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Your search keyword '"Niu, Chaoshi"' showing total 155 results
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155 results on '"Niu, Chaoshi"'

23. Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells

Author

Zhu, Qiuhong, primary, Liang, Panpan, additional, Meng, Hao, additional, Li, Fangzhen, additional, Miao, Wei, additional, Chu, Cuiying, additional, Wang, Wei, additional, Li, Dongxue, additional, Chen, Cong, additional, Shi, Yu, additional, Yu, Xingjiang, additional, Ping, Yifang, additional, Niu, Chaoshi, additional, Wu, Hai-bo, additional, Zhang, Aili, additional, Bian, Xiu-wu, additional, and Zhou, Wenchao, additional

Published
2024
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29. Stereotactic co-axial projection imaging for augmented reality neuronavigation: a proof-of-concept study

Author

Wu, Bingxuan, Liu, Peng, Xiong, Chi, Li, Chenmeng, Zhang, Fan, Shen, Shuwei, Shao, Pengfei, Yao, Peng, Niu, Chaoshi, and Xu, Ronald

Subjects
Original Article, Radiology, Nuclear Medicine and imaging
Abstract

BACKGROUND: Lack of intuitiveness and poor hand-eye coordination present a major technical challenge in neurosurgical navigation. METHODS: We developed an integrated dexterous stereotactic co-axial projection imaging (sCPI) system featuring orthotopic image projection for augmented reality (AR) neurosurgical navigation. The performance characteristics of the sCPI system, including projection resolution and navigation accuracy, were quantitatively verified. The resolution of the sCPI was tested with a USAF1951 resolution test chart. The stereotactic navigation accuracy of the sCPI was measured using a calibration panel with a 7×7 circle array pattern. In benchtop validation, the navigation accuracy of the sCPI and the BrainLab Kick Navigation Station was compared using a skull phantom with 8 intracranial targets. Finally, we demonstrated the potential clinical application of sCPI through a clinical trial. RESULTS: The resolution test showed that the resolution of the sCPI was 1.3 mm. In a stereotactic navigation accuracy test, the maximum and minimum error of the sCPI was 2.9 and 0.3 mm, and the mean error was 1.5 mm. The stereotactic navigation accuracy test also showed that the navigation error of the sCPI would increase with the pitch and yaw angle, but there was no obvious difference in navigation errors caused by different yaw directions, which meant that the navigation error is unbiased across all directions. The benchtop validation showed that the average navigation errors for the sCPI system and the Kick Navigation Station were 1.4±0.8 and 1.8±0.7 mm, the medians were 1.3 and 1.9 mm, and the average preparation times were 3 min 24 sec and 6 min 8 sec, respectively. The clinical feasibility of sCPI-assisted neurosurgical navigation was demonstrated in a clinical study. In comparison with the BrainLab device, the sCPI system required less time for preoperative preparation and enhanced the clinician experience in intraoperative visualization and navigation. CONCLUSIONS: The sCPI technique can be potentially used in many surgical applications for intuitive visualization of medical information and intraoperative guidance of surgical trajectories.

Published
2022

50. Differential expression and significance of miRNAs in plasma extracellular vesicles of patients with Parkinson's disease.

Author

Xie, Shishuai, Niu, Wanxiang, Xu, Feng, Wang, Yuping, Hu, Shanshan, and Niu, Chaoshi

Subjects
PARKINSON'S disease, EXTRACELLULAR vesicles, MICRORNA, RECEIVER operating characteristic curves, ALPHA-synuclein
Abstract

To study the feasibility of plasma extracellular vesicles (EVs) miRNAs as diagnostic biomarkers for Parkinson's disease (PD). Plasma EVs were isolated from 30 PD patients and 30 age- and sex-matched healthy controls. Plasma EVs miRNAs were analysed by qRT-PCR. SH-SY5Y cells were induced by different concentrations of 1-Methyl-4-phenil-pyridinium (MPP+) to obtain PD cellular model. The levels of miRNAs and α-synuclein (α-syn) in PD cellular model were analysed by qRT-PCR and Western blot. Receiver operating characteristic (ROC) curve analysis was performed to determine the diagnostic usefulness of the miRNAs in plasma EVs for PD. The gene ontology (GO) and KEGG pathways of the target genes of miRNAs were analysed by softwares. The level of hsa-miR-30c-2-3p in plasma EVs was significantly higher in PD patients than that in controls, and the levels of hsa-miR-15b-5p, hsa-miR-138-5p, hsa-miR-338-3p, hsa-miR-106b-3p and hsa-miR-431-5p in plasma EVs were lower in PD patients than that in controls. When compared with the control group, the area under the curve (AUC) values for hsa-miR-15b-5p, hsa-miR-30c-2-3p, hsa-miR-138-5p, hsa-miR-431-5p, hsa-miR-338-3p and hsa-miR-106b-3p were all greater than 0.6. The target genes of hsa-miR-15b-5p, hsa-miR-30c-2-3p, hsa-miR-138-5p and hsa-miR-338-3p were enriched in dopaminergic synapse and PD pathway. The hsa-miR-15b-5p, hsa-miR-30c-2-3p, hsa-miR-138-5p, hsa-miR-106b-3p, hsa-miR-338-3p and hsa-miR-431-5p may be used as potential biomarkers for the diagnosis of PD, and the combined diagnostic accuracy of hsa-miR-15b-5p, hsa-miR-30c-2-3p, hsa-miR-138-5p and hsa-miR-106b-3p was better. The target genes of hsa-miR-15b-5p, hsa-miR-30c-2-3p, hsa-miR-138-5p and hsa-miR-338-3p may regulate the expression of dopamine by dopaminergic synapse and PD pathway. Isolation and identification of plasma EVs. The miRNAs in plasma EVs may be used as potential biomarkers for the diagnosis of PD. When SH-SY5Y cells were induced by different concentrations of MPP+, the levels of miRNAs and α-syn changed gradually. The target genes of miRNAs were enriched in dopaminergic synapse and PD pathway. The target genes of miRNAs may regulate the expression of dopamine. [ABSTRACT FROM AUTHOR]

Published
2022
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