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Staphylococcus pseudintermedius is a frequent cause of infections in dogs. Infectious isolates of this coagulase-positive staphylococcal species are often methicillin- and multidrug-resistant, which complicates therapy. In staphylococci, methicillin resistance is encoded by determinants found on mobile genetic elements called Staphylococcal Chromosome Cassette mec (SCCmec), which, in addition to methicillin resistance factors, sometimes encode additional genes, such as further resistance factors and, rarely, virulence determinants. In this study, we analyzed SCCmec in a collection of infectious methicillin-resistant S. pseudintermedius (MRSP) isolates from predominant lineages in the United States. We found that several lineages characteristically have specific types of SCCmec elements and Agr types and harbor additional factors in their SCCmec elements that may promote virulence or affect DNA uptake. All isolates had SCCmec-encoded restriction–modification (R-M) systems of types I or II, and sequence types (STs) ST84 and ST64 had one type II and one type I R-M system, although the latter lacked a complete methylation enzyme gene. ST68 isolates also had an SCCmec-encoded CRISPR system. ST71 isolates had a psm-mec gene, which, in all but apparently Agr-dysfunctional isolates, produced a PSM-mec peptide toxin, albeit at relatively small amounts. This study gives detailed insight into the composition of SCCmec elements in infectious isolates of S. pseudintermedius and lays the genetic foundation for further efforts directed at elucidating the contribution of identified accessory SCCmec factors in impacting SCCmec-encoded and thus methicillin resistance-associated virulence and resistance to DNA uptake in this leading canine pathogen. [ABSTRACT FROM AUTHOR]

Organizations may hire newcomers as a source of creativity, bringing fresh ideas and novel solutions to benefit organizational performance. However, the conditions that foster newcomer innovation are not well understood. Drawing on behavioral plasticity and cue consistency theories, we investigate the combined influence of new job self-efficacy and two work design factors (work autonomy and work demands) affecting how supervisor creativity expectations (SCEs) translate into newcomers behaving innovatively. Two-wave data were collected from 108 graduates of a university in China. Results using reliability-corrected single indicator latent moderated structural equation modeling (RCSLMS) supported our hypotheses. Thus, SCEs predicted newcomer innovative behavior more strongly for newcomers with low new job self-efficacy. Moreover, supporting cue consistency theory, newcomers who perceived high SCEs and low new job self-efficacy demonstrated the highest level of innovative behavior when work autonomy was high or work demands were low. These results broaden the application of behavioral plasticity theory for understanding newcomer behaviors. Further, our findings emphasize the importance of consistent work environment cues to encourage newcomer innovation. [ABSTRACT FROM AUTHOR]

Dowager's hump is described as excessive kyphotic curvature in the thoracic spine with a Cobb angle of more than 40 degrees. This case report presents a 61 years old female office clerk who experienced headaches and neck pain for 3 years that extended into her right shoulder and upper chest. She consulted her primary care physician two months before seeing the chiropractor when the neck pain worsened. A diagnosis of cervicalgia related to osteoarthritis was made based on cervical and thoracic X-ray findings. The patient received non-steroid anti-inflammatory drugs (celecoxib and etoricoxib) and stretching exercises at home. At the onset of chiropractic care, radiographs showed loss of cervical lordosis, narrowing at the C4-5, C5-C6, and C6-7 intervertebral disc space with marginal osteophytes. Based on these findings, a working diagnosis of cervicogenic headache was established. After treatment for 9 months, the patient showed improvement in symptoms and function from cervical curve radiographic change and dextro-convexity of the thoracic spine. Avoiding forward head flexion and maintaining correct posture in daily activities will be key mechanisms to prevent the reoccurrence of Dowager's hump. The improvement of symptoms following chiropractic therapy has been shown to correlate with radiographic markers of spinal realignment. [ABSTRACT FROM AUTHOR]

Drawing on broaden-and-build theory and threat-rigidity hypothesis, we theorized and tested a multilevel model to examine the moderating effects of transformational leadership (TFL) on the team-level process that links positive/negative group affective tone (PGAT/NGAT) to team innovation via information elaboration. Data were collected from 299 team members and 65 leaders from Taiwanese companies at two time points. The multilevel path analysis demonstrated support for a positive indirect effect of PGAT on team innovation via information elaboration and a negative indirect effect of NGAT on team innovation via information elaboration. The positive indirect effect of PGAT on team innovation via information elaboration was found to be stronger when TFL was high rather than low. However, TFL did not attenuate the negative effects of NGAT. Negative group affective tone was negatively related to information elaboration when TFL was high, whereas NGAT had no significant relationship with information elaboration when TFL was low. Theoretical and practical implications are discussed. [ABSTRACT FROM AUTHOR]

In contrast to the virulent human skin commensal Staphylococcus aureus, which secretes a plethora of toxins, other staphylococci have much reduced virulence. In these species, commonly the only toxins are those of the phenolsoluble modulin (PSM) family. PSMs are species-specific and have only been characterized in a limited number of species. S. xylosus is a usually innocuous commensal on the skin of mice and other mammals. Prompted by reports on the involvement of PSMs in atopic dermatitis (AD) and the isolation of S. xylosus from mice with AD-like symptoms, we here identified and characterized PSMs of S. xylosus with a focus on a potential involvement in AD phenotypes. We found that most clinical S. xylosus strains produce two PSMs, one of the shorter a- and one of the longer b-type, which were responsible for almost the entire lytic and pro-inflammatory capacities of S. xylosus. Importantly, PSMa of S. xylosus caused lysis and degranulation of mast cells at degrees higher than that of S. aureus d-toxin, the main PSM previously associated with AD. However, S. xylosus did not produce significant AD symptoms in wild-type mice as opposed to S. aureus, indicating that promotion of AD by S. xylosus likely requires a predisposed host. Our study indicates that non-specific cytolytic potency rather than specific interaction underlies PSM-mediated mast cell degranulation and suggest that the previously reported exceptional potency of d-toxin of S. aureus is due to its high-level production. Furthermore, they suggest that species that produce cytolytic PSMs, such as S. xylosus, all have the capacity to promote AD, but a high combined level of PSM cytolytic potency is required to cause AD in a non-predisposed host. [ABSTRACT FROM AUTHOR]

Social dominance orientation (SDO) is a widely researched construct that indexes a preference for hierarchical intergroup relations. However, it remains unclear whether this preference (a) motivates people to seek out occupations that enhance hierarchical relations between groups (i.e., occupational assortment), (b) develops as a result of working within hierarchy-enhancing occupations (i.e., occupational socialization), or (c) both. One reason for this gap is that the large-scale longitudinal data required to simultaneously model assortment and socialization processes are scarce. In this study, we analyzed data from two waves of longitudinal data (spaced either 1, 3, or 5 years apart) from a nationwide sample of adults (N = 3,452–4,412) who were already working in either hierarchy-enhancing occupations (e.g., law enforcement) or hierarchy-attenuating occupations (e.g., social work). Results showed that SDO predicted an increased probability of working in a hierarchy-enhancing occupation 3 and 5 years later. Working in a hierarchy-enhancing occupation was also positively associated with SDO after 1 and 5 years. These patterns generally suggest that occupations both shape, and are shaped by, intergroup beliefs. [ABSTRACT FROM AUTHOR]

Using a two-wave survey of 315 workers in a lean manufacturing plant, this study examines how work intensification affects employee wellbeing and how its effects may be ameliorated. It demonstrates that work intensification is transmitted into poorer wellbeing through greater emotional exhaustion. It shows that this mediation process is moderated by line-manager support, which buffers the relationship between emotional exhaustion and wellbeing. The study suggests that the health-impairing risks of high work intensity in lean settings can be reduced through better supervisory support. Ensuring that line managers have the opportunity, skills and motivation to offer good support to workers is a vital aspect of the interventions needed to counteract the health risks posed by lean production. [ABSTRACT FROM AUTHOR]

Staphylococcus aureus is one of the most frequent worldwide causes of morbidity and mortality due to an infectious agent. This pathogen can cause a wide variety of diseases, ranging from moderately severe skin infections to fatal pneumonia and sepsis. Treatment of S. aureus infections is complicated by antibiotic resistance and a working vaccine is not available. There has been ongoing and increasing interest in the extraordinarily high number of toxins and other virulence determinants that S. aureus produces and how they impact disease. In this review, we will give an overview of how S. aureus initiates and maintains infection and discuss the main determinants involved. A more in-depth understanding of the function and contribution of S. aureus virulence determinants to S. aureus infection will enable us to develop anti-virulence strategies to counteract the lack of an anti-S. aureus vaccine and the ever-increasing shortage of working antibiotics against this important pathogen. [ABSTRACT FROM AUTHOR]