1. Two new supramolecular Ag(I) coordination polymers: luminescent properties and treatment activity on glioblastoma.
- Author
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Yan, Xiao-Feng, Sun, Yu-Qiang, and Li, Qing-Wei
- Subjects
- *
GLIOBLASTOMA multiforme , *COORDINATION polymers , *CELLULAR signal transduction , *LUMINESCENCE - Abstract
Two new Ag(I) coordination polymers, namely [Ag(bpp)]·0.5 n(1,5-NDSA)·n(H2O) (1) and [Ag2(bpp)2]n·n(2,7-NDSA)·2 n(H2O)·n(CH3CN) (2) (Na2(1,5-NDSA) = sodium 1,5-naphthalenedisulfonate dibasic, Na2(2,7-NDSA) = sodium 1,5-naphthalenedisulfonate dibasic, bpp is 1,3-bis(4-pyridyl)propane), were generated via the solution evaporation method under room temperature. Moreover, the solids of these two compounds display strong luminescence emission at RT. And the application values of the compounds against the glioblastoma treatment were determined, and the corresponding mechanism was simultaneously tested. The analysis of CCK-8 was first implemented and the glioblastoma viability was measured. The real-time RT-PCR was next performed, and the signaling pathway activation of VEGF in glioblastoma cells was tested after treating by the above compound. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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