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It should, however, be noted that such approximations have ultimately allowed the authors to conduct a comprehensive analysis of thousands of images from multiple studies, which further substantiates their findings. We congratulate the authors on an interesting paper which combines the ideas of shape analysis with longitudinal data analysis. This, of course, loses some of the elegance of the SRNF framework, but at a considerable ease of preserving the topology of the data and avoiding Euclidean approximations. [Extracted from the article]