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This paper investigates the causal effect of COVID-19 quarantine measures on the electricity consumption of different types of regulated customers. In particular, the average energy consumption of a group of customers in Chile is examined, exploiting the weekly variations in the application of the stages of the Step by Step Plan as a natural experiment. Step by Step Plan was the Chile COVID containment strategy, which involved implementing partial lockdowns based on the COVID incidence in the municipalities, and adjusted on a weekly basis. An econometric model is specified, and estimated using the technique Difference-in-Difference-in-Difference (DDD) to quantify the causal impact of these measures. After applying the model, it is found that the quarantine measures have had a negative effect on the trend weekly consumption of customers located in municipalities where some of the phases of the Plan have been applied. This effect is significantly different depending on each stage of the plan analysis, and statistically significant. It is also observed that, on average, the savings for a representative customer in the sample range from $ 8 to $ 6. 15 for some municipalities, and the sample costs range from $ 0. 02 to $ 0. 26 for others, depending on the municipality analyzed. The results can be expressed in a total of 2.95 tons less CO 2 emitted on a monthly basis. This shows a great impact in terms of sustainability and planning of energy demand and supply. • Quarantines by Covid 19 affected energy consumption, like a "Natural Experiment". • Using Panel Data of 400 thousand observations with geographic, temporal and Daylight Saving Time controls. • Difference-in-Difference-in-Difference method to quantify causal impact of quarantines on electric consumption. • Applying quarantines generated Energetic Savings from 8 cents to 6.15 dollars depending on client type. • An Event Study was designed to check the estimation results. [ABSTRACT FROM AUTHOR]

Cardiac Purkinje networks are a fundamental part of the conduction system and are known to initiate a variety of cardiac arrhythmias. However, patient-specific modeling of Purkinje networks remains a challenge due to their high morphological complexity. This work presents a novel method based on optimization principles for the generation of Purkinje networks that combines geometric and activation accuracy in branch size, bifurcation angles, and Purkinje-ventricular-junction activation times. Three biventricular meshes with increasing levels of complexity are used to evaluate the performance of our approach. Purkinje-tissue coupled monodomain simulations are executed to evaluate the generated networks in a realistic scenario using the most recent Purkinje/ventricular human cellular models and physiological values for the Purkinje-ventricular-junction characteristic delay. The results demonstrate that the new method can generate patient-specific Purkinje networks with controlled morphological metrics and specified local activation times at the Purkinje-ventricular junctions. [ABSTRACT FROM AUTHOR]

Personalized cardiac electrophysiology simulations have demonstrated great potential to study cardiac arrhythmias and help in therapy planning of radio-frequency ablation. Its application to analyze vulnerability to ventricular tachycardia and sudden cardiac death in infarcted patients has been recently explored. However, the detailed multi-scale biophysical simulations used in these studies are very demanding in terms of memory and computational resources, which prevents their clinical translation. In this work, we present a fast phenomenological system based on cellular automata (CA) to simulate personalized cardiac electrophysiology. The system is trained on biophysical simulations to reproduce cellular and tissue dynamics in healthy and pathological conditions, including action potential restitution, conduction velocity restitution and cell safety factor. We show that a full ventricular simulation can be performed in the order of seconds, emulate the results of a biophysical simulation and reproduce a patient's ventricular tachycardia in a model that includes a heterogeneous scar region. The system could be used to study the risk of arrhythmia in infarcted patients for a large number of scenarios. [ABSTRACT FROM AUTHOR]

The Purkinje system is a heart structure responsible for transmitting electrical impulses through the ventricles in a fast and coordinated way to trigger mechanical contraction. Estimating a patient-specific compatible Purkinje Network from an electro-anatomical map is a challenging task, that could help to improve models for electrophysiology simulations or provide aid in therapy planning, such as radiofrequency ablation. In this study, we present a methodology to inversely estimate a Purkinje network from a patient’s electro-anatomical map. First, we carry out a simulation study to assess the accuracy of the method for different synthetic Purkinje network morphologies and myocardial junction densities. Second, we estimate the Purkinje network from a set of 28 electro-anatomical maps from patients, obtaining an optimal conduction velocity in the Purkinje network of 1.95 ± 0.25 m/s, together with the location of their Purkinje-myocardial junctions, and Purkinje network structure. Our results showed an average local activation time error of 6.8±2.2 ms in the endocardium. Finally, using the personalized Purkinje network, we obtained correlations higher than 0.85 between simulated and clinical 12-lead ECGs. [ABSTRACT FROM AUTHOR]