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3. List of contributors

Author

Abalo, Raquel, primary, Abdelghffar, Eman A., additional, Abdelkhalek, Yasmin M., additional, Acuña, Sabrina, additional, Adeyemo, Oluwatobi, additional, Ahlawat, Jyoti, additional, Ahmad, Aftab, additional, Ahsan, Khansa, additional, Ajeigbe, Olufunke Florence, additional, Alberto-Silva, Carlos, additional, Ali, Javed, additional, Almeida, Carlos Gabriel Moreira, additional, Almeida, Áurea Maria Alves Nunes, additional, Alves, Anna Beatriz Pereira Simões, additional, Anamelechi, Joy, additional, Andreatini, R., additional, Arbo, Bruno Dutra, additional, Arent, Camila O., additional, Ashraf, Hagar, additional, Aslim, Belma, additional, Atarase, Oyepeju, additional, Awasthi, Rajendra, additional, Baboota, Sanjula, additional, Bagatini, Margarete Dulce, additional, Bakrim, Saad, additional, Barajas-Saucedo, C.E., additional, Bassols, Anna, additional, Batagin-Neto, Augusto, additional, Benameur, Tarek, additional, Bermúdez-Guzmán, M.J., additional, Bernardi, María Alejandra, additional, Bertollo, Amanda Gollo, additional, Beulaja, M., additional, Bhattacharya, Pallab, additional, Binda, Nancy Scardua, additional, Bisagno, Verónica, additional, Boeira, Silvana Peterini, additional, Bonjorno, Andressa Francielli, additional, Borah, Anupom, additional, Borsini, Alessandra, additional, Botelho, Maria Eduarda M., additional, Boudreau, Luc H., additional, Bouyahya, Abdelhakim, additional, Brimson, James Michael, additional, Bujtor, Melissa, additional, Büsselberg, Dietrich, additional, Butt, Arthur Morgan, additional, Čagalj, Martina, additional, Candeias, Emanuel, additional, Cardoso, Sandra Morais, additional, Carlini, Celia R., additional, Carrazoni, Thiago, additional, Carreira, Rodrigo Barreto, additional, Carrera-González, María Pilar, additional, Castro e Silva, Juliana Helena, additional, Catherene, M. Livya, additional, Chamorro, María E., additional, Charlotte, Lechevallier, additional, Chaudhary, Antra, additional, Chiba, Diego Eidy, additional, Choonara, Yahya E., additional, Chukwudozie, Kingsley Ikechukwu, additional, Convertini, Paolo, additional, Correa, Florencia, additional, Costa, Silvia Lima, additional, Cox, Paul Alan, additional, Crispi, Stefania, additional, Cuciniello, Rossana, additional, urko-Cofek, Božena, additional, da Cunha, Israel Cordeiro Eller, additional, da Rocha Fernandes, Livia, additional, da Silva, Gilnei Bruno, additional, da Silva, Juliana Figueira, additional, da Silva, Victor Diogenes Amaral, additional, Dakka, Nadia, additional, Dal Belo, Cháriston André, additional, Datta, Aishika, additional, de Almeida, Monique Marylin Alves, additional, de Araújo, Fillipe Mendes, additional, de Bari, Lidia, additional, de Faria Lopes, Giselle Pinto, additional, de Gomes, Marcelo Gomes, additional, de Oliveira, Juciele Valéria Ribeiro, additional, de Oliveira, Marcos Roberto, additional, de Oliveira, Êndel Alves Gomes, additional, de Sampaio Schitine, Clarissa, additional, de Souza, Suzana Braga, additional, de Souza, Veronica Moreira, additional, Del Fabbro, Lucian, additional, Dhiman, Neerupma, additional, Di Meo, Francesco, additional, Dias Costa, Maria de Fatima, additional, do Nascimento, Ravena Pereira, additional, Dora, Cristiana Lima, additional, dos Santos, Balbino Lino, additional, dos Santos, Cleonice Creusa, additional, dos Santos, Jean Leandro, additional, dos Santos, Michele Goulart, additional, Dourado, Naiara Silva, additional, El Idrissi, Abdeslem, additional, El Menyiy, Naoual, additional, Eldahshan, Omayma A., additional, El-Nashar, Heba A.S., additional, El-Shazly, Mohamed, additional, Empadinhas, Nuno, additional, Esteban, S., additional, Esteves, A. Raquel, additional, Ezenandu, Emmanuel Obinna, additional, Ezeorba, Timothy Prince Chidike, additional, Ezeudoka, Brendan Chukwuemeka, additional, Fagiolino, Pietro, additional, Farombi, Ebenezer O., additional, Ferreira, Rafael Short, additional, Finnie, John W., additional, Furian, Ana Flávia, additional, Gaitán-Hinojosa, M.A., additional, Galván-Hernández, A.R., additional, García-Villalvazo, P.E., additional, Garg, Chahat, additional, Gazerani, Parisa, additional, Ghosh, Bijoyani, additional, Gomez, Marcus Vinícius, additional, González-Bulnes, Antonio, additional, Goyal, Lav, additional, Grewal, Amarjot Kaur, additional, Grubi Kezele, Tanja, additional, Guedes, Beatriz, additional, Guevara, Natalia, additional, Gutierrez, Antonia, additional, Habtemariam, Solomon, additional, Haghdoost-Yazdi, Hashem, additional, Hassoun, Abdo, additional, Heidari, Reza, additional, Hernández-González, Ignacio, additional, Horn, Ana Paula, additional, Hort, Mariana Appel, additional, Hritcu, Lucian, additional, Hyslop, Stephen, additional, Ibarra-Vega, R., additional, Ignácio, Zuleide Maria, additional, Ikeji, Cynthia Nwamaka, additional, Infantino, Vittoria, additional, James, Adewale Segun, additional, Jauquet, Mélissa, additional, Jimenez-García, M., additional, Jiménez-Vargas, J.M., additional, Junge, Stephanie, additional, Kalapos, Miklós Péter, additional, Kalra, Palak, additional, Kanazawa, L.K.S., additional, Kanekar, Shami, additional, Kargieman, Lucila, additional, Kaur, Jasleen, additional, Kaushik, Medha, additional, Kaushik, Pooja, additional, Khan, Farha Deeba, additional, Kharkwal, Harsha, additional, Komane, Patrick P., additional, Kubatka, Peter, additional, Kulkarni, G.T., additional, Kumar, Pradeep, additional, Kumar, Shobhit, additional, la Torre, Maria Ester, additional, Lahyaoui, Manal, additional, Lefebvre, Kathi A., additional, Leite, José Roberto S.A., additional, Lemarchand, Eloïse, additional, Lino-López, G.J., additional, Lopes, Flávia Garcia, additional, Lopes, Juliana Romano, additional, Lopez del Castillo, Ines, additional, López-Gómez, Laura, additional, Loureiro, Joana, additional, Luhach, Kanishk, additional, Magalhães, João Duarte, additional, Mahalakshmi, K., additional, Malar, Dicson Sheeja, additional, Maldonado, Cecilia, additional, Maltaneri, Romina E., additional, Manikandan, R., additional, Manosso, Luana M., additional, Marciniak, Stefan J., additional, Marín-Prida, Javier, additional, Marques, Magno da Silva, additional, Martínez-Martos, José Manuel, additional, Martyniuk, Christopher J., additional, Matosinhos, Rafaela Cunha, additional, Maurya, Shashank Kumar, additional, Melo-Marques, Inês, additional, Messina, Antonietta, additional, Messina, Giovanni, additional, Metcalf, James S., additional, Mihaiela, Cornea-Cipcigan, additional, Miralles, A., additional, Mishra, Rajeev, additional, Mishra, Rajnikant, additional, Monda, Marcellino, additional, Monda, Vincenzo, additional, Moranta, D., additional, Moreira, Daniel C., additional, Moreno-Gonzalez, Ines, additional, Morin, Pier, additional, Munawar, Nayla, additional, Naqvi, Saba, additional, Nedel, Cláudia Beatriz, additional, Nelissen, E., additional, Nesse, Alcira B., additional, Nigdelioglu Dolanbay, Serap, additional, Nunes-Costa, Daniela, additional, Ojo, Mercy Olubunmi, additional, Okeke, Emmanuel Sunday, additional, Okoye, Charles Obinwanne, additional, Okoye, Henrietta Ukamaka, additional, Oliveira, R.M.W., additional, Oliveira, Raquel Soares, additional, Ommati, Mohammad Mehdi, additional, Onaolapo, Adejoke Y., additional, Onaolapo, Olakunle J., additional, Panaro, Maria Antonietta, additional, Pappalardo, Ilaria, additional, Parimalanandhini, D., additional, Parvez, Suhel, additional, Patel, Mayank, additional, Pavan, Aline Renata, additional, Pedro, Lucas C., additional, Pentón-Rol, Giselle, additional, Pereira, Erica Patrícia, additional, Pereira-Santos, A. Raquel, additional, Pérez-Valle, Jorge, additional, Perissinotti, Paula P., additional, Phadke, Girija Gajanan, additional, Piermartiri, Tetsade C.B., additional, Pinto, João Victor Krüger, additional, Pizzolorusso, Ilaria, additional, Polito, Rita, additional, Porro, Chiara, additional, Portaro, Fernanda Calheta Vieira, additional, Prasad, K.V.S.R.G., additional, Prasanth, Mani Iyer, additional, Prickaerts, J., additional, Prokai, Laszlo, additional, Prokai-Tatrai, Katalin, additional, Quevedo, João, additional, Rabbani, Syed Arman, additional, Raj, Khadga, additional, Ramírez-Expósito, María Jesús, additional, Ramis, M.R., additional, Rana, Nikita, additional, Rathod, Nikheel Bhojraj, additional, Rawat, Kajal, additional, Retana-Marquez, Socorro, additional, Réus, Gislaine Z., additional, Ribeiro, Paulo Roberto, additional, Ríos-Bracamontes, E.F., additional, Rivero-Echeto, María Celeste S., additional, Rodica, Mrgoan, additional, Rodríguez-Leone, Nazarena, additional, Roussel, Benoit D., additional, Ruggiero, Melania, additional, Rupasree, P., additional, Saha, Lekha, additional, Salau, Veronica F., additional, Sangeetha, R., additional, Sardana, Satish, additional, Sarduy-Chávez, Rocío de la Caridad, additional, Sarmah, Deepaneeta, additional, Sarubbo, F., additional, Schimith, Lucia Emanueli, additional, Shahidul Islam, Md., additional, Sharika, Rajasekharan, additional, Sharma, Bhupesh, additional, Sharma, Poonam, additional, Sharma, Shrestha, additional, Shrivastava, Rahul, additional, Siddique, Yasir Hasan, additional, Silva, Marilyn H., additional, Šimat, Vida, additional, Singh, Gyanendra, additional, Singh, Neha, additional, Singh, Shamsher, additional, Singh, Thakur Gurjeet, additional, Singh, Varinder, additional, Sirin, Seda, additional, Soares, Janaina Ribeiro Pereira, additional, Souza, Cleide dos Santos, additional, Souza, Nara, additional, Srivastava, Vikas, additional, Su, Kuan-Pin, additional, Sujatha, D., additional, Sukach, Volodymyr, additional, Sunitha, S., additional, Tabassum, Heena, additional, Tasca, Carla I., additional, Tasker, R. Andrew, additional, Tasleem, Ammar, additional, Tejada, S., additional, Tencomnao, Tewin, additional, Torres, Rosimere Oliveira, additional, Triniac, Hortense, additional, Tripathi, Swapnil, additional, Trotta, Teresa, additional, Ugbaja, Regina Ngozi, additional, Ugbaja, Victory Chukwudalu, additional, Ugwor, Emmanuel Ifeanyichukwu, additional, Urbano, Francisco J., additional, Uzal, Francisco A., additional, Valdez-Velazquez, L.L., additional, Vaz, Gustavo Richter, additional, Vázquez, Marta, additional, Vegas-Gomez, Laura, additional, Victor, Mauricio Moraes, additional, Villalba, Sofia, additional, Villano, Ines, additional, Vinadé, Lucia, additional, Vital, M.A.B.F., additional, Vittori, Daniela C., additional, Vivien, Denis, additional, Yachou, Yassine, additional, Yeste, Natalia, additional, Zaman, Khadiza, additional, Zavalza-Gálvez, D.I., additional, Zeb, Alam, additional, and Zhai, Kevin, additional

Published
2024
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13. Beyond Barriers: Addressing Challenges and Opportunities of People with Disability During the Pandemic.

Author

Aggarwal, Sumit, Tabassum, Heena, Agarwal, Pragati, Grover, Ashoo, and Singh, Ravinder

Subjects
*FAMILIES & psychology, *HEALTH services accessibility, *HEALTH self-care, *MENTAL health, *FUNCTIONAL status, *SOCIAL support, *COVID-19 pandemic, *PEOPLE with disabilities, *WELL-being, *SOCIAL stigma
Abstract

People with disabilities often experience worse health outcomes than ordinary people because of multiple barriers to accessing healthcare. These inequalities are particularly exposed during the pandemic, indicating an urgent need to strengthen health systems, so that they are inclusive and responsive to the needs of these people during crises. These people are particularly affected by changes in routine services because of diversion of healthcare staff and facilities to respond to the pandemic, e.g., rehabilitation and medications. The combination of these factors substantially imparts negative impacts on their functioning and well-being. Health services research can help address the challenges of maintaining continuity of care during crises as well as addressing systematic inequalities in the health sector that marginalize people with disabilities even during noncrisis times. Therefore, research is needed to understand the health service design and to identify strategies to maximize active participation from this population. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Contributors

Author

Abdolghaffari, Amir Hossein, primary, Abdollahi, Mohammad, additional, Alberdi, Elena, additional, Asghari, Mohammad Hossein, additional, Baskaran, Vallikannan, additional, Bernatoniene, Jurga, additional, Bhoomika, S., additional, Bouchez, C.L., additional, Camougrand, Nadine, additional, Capetillo-Zarate, Estibaliz, additional, Castela, Ana C., additional, Cecchini, Alessandra Lourenço, additional, Chattipakorn, Nipon, additional, Chattipakorn, Siriporn C., additional, Chayanika, G., additional, Cino, Jaco, additional, Coelho, Patrícia, additional, Cossarizza, Andrea, additional, Cuvellier, S., additional, Dave, A., additional, De Gaetano, Anna, additional, de Oliveira, Marcos Roberto, additional, Devin, Anne, additional, Di Meo, Sergio, additional, Duvezin-Caubet, S., additional, Farruggio, Serena, additional, Fasciolo, Gianluca, additional, Fenton, Valeska, additional, Gerk, Phillip M., additional, Ghosh, Noyel, additional, Gonçalves, Vanessa F., additional, Grossini, Elena, additional, Hassani, Shokoufeh, additional, Hebert-Chatelain, Etienne, additional, Jakstas, Valdas, additional, Jayapala, Naveen, additional, Kalvala, Anil Kumar, additional, Kennedy, Brian, additional, Kim, Hyeyoung, additional, Kim, Suhn Hyung, additional, Kopustinskiene, Dalia Marija, additional, Kosuru, Ramoji, additional, Kumar, Ashutosh, additional, Lagoa, Ricardo, additional, Legros, Sabastian, additional, Leurcharusmee, Prangmalee, additional, Luiz, Rodrigo Cabral, additional, Machado, Ivo F., additional, Maghsoudi, Armin Salek, additional, Manning, Jaylin, additional, Manon, Stéphen, additional, Marotta, Patrizia, additional, Marques-da-Silva, Dorinda, additional, Mathews, Valuparampil Varghese, additional, Matute, Calos, additional, Mazat, J.P., additional, Mistry, Mahima, additional, Molinié, T., additional, Moloudizargari, Milad, additional, Momtaz, Saeideh, additional, Moradi, Fereshteh, additional, Morkuniene, Ramune, additional, Nair, Raveendran Harikumaran, additional, Napolitano, Gaetana, additional, Pain, P., additional, Panella, Massimiliano, additional, Palmeira, Carlos M., additional, Panneerselvam, Chermakani, additional, Parvez, Suhel, additional, Paumard, P., additional, Perumal, Madan Kumar, additional, Pillai, Prakash P., additional, Pinti, Marcello, additional, Plafker, Scott M., additional, Potalivo, Emily, additional, Rabelo, Ana Carolina Silveira, additional, Rahul, K., additional, Rajasekar, Janani, additional, Ransac, S., additional, Rego, Ana Cristina Carvalho, additional, Rigoulet, M., additional, Rocha, Selena, additional, Rodrigues, Joaquim Rui, additional, Rolo, Anabela P., additional, Ruiz, Asier, additional, Sánchez-Gómez, Maria Victoria, additional, Sawaddiruk, Passakorn, additional, Sil, Parames C., additional, Singh, Sanjay, additional, Solodka, Kateryna, additional, Soni, S., additional, Sreepriya, Meenakshisundaram, additional, Stuart, Jeffrey A., additional, Sudhandiran, Ganapasam, additional, Syamala, Soumyakrishnan, additional, Tabassum, Heena, additional, Tan, Sijie, additional, Teodoro, João S., additional, Vadivel, Dinesh Babu, additional, Venditti, Paola, additional, Vijay Kumar, A., additional, Vijayakumar, Mahalingam Rajamanickam, additional, Vineetha, Radhakrishnan Chandraprabha, additional, Wong, Esther, additional, and Zyla, Katarzyna, additional

Published
2022
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18. Statistical optimization of process variables for agarase production using Microbacterium sp. SS5 strain from non-marine sources.

Author

Labade, Dinesh, Sevamani, Selvaraju, Tabassum, Heena, Madhyastha, Harishkumar, and Wani, Minal

Subjects
MICROBACTERIUM, AGAR, INDUSTRIAL wastes, FACTORS of production, OLIGOSACCHARIDES, INDEPENDENT variables
Abstract

Agar oligosaccharides are thought to be valuable biomolecules with high bioactivity potential, along with a wide range of applications and advantages. The current study aimed to optimize the culture parameters required to produce agarase enzyme and agar oligosaccharides from industrial waste agar. Microbacterium spp. strain SS5 was isolated from a non-marine source and could synthesize oligo derivatives for use in a variety of industries ranging from food to pharmaceuticals. In addition, the strain and culture conditions were optimized to maximize extracellular agarase production. The bacterium grew best at pH 5.0 − 9.0, with an optimal pH of 7.5 − 8.0; temperatures ranging from 25 to 45 °C, with an optimal of 35 °C; and carbon and nitrogen concentrations of 0.5% each. Plackett-Burman experimental design and response surface methods were used to optimize various process parameters for agarase production by Microbacterium spp. strain SS5. Using the Plackett-Burman experimental design, eleven process factors were screened, and agar, beef extract, CaCl2, and beginning pH were found as the most significant independent variables affecting agarase production with confidence levels above 90%. To determine the optimal concentrations of the identified process factors on agarase production, the Box- Behnken design was used. Agarase production by Microbacterium spp. strain SS5 after optimization was 0.272 U/mL, which was determined to be greater than the result obtained from the basal medium (0.132 U/mL) before screening using Plackett-Burman and BBD with a fold increase of 2.06. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Screening and characterization of agarolytic bacteria from different sources.

Author

Labade, Dinesh, Tabassum, Heena, and Wani, Minal

Subjects
*AGAR, *PLANT tissue culture, *GRAM-negative bacteria, *BACTERIAL enzymes, *OLIGOSACCHARIDES
Abstract

According to the results of our investigation, distinct bacterial isolates capable of breaking down agar were found in various nonmarine environments. The deficiency of reducing sugar in the control media demonstrates that the agar in the experiment is broken down by the bacteria to produce various oligosaccharides because the viscosity of the medium containing the agar was found to have been extremely high before inoculation, reducing with incubation duration and attaining a maximum after 48 hours. These isolates were subsequently used in tests along with additional investigation since they could create reducing sugar. Interestingly, the deterioration of agar appears to be mainly caused by Gram-negative bacteria. In order to study the agarase properties, the relative quantity of the enzyme secreted by the bacteria that hydrolyze the agar was used. The detection of extracellular agarase surrounding the colonies and the absence of stained halos on iodine-treated agar plates show that the agarase diffusing from the bacteria impacted the characteristics of the gel. Inconclusion, these agarsase-producing bacteria can be exploited for industrial applications. Waste agar from the plant tissue culture business can be utilized for a range of applications and this degraded agar can be explored for reliable and ecologically safe alternatives. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Naringenin mitigates behavioral alterations and provides neuroprotection against 3-nitropropinoic acid-induced Huntington's disease like symptoms in rats.

Author

Salman, Mohd, Sharma, Pooja, Alam, Md. Iqbal, Tabassum, Heena, and Parvez, Suhel

Subjects
RATS, HUNTINGTON disease, GLIAL fibrillary acidic protein, NARINGENIN, SYMPTOMS, MONOAMINE oxidase
Abstract

Naringenin is a powerful antioxidant and anti-inflammatory flavonoid which has been widely used as a therapeutic agent in various toxic models. However, few studies have clearly discussed the neuromodulatory effects of naringenin against different neurodegenerative disorders. We investigated the neuroprotective efficacy of naringenin against 3-nitropropionic acid (3-NP)-induced neurobehavioral, biochemical and histopathological alterations in rats. Albino Wistar rats were randomly divided into three experimental groups. Group 1, the vehicle administered group, received saline. Group 2 received 3-NP (20 mg/kg body weight, i.p.) for 4 consecutive days. Group 3 received naringenin (50 mg/kg body weight, p.o.) twice daily for a period of 4 days, 30 min before and 6 h after the 3-NP administration. On the 5th day, neurobehavioral experiments were performed to access the behavioral outcomes and the striatum tissue was used for analysis of the monoamine oxidase (MAO) activity and serotonin (5-HT) levels. In addition, astrocytes activation was observed by glial fibrillary acidic protein (GFAP) immunostaining. Our results showed that naringenin co-treatment provides neuroprotection against 3-NP-induced neurological disorders. Naringenin also increased the MAO activity and 5-HT levels in the striatum. Moreover, co-treatment with naringenin reduced the expression of GFAP protein in the striatal part and significantly attenuated the neuronal cell death. The findings of the present study suggest that naringenin provides neuroprotection and mitigates neurobehavioral alterations in experimental rats. The results show that co-treatment with naringenin ameliorates 3-NP-induced HD-like symptoms in rats. [ABSTRACT FROM AUTHOR]

Published
2022
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36. Chrysin ameliorates 3 nitropropinoic acid induced neurotoxicity targeting behavioural, biochemical and histological alterations.

Author

Haider, Madiha, Salman, Mohd., Kaushik, Pooja, Bharadwaj, Neha, Aggarwal, Nidhi Bharal, Tabassum, Heena, and Parvez, Suhel

Subjects
MONOAMINE oxidase, HUNTINGTON disease, NEUROTOXICOLOGY, GRIP strength, LABORATORY rats
Abstract

Huntington disease (HD) is an autosomal dominant inheritance neurodegenerative disorder. 3-Nitropropanoic acid (3-NP) is a mitochondrial toxin that induces HD-like symptoms and thus serves as a good experimental model of HD. Chrysin (5, 7-dihydroxyflavone) is a natural flavonoid that have multiple biological activities. The present work was aimed to evaluate the neuroprotective efficacy of Chrysin in rat brain, under the influence of 3-NP treatment, by studying neurobehavioral and biochemical alterations alongwith histo-architectural changes. Male Wistar rats (220–250 g) were used in the study and were divided into three groups following randomization. Each group comprised of nine animals. Group I animals served as control group and administered with normal saline (orally) as vehicle. Animals of Group II were treated with 3-NP for four successive days, at the dose of 20 mg/kg, intraperitoneally (i.p.). Animals that received Chrysin for the period of four consecutive days with the dose of 50 mg/kg, orally twice daily (30 min pre-treatment and 6 h post-treatment) following 3-NP administration served as Group III. After the treatment regime, animals were evaluated for neurobehavioral alterations and brain homogenates were used for estimation of neurotoxicity marker activity and neurotransmitter level along with histological assessment. The significant alteration in neurobehavioral, biochemical and neuronal structure in striatal part of brain was observed in the 3-NP administered (Group II) animals. It was observed that co-treatment of Chrysin with 3-NP treated rats the rotarod performance, grip strength, stride length as well as monoamine oxidase activity and serotonin levels were elevated. The results of this study reveal that Chrysin treatment alleviated the neurobehavioral, biochemical and histological alterations against HD symptoms in rats. [ABSTRACT FROM AUTHOR]

Published
2022
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37. Piperine mitigates behavioral impairments and provides neuroprotection against 3-nitropropinoic acid-induced Huntington disease-like symptoms.

Author

Salman, Mohd, Tabassum, Heena, and Parvez, Suhel

Subjects
*TERMINATION of treatment, *MONOAMINE oxidase, *HUNTINGTON disease, *LABORATORY rats, *SYMPTOMS
Abstract

Background: Piperine (PIP) is a powerful anti-oxidant and anti-inflammatory alkaloid which has been widely used in the treatment of various pathological conditions. However, few studies have clearly discussed the protective effects and potential mechanism of PIP in different neurological diseases. The aim of this study was to investigate the neuroprotective effect of PIP against 3-nitropropioninc acid (3-NP) induced neurobehavioral, biochemical and histopathological alterations in animals. Methods: Adult male Wistar rats were randomly divided into three groups. Group 1, the vehicle administered control group, received normal saline (p.o.). Group 2 received 3-NP (20 mg/kg.b.wt., i.p.) for 4 consecutive days. Group 3 received PIP (10 mg/kg.b.wt., p.o.) twice daily for a period of 4 days, 30 min before and 6 h after the 3-NP injection. Upon termination of treatment schedule, behavioral experiments were performed to access the behavioral outcomes. The brain striatal tissue was used for the estimation of monoamine oxidase activity and serotonin level. In addition, astrocytes activation was observed by GFAP immunostaining. Results: Our results showed that 3-NP induced behavioral impairments are attenuated by PIP co-treatment. Next, the extent of neuronal loss and astrocytes activation was reduced in the striatal brain region in PIP treated rats. Finally, it was observed that PIP alleviated the behavioral, biochemical, immunohistochemical and histological alterations. Conclusion: The results of the current study reveal the neuroprotective competency of PIP against Huntington disease like symptoms in rats. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Assessment of hyaluronic acid-modified imatinib mesylate cubosomes through CD44 targeted drug delivery in NDEA-induced hepatic carcinoma.

Author

Nisha, Raquibun, Kumar, Pranesh, Kumar, Umesh, Mishra, Nidhi, Maurya, Priyanka, Singh, Priya, Tabassum, Heena, Alka, Singh, Samipta, Guleria, Anupam, and Saraf, Shubhini A.

Subjects
*CD44 antigen, *BCL-2 proteins, *IMATINIB, *NILOTINIB, *STAINS & staining (Microscopy), *HYALURONIC acid, *METABOLOMICS
Abstract

[Display omitted] • Cubosomes have a higher surface area and volume due to its unique geometry. • Chitosan and Hyaluronic acid inhibits opsonization and RES clearance. • Hyaluronic acid modified cubosomes utilized to actively target CD44 receptors. • They suppress tumour nodules, activate caspases, upregulate BAX and downregulate Bcl-2. • Serum metabolomics revealed restoration of metabolites to normal levels. This study aimed at the development of hyaluronic acid-functionalised imatinib mesylate cubosomes (HA-IM-CBs) that might be useful in CD44 targeting against hepatic cancer. The HA-IM-CBs had a 130.7 ± 2.92 nm particle size, −31.40 ± 2.76 mV zeta potential, and 76.14 ± 2.69% release. The architecture of HA-IM-CBs was confirmed using HR-TEM and AFM. When compared to plain IM and IM-CBs, in vitro experiments revealed that HA-IM-CBs outperformed by significantly reducing cell viability. DAPI staining and ROS corroborated the apoptotic effects. Biodistribution and Pharmacokinetics studies showed that HA-IM-CBs exhibit a higher drug concentration in tumour tissue and better pharmacokinetic activity. This is the first study to show that HA-IM-CBs had CD44 targeting activity against HCC. CD44 regulates apoptosis via Bcl-2 family proteins and caspases, which interact with HA. Higher levels of e-NOS, BAD, BAX, and Cyt C and lower expressions of Bcl-xl, i-NOS, and Bcl-2 demonstrated the anti-HCC potential of HA-IM-CBs in qrt-PCR investigations. The remarkable therapeutic potential of HA-IM-CBs began with substantial stimulation of CD44 regulated caspase-mediated mitochondrial apoptotic pathway, accountable for their anti-HCC activity. The perturbed metabolites are restored to acceptable levels as indicated by metabolomic studies (1H NMR). Interestingly, the antineoplastic effect of HA-IM-CBs was proven to be potentially valuable against HCC. [ABSTRACT FROM AUTHOR]

Published
2022
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