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Simple Summary: The genus Diploderma Hallowell, 1861 (Squamata, Agamidae), currently consists of 46 species, which are distributed across East Asia (inclusive of Japan) and the northern part of the Indochinese Peninsula, primarily inhabiting dry valley regions in Western China. This article introduces a novel species of Diploderma based on its unique morphological features and molecular evidence, discovered in the lower valley of the Dadu River in Sichuan Province, Western China. Phylogenetic analysis using ND2 data suggests that this new taxon is distinct from its congeners. Morphologically, the new species can be differentiated from other Diploderma species by an assemblage of 46 specific characteristics. Principal component analysis (PCA) further demonstrates that this new species is clearly distinguishable from its closest relative, D. splendidum. Given these multiple lines of evidence, we describe this species from the lower Dadu River valley as a newly identified species, D. daduense sp. nov. This discovery brings the total number of recognized species within the genus Diploderma to 47. This study describes a novel species of Diploderma (Squamata, Agamidae) from the lower valley of the Dadu River of the Sichuan Province of Western China based on its distinct morphological features and molecular evidence. D. daduense sp. nov. can be distinguished from its congeners by its tympanum concealed; head mainly green-yellow, supplemented by black; skin folds under the nuchal and dorsal crest obviously present in adult males only, its vertebral crest discontinuous between nuchal and dorsal sections with a distinct gap; transverse gular fold present but not obvious in some individuals; gular spot absent in both sexes; dorsolateral stripes green-yellow anteriorly, cyan in the center and blurry off-white posteriorly in adult males, the upper edge of dorsolateral stripes strongly jagged in adult males; no radial stripes around the eyes; inner-lip coloration smoky-white, and the coloration of the tongue and oral cavity as a light-flesh color in life; bright green-yellow transverse stripes on dorsal body in males; black patches are evenly distributed along the vertebral line between the dorsolateral stripes from the neck to the base of the tail in males; beech-brown or gray-brown line along the vertebral line with heart-shaped or diamond-shaped black patches on the dorsal body in females; and supratemporals fewer than four on at least one side. The phylogenetic tree based on mitochondrial ND2 sequences indicates that D. daduense sp. nov. forms an independent clade with strong support 1/100 in ML bootstrap/Bayesian posterior probability and is the sister group to D. splendidum. At the inter-species level, the p-distance is at least 6.95%, further confirming that an independent species had been identified. Our work raises the number of species within the genus Diploderma to 47. [ABSTRACT FROM AUTHOR]

Chlorophyll is a vital indicator of vegetation growth; exploring its relationship with external influencing factors is essential for studies such as chlorophyll remote sensing retrieval and vegetation growth monitoring. However, there has been limited in-depth exploration of the spatial distribution of leaf chlorophyll content (LCC) and its influencing factors across large-scale areas with varying climates and terrains. To investigate the primary influencing factors and degrees of various environmental factors on LCC, this study employed the Geodetector Model (GDM) and the LCC satellite products in Sichuan Province in 2020 to investigate the impact of relationships between nine environmental factors (meteorology, topography, and vegetation types) and the ecosystem LCC at a regional scale. The results indicated the following: (1) Elevation (q-value = 49.31%) is the primary factor determining photosynthesis in Sichuan Province, followed by temperature (46.10%) and vegetation types (40.73%). The impact of topographical factors on LCC distribution is higher than that of meteorological factors and vegetation types in terrain with complex topography. The elevation effectively distinguishes the variations in climate factors and vegetation types. (2) Combining the influencing factors pairwise increased the combined q-values. The combination of elevation with other factors yielded the highest combined q-value. (3) The q-values for all influencing factors are higher in winter and spring and lowest in summer. Different influencing factors exhibited more substantial constraints on vegetation photosynthesis during winter and spring, significantly reducing influence during summer. (4) The different primary factors drive or constrain vegetation photosynthesis in different climate zones due to their distinct temperature and humidity characteristics. The findings of this study provide a basis for future research on vegetation change analysis and dynamic monitoring of vegetation LCC in different terrains. [ABSTRACT FROM AUTHOR]

Simple Summary: To screen and identify single nucleotide polymorphisms (SNPs) associated with geese meat quality traits, we performed genome-wide association study (GWAS) in a population of male Sichuan white geese (a Chinese local breed) at 70 days old to screen the SNPs in the goose genome. Additionally, genotypes of the selected SNPs associated with goose meat were detected using the matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOP MS) method. The results revealed 43 SNPs that showed potentially significant associations with these traits. Additionally, we detected 28 annotated genes as potential candidate genes for the five meat quality traits. The enrichment analysis of genes within a 1Mb vicinity of SNPs showed potentially significant enrichment in the protein digestion and absorption pathway, as well as the Glycolipid metabolism pathway. The findings of this study offer novel genetic markers and candidate genes that can be used for marker-assisted selection of geese, laying the groundwork for understanding the genetic basis of goose meat quality traits and establishing a foundation for comprehending their genetic basis. (1) Background: Goose meat is highly valued for its economic significance and vast market potential due to its desirable qualities, including a rich nutritional profile, tender texture, relatively low-fat content, and high levels of beneficial unsaturated fatty acids. However, there is an urgent need to improve goose breeding by identifying molecular markers associated with meat quality. (2) Methods: We evaluated meat quality traits, such as meat color, shear force (SF), cooking loss rate (CLR), and crude fat content (CFC), in a population of 215 male Sichuan white geese at 70 days of age. A GWAS was performed to identify potential molecular markers associated with goose meat quality. Furthermore, the selected SNPs linked to meat quality traits were genotyped using the MALDI-TOP MS method. (3) Results: A dataset of 2601.19 Gb of WGS data was obtained from 215 individuals, with an average sequencing depth of 10.89×. The GWAS revealed the identification of 43 potentially significant SNP markers associated with meat quality traits in the Sichuan white goose population. Additionally, 28 genes were identified as important candidate genes for meat quality. The gene enrichment analysis indicated a substantial enrichment of genes within a 1Mb vicinity of SNPs in both the protein digestion and absorption pathway and the Glycerolipid metabolism pathway. (4) Conclusion: This study provides valuable insights into the genetic and molecular mechanisms underlying goose meat quality traits, offering crucial references for molecular breeding in this field. [ABSTRACT FROM AUTHOR]

There are various styles of faults, folds, and unconformity structures in the southwestern Sichuan Basin, which have an important impact on hydrocarbon preservation. Based on the data of regional geological, seismic, formation water characteristics, caprock characteristics, and production, the hydrocarbon preservation conditions of the key horizons (Cambrian, Upper Permian, and Triassic) were analyzed. Southwestern Sichuan Basin margin structure has two obvious tectonic layers (the upper and lower). The upper tectonic layer is dominated by Middle Triassic detachment faults and derived thrust faults, while the lower tectonic layer has concealed structures composed of basement detachment faults and derived thrust faults. There are mainly NE, near-SN, NW, and near-EW faults. The outcrops are in the Middle-Cenozoic strata, changing from old to new from outside the Basin to inside the Basin. There are three main sets of high-quality caprocks, i.e., the mudstone of the bottom of the Xujiahe Formation, the gypsum-salt rocks of the Middle-Lower Triassic, and the Lower Cambrian mudstone. Based on the faults, outcrops, formation water type, mineralization, and caprock characteristics, the hydrocarbon preservation evaluation system was established, which divides into the areas of Class I, II, and III. The distribution range of the favorable areas of different horizons has good inheritance, and the hydrocarbon preservation conditions gradually improve from outside the basin to inside the basin. Class I favorable areas are the most widely distributed and are mainly located within the basin, with the characteristics of a low degree of fault development, relatively new outcropping strata, CaCl2 formation water type, and large caprock thickness. [ABSTRACT FROM AUTHOR]

This study investigated drug-resistant tuberculosis (DR-TB) in the Yi ethnic group. The study was designed to identify risk factors for DR-TB and its relationship with HIV/AIDS. To establish the resistance to antituberculosis drugs, whole-genome sequencing (WGS) was performed using culture-positive Mycobacterium tuberculosis samples collected from people of the Yi ethnic group from March 2019 to March 2021. Baseline characteristics were obtained from China's tuberculosis surveillance system. A total of 116 M. tuberculosis strains were included in the final analysis. Lineage 2.2 (75.86%) was the dominant sublineage, followed by lineage 4.5 (18.97%) and lineage 4.4 (5.17%). The rates of rifampicin-resistant (RR-TB), multidrug-resistant (MDR-TB), and preextensively drug-resistant TB (pre-XDR-TB) were 18.97%, 10.34%, and 6.03%, respectively. Drug-resistant strains were not found in the elderly (age ≥ 65 years). The proportions of RR/MDR-TB and pre-XDR-TB cases among re-treatment patients were higher than those among new patients ( χ 2 = 12.155 , P = 0.003 ; χ 2 = 22.495 , P = 0.001 , respectively). The pre-XDR-TB case proportions were higher among female patients than among males and higher among referred patients ( χ 2 = 5.456 , P = 0.032 ; χ 2 = 15.134 , P = 0.002 , respectively). The rates of RR/MDR-TB and pre-XDR-TB did not differ appreciably among groups with different HIV infection statuses nor lineage populations. DR-TB poses a serious challenge to the Yi ethnic group. Re-treatment patients, women, and referred patients were at high risk of MDR/RR-TB or pre-XDR-TB while HIV and lineage 2 had negligible association with drug resistance. Whole-genome sequencing should be used to guide the design of treatment regimens and to tailor public interventions. [ABSTRACT FROM AUTHOR]

Obstructive sleep apnea hypoventilation syndrome (OSAHS) is a common sleep breathing disorder closely associated with cardiovascular disease. However, the respiratory sleep and related cardiovascular parameters on the apnea and hypopnea index (AHI) and life quality of primary snoring are unclear. We launched a cohort study focused on the association between respiratory sleep and cardiovascular-related parameters and apnea and hypopnea index, incorporating data from 218 patients with primary snoring in our medical center between Jun 1, 2015, and Apr 1, 2016. Thirty patients from Sichuan Cancer Hospital were used for validation. Patients with longer apnea time were more likely to progress to higher AHI (> 30) than controls (OR = 5.66, 95% CI = [2.79, 11.97], p < 0.001). Similarly, if patients have a higher value of diastolic blood pressure, they will also have a higher AHI (> 30) (HR [95% CI] = 3.42 [1.14, 13.65], p = 0.043). According to multivariate analysis, longest apnea time, the mean percentage of SaO2, and neckline length were independent risk factors of overall survival. A predictive model developed based on these factors above yielded a favorable agreement (C-index = 0.872) on the calibration curve. Thirty patients conducted external validation from Sichuan Cancer Hospital, displaying an AUC of 0.833 (0.782–0.884). Increased diastolic blood pressure and apnea time affect AHI level. An AHI prediction model based on these factors above can help clinicians predict the risk of high AHI events. [ABSTRACT FROM AUTHOR]

Background: Poor air quality can result in a variety of respiratory disorders. However, the air quality index (AQI) and the level of fine particulate matter (PM2.5) on the progression and prognosis of nonsmall‐cell lung cancer (NSCLC) are unclear. Methods: We launched a cohort study focused on the relationship between air quality and overall survival as well as progression, incorporating data from 590 patients with NSCLC in our medical center between November 1, 2013 and March 1, 2016. Forty‐nine patients from Sichuan Cancer Hospital were used for validation. Results: Cases with poorer AQI 6 months before NSCLC diagnosis were more likely to progress to stage III to IV NSCLC than controls (OR = 2.61, 95% CI 1.35–5.24, p = 0.005). Similarly, if exposed to high levels of PM2.5 during these 6 months, overall survival was poor (HR [95% CI] = 1.53 [1.13, 2.07], p = 0.006). According to multivariate analysis, age, gender, KPS, PM2.5, hyperlipemia, and NSCLC stage were independent risk factors of overall survival. A predictive model developed by these factors above yielded a favorable agreement (C‐index = 0.758) on the calibration curve. External validation was conducted by 46 patients from Sichuan Cancer Hospital displaying an AUC of 0.724 (0.684–0.763). Conclusions: PM2.5 and AQI levels affect disease progression and long‐term survival in NSCLC patients. An overall survival prediction model based on the PM2.5 level can help clinicians predict the risk of death in NSCLC. [ABSTRACT FROM AUTHOR]

The Lower Silurian Longmaxi Formation in the southern Sichuan Basin is composed of a series of dark carbonaceous shales deposited in a hydrostatic shelf reduction environment. In this study, the ratio of uranium to thorium (U/Th), the total organic carbon (TOC), and the biological silicon content (SiBio) were selected as the characteristic parameters to precisely analyze the sedimentary environment and its impact on reservoir quality. The results show that the Weiyuan area in the Early Silurian Longmaxi period experienced two transgression-regression cycles, forming two third-class sequences, SSQ1 and SSQ2, which can be divided into six sedimentary microfacies: organic-rich siliceous argillaceous shelf, organic-rich silicon-containing argillaceous shelf, organic-rich silty argillaceous shelf, deep-water silty argillaceous shelf, shallow-water silty argillaceous shelf, and shallow-water argillaceous silty shelf microfacies. The organic-rich siliceous argillaceous shelf and organic-rich silicon-containing argillaceous shelf microfacies developed in the deepest transgressive system tract (TST1), with high U/Th, high TOC, and high SiBio, which are identified as the main control facies for reservoir development. These two microfacies are located in the middle of the study area, while a transition occurs in the east affected by the Neijiang Uplift. According to the classification criteria proposed in this article, the favourable shale gas reservoirs in Weiyuan area are characterized with high U/Th (>1.25), high TOC (>3%), and high SiBio (>15%). This paper proposed an evaluation method for shale sedimentary facies based on elemental and electrical logging characteristics, avoiding the limitations of core samples, which makes the quantitative division of shale sediments and the efficient recognition of high-quality reservoirs available. It is of great significance for delineating the potential production areas in the study area and beneficial for the scaled development of shale gas reservoirs. [ABSTRACT FROM AUTHOR]