of axially chiral molecules. We report herein enantioselective synthesis of 3-(N-indolyl)quinolines having both C–N axial chirality and carbon central chirality by a photoredox Minisci-type addition reaction catalyzed by a chiral lithium phosphate/Ir-photoredox complex. The catalytic system enabled access to a unique class of 3-(N-indolyl)quinolines with high chemo-, regio-, and stereoselectivities in good yields through the appropriate choice of an acid catalyst and a photocatalyst. This is the first example of the synthesis of 3-(N-indolyl)quinoline atropisomers in a highly enantioselective manner. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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