Search

Showing total 3 results
Start Over Search Limiters Peer Reviewed Topic imaging systems Publication Year Range Last 3 years
3 results

1. Printed 384‐Well Microtiter Plate on Paper for Fluorescent Chemosensor Arrays in Food Analysis.

Author

Lyu, Xiaojun, Sasaki, Yui, Ohshiro, Kohei, Tang, Wei, Yuan, Yousi, and Minami, Tsuyoshi

Subjects
*FOOD chemistry, *MICROPLATES, *AMINO acid analysis, *IMAGING systems, *IMAGE analysis
Abstract

We propose a printed 384‐well microtiter paper‐based fluorescent chemosensor array device (384‐well microtiter PCAD) to simultaneously categorize and discriminate saccharides and sulfur‐containing amino acids for food analysis. The 384‐well microtiter PCAD requiring 1 μL/4 mm2 of each well can allow high‐throughput sensing. The device embedded with self‐assembled fluorescence chemosensors displayed a fingerprint‐like response pattern for targets, the image of which was rapidly captured by a portable digital camera. Indeed, the paper‐based chemosensor array system combined with imaging analysis and pattern recognition techniques not only successfully categorized saccharides and sulfur‐containing amino acids but also classified mono‐ and disaccharide groups. Furthermore, the quantitative detectability of the printed device was revealed by a spike and recovery test for fructose and glutathione in a diluted freshly made tomato juice. We believe that the 384‐well microtiter PCAD using the imaging analysis system will be a powerful sensor for multi‐analytes at several categorized groups in real samples. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

3. Optical coherence tomography of small intestine allograft biopsies using a handheld surgical probe

Author

Adam Wax, Alton B. Farris, Zachary A. Steelman, Debra L. Sudan, Evan T. Jelly, Stuart J. Knechtle, Robin Schmitz, and Jean Kwun

Subjects
Paper, medicine.medical_specialty, genetic structures, diagnostic imaging, Biopsy, Biomedical Engineering, gastroenterology, imaging systems, Imaging, Biomaterials, Optical coherence tomography, Surgical probe, Medical imaging, Animals, Medicine, Sampling (medicine), optical coherence tomography, medicine.diagnostic_test, business.industry, Endoscopy, Gold standard (test), Allografts, Macaca mulatta, eye diseases, Atomic and Molecular Physics, and Optics, Small intestine, Electronic, Optical and Magnetic Materials, medicine.anatomical_structure, sense organs, Radiology, business, Tomography, Optical Coherence
Abstract

Significance: The current gold standard for monitoring small intestinal transplant (IT) rejection is endoscopic visual assessment and biopsy of suspicious lesions; however, these lesions are only superficially visualized by endoscopy. Invasive biopsies provide a coarse sampling of tissue health without depicting the true presence and extent of any pathology. Optical coherence tomography (OCT) presents a potential alternative approach with significant advantages over traditional white-light endoscopy. Aim: The aim of our investigation was to evaluate OCT performance in distinguishing clinically relevant morphological features associated with IT graft failure. Approach: OCT was applied to evaluate the small bowel tissues of two rhesus macaques that had undergone IT of the ileum. The traditional assessment from routine histological observation was compared with OCT captured using a handheld surgical probe during the days post-transplant and subsequently was compared with histophaology. Results: The reported OCT system was capable of identifying major biological landmarks in healthy intestinal tissue. Following IT, one nonhuman primate (NHP) model suffered a severe graft ischemia, and the second NHP graft failed due to acute cellular rejection. OCT images show visual evidence of correspondence with histological signs of IT rejection. Conclusions: Results suggest that OCT imaging has significant potential to reveal morphological changes associated with IT rejection and to improve patient outcomes overall.

Published
2021