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Your search keyword '"Shi, Zhumei"' showing total 12 results
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12 results on '"Shi, Zhumei"'

4. SREBP2 maintains glioblastoma stem cells through keeping the balance between cholesterol biosynthesis and uptake

Author

Gu, Danling, primary, Zhou, Fengqi, additional, You, Hao, additional, Gao, Jiancheng, additional, Kang, Tao, additional, Dixit, Deobrat, additional, Wu, Qiulian, additional, Yang, Kailin, additional, Ci, Shusheng, additional, Shan, Danyang, additional, Fan, Xiao, additional, Yuan, Wei, additional, Zhang, Qian, additional, Lu, Chenfei, additional, Li, Daqi, additional, Zhao, Ningwei, additional, Shi, Zhumei, additional, Gao, Wei, additional, Lin, Fan, additional, Man, Jianghong, additional, Wang, Qianghu, additional, Qian, Xu, additional, Mack, Stephen C, additional, Tao, Weiwei, additional, Agnihotri, Sameer, additional, Zhang, Nu, additional, You, Yongping, additional, Rich, Jeremy N, additional, Zhang, Junxia, additional, and Wang, Xiuxing, additional

Published
2023
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5. PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma

Author

Zhao, Mengjie, primary, Li, Yanhui, additional, Lu, Chenfei, additional, Ding, Fangshu, additional, Xu, Miao, additional, Ge, Xin, additional, Li, Mengdie, additional, Wang, Zhen, additional, Yin, Jianxing, additional, Zhang, Junxia, additional, Wang, Xiefeng, additional, Ge, Zehe, additional, Xiao, Hong, additional, Xiao, Yong, additional, Liu, Hongyi, additional, Liu, Wentao, additional, Cao, Yuandong, additional, Wang, Qianghu, additional, You, Yongping, additional, Wang, Xiuxing, additional, Yang, Kun, additional, Shi, Zhumei, additional, and Qian, Xu, additional

Published
2023
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10. β2-Microglobulin Maintains Glioblastoma Stem Cells and Induces M2-like Polarization of Tumor-Associated Macrophages

Author

Li, Daqi, primary, Zhang, Qian, additional, Li, Lu, additional, Chen, Kexin, additional, Yang, Junlei, additional, Dixit, Deobrat, additional, Gimple, Ryan C., additional, Ci, Shusheng, additional, Lu, Chenfei, additional, Hu, Lang, additional, Gao, Jiancheng, additional, Shan, Danyang, additional, Li, Yangqing, additional, Zhang, Junxia, additional, Shi, Zhumei, additional, Gu, Danling, additional, Yuan, Wei, additional, Wu, Qiulian, additional, Yang, Kailin, additional, Zhao, Linjie, additional, Qiu, Zhixin, additional, Lv, Deguang, additional, Gao, Wei, additional, Yang, Hui, additional, Lin, Fan, additional, Wang, Qianghu, additional, Man, Jianghong, additional, Li, Chaojun, additional, Tao, Weiwei, additional, Agnihotri, Sameer, additional, Qian, Xu, additional, Shi, Yu, additional, You, Yongping, additional, Zhang, Nu, additional, Rich, Jeremy N., additional, and Wang, Xiuxing, additional

Published
2022
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12. SP1-upregulated LBX2-AS1 promotes the progression of glioma by targeting the miR-491-5p/LIF axis.

Author

Li W, Soufiany I, Lyu X, Lu C, Wei Y, Shi Z, and You Y

Abstract

Background: Mounting evidences have shown the importance of lncRNAs in carcinogenesis and cancer progression. LBX2-AS1 is identified as an oncogenic lncRNA that is abnormally expressed in gastric cancer and lung cancer samples. This study aims to explore the potential role of LBX2-AS1 in regulating proliferation and EMT in glioma, and the underlying mechanism. Methods: Relative levels of LBX2-AS1 in glioma samples and cell lines were detected by qRT-PCR and FISH. In vivo and in vitro regulatory effects of LBX2-AS1 on proliferation and EMT were examined in the xenograft glioma model and glioma cells. The interaction between SP1 and LBX2-AS1 was assessed by ChIP. Through bioinformatic analyses, dual-luciferase reporter assay, RIP and Western blot, the regulation of LBX2-AS1 and miR-491-5p on the target gene LIF was identified. Results: LBX2-AS1 was upregulated in glioma samples and cell lines, and its transcription was promoted by binding to the transcription factor SP1. As a lncRNA mainly distributed in the cytoplasm, LBX2-AS1 sponge miR-491-5p to further upregulate LIF. The subsequent activated LIF/STAT3 signaling was responsible for promoting proliferation and EMT in glioma. Conclusion: LBX2-AS1 is upregulated by SP1 in glioma, which promotes the progression of glioma by targeting the miR-491-5p/LIF axis. In view of this, LBX2-AS1 is suggested as a novel diagnostic biomarker and therapeutic target of glioma., Competing Interests: Competing Interests: The authors have declared that no competing interest exists., (© The author(s).)

Published
2021
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