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Thin-walled tubular structures are widely employed in applications. The current study proposes an innovative cost-saving and eco-friendly thin-walled cylinder concept using recycled beverage cans. Axial compression experiments are conducted to characterize the crushing performance under quasi-static and dynamic loading. Besides, the polyurethane foam (PUF)-filled beverage cans are fabricated to improve the compression resistance and energy absorption capacity. Experimental results show that empty beverage cans behave as a typical Type-II absorber and fail by local buckling of the cylinder belly. The initial peak force increases with deformation rates while the highest mean crushing force is obtained at compressive velocity of 50 mm/min. In contrast, PUF-filled beverage cans collapse with a progressive folding process and present significant improvement in crashworthiness. Experimental results are compared with theoretical analysis and conventional energy absorbers to clarify the crashworthiness. In addition, the interaction effect between the PUF fillings and the recycled beverage cans is discussed comprehensively. [ABSTRACT FROM AUTHOR]

Some cancers such as human breast cancer, prostate cancer, and lung cancer easily metastasize to bone, leading to osteolysis and bone destruction accompanied by a complicated microenvironment. Systemic administration of bisphosphonates (BP) or denosumab is the routine therapy for osteolysis but with non-negligible side effects such as mandibular osteonecrosis and hypocalcemia. Thus, it is imperative to exploit optimized drug delivery systems, and some novel nanotechnology and nanomaterials have opened new horizons for scientists. Targeted and local drug delivery systems can optimize biodistribution depending on nanoparticles (NPs) or microspheres (MS) and implantable biomaterials with the controllable property. Drug delivery kinetics can be optimized by smart and sustained/local drug delivery systems for responsive delivery and sustained delivery. These delicately fabricated drug delivery systems with special matrix, structure, morphology, and modification can minimize unexpected toxicity caused by systemic delivery and achieve desired effects through integrating multiple drugs or multiple functions. This review summarized recent studies about optimized drug delivery systems for the treatment of cancer metastatic osteolysis, aimed at giving some inspiration in designing efficient multifunctional drug delivery systems. [ABSTRACT FROM AUTHOR]