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As researchers suggested, there is no way back for transatlantic politics; it has suffered severe setbacks that cannot be undone in recent years. Although the Biden win promises opportunities for EU-US cooperation, the EU's drive for strategic autonomy would not turn a halt given that the great leap forward for European policymakers and strategists would be to acknowledge that Europe's "autonomy" is actually in the transatlantic interests. Nevertheless, the transatlantic partnership is torn from a "thickening" tie that has bound the US and EU together for decades. Consequently, President Biden's transatlantic strategy to retie would undoubtedly pose challenges for European relations with China. The United States is increasingly intent on decoupling its economy and its technology sector from China as part of the new cold war cliché between the two. Nevertheless, the EU-China partnership has been working closely for the past few decades, and China's market has a great appeal to the world. The time has come for the EU to consider how to survive the turmoil of US-China decoupling caused by the two superpowers' agendas. This paper analyzes the critical transformation in light of not only the politics of today but also the structural trends in the global balance of power between the US and China. And explains the reasons why the pitfalls of US-China decoupling shape the dynamics of European ties with China in the last decade. This paper focuses on the issues: i) The EU's alterations of the EU-China partnership dealing with an increasingly assertive China; ii) US and China on the path to inevitable economic decoupling; iii) The EU drives for strategic autonomy aiming at enhancing the competitiveness in the high tech sector; iv) EU's ambition of safeguarding and reinvigorating cooperation over climate change and global health through the engagement of EU-China Investment Agreement. [ABSTRACT FROM AUTHOR]