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This study used Bayesian Regulated Neural Networks (BRNN) with 10-fold cross-validation to accurately forecast fading effects of plasma treatment on cotton fabrics for a given set of parameters. By training six independent BRNN models, a reduction in model complexity and an enhancement in generalizability to unknown datasets were achieved. The input comprises plasma treatment parameters and color measurements of the cotton fabric before fading, while the output comprises color measurements after fading. The plasma treatment parameters included color depth, air (oxygen) concentration, water content and treatment time. Color measurements included CIE L*a*b*C*h and K/S values. Furthermore, 162 datasets derived from two-color mixed-dye cotton fabrics were utilized for training and testing. The outcomes revealed superior prediction performance of the BRNN compared to the Levenberg-Marquardt Neural Networks, with R2 values approaching 1 and 82.35% to 94.12% of the sample predictions lying within the acceptable color difference range. Through global sensitivity analysis, the impact of treatment parameters on fading effects was quantified, providing a scientific basis for parameter adjustment. This study not only elucidated the mechanism of plasma treatment-induced fading but also offers effective prediction tools for the intelligent and digital development of the fashion clothing fading domain. [ABSTRACT FROM AUTHOR]