Search

With the development of the times, UAVs are gradually promoted and popularized in military and civil fields, and the future airspace will also face more security risks. This paper combines the graph theory network algorithm to plan the initial path of UAV inspection and completes the dynamic collision avoidance path planning in the process of UAV inspection through the established joint model of UAV inspection sensing and avoidance. At the same time, the ant colony algorithm is introduced to improve the graph theory network algorithm to solve the dynamic collision avoidance optimal path in the process of UAV inspection. On this basis, simulation experiments of path planning design for UAV collision avoidance and kinematic simulation with two-fold priority judgment are carried out, and the kinematic parameters corresponding to the collision avoidance path are selected as the analysis anchor points. The extreme values of horizontal speed, climb speed, trajectory inclination angular rate, and heading angular rate are 31.6 m/s, 3 m/s, 5.7°/s, and 18.4°/s, respectively, which are within the given constraints, and verify the reasonableness and effectiveness of the proposed optimization scheme. The average time of the proposed algorithm is 0.0458s, which is much lower than the corresponding 0.7105s of the original scheme algorithm, through data comparison of simulation experiments and experimental validation. Using a graph theory network algorithm, the proposed optimization scheme is more efficient and stable and has a higher success rate for collision avoidance.

A growing body of research has provided evidence for the foreign language effect on thinking, notably decision-making. Our prior work found reduction of recency effect following positive feedback in a foreign language as compared to the native tongue during even-probability gambling. However, the fundamental mechanisms underlying this effect remain unclear. The present study, therefore, aims to probe into this by engaging Chinese-English bilinguals in a functional magnetic resonance imaging version of our gambling task, which required participants to make decisions between playing and leaving equal-odds bets whilst manipulating language and valence of feedback. Results showed fewer 'play' choices following positive feedback presented in English relative to Chinese while no cross-language differences were observed after negative feedback. This valence-dependent language effect on risk-taking behaviour was supported by a language-emotion-decision neural circuit involving interplay between the right lingual gyrus, left fusiform gyrus, and right inferior frontal gyrus. Overall, our findings suggest valence-differential mechanisms of the foreign language effect in the risky decision. That is, the use of a foreign language in feedback presentation attenuates emotional reaction to positive feedback and thus diminishes subsequent risk-taking behaviour. Differently, negative counterparts seem to trigger detachment from negative emotion, leading to dissociation between feedback-encoding and decision-making. [ABSTRACT FROM AUTHOR]

Bone defects are characterized by a hypoxic environment, which affects bone tissue repair. However, the role of hypoxia in the repair of alveolar bone defects remains unclear. Human periodontal ligament stem cells (hPDLSCs) are high‐quality seed cells for repairing alveolar bone defects, whose behavior changes under hypoxia. However, their mechanism of action is not known and needs to be elucidated. We hypothesized that hypoxia might be beneficial to alveolar bone defect repair and the osteogenic differentiation of hPDLSCs. To test this hypothesis, cobalt chloride (CoCl2) was used to create a hypoxic environment, both in vitro and in vivo. In vitro study, the best osteogenic effect was observed after 48 h of hypoxia in hPDLSCs, and the AKT/mammalian target of rapamycin/eukaryotic translation initiation factor 4e‐binding protein 1 (AKT/mTOR/4EBP‐1) signaling pathway was significantly upregulated. Inhibition of the AKT/mTOR/4EBP‐1 signaling pathway decreased the osteogenic ability of hPDLSCs under hypoxia and hypoxia‐inducible factor 1 alpha (HIF‐1α) expression. The inhibition of HIF‐1α also decreased the osteogenic capacity of hPDLSCs under hypoxia without significantly affecting the level of phosphorylation of AKT/mTOR/4EBP‐1. In vitro study, Micro‐CT and tissue staining results show better bone regeneration in hypoxic group than control group. These results suggested that hypoxia promoted alveolar bone defect repair and osteogenic differentiation of hPDLSCs, probably through AKT/mTOR/4EBP‐1/HIF‐1α signaling. These findings provided important insights into the regulatory mechanism of hypoxia in hPDLSCs and elucidated the effect of hypoxia on the healing of alveolar bone defects. This study highlighted the importance of physiological oxygen conditions for tissue engineering. [ABSTRACT FROM AUTHOR]

In screening for natural fungicidal leads, two series of novel 3-aryl-isoquinoline derivatives 8 and 9 were designed and synthesized based on sanguinarine, chelerythrine and berberine. Their structures were confirmed by 1D, 2D NMR and HRMS. Most of the title compounds showed medium to excellent antifungal activity in vitro at 50 mg/L, which were much more active than the lead of sanguinarine. Especially, 9f possessed the best effective against Alternaria solani (80.4%), Alternaria alternata (88.2%) and Physalospora piricola (93.8%). Furthermore, the EC50 of 9f (3.651 mg/L) against P. piricola was marginally better than chlorothalonil (3.869 mg/L). In vivo antifungal activity of 9f against P. piricola was studied on apples. The curative and protection results at the dosage of 50 and 100 mg/L showed as 70.45 ~ 81.67% and 64.96 ~ 80.34%, respectively, which were equal to that of chlorothalonil (80.30 ~ 86.67%, 73.08 ~ 76.92%). Molecular electrostatic potential and molecular docking analysis revealed that 9f was fully covered by positive potential contour, which was easier to interact with the negative amino acid resides of succinate dehydrogenase than 8f. 9f could be used as a novel antifungal lead compound for further study. Two series of novel isoquinoline derivatives 8, 9 containing 3-aryl were rational designed and synthesized based on quaternary isoquinoline alkaloids. The bioassay and interaction mechanism studies indicated that 9f should be considered as potential antifungal lead. [ABSTRACT FROM AUTHOR]

Previous research has shown that using foreign languages reduces cognitive biases. Here, we investigate whether this foreign-language effect extends to self-related cognition – in particular, the self-positivity bias, which refers to automatic association of oneself with positive information and has a facilitation role in maintaining mental health. We applied event-related brain potentials and oscillations in the implicit association test where Chinese–English bilinguals responded to category words (self vs. others) and attribute words (positive vs. negative) in either their native language Chinese or their foreign language English. In response to Chinese words, a self-positivity bias occurred, indexed by a positive D -score in reaction times as well as by smaller N200, larger P3-like/LPC responses, and lower alpha desynchronization when self words were associated with positive relative to negative traits. However, the bias was diminished in the English context. Overall, our findings provide important implications for language choices when self-protective mechanisms should be enhanced. [ABSTRACT FROM AUTHOR]