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21 results on '"Patel, Rachana"'

4. Qualification of In Vitro Dissolution Absorption System 2 (IDAS2) with Caco-2 and MDCK Cell Monolayers: Dose Sensitivity Study Using BCS Class I and III Drugs

Author

Higashino, Haruki, primary, Develin, Corey Francis, additional, Higashino, Chie, additional, Lim, Tyler Chae-Hoon, additional, Miezeiewski, Blair Jean, additional, Rawa, Susan Lynn, additional, Strab, Robert John, additional, Patel, Rachana, additional, and Bhoopathy, Siddhartha, additional

Published
2024
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7. Prevalence of Methicillin-resistant Staphylococcus aureus and its antibiotic sensitivity in clinical samples in Tertiary Care Hospital.

Author

Parmar, Kajal, Patel, Dhwani, Mavani, Monika, Javadekar, Tanuja, and Patel, Rachana

Subjects
METHICILLIN-resistant staphylococcus aureus, STAPHYLOCOCCUS aureus, STAPHYLOCOCCUS aureus infections, ANTIBIOTICS, MICROBIAL sensitivity tests
Abstract

Introduction: Staphylococcus aureus is responsible for causing a variety of human infections, which may range from minor skin diseases to life-threatening infections. It colonizes healthy individuals and causes severe infection in hospitalized patients. Staphylococcus aureus infections used to respond to ß-lactam and related group of antibiotics but the emergence of Methicillin-resistant S. aureus (MRSA) has posed a serious therapeutic challenge. The present study aimed to determine prevalence of Methicillin-resistant Staphylococcus aureus in Dhiraj General Hospital, Gujarat and to determine antibiotic sensitivity pattern of Methicillin resistant Staphylococcus aureus in various samples and to determine inducible clindamycin resistance strains out of Methicillin resistant Staphylococcus aureus at Dhiraj General Hospital. Materials and methods: The present study was conducted in Microbiology Department of SBKS MI and RC during January 2022 to December 2022. The study comprised of 114 coagulase-positive staphylococci (COPS), isolated from a total of 1470 clinical specimens (like pus, blood, urine, high vaginal swab, sputum, etc.) of patients admitted in Dhiraj General hospital attached to SBKS MI and RC, Hospital, Waghodia, Gujarat. All the isolates were identified by standard procedures. Antimicrobial susceptibility test was carried out on each bacterial isolate using the disc diffusion method on Muller Hinton agar (MHA). Data were entered and analyzed statistically. Results: During one year of study period, a total of 1470 positive culture samples were there. Out of that, 114 positive samples of Staphylococcus aureus were isolated. Out of total Staphylococcus aureus positive samples, 24 strains of Methicillin resistant Staphylococcus aureus (MRSA) were detected. Out of total MRSA, 10 inducible clindamycin resistant Staphylococcus aureus were detected. Conclusion: To conclude, we can say that Vancomycin and Teicoplanin is the drug of choice in MRSA patients. As MRSA is an alarming issue for the health system, one should always think about drug sensitivity test before starting treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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8. The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels

Author

Sandilands, Emma, primary, Freckmann, Eva C., additional, Cumming, Erin M., additional, Román-Fernández, Alvaro, additional, McGarry, Lynn, additional, Anand, Jayanthi, additional, Galbraith, Laura, additional, Mason, Susan, additional, Patel, Rachana, additional, Nixon, Colin, additional, Cartwright, Jared, additional, Leung, Hing Y., additional, Blyth, Karen, additional, and Bryant, David M., additional

Published
2023
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9. Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function

Author

Román-Fernández, Alvaro, primary, Mansour, Mohammed A., additional, Kugeratski, Fernanda G., additional, Anand, Jayanthi, additional, Sandilands, Emma, additional, Galbraith, Laura, additional, Rakovic, Kai, additional, Freckmann, Eva C., additional, Cumming, Erin M., additional, Park, Ji, additional, Nikolatou, Konstantina, additional, Lilla, Sergio, additional, Shaw, Robin, additional, Strachan, David, additional, Mason, Susan, additional, Patel, Rachana, additional, McGarry, Lynn, additional, Katoch, Archana, additional, Campbell, Kirsteen J., additional, Nixon, Colin, additional, Miller, Crispin J., additional, Leung, Hing Y., additional, Le Quesne, John, additional, Norman, James C., additional, Zanivan, Sara, additional, Blyth, Karen, additional, and Bryant, David M., additional

Published
2023
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13. SEGMENTAL AND SPECIFIC CHROMOSOMAL ANEUPLOIDIES ARE INCREASED IN EMBRYOS OF CONSANGUINE COUPLES AFTER IVI/ICSI WITH PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDIES (PGT-A)

Author

Melado, Laura, primary, Barbara, Lawrenz, additional, Nogueira, Daniela, additional, Patel, Rachana, additional, Vitorino, Raquel Loja, additional, Marqueta, Laura, additional, Ruiz, Francisco Javier, additional, Bayram, Asina, additional, Elkhatib, Ibrahim, additional, and Fatemi, Human M.M., additional

Published
2022
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14. Phase II proof of concept study of atorvastatin in castration resistant prostate cancer

Author

Rushworth, Linda K., Loveridge, Carolyn, Salji, Mark, MacLeod, Martin, Mui, Ernest, Sumpton, David, Neilson, Matthew, Hedley, Ann, Alexander, Laura, McCartney, Elaine, Patel, Rachana, Wallace, Jan, Delles, Christian, Jones, Robert, and Leung, Hing Y.

Abstract

Objectives:\ud To test for evidence of statin-mediated effects in patients with castration resistant prostate cancer as post-diagnosis use of statins in patients with prostate cancer is associated with favourable survival outcome. Enhanced tumoral cholesterol uptake can drive castration resistant prostate cancer (CRPC). However, it remains unclear whether these associations result from confounding factors or directly from statin mediated effects.\ud \ud Patients and Methods:\ud The SPECTRE trial was a 6-weeks long proof-of-concept single-arm Phase II treatment trial combining atorvastatin and androgen deprivation therapy in patients with CRPC (regardless of the metastatic status), designed to test for evidence of statin-mediated effects in patients with CRPC. The primary study endpoint was the proportion of patients achieving ≥50% drop from baseline in PSA levels at any time over the 6-week period of atorvastatin medication (PSA response). Exploratory endpoints include PSA velocity and mass spectrometrically identified serum metabolites.\ud \ud Results:\ud At scheduled interim analysis, one of twelve patients experienced a ≥50% drop in PSA levels (primary endpoint), with ≥2 patients satisfying the primary endpoint required for further recruitment. All 12 experienced substantial falls in serum cholesterol levels following statin treatment. While all patients had comparable pre-study PSA velocities, 6 of 12 patients showed decreased PSA velocities following statin treatment, suggestive of disease stablisation. Unbiased metabolomics analysis on serial weekly blood samples identified tryptophan to be the dominant metabolite associated with patient response to statin.\ud \ud Conclusions:\ud Data from the SPECTRE study provides the first evidence of statin mediated effects on CRPC and early sign of disease stabilisation. Our data also highlights the possibility of altered tryptophan metabolism being associated with tumour response.

Published
2022

15. Cyclocreatine Suppresses Creatine Metabolism and Impairs Prostate Cancer Progression

Author

Patel, Rachana, primary, Ford, Catriona A., additional, Rodgers, Lisa, additional, Rushworth, Linda K., additional, Fleming, Janis, additional, Mui, Ernest, additional, Zhang, Tong, additional, Watson, David, additional, Lynch, Victoria, additional, Mackay, Gillian, additional, Sumpton, David, additional, Sansom, Owen J., additional, Vande Voorde, Johan, additional, and Leung, Hing Y., additional

Published
2022
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16. Multi-omics and pathway analysis identify potential roles for tumour n-acetyl\ud aspartate accumulation in murine models of castration resistant prostate cancer

Author

Salji, Mark J., Blomme, Arnaud, Däbritz, J. Henry M., Repiscak, Peter, Lilla, Sergio, Patel, Rachana, Sumpton, David, Van Den Broek, Niels J. F., Daly, Ronan, Zanivan, Sara, and Leung, Hing Y.

Abstract

Castration-resistant prostate cancer (CRPC) is incurable and remains a significant worldwide challenge (Oakes and Papa, 2015). Matched untargeted multi-level omic datasets may reveal biological changes driving CRPC, identifying novel biomarkers and/or therapeutic targets. Untargeted RNA sequencing, proteomics, and metabolomics was performed on xenografts derived from three independent sets of hormone naïve and matched CRPC human cell line models of local, lymph node and bone metastasis grown as murine orthografts. Collectively, we tested the feasibility of muti-omics analysis on models of CRPC in revealing pathways of interest for future validation investigation. Untargeted metabolomics revealed NAA and NAAG commonly accumulating in CRPC across three independent models and proteomics showed upregulation of related enzymes, namely N-Acetylated Alpha-Linked Acidic Dipeptidases (FOLH1/NAALADL2). Based on pathway analysis integrating multiple omic levels we hypothesise that increased NAA in CRPC may be due to upregulation of NAAG hydrolysis via NAALADLases providing a pool of Acetyl Co-A for upregulated sphingolipid metabolism and a pool of glutamate and aspartate for nucleotide synthesis during tumour growth.

Published
2022

17. Multi-omics & pathway analysis identify potential roles for tumor N-acetyl aspartate accumulation in murine models of castration-resistant prostate cancer

Author

Salji, Mark J., primary, Blomme, Arnaud, additional, Däbritz, J. Henry M., additional, Repiscak, Peter, additional, Lilla, Sergio, additional, Patel, Rachana, additional, Sumpton, David, additional, van den Broek, Niels J.F., additional, Daly, Ronan, additional, Zanivan, Sara, additional, and Leung, Hing Y., additional

Published
2022
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19. THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer

Author

Blomme, Arnaud, primary, Peter, Coralie, additional, Mui, Ernest, additional, Rodriguez Blanco, Giovanny, additional, An, Ning, additional, Mason, Louise M, additional, Jamieson, Lauren E, additional, McGregor, Grace H, additional, Lilla, Sergio, additional, Ntala, Chara, additional, Patel, Rachana, additional, Thiry, Marc, additional, Kung, Sonia H Y, additional, Leclercq, Marine, additional, Ford, Catriona A, additional, Rushworth, Linda K, additional, McGarry, David J, additional, Mason, Susan, additional, Repiscak, Peter, additional, Nixon, Colin, additional, Salji, Mark J, additional, Markert, Elke, additional, MacKay, Gillian M, additional, Kamphorst, Jurre J, additional, Graham, Duncan, additional, Faulds, Karen, additional, Fazli, Ladan, additional, Gleave, Martin E, additional, Avezov, Edward, additional, Edwards, Joanne, additional, Yin, Huabing, additional, Sumpton, David, additional, Blyth, Karen, additional, Close, Pierre, additional, Murphy, Daniel J, additional, Zanivan, Sara, additional, and Leung, Hing Y, additional

Published
2022
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20. Safe Delivery application with facilitation increases knowledge and confidence of obstetric and neonatal care among frontline health workers in India

Author

Sarin, Enisha, primary, Dastidar, SouravGhosh, additional, Bisht, Nitin, additional, Bajpayee, Devina, additional, Patel, Rachana, additional, Sodha, TarunSingh, additional, Bhandari, Aditya, additional, Mohanty, JayaSwarup, additional, Dey, Surajit, additional, Chandra, Subodh, additional, Agrawal, Ritu, additional, Saboth, Prasant, additional, and Kumar, Harish, additional

Published
2022
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21. Experiences From an Implementation Model of ARI Diagnostic Device in Pneumonia Case Management Among Under-5 Children in Peripheral Healthcare Centers in India.

Author

Kumar, Harish, Sarin, Enisha, Saboth, Prasant, Jaiswal, Avinash, Chaudhary, Nidhi, Mohanty, Jaya Swarup, Bisht, Nitin, Tomar, Shailendra Singh, Gupta, Anil, Panda, Ranjan, Patel, Rachana, Kumar, Arvind, Gupta, Sachin, and Alwadhi, Varun

Abstract

Objectives: To address pneumonia, a major killer of under-5 children in India, a multimodal pulse oximeter was implemented in Health and Wellness Centers. Given the evidence of pulse oximetry in effective pneumonia management and taking into account the inadequate skills of front-line healthcare workers in case management, the device was introduced to help them readily diagnose and treat a child and to examine usability of the device. Design: The implementation was integrated with the routine OPD of primary health centers for 15 months after healthcare workers were provided with an abridged IMNCI training. Monthly facility data was collected to examine case management with the diagnostic device. Feedback on usefulness of the device was obtained. Setting: Health and Wellness Centers (19) of 7 states were selected in consultation with state National Health Mission based on patient footfall. Participants: Under-5 children presenting with ARI symptoms at the OPD. Results: Of 4846 children, 0.1% were diagnosed with severe pneumonia and 23% were diagnosed with pneumonia. As per device readings, correct referrals were made of 77.6% of cases of severe pneumonia, and 81% of pneumonia cases were correctly given antibiotics. The Pulse oximeter was highly acceptable among health workers as it helped in timely classification and treatment of pneumonia. It had no maintenance issue and battery was long-lasting. Conclusion: Pulse oximeter implementation was doable and acceptable among health workers. Together with IMNCI training, PO in primary care settings is a feasible approach to provide equitable care to under-5 children. [ABSTRACT FROM AUTHOR]

Published
2021
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