Two novel metal–organic compounds have been prepared via altering metal ions under the hydrothermal conditions, i.e. [Zn(HL)(4,4′-bipy)(H2O)2]n (1) and [Cd(HL)(4,4′-bipy)]n (2) (4,4′-bipy = 4,4′-bipyridine and H3L = 5-(4-carboxyphenoxy)-isophthalic acid). Moreover, the luminescent performances and stabilities of the two compounds were also investigated. For the prevention and treatment evaluation of compounds 1 and 2 in this present research, serious of biological experiments were performed in this study. Firstly, the non-invasive blood pressure monitoring was used for blood pressure determination. In addition to this, the real time RT-PCR assay was conducted in this study for the assessment of the α receptor expression on the vascular endothelial cells. [ABSTRACT FROM AUTHOR]