12 results on '"Yong Wang"'
Search Results
2. Robust radiosensitization of hemoglobin-curcumin nanoparticles suppresses hypoxic hepatocellular carcinoma
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Ruoling Gao, Yuan Gu, Ying Yang, Yuping He, Wenpeng Huang, Ting Sun, Zaixiang Tang, Yong Wang, and Wei Yang
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Hemoglobin ,Curcumin ,Nanoparticles ,Radiotherapy ,Hypoxia ,Hepatoma ,Biotechnology ,TP248.13-248.65 ,Medical technology ,R855-855.5 - Abstract
Abstract Background Radioresistance inducing by hypoxic microenvironment of hepatocellular carcinoma is a major obstacle to clinical radiotherapy. Advanced nanomedicine provides an alternative to alleviate the hypoxia extent of solid tumor, even to achieve effective synergistic treatment when combined with chemotherapy or radiotherapy. Results Herein, we developed a self-assembled nanoparticle based on hemoglobin and curcumin for photoacoustic imaging and radiotherapy of hypoxic hepatocellular carcinoma. The fabricated nanoparticles inhibited hepatoma migration and vascular mimics, and enhanced the radiosensitivity of hypoxic hepatoma cells in vitro via repressing cell proliferation and DNA damage repair, as well as inducing apoptosis. Benefit from oxygen-carrying hemoglobin combined with polyphenolic curcumin, the nanoparticles also effectively enhanced the photoacoustic contrast and the efficacy of radiotherapy for hepatocellular carcinoma in vivo. Conclusions Together, the current study offered a radiosensitization platform for optimizing the efficacy of nanomedicines on hypoxic radioresistant tumor. Graphical Abstract
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- 2022
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3. Detection Methods of Nanoparticles Synthesized by Gas-Phase Method: A Review
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Xiushuo Zhang, Xiaolong Zhao, Hongsheng Li, Xiaorui Hao, Jing Xu, Jingjing Tian, and Yong Wang
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gas-phase method ,nanoparticles ,detection methods ,review ,expectation ,Chemistry ,QD1-999 - Abstract
The detection of nanoparticles is the basis of the study of synthesis mechanism, active regulation of the synthesis process, and the study of nanoparticle properties after synthesis. It is significantly meaningful to the academia and engineering industry. Although there are many relevant detection methods at present, each method has its own advantages and disadvantages, and their measurement quantity and application conditions are also different. There is a lack of unified sorting and generalization. In this paper, the significance of detection of nanoparticles synthesized by a gas-phase method is introduced, the development of detection technology is reviewed, and the future is prospected. It is hoped that this paper will provide a reference for the detection of nanoparticles under various conditions and for the development of new detection methods.
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- 2022
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4. An Enhanced Performance of Glucose Biosensor Based on TiO2 Nanorod Arrays Decorated with Ag Nanoparticles.
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Minghui Chen, Jin Liu, Pengzhao Chang, Shaohui Zheng, and Yong Wang
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NANORODS ,GLUCOSE ,BIOSENSORS ,NANOPARTICLES ,CARBON paper ,GLUCOSE analysis ,HYDROTHERMAL synthesis ,GLUCOSE oxidase - Abstract
In this study, TiO
2 nanorod arrays (NAs) on carbon paper (CP) substrates were prepared via hydrothermal synthesis. Then, Ag nanoparticles (NPs) were deposited on the surface of the TiO2 NAs to enhance the electrocatalytic activity and analysis ability of the electrode for H2 O2 . Thereafter, GOx was modified on the surface of the Ag NPs-TiO2 NAs/CP via the cross-linking method for the detection of glucose. The GOx/Ag NPs-TiO2 NAs/CP integrates the functions of the specific recognition of glucose, signal transduction, and signal amplification. In an in vitro test, this GOx/Ag NPs-TiO2 NAs/CP biosensor shows a sensitivity of 0.182 mA mM-1 cm-2 , which is 6.6-fold that for the GOx/CP sensor (0.0276 mA mM-1 cm-2 ). The sensor can transduce the GOx-catalyzed reaction into significant current signals within 5 s. The relationship between the glucose concentration and the sensitivity to glucose is linear with the correlation coefficient R² of 0.9996 in the range of 0-0.9 mM, and the detection limit was estimated to be 1.6 µM. [ABSTRACT FROM AUTHOR]- Published
- 2023
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5. Pulmonary toxicity of tungsten trioxide nanoparticles in an inhalation study and an intratracheal instillation study
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Takashi Marui, Taisuke Tomonaga, Hiroto Izumi, Yukiko Yoshiura, Chinatsu Nishida, Hidenori Higashi, Ke‐Yong Wang, Miyako Shijo, Masaru Kubo, Manabu Shimada, and Yasuo Morimoto
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Male ,Public Health, Environmental and Occupational Health ,Animals ,Nanoparticles ,Water ,Bronchoalveolar Lavage Fluid ,Lung ,Rats, Inbred F344 ,Rats - Abstract
We conducted inhalation and intratracheal instillation studies in order to examine the effects of tungsten trioxide (WOIn the inhalation study, male 10-week-old Fischer 334 rats were classified into 3 groups. The control, low-dose, and high-dose groups inhaled clean air, 2, and 10 mg/mThe inhalation and instillation of WOOur results suggest that WO
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- 2022
6. Two-stage assembly of nanoparticle superlattices with multiscale organization
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Yuxiang Dong, Jiliang Liu, Xuanzhao Lu, Jialin Duan, Liqi Zhou, Lizhi Dai, Min Ji, Ningning Ma, Yong Wang, Peng Wang, Jun-Jie Zhu, Qianhao Min, Oleg Gang, and Ye Tian
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Mechanical Engineering ,Nanoparticles ,Nanotechnology ,General Materials Science ,Bioengineering ,QD ,General Chemistry ,DNA ,Condensed Matter Physics ,QH426 ,QC ,Nanostructures - Abstract
Self-assembly processes, while promising for enabling the fabrication of complexly organized nanomaterials from nanoparticles, are often limited in creating structures with multiscale order. These limitations are due to difficulties in practically realizing the assembly processes required to achieve such complex organizations. For a long time, a hierarchical assembly attracted interest as a potentially powerful approach. However, due to the experimental limitations, intermediate-level structures are often heterogeneous in composition and structure, which significantly impacts the formation of large-scale organizations. Here, we introduce a two-stage assembly strategy: DNA origami frames scaffold a coordination of nanoparticles into designed 3D nanoclusters, and then these clusters are assembled into ordered lattices whose types are determined by the clusters' valence. Through modulating the nanocluster architectures and intercluster bindings, we demonstrate the successful formation of complexly organized nanoparticle crystals. The presented two-stage assembly method provides a powerful fabrication strategy for creating nanoparticle superlattices with prescribed unit cells.
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- 2022
7. Preclinical safety and hepatotoxicity evaluation of biomineralized copper sulfide nanoagents
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Ya-Nan Xia, He Zu, Haoxiang Guo, Tianyan Jiang, Siqi Yang, Huan Yu, Shaodian Zhang, Heng Ding, Xiaoyu Li, Yangyun Wang, Yong Wang, and Leshuai W. Zhang
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Biomedical Engineering ,Pharmaceutical Science ,Molecular Medicine ,Medicine (miscellaneous) ,Animals ,Nanoparticles ,Bioengineering ,Serum Albumin, Bovine ,Chemical and Drug Induced Liver Injury ,Sulfides ,Applied Microbiology and Biotechnology ,Copper ,Rats - Abstract
Albumin-biomineralized copper sulfide nanoparticles (Cu2−xS NPs) have attracted much attention as an emerging phototheranostic agent due to their advantages of facile preparation method and high biocompatibility. However, comprehensive preclinical safety evaluation is the only way to meet its further clinical translation. We herein evaluate detailedly the safety and hepatotoxicity of bovine serum albumin-biomineralized Cu2−xS (BSA@Cu2−xS) NPs with two different sizes in rats. Large-sized (LNPs, 17.8 nm) and small-sized (SNPs, 2.8 nm) BSA@Cu2−xS NPs with great near-infrared absorption and photothermal conversion efficiency are firstly obtained. Seven days after a single-dose intravenous administration, SNPs distributed throughout the body are cleared primarily through the feces, while a large amount of LNPs remained in the liver. A 14-day subacute toxicity study with a 28-day recovery period are conducted, showing long-term hepatotoxicity without recovery for LNPs but reversible toxicity for SNPs. Cellular uptake studies indicate that LNPs prefer to reside in Kupffer cells, leading to prolonged and delayed hepatotoxicity even after the cessation of NPs administration, while SNPs have much less Kupffer cell uptake. RNA-sequencing analysis for gene expression indicates that the inflammatory pathway, lipid metabolism pathway, drug metabolism-cytochrome P450 pathway, cholesterol/bile acid metabolism pathway, and copper ion transport/metabolism pathway are compromised in the liver by two sizes of BSA@Cu2−xS NPs, while only SNPs show a complete recovery of altered gene expression after NPs discontinuation. This study demonstrates that the translational feasibility of small-sized BSA@Cu2−xS NPs as excellent nanoagents with manageable hepatotoxicity. Graphical Abstract
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- 2022
8. Progress in cancer drug delivery based on AS1411 oriented nanomaterials
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Xin Tong, Lu Ga, Jun Ai, and Yong Wang
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Targeted drug delivery ,Biomedical Engineering ,Pharmaceutical Science ,Medicine (miscellaneous) ,Bioengineering ,Antineoplastic Agents ,Review ,Aptamers, Nucleotide ,Applied Microbiology and Biotechnology ,Drug Delivery Systems ,Oligodeoxyribonucleotides ,AS1411 ,Cell Line, Tumor ,Neoplasms ,Cancer treatment ,Medical technology ,Molecular Medicine ,Nanoparticles ,R855-855.5 ,TP248.13-248.65 ,Analytical imaging ,Biotechnology ,Nanomaterials - Abstract
Targeted cancer therapy has become one of the most important medical methods because of the spreading and metastatic nature of cancer. Based on the introduction of AS1411 and its four-chain structure, this paper reviews the research progress in cancer detection and drug delivery systems by modifying AS1411 aptamers based on graphene, mesoporous silica, silver and gold. The application of AS1411 in cancer treatment and drug delivery and the use of AS1411 as a targeting agent for the detection of cancer markers such as nucleoli were summarized from three aspects of active targeting, passive targeting and targeted nucleic acid apharmers. Although AS1411 has been withdrawn from clinical trials, the research surrounding its structural optimization is still very popular. Further progress has been made in the modification of nanoparticles loaded with TCM extracts by AS1411. Graphical Abstract
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- 2021
9. Electron penetration triggering interface activity of Pt-graphene for CO oxidation at room temperature
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Xinhe Bao, Yanping Zheng, Ye Wang, Yunchuan Tu, Liang Yu, Chao Ma, Dehui Deng, Jingting Hu, Zhongmiao Gong, Wujun Zhang, Yong Wang, Fan Yang, Mingshu Chen, Pengju Ren, and Yi Cui
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inorganic chemicals ,Materials science ,Science ,Alloy ,Oxide ,General Physics and Astronomy ,Nanoparticle ,engineering.material ,Heterogeneous catalysis ,General Biochemistry, Genetics and Molecular Biology ,Article ,law.invention ,Catalysis ,chemistry.chemical_compound ,Adsorption ,Transition metal ,law ,Multidisciplinary ,Graphene ,General Chemistry ,Chemical engineering ,chemistry ,engineering ,Nanoparticles - Abstract
Achieving CO oxidation at room temperature is significant for gas purification but still challenging nowadays. Pt promoted by 3d transition metals (TMs) is a promising candidate for this reaction, but TMs are prone to be deeply oxidized in an oxygen-rich atmosphere, leading to low activity. Herein we report a unique structure design of graphene-isolated Pt from CoNi nanoparticles (PtǀCoNi) for efficiently catalytic CO oxidation in an oxygen-rich atmosphere. CoNi alloy is protected by ultrathin graphene shell from oxidation and therefore modulates the electronic property of Pt-graphene interface via electron penetration effect. This catalyst can achieve near 100% CO conversion at room temperature, while there are limited conversions over Pt/C and Pt/CoNiOx catalysts. Experiments and theoretical calculations indicate that CO will saturate Pt sites, but O2 can adsorb at the Pt-graphene interface without competing with CO, which facilitate the O2 activation and the subsequent surface reaction. This graphene-isolated system is distinct from the classical metal-metal oxide interface for catalysis, and it provides a new thought for the design of heterogeneous catalysts., Achieving CO oxidation at room temperature is significant for gas purification but remains challenging to perform. Here, the authors report design of graphene-isolated Pt from cobalt-nickel nanoparticles for efficiently catalytic CO oxidation in an oxygen-rich atmosphere.
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- 2021
10. Ultrasensitive detection of small biomolecules using aptamer-based molecular recognition and nanoparticle counting
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Ruiting Xu, Lidya Abune, Brandon Davis, Leixin Ouyang, Ge Zhang, Yong Wang, and Jiang Zhe
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Adenosine ,Electrochemistry ,Biomedical Engineering ,Biophysics ,Metal Nanoparticles ,Nanoparticles ,Reproducibility of Results ,Biosensing Techniques ,General Medicine ,Aptamers, Nucleotide ,Biotechnology - Abstract
Detection of small biomolecules is critical for understanding molecular mechanisms in biological systems and performing in vitro diagnosis in clinics. Current antibody based detection methods face large challenges in detecting small biomolecules at low concentrations. We report a new method for detecting small biomolecules based on molecular recognition and nanoparticle (NP) counting. Aptamer-functionalized NPs are attached to complementary sequence (CS)-conjugated microparticle (MP) carriers. In the presence of target small biomolecules at ultra low concentrations, NPs would be released from the MP carriers. Coupled with a resistive pulse sensor (RPS) using a micropore that counts the released NPs, this method can measure the concentrations of target biomolecules at low concentrations with high sensitivity and high throughput. Adenosine was used as a model to demonstrate the feasibility of this method. It is demonstrated that this method can detect a wide range of adenosine concentrations with a low detection limit of 0.168 nM, which is 10 times lower than that of the ELISA kit. With its simple structure, high sensitivity, and high reproducibility, this detection method holds great potential for the ultrasensitive detection of low abundance small biomolecules.
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- 2022
11. Tumor-targeted Gd-doped mesoporous Fe3O4 nanoparticles for T1/T2 MR imaging guided synergistic cancer therapy.
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Shaohui Zheng, Shang Jin, Min Jiao, Wenjun Wang, Xiaoyu Zhou, Jie Xu, Yong Wang, Peipei Dou, Zhen Jin, Changyu Wu, Jingjing Li, Xinting Ge, and Kai Xu
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MAGNETIC resonance imaging ,CANCER treatment ,PHOTOTHERMAL conversion ,CONTRAST effect ,IRON oxide nanoparticles ,NANOPARTICLES - Abstract
In this study, a novel intelligent nanoplatform to integrate multiple imaging and therapeutic functions for targeted cancer theranostics. The nanoplatform, DOX@Gd-MFe
3 O4 NPs, was constructed Gd-doped mesoporous Fe3 O4 nanoparticles following with the doxorubicin (DOX) loading in the mesopores of the NPs. The DOX@Gd-MFe3 O4 NPs exhibited good properties in colloidal dispersity, photothermal conversion, NIR triggered drug release, and high T1 /T2 relaxicity rate (r1 =9.64mM-1 s-1 , r2 = 177.71mM-1 s-1 ). Benefiting from the high MR contrast, DOX@Gd-MFe3O4 NPs enabled simultaneous T1 /T2 dual-modal MR imagining on 4T1 bearing mice in vivo and the MR contrast effect was further strengthened by external magnetic field. In addition, the DOX@Gd-MFe3 O4 NPs revealed the strongest inhibition to the growth of 4T1 in vitro and in vivo under NIR irradiation and guidance of external magnetic field. Moreover, biosafety was also validated by in vitro and in vivo tests. Thus, the prepared DOX@Gd-MFe3 O4 NPs would provide a promising intelligent nanoplatform for dual-modal MR imagining guided synergistic therapy in cancer theranostics. [ABSTRACT FROM AUTHOR]- Published
- 2021
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12. Current perspectives and trends in nanoparticle drug delivery systems in breast cancer: bibliometric analysis and review
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Sheng Sun, Ye-hui Wang, Xiang Gao, He-yong Wang, Lu Zhang, Na Wang, Chun-mei Li, and Shao-quan Xiong
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bibliometrics ,visualization ,breast cancer ,nanoparticle drug delivery systems ,nanoparticles ,Biotechnology ,TP248.13-248.65 - Abstract
The treatment of breast cancer (BC) is a serious challenge due to its heterogeneous nature, multidrug resistance (MDR), and limited therapeutic options. Nanoparticle-based drug delivery systems (NDDSs) represent a promising tool for overcoming toxicity and chemotherapy drug resistance in BC treatment. No bibliometric studies have yet been published on the research landscape of NDDS-based treatment of BC. In this review, we extracted data from 1,752 articles on NDDS-based treatment of BC published between 2012 and 2022 from the Web of Science Core Collection (WOSCC) database. VOSviewer, CiteSpace, and some online platforms were used for bibliometric analysis and visualization. Publication trends were initially observed: in terms of geographical distribution, China and the United States had the most papers on this subject. The highest contributing institution was Sichuan University. In terms of authorship and co-cited authorship, the most prolific author was Yu Zhang. Furthermore, Qiang Zhang and co-workers have made tremendous achievements in the field of NDDS-based BC treatment. The article titled “Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications” had the most citations. The Journal of Controlled Release was one of the most active publishers in the field. “Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries” was the most cited reference. We also analysed “hot” and cutting-edge research for NDDSs in BC treatment. There were nine topic clusters: “tumour microenvironment,” “nanoparticles (drug delivery),” “breast cancer/triple-negative breast cancer,” “combination therapy,” “drug release (pathway),” “multidrug resistance,” “recent advance,” “targeted drug delivery”, and “cancer nanomedicine.” We also reviewed the core themes of research. In summary, this article reviewed the application of NDDSs in the treatment of BC.
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- 2023
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