1. Utilizing Histopathology to Predict Success with Macrolide Therapy in CRS Patients.
- Author
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Workman AD, Chang J, Lerner DK, Wilensky J, Montone KT, Bosso JV, Palmer JN, Adappa ND, and Kohanski MA
- Subjects
- Humans, Macrolides therapeutic use, Chronic Disease, Anti-Bacterial Agents therapeutic use, Sinusitis surgery, Rhinitis surgery, Eosinophilia complications, Nasal Polyps complications
- Abstract
There is currently interest regarding CRSsNP patients with refractory symptomatology following functional endoscopic sinus surgery, and which of these patients can derive benefit from low-dose macrolide therapy. In the present study, we analyze a cohort of over fifty CRSsNP patients on macrolide therapy; structured histopathological findings at the time of surgery were analyzed against the success of macrolide treatment. Independently, fibrosis, absence of squamous metaplasia, absence of eosinophilia, presence of neutrophilic infiltrate, and lymphoplasmocytic predominance were all associated with objective success of macrolide treatment; these findings may allow clinicians to more appropriately select patients for this therapy., (© 2024 The American Laryngological, Rhinological and Otological Society, Inc.)
- Published
- 2024
- Full Text
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