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In this paper, we explore what the travel restrictions during the COVID-19 pandemic reveal about the changing geographies of mobilities and the making of homo sacer, the latter constituted through differentiated control of mobilities. Implemented to protect U.S. public health, travel restrictions imposed on travelers from Mainland China during the early days of the pandemic exemplify how sovereign power that declares a state of emergency and creates bare life can be readily applied to groups of people who previously had privileged access to global mobility. In this sense, bare life does not refer to fixed and disadvantaged social categories but is rather contingently and contextually constituted, through the works of hybrid sovereign regimes. At the same time, however, these travelers are not reduced to a state of zero-agency but reside within a liminal space between soft and hard cosmopolitanisms, as they can still deploy agency and cosmopolitan capital to achieve certain degrees of mobility. By examining how Chinese travelers navigated various travel restrictions and the constantly changing policies to travel to the U.S., this paper explores new spaces of exception and forms of bare life, and argues that homo sacer is dynamically, relationally and recursively constructed, both through apparatus of control and the agency of travelers. [ABSTRACT FROM AUTHOR]

The development of polysaccharide drugs requires a thorough understanding of their quantitative and pharmacokinetic properties. However, the complexity of biological samples presents a challenge for direct analysis using UHPLC-QTOF MS. Therefore, it is essential to establish a method for the selective enrichment of polysaccharides. In this study, we developed an efficient method for the quantitative determination of polysaccharides by integrating magnetic molecularly imprinted polymers (MIPs) for sample pretreatment and UHPLC-QTOF MS for analysis. The MIPs were prepared using molecularly imprinted and boric acid affinity technologies, which combined the advantages of specific recognition and reversible binding to polysaccharides. The MIPs exhibited high dispersibility and uniform particle size, and adsorption experiments demonstrated their specific recognition of BG136, a polysaccharide with immunological activity. The proposed method was used for the purification and enrichment of BG136 in plasma with recoveries between 91.29% and 113.03%. This simple method demonstrated high selectivity, fast separation, and satisfactory recoveries providing an approach for polysaccharide determination with UHPLC-QTOF MS. [ABSTRACT FROM AUTHOR]

We investigate sequential change point estimation and detection in univariate nonparametric settings, where a stream of independent observations from sub-Gaussian distributions with a common variance factor and piecewise-constant but otherwise unknown means are collected. We develop a simple CUSUM-based methodology that provably control the probability of false alarms or the average run length while minimizing, in a minimax sense, the detection delay. We allow for all the model parameters to vary in order to capture a broad range of levels of statistical hardness for the problem at hand. We further show how our methodology is applicable to the case in which multiple change points are to be estimated sequentially. [ABSTRACT FROM AUTHOR]

This study systematically reviewed the relevant studies and summarized the associations of objective measures of residential neighborhood built-environment attributes with sedentary time among adults. Published studies were obtained from PubMed and Scopus, restricting to those published in English language peer-reviewed journals to Oct. 2021. There were nine studies and 48 instances of estimated associations. Most instances showed no statistical-significant associations; by contrast, few instances showed that adults living in a neighborhood characterized by a high density of local destinations and connected intersections were associated with less sedentary time. The findings suggest that a high density of destinations and street intersections around residence may provide opportunities to transfer and access to services, thus reducing the sedentary time. Future research strengthening the research design and measurements are needed to investigate the potential explanations of the associations between residential neighborhood built environments and sedentary time in adults. [ABSTRACT FROM AUTHOR]

Exemplarism – the view that exemplary people, whom we admire, are the bearers of our moral concepts – presents considerable challenges to the (widely-assumed) place of moral theory in how we learn to be moral. Exemplarism has been garnered by Amy Olberding to articulate a Confucian approach to moral learning. This paper extends Exemplarism by considering how it may be put into practice, based on a seminal Confucian text, the Analects of Confucius. To date, the majority of discussions on Confucian ethics that have brought Confucian philosophy to the attention of Anglophone scholars tend to focus on conceptually-based matters. There remain questions regarding how these values may be inculcated and embodied in our moral lives. Central to our proposal is the practice of reflective observation (guan 觀), comprised by three integrated components: observation, evaluation, and emulation. Observing, reflectively, is important not only for an individual's acculturation to existing norms and practices but also for how they may subsequently exercise some latitude over their moral practices. Our reflections offer a practical approach to Confucian moral learning. In doing so, we demystify moral learning in Confucianism and open up avenues for future cross-tradition dialogues on moral education. [ABSTRACT FROM AUTHOR]

Feminist scholars have highlighted the potential of care ethics to challenge the neoliberal social paradigm by underscoring the power of emotion and affect in shaping intersubjectivity. In a similar vein, Hardt and Negri (2001, 2005) stressed the power of affect to challenge capitalism. Other scholars, however, have challenged these positive aspects of emotion in care practices, citing the potential harm caused when affective ties to care recipients or the obligation to provide emotional care exploits workers. This article discusses the paradox of care that simultaneously enables and hurts, nurtures and harms. Based on ethnographic field work in five Chinese state-owned social welfare institutions (SWIs) caring for orphans, this article argues that the emotional labor in SWIs on the one hand produces intersubjectivity among caregivers and children in their care, and on the other hand it harms caregivers emotionally, leading them to use strategies such as drawing emotional boundaries with the orphans to protect themselves from the pain of losing "their" children when they are adopted. This article contributes to the geography of care literature by challenging the fantasy and romanticization of affect in care settings and stressing the paradox of care and affect. [ABSTRACT FROM AUTHOR]

Recently the Chinese government has been actively collaborating with nonprofit nongovernmental organizations to provide social welfare services to older adults at the community level. The role played by NGOs in facilitating governance has only recently gained attention in the literature on Chinese NGOs and urban governance. Addressing this gap, the paper advances geographers' understanding of State–NGO collaborations in facilitating urban governance in the Chinese context using fieldwork in Beijing and Shanghai on the provision of community eldercare services as an example. It also explains the political control of these NGOs and their changing role in the eldercare market. We argue that collaborations between the state and NGOs in China have gradually transferred eldercare services to the NGOs, and led to a fragmented welfare system, which, as a consequence, has facilitated entrepreneurial urban governance. The paper sheds light on community-based organizations, their collaboration with local governments, and how they have become not only welfare providers but a significant site for social control. [ABSTRACT FROM AUTHOR]

This paper examines factors influencing on student evaluations of teaching (SET) with consideration of disciplinary variations. Data were obtained from a university in Guangzhou of China and consisted of 1443 undergraduate course ratings collected from 19 schools over two semesters. The students and courses are classified into hard and soft disciplinary groupings and divided into four sub-groups for further comparison. The result of the ANOVA test showed significant difference in the mean SET scores across four subgroups; and results of linear models reflect students who major in hard discipline tend to give higher SET scores regardless of the course’s feature. In addition, there was also evidence of possible biases in the ratings according to the features of teachers, students and courses. Overall, the disciplinary differences would need to be considered when decisions are being made on the basis of the SET scores, especially for cross-school evaluation. [ABSTRACT FROM AUTHOR]

Young drivers are more likely to be involved in traffic accidents. The study aims to explore mechanisms behind distracted driving behaviour, traffic safety environment, driving responsibility, and hazard perception. A conceptual model is proposed based on Stimulus-Organism-Response (S-O-R) theory. The self-reported data from 367 drivers are used to estimate and modify the model based on exploratory factor analysis, structural equation modelling, and bias-corrected bootstrap method. The regression relationships and the mediators have been identified. The traffic safety environment including the traffic enforcement and the driving condition isn't related to the distracted driving behaviour. The traffic enforcement is associated the driving responsibility, the relationships between the driving responsibility, the hazard perception and the driving condition are significant, and the relationships between the distracted driving behaviour, the driving responsibility and the hazard perception are noteworthy. A positive traffic safety environment is beneficial to the safety of young drivers. The sense of driving responsibility and the self-cognition of hazard perception need attention for the early intervention of young drivers' distracted driving behaviours. [ABSTRACT FROM AUTHOR]

The ladybird beetle, Coccinella septempunctata, is an important predator of soft-bodied insects. To further optimise an artificial diet for rearing the ladybird beetle, we investigated the effects of juvenile hormone (JH), honey, shrimp, rape pollen, lard, and other factors on the biological characteristics of C. septempunctata. Survival and pupation rates of larvae were decreased when JH and lard were added to the artificial diet; however, the addition of lard increased egg hatching to 73.70%, which was significantly higher than the control diet (50.56%). Adding honeybee pupae to the artificial diet shortened the preoviposition period to 7.64 d, compared to 10.36 d in the control diet. Adding honey, shrimp, and honeybee pupae to the diet resulted in 465.12, 452.35, and 423.01 eggs laid, respectively, which was significantly higher than the control diet. The pupation and emergence rates of C. septempunctata larvae fed an artificial diet without JH were significantly higher than those fed an artificial diet with JH; thus, JH and lard should not be added to artificial diets during the larval stage. During the adult stage, adding rape pollen, shrimp, honey, lard, and honeybee pupae to the diet could improve the fecundity of C. septempunctata. These results will be helpful for optimising artificial diets for the mass production of C. septempunctata. [ABSTRACT FROM AUTHOR]

More couples worldwide, delay their childbearing years. The increase in age causes a gradual decrease in female ovarian function and fertility, leading to an exponential decrease in women over 35 years of age having children. Although promising for some, assisted reproductive technology (ART) is not promising for older women. Decreased fertility in advanced age has become a growing concern in the field of reproduction. In this study, high-throughput transcriptome sequencing was used to identify the differentially expressed genes (DEGs) in the ovarian granulosa cells (GCs) of older women (aged 35–44) with infertility and younger women (aged 25–34). The enriched functions and signaling pathways of DEGs were analyzed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). The function of DEGs were analyzed and predicted combined with clinical ART data. Sequencing results were verified by quantitative reverse transcription-polymerase chain reaction. Retrospective clinical data and bioinformatics analyses revealed marked reductions in the retrieved oocyte, metaphase II oocyte, 2PN fertilization, and effective embryo numbers in older women. Although the clinical pregnancy and live birth rates did not differ notably between the groups, the miscarriage rate increased significantly in older women. In total, 620 DEGs were identified, of which 246 were upregulated, and 374 were downregulated in the older group. GO, and KEGG analyses indicated that the mechanism of fertility decline in older women was probably related to chronic inflammation, cytokine receptor interaction, and oxidative stress. In conclusion, combined with basic clinical ART data and pregnancy outcomes, we tried to provide a more intuitive and in-depth understanding of age-related reduction in ovarian function and pathogenesis of infertility with regard to chronic inflammation and oxidative stress. [ABSTRACT FROM AUTHOR]

The use of laser scanning in the realm of bridge assessment has been primarily limited to measuring large bridge dimensions. Given the scale of these measurements compared to standard accuracy metrics for LiDAR sensors, it follows that they may be captured with relatively small errors (<1%). This paper explores LiDAR's capacity to (a) estimate smaller cross-section dimensions of an operating bridge, and (b) quantify the observed errors in terms of capacity calculations (as opposed to simple percent errors). To satisfy these objectives, sixteen LiDAR scans of an eleven-span steel girder bridge were completed under normal operating conditions. Various dimensional quantities were extracted from the data both directly and using standard plane-fitting approaches (Plane Fitting, Ransac). Results indicated that dimensions obtained from Plane Fitting resulted in flexural capacities 4%-7% less than those computed using the dimensions from the bridge plans. The Ransac method estimated errors within 7%-10%, while the dimensions obtained directly from the point cloud data resulted in capacity errors of 9%-13%. Due to common errors sources, all dimensions were conservatively estimated throughout this study. However, the observed distortion of elements due to fabrication stresses, showed to have the potential of overestimation of dimensions if planar assumptions are made. [ABSTRACT FROM AUTHOR]

Torsades de pointes (TdP) is an irregular heart rhythm characterized by faster beat rates and potentially could lead to sudden cardiac death. Much effort has been invested in understanding the drug-induced TdP in preclinical studies. However, a comprehensive statistical learning framework that can accurately predict the drug-induced TdP risk from preclinical data is still lacking. We proposed ordinal logistic regression and ordinal random forest models to predict low-, intermediate-, and high-risk drugs based on datasets generated from two experimental protocols. Leave-one-drug-out cross-validation, stratified bootstrap, and permutation predictor importance were applied to estimate and interpret the model performance under uncertainty. The potential outlier drugs identified by our models are consistent with their descriptions in the literature. Our method is accurate, interpretable, and thus useable as supplemental evidence in the drug safety assessment. [ABSTRACT FROM AUTHOR]

Anastomosis of renal artery and renal vein in mouse models of kidney transplantation is technically challenging. Conventional technique using suture may result in vascular thrombosis. We developed a simple cuff method to anastomose both renal artery and vein. Briefly, the left renal artery was occluded at the junction with abdominal aorta using a small vessel clip, transected at the renal hilum, irrigated with heparinized saline, and passed through the lumen of a seamless tubing made of polyimide. The loose end of the artery was everted over the cuff and secured using an 8-0 silk suture. The cuffed artery was inserted into the donor renal artery and secured with an 8-0 suture. Anastomosis of the renal vein was performed similarly. Isograft transplantation was conducted using BALB/c mice as donor and recipient mice (n = 20). The total operative time was 77 ± 3 min, and the cold ischemic time of the graft kidney was minimized to 20 min. One animal was excluded due to anatomic variant vessels and another one died at three day after surgery without thrombosis. Serum creatinine increased insignificantly after transplantation and remained stable over 12 weeks posttransplant. Five recipient mice were sacrificed for histologic examination at 12 weeks after transplantation. No vascular thrombosis was observed at the site of anastomosis. The isografts showed no evidence of acute and chronic lesions such as extinctive ischemic sclerosis and interstitial fibrosis. In summary, cuff anastomosis can be used to eliminate thrombosis formation in the mouse model of kidney transplantation. [ABSTRACT FROM AUTHOR]

Jiangxititan ganzhouensis gen. et sp. nov. is a new titanosaurian sauropod recovered from the Upper Cretaceous (Maastrichtian) Nanxiong Formation of Jiangxi Province, southern China. It is characterised by: (1) posterior cervical and anterior dorsal centra strongly compressed dorsoventrally; (2) accessory horizontal laminae present within the anterior dorsal pleurocoels; (3) posterior cervical and anterior dorsal neural arches low; (4) posterior cervical and anterior dorsal neural spines deeply bifurcated and widely separated; (5) inverted ‘V’ lamina formed by the left and right medial spinoprezygapophyseal laminae present at the anterior margin of the bifid point in posteriormost cervical and anteriormost dorsal neural spines; (6) triangular fossa formed by the metapophysis, medial and lateral spinoprezygapophyseal laminae present at the anterior margins of the posteriormost cervical and anteriormost dorsal neural spines; (7) postzygapophyses in the posterior cervical vertebrae fan-shaped; (8) medial and lateral spinopostzygapophyseal laminae present in the anterior dorsal vertebrae; and (9) anterior dorsal rib short and gracil. Our phylogenetic analysis places Jiangxititan within the deeply-nested titanosauriform clade Lognkosauria and the sympatric Gannansaurus in a much earlier-diverging lineage. This new discovery thus demonstrates the presence of both early-diverging and late-diverging titanosauriform sauropods in the Late Cretaceous Ganzhou dinosaur fauna. [ABSTRACT FROM AUTHOR]

In this technical report, we will discuss several recent developments at BL02B of the Shanghai Synchrotron Radiation Facility (SSRF), with our focus on I in-situ i capabilities by X-ray photoelectron spectroscopy and X-ray absorption spectroscopy (XAS). Compared with TEY mode XAS, the AEY mode XAS obtained from the I m i RAS can further increase the surface sensitivity. After 50 years of effort, near-ambient or ambient pressure X-ray photoelectron spectroscopy (NAP-XPS or APXPS) has become a useful tool for studying gas and liquid molecules in environmental science [[1], [3]]. Together with the I in-situ i capability of the APXPS system, the AP I m i RAS can extend the HERED mode XAS for the I in-situ i investigation of electronic structure. [Extracted from the article]

Aminoglycoside antibiotics exhibit broad-spectrum antibacterial activity, good efficacy, and stability. However, due to the emergence of antibiotic resistance, their use as broad-spectrum antibiotics is restricted. Bacteria producing the bifunctional enzyme, 6′-aminoglycoside acetyltransferase 2″-aminoglycoside phosphotransferase [AAC(6′)-APH(2″)], can modify aminoglycoside antibiotics, leading to the emergence of clinical drug resistance. A method based on ultra-high performance liquid chromatography–mass spectrometry (UHPLC-MS) is reported to monitor the modification of aminoglycoside antibiotics and to screen potential inhibitors of AAC(6′)-APH(2″) from marine natural products. Instead of using purified AAC(6′)-APH(2″), Escherichia coli cells harboring AAC(6′)-APH(2″) were employed. In vivo enzyme assays, conducted in the physiological environment, compensated for the disparity between in vitro responses and those in living cells. The inhibition zone method was used to verify the reliability of the UHPLC-MS results. From a library of 63 marine natural products, Mer-C-3 and Mer-c-8e pyridine alkaloids were shown to provide inhibitory activity against AAC(6′)-APH(2″) in living bacteria. The UHPLC-MS-based approach offers improved speed, convenience, and sensitivity compared with the traditional inhibition zone assay for the screening of enzyme inhibitors. [ABSTRACT FROM AUTHOR]

The mission of the Institute of Industrial and Systems Engineers (IISE) is to serve those who solve complex and critical problems of the world. Notably, the research–practice gap in Operations Management (OM) marginalizes the value and relevance of the IISE. To maintain and enhance the impact of the IISE, we identify major bottlenecks that limit the industrial installation of OM research outcomes. Ranked by the relative importance, the three bottlenecks are verifying the performance improvement, building trust with practitioners, and balancing model accuracy and simplicity, respectively, in the stages of value verification, implementation and development. We propose potential research opportunities and illustrate the challenges and opportunities using real case studies from three Fortune Global 500 companies. In particular, we emphasize the role of data-driven decision methods in dealing with the three bottlenecks. [ABSTRACT FROM AUTHOR]

Based on the monitoring data of atmospheric pollutants and the meteorological data in Harbin in 2017, the temporal spatial distribution characteristics of PM2.5 pollution and the relationships between PM2.5 concentration and meteorological factors in this region were analyzed. The PM2.5 concentration data and the meteorological data in 2017 were comprehensively analyzed by using ArcGIS and R. The results show that spatially, the PM2.5 concentration in the central districts of Harbin are high in the southeast and low in the northwest; temporally, PM2.5 pollution is most serious in autumn and winter, with multiple spells of heavy pollution and an obvious "weekend effect", while the air quality is better in spring and summer; overall, relative humidity is positively correlated to PM2.5 concentration, while temperature, wind direction, and wind speed are negatively correlated to PM2.5 mass concentration, and low wind speed and high relative humidity are major contributors to increase of PM2.5 concentration. Implications: Highlight: The use of big data to deal with the data of air pollution and meteorology. Key points: The air pollution data of Harbin in autumn and winter is more serious than that in spring and summer, and is closely related to meteorological factors. Attraction: Big data is used to process air pollution data and meteorological data, and R language is used to describe the relationship between them. [ABSTRACT FROM AUTHOR]