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The immune mechanisms of long coronavirus disease 2019 (COVID) are not yet fully understood. We aimed to investigate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–specific memory immune responses in discharged COVID-19 patients with and without long COVID symptoms. In this cross-sectional study, we included 1041 hospitalized COVID-19 patients with the original virus strain in Wuhan (China) 12 months after initial infection. We simultaneously conducted a questionnaire survey and collected peripheral blood samples from the participants. Based on the presence or absence of long COVID symptoms during the follow-up period, we divided the patients into 2 groups: a long COVID group comprising 480 individuals and a convalescent group comprising 561 individuals. Both groups underwent virus-specific immunological analyses, including enzyme-linked immunosorbent assay, interferon-γ-enzyme-linked immune absorbent spot, and intracellular cytokine staining. At 12 months after infection, 98.5% (1026/1041) of the patients were found to be seropositive and 93.3% (70/75) had detectable SARS-CoV-2-specific memory T cells. The long COVID group had significantly higher levels of receptor binding domain (RBD)–immunoglobulin G (IgG) levels, presented as OD450 values, than the convalescent controls (0.40 ± 0.22 vs 0.37 ± 0.20; P =.022). The magnitude of SARS-CoV-2-specific T-cell responses did not differ significantly between groups, nor did the secretion function of the memory T cells. We did not observe a significant correlation between SARS-CoV-2-IgG and magnitude of memory T cells. This study revealed that long COVID patients had significantly higher levels of RBD-IgG antibodies when compared with convalescent controls. Nevertheless, we did not observe coordinated SARS-CoV-2-specific cellular immunity. As there may be multiple potential causes of long COVID, it is imperative to avoid adopting a "one-size-fits-all" approach to future treatment modalities. [ABSTRACT FROM AUTHOR]

The pandemic COVID-19 which has spread over the world in early 2020 has caused significant impacts not only on health and life, but also on production activities and freight work. However, few studies were about the effect of COVID-19 on the performance of cities' logistics. Hence, this study focuses on the Belt and Road Initiative (BRI) and compares the changes in logistics performance from a spatial perspective caused by COVID-19 that are reflected on the highway freight between its 18 node cities in 2019 and 2020 of the same periods for 72 days. This study uses the entropy weight method to reflect the impact that COVID-19 has caused to the logistics level. Based on the modified gravity model, the impact on the logistics spatial connection between node cities was analyzed. These two aspects have been combined to analyze the logistics performance. The results show that the node cities have been affected by COVID-19 dissimilarly, and the impact has regional characteristics. The logistics level and spatial connection of Wuhan are the most seriously declined. The decline in logistics level has the same spatial variation law as the confirmed cases. The logistics connection between Wuhan and the surrounding node cities and the three-node cities in the northeast of China are also severely affected by the pandemic because of the expressway control policies. The regional distribution of logistics performance has differences, and the correlation of the logistics level and logistics spatial connection decreases. Besides, this study puts forward different recovery suggestions and policies for different belts in the BRI, such as focusing on restoring areas and giving full play to the role of the Chengdu-Chongqing urban agglomeration and logistics corridor. Finally, further provides corresponding suggestions for reducing the impact of emergencies from the perspectives of logistics hubs. • The impact of the COVID-19 pandemic on the cities' logistics performance from China's highway freight transport. • The differences in logistics level and spatial connection of node cities in BRI affected by COVID-19 over the same period. • The impact of pandemic policy on logistics performance was explored. • The suggestions for reducing the impact of emergencies from the perspectives of logistics hubs and different belts. [ABSTRACT FROM AUTHOR]

The pandemic caused by coronavirus disease 2019(COVID-19) continues to disrupt the global supply chain system, bringing new risks and challenges. The uncertainty created by COVID-19 makes it is difficult for various industries to deal with the pandemic. Since the pandemic, the supply chain's resilience has been discussed and examined in some studies. However, most existing works start from a single industry perspective or pay more attention to the disturbance caused by changes in the production side. Supply chain networks of different industries, mainly transport networks, are relatively limited under the epidemic's impact. In this paper, from the perspective of highway freight transport, a comprehensive competitiveness evaluation framework was proposed to reveal and the disruption and resilience of the supply chain under the outbreak based on nine indexes with five dimensions, including efficiency, capacity, activity, connectivity, and negotiability. Based on the availability of the data(Large-scale truck trajectory), we sorted out seven categories of Chinese industries(related to highway transport) and divided them into four categories respectively: (a) Slight disruption and worse resilience; (b) Slight disruption and remarkable resilience; (c) Serious disruption and worse resilience; (d) Serious disruption and remarkable resilience. The measurement results of supply chain network performance show that the industries (cold-chain, general products, and other industries) dominated by "Efficiency - Negotiability - Connectivity" are slightly disrupted (about 33%), forming a spatial diffusion with Wuhan(the city where the pandemic first broke out) as the disrupted center, spreading outward in a circle structure. Simultaneously, five urban agglomerations surrounding it have been impacted. By contrast, due to the strict isolation measures, the industries (building materials, construction, engineering, and high-value products industry) more vulnerable to be disrupted seriously (about 82%) tend to be the pattern of "Capacity - Activity". However, a large-scale centralized disruption was observed in the Triangle of Central China urban agglomeration was presented, resulting in almost stagnation of industry development. Meanwhile, as the future of the pandemic remains uncertain, the supply chain represented by the engineering industry, construction industry, etc are deserved to be paid more attention in line with they are prone to large-scale centralized damage due to the disruption of a single city node. • Disruption and resilience of multi-industry supply chain under COVID-19 epidemic. • Multi-dimensional comprehensive competitiveness evaluation framework for supply chain performance. • Supply chain destruction and repair performance of seven industries in China under COVID-19 epidemic. • Characteristic differences of supply chain between different industries from the perspective of highway freight transport. [ABSTRACT FROM AUTHOR]