1. Biomarkers of Inflammation and Oxidative Stress among Adult Former Smoker, Current E-Cigarette Users--Results from Wave 1 PATH Study.
- Author
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Christensen, Carol H., Chang, Joanne T., Rostron, Brian L., Hammad, Hoda T., van Bemmel, Dana M., Del Valle-Pinero, Arseima Y., Baoguang Wang, Mishina, Elena V., Faulcon, Lisa M., DePina, Ana, Brown-Baker, La'Nissa, Kimmel, Heather L., Lambert, Elizabeth, Blount, Benjamin C., Vesper, Huber W., Lanqing Wang, Goniewicz, Maciej L., Hyland, Andrew, Travers, Mark J., and Hatsukami, Dorothy K.
- Abstract
Background: Former smokers who currently use e-cigarettes have lower concentrations of biomarkers of tobacco toxicant exposure than current smokers. It is unclear whether tobacco toxicant exposure reductions may lead to health risk reductions. Methods: We compared inflammatory biomarkers (high-sensitivity C-reactive protein, IL6, fibrinogen, soluble intercellular adhesion molecule-1) and an oxidative stress marker (F2-isoprostane) among 3,712 adult participants in Wave 1 (2013-2014) of the Population Assessment of Tobacco and Health Study by tobacco user groups: dual users of cigarettes and e-cigarettes; former smokers who currently use e-cigarettes-only; current cigarette-only smokers; former smokers who do not currently use any tobacco; and never tobacco users. We calculated geometric means (GM) and estimated adjusted GM ratios (GMR). Results: Dual users experienced greater concentration of F2-isoprostane than current cigarette-only smokers [GMR 1.09 (95% confidence interval, CI, 1.03-1.15)]. Biomarkers were similar between former smokers who currently use e-cigarettes and both former smokers who do not use any tobacco and never tobacco users, but among these groups most biomarkers were lower than those of current cigarette-only smokers. The concentration of F2-isoprostane decreased by time since smoking cessation among both exclusive e-cigarette users (P
trend = 0.03) and former smokers who do not currently use any tobacco (Ptrend = 0.0001). Conclusions: Dual users have greater concentration of F2-isoprostane than smokers. Exclusive e-cigarette users have biomarker concentrations that are similar to those of former smokers who do not currently use tobacco, and lower than those of exclusive cigarette smokers. [ABSTRACT FROM AUTHOR]- Published
- 2021
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