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Since the outbreak of the global COVID-19 pandemic in Wuhan, China, in 2019, its impact has been seen worldwide. Early identification of COVID-19 is very crucial, as it keeps the infected people isolated from other people, thus minimizing the risk of further transmission. The standard diagnostic approach is based on RT-PCR. However, due to the scarcity of PCR kits in some regions and the costs associated with this technique, there is a growing demand for alternative solutions. Recently, diagnosis of COVID-19 by medical imaging has been recognized as a valid clinical practice. Meanwhile, the massive increase in COVID-19 cases has put considerable pressure on radiologists responsible for interpreting these scans. This paper introduces an automated detection approach as a rapid alternative for COVID-19 diagnosis. We present a deep CNN model to differentiate between normal and pneumonia cases, as well as patients with COVID-19. Our approach is based on EfficientNet-B7 architecture and improved with Squeeze and Excitation block as an attention mechanism. In addition, we propose an innovative architecture that combines CNN with SVM to achieve the best performance. Experimental results show that the proposed framework provides better performance than existing SOTA methods, with an average accuracy of 97.50%, while the precision and recall of COVID-19 are both 100%. [ABSTRACT FROM AUTHOR]

The recent pandemic caused by the Coronavirus Disease (COVID-19) first surfaced in Wuhan, China in December 2019. This paper presents an expert system for the diagnosis of COVID-19 based on its symptoms to aid people in taking precautionary measures. When experts are not available, an expert system that can effectively diagnose the disease is crucial. It takes the place of one or more experts in decision-making and problem-solving. An expert system for diagnosis of COVID-19 is a system developed to recognize early COVID-19 symptoms that individuals may experience by allowing users to directly check the disease with results that can serve as a foundation for additional testing. This study's primary goal is to identify useful COVID-19 detection patterns or knowledge by examining the historical data we have obtained from the Kaggle dataset. The patterns are presented as rules, which are given to the expert system after consultation with a domain expert. A total of 1,048,575 pieces of data were used for model training and testing. To detect COVID-19 disease, we employ a PART rule-based algorithm, which performed 92.47% accurately in a 10-fold cross-validation test. We can therefore draw the conclusion that the algorithm produces a promising result and that the expert system aids in the diagnosis of the disease. The system offers a suggestion in line with the identified symptom. [ABSTRACT FROM AUTHOR]

The novel coronavirus illness (COVID-19) outbreak, which began in a seafood market in Wuhan, Hubei Province, China, in mid-December 2019, has spread to almost all countries, territories, and places throughout the world. And since the fault in diagnosis of a disease causes a psychological impact, this was very much visible in the spread of COVID-19. This research aims to address this issue by providing a better solution for diagnosis of the COVID-19 disease. The paper also addresses a very important issue of having less data for disease prediction models by elaborating on data handling techniques. Thus, special focus has been given on data processing and handling, with an aim to develop an improved machine learning model for diagnosis of COVID-19. Random Forest (RF), Decision tree (DT), K-Nearest Neighbor (KNN), Logistic Regression (LR), Support vector machine, and Deep Neural network (DNN) models are developed using the Hospital Israelita Albert Einstein (in São Paulo, Brazil) dataset to diagnose COVID-19. The dataset is pre-processed and distributed DT is applied to rank the features. Data augmentation has been applied to generate datasets for improving classification accuracy. The DNN model dominates overall techniques giving the highest accuracy of 96.99%, recall of 96.98%, and precision of 96.94%, which is better than or comparable to other research work. All the algorithms are implemented in a distributed environment on the Spark platform. [ABSTRACT FROM AUTHOR]

COVID-19 was first discovered in Wuhan, China, in December 2019 and has since spread worldwide. An automated and fast diagnosis system needs to be developed for early and effective COVID-19 diagnosis. Hence, we propose two-and three-classifier diagnosis systems for classifying COVID-19 cases using transfer-learning techniques. These systems can classify X-ray images into three categories: healthy, COVID-19, and pneumonia cases. We used two X-ray image datasets (DATASET-1 and DATASET-2) collected from state-of-the-art studies and train the systems using deep learning architectures, such as VGG-19, NASNet, and MobileNet2, on these datasets. According to the validation and testing results, our proposed diagnosis systems achieved excellent results with the VGG-19 architecture. The two-classifier diagnosis system achieved high sensitivity for COVID-19, with 99.5% and 100% on DATASET-1 and DATASET-2, respectively. The three-classifier diagnosis system achieves high sensitivity for COVID-19, with 98.4% and 100% on DATASET-1 and DATASET-2, respectively. The high sensitivity of these diagnostic systems for COVID-19 will significantly improve the speed and precision of COVID-19 diagnosis. [ABSTRACT FROM AUTHOR]

To investigate the duration of humoral immune response in convalescent coronavirus disease 2019 (COVID-19) patients, we conduct a 12-month longitudinal study through collecting a total of 1,782 plasma samples from 869 convalescent plasma donors in Wuhan, China and test specific antibody responses. The results show that positive rate of IgG antibody against receptor-binding domain of spike protein (RBD-IgG) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the COVID-19 convalescent plasma donors exceeded 70% for 12 months post diagnosis. The level of RBD-IgG decreases with time, with the titer stabilizing at 64.3% of the initial level by the 9th month. Moreover, male plasma donors produce more RBD-IgG than female, and age of the patients positively correlates with the RBD-IgG titer. A strong positive correlation between RBD-IgG and neutralizing antibody titers is also identified. These results facilitate our understanding of SARS-CoV-2-induced immune memory to promote vaccine and therapy development. COVID-19 pandemic is a global health risk, but our understanding on the induced durable immunity remains scarce. Here the authors assess antibody responses in 869 convalescent COVID-19 patients to find that specific antibody titers reduce with time, and the RBD-IgG positive rate exceed 70% at 12 month post diagnosis, with male and older patients showing stronger responses. [ABSTRACT FROM AUTHOR]

Background Since December 2019, coronavirus disease (COVID-19) has affected over 50 000 people in Wuhan, China. However, the number of daily infection cases, hospitalization rate, lag time from onset to diagnosis date and their associations with measures introduced to slow down the spread of COVID-19 have not been fully explored. Methods This study recruited 6872 COVID-19 patients in the Wuchang district, Wuhan. All of the patients had an onset date from 21 December 2019 to 23 February 2020. The overall and weekly hospitalization rate and lag time from onset to diagnosis date were calculated. The number of daily infections was estimated by the back-projection method based on the number of daily onset cases. Their association with major government reactions and measures was analyzed narratively. Results The overall hospitalization rate was 45.9% (95% CI 44.7 to 47.1%) and the mean lag time from onset to diagnosis was 11.1±7.4 d. The estimated infection curve was constructed for the period from 14 December 2019 to 23 February 2020. Raising public awareness regarding self-protecting and social distancing, as well as the provision of timely testing and inpatient services, were coincident with the decline in the daily number of infections. Conclusion Early public awareness, early identification and early quarantine, supported by appropriate infrastructure, are important elements for containing the spread of COVID-19 in the community. [ABSTRACT FROM AUTHOR]