1. T-cell activation state differentially contributes to neuropsychiatric complications in women with HIV
- Author
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Williams, Dionna W, Flores, Bianca R, Xu, Yanxun, Wang, Yuezhe, Yu, Danyang, Peters, Brandilyn A, Adedimeji, Adebola, Wilson, Tracey E, Merenstein, Daniel, Tien, Phyllis C, Cohen, Mardge H, Weber, Kathleen M, Adimora, Adaora A, Ofotokun, Igho, Fischl, Margaret, Turan, Janet, Turan, Bülent, Laumet, Geoffroy, Landay, Alan L, Dastgheyb, Raha M, Gange, Stephen J, Weiser, Sheri D, and Rubin, Leah H
- Subjects
Biomedical and Clinical Sciences ,Immunology ,Mental Health ,Depression ,Clinical Research ,Neurosciences ,Behavioral and Social Science ,Mental health ,Good Health and Well Being ,Cognition ,HIV ,T-cell function ,Women ,Clinical sciences - Abstract
Neuropsychiatric complications are common among women with HIV (WWH). The pathophysiological mechanisms underlying these complications are not fully known but likely driven in part by immune modulation. We examined associations between T-cell activation states which are required to mount an effective immune response (activation, co-stimulation/normal function, exhaustion, senescence) and neuropsychiatric complications in WWH. 369 WWH (78% HIV RNA undetectable/
- Published
- 2022