1. Isolongifolene-loaded chitosan nanoparticles synthesis and characterization for cancer treatment.
- Author
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Manimaran, Dharmar, Elangovan, Namasivayam, Mani, Panagal, Subramanian, Kumaran, Ali, Daoud, Alarifi, Saud, Palanisamy, Chella Perumal, Zhang, Hongxia, Rangasamy, Kowsalya, Palanisamy, Vasan, Mani, Renuka, Govarthanan, Kavitha, Aruni, Wilson, Shanmugam, Rajeshkumar, Srinivasan, Guru Prasad, and Kalirajan, Aruncahllam
- Subjects
CHITOSAN ,SCANNING transmission electron microscopy ,FOURIER transform infrared spectroscopy ,TRANSMISSION electron microscopy ,CANCER treatment ,NANOPARTICLES - Abstract
Recent breakthroughs in the field of nanoparticle-based therapeutic delivery methods have changed the standpoint of cancer therapy by effectively delaying the process of disease development. Nanoparticles have a unique capacity of good penetrating ability than other therapeutic leads used in traditional therapeutics, and also, they have the highest impact on disease management. In the current study isolongifolene-loaded Chitosan nanoparticles have been formulated, synthesized and then characterized by the use of Fourier Transform Infrared Spectroscopy, X-ray Diffraction, Scanning Electron Microscopy and Transmission Electron Microscopy. Further, the characterized chitosan nano formulation was evaluated for hemocompatibility, plasma stability, and in-vitro release. Isolongifolene-loaded chitosan nanoparticles were found to be compatible with plasma and also, they exhibited a constant release pattern. Hence, chitosan-loaded nanoparticles could be employed as an excellent adjuvant in cancer therapeutic, to combat the multi-drug resistance in solid tumors. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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