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139 results on '"Veelken, Hendrik"'

2. Real-world routine diagnostic molecular analysis for TP53 mutational status is recommended over p53 immunohistochemistry in B-cell lymphomas

Author

de Haan, Lorraine M., de Groen, Ruben A. L., de Groot, Fleur A., Noordenbos, Troy, van Wezel, Tom, van Eijk, Ronald, Ruano, Dina, Diepstra, Arjan, Koens, Lianne, Nicolae-Cristea, Alina, Hartog, Wietske C. E. den, Terpstra, Valeska, Ahsmann, Els, Dekker, Tim J. A., Sijs-Szabo, Aniko, Veelken, Hendrik, Cleven, Arjen H. G., Jansen, Patty M., and Vermaat, Joost S. P.

Published
2023
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4. Monitoring for virus-specific T-cell responses and viremia in allogeneic HSCT recipients: a survey from the EBMT Cellular Therapy & Immunobiology Working Party

Author

Greco, Raffaella, Hoogenboom, Jorinde D., Bonneville, Edouard F., Anagnostopoulos, Achilles, Cuoghi, Angela, Dalle, Jean-Hugues, Weissinger, Eva M., Lang, Peter, Galaverna, Federica, Martino, Massimo, Maschan, Alexei, Mauz-Körholz, Christine, Noviello, Maddalena, Passweg, Jakob, Peccatori, Jacopo, Rovira, Montserrat, Solano, Carlos, Veelken, Hendrik, Velardi, Andrea, Wagner-Drouet, Eva Maria, Zhang, Xi, Ciceri, Fabio, Bonini, Chiara, Vago, Luca, Ruggeri, Annalisa, and Chabannon, Christian

Published
2023
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5. R-CODOX-M/R-IVAC versus DA-EPOCH-R in patients with newly diagnosed Burkitt lymphoma (HOVON/SAKK): final results of a multicentre, phase 3, open-label, randomised trial

Author

Chamuleau, Martine E D, Stenner, Frank, Chitu, Dana A, Novak, Urban, Minnema, Monique C, Geerts, Paul, Stevens, Wendy B C, Zenz, Thorsten, van Imhoff, Gustaaf W, Wu, Ka Lung, Demandt, Astrid M P, Kersten, Marie Jose, Terpstra, Wim E, Tick, Lidwine W, Deeren, Dries, Van Den Neste, Eric, Gregor, Michael, Veelken, Hendrik, Böhmer, Lara H, Caspar, Clemens B, Mutsaers, Pim, Refos, Jeannine M, Sewsaran, Robby, Fu, Liping, Seefat, Rianne L, Uyl-de Groot, Carin A, Dirnhofer, Stefan, Van Den Brand, Michiel, de Jong, Daphne, Nijland, Marcel, and Lugtenburg, Pieternella

Published
2023
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6. CaClust: linking genotype to transcriptional heterogeneity of follicular lymphoma using BCR and exomic variants

Author

Oksza-Orzechowski, Kazimierz, primary, Quinten, Edwin, additional, Shafighi, Shadi Darvish, additional, Kiełbasa, Szymon M., additional, van Kessel, Hugo, additional, de Groen, Ruben A.L., additional, Vermaat, Joost S.P., additional, Seplúveda-Yáñez, Julieta H., additional, Navarrete, Marcelo A., additional, Veelken, Hendrik, additional, van Bergen, Cornelis A.M., additional, and Szczurek, Ewa M., additional

Published
2024
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7. Risk factors for graft-versus-host-disease after donor lymphocyte infusion following T-cell depleted allogeneic stem cell transplantation

Author

Koster, Eva A. S., primary, von dem Borne, Peter A., additional, van Balen, Peter, additional, Marijt, Erik W. A., additional, Tjon, Jennifer M. L., additional, Snijders, Tjeerd J. F., additional, van Lammeren, Daniëlle, additional, Veelken, Hendrik, additional, Falkenburg, J. H. Frederik, additional, Halkes, Constantijn J. M., additional, and de Wreede, Liesbeth C., additional

Published
2024
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8. Long-term results and GvHD after prophylactic and preemptive donor lymphocyte infusion after allogeneic stem cell transplantation for acute leukemia

Author

Schmid, Christoph, Labopin, Myriam, Schaap, Nicolaas, Veelken, Hendrik, Brecht, Arne, Stadler, Michael, Finke, Juergen, Baron, Frederic, Collin, Matthew, Bug, Gesine, Ljungman, Per, Blaise, Didier, Tischer, Johanna, Bloor, Adrian, Kulagin, Aleksander, Giebel, Sebastian, Gorin, Norbert-Claude, Esteve, Jordi, Ciceri, Fabio, Savani, Bipin, Nagler, Arnon, and Mohty, Mohamad

Published
2022
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9. Venetoclax consolidation after fixed-duration venetoclax plus obinutuzumab for previously untreated chronic lymphocytic leukaemia (HOVON 139/GiVe): primary endpoint analysis of a multicentre, open-label, randomised, parallel-group, phase 2 trial

Author

Kersting, Sabina, Dubois, Julie, Nasserinejad, Kazem, Dobber, Johan A, Mellink, Clemens, van der Kevie-Kersemaekers, Anne-Marie F, Evers, Ludo M, de Boer, Fransien, Koene, Harry R, Schreurs, John, van der Klift, Marjolein, Velders, Gerjo A, van der Spek, Ellen, van der Straaten, Hanneke M, Hoogendoorn, Mels, van Gelder, Michel, Posthuma, Eduardus F M, Visser, Hein P J, Houtenbos, Ilse, Idink, Cecile A M, Issa, Djamila E, Dompeling, Ellen C, van Zaanen, Henk C T, Veelken, Hendrik, Levenga, Henriette, Tick, Lidwine W, Terpstra, Wim E, Tonino, Sanne H, Boyer, Michelle, Mobasher, Mehrdad, Levin, Mark-David, and Kater, Arnon P

Published
2022
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10. A transcriptomic based deconvolution framework for assessing differentiation stages and drug responses of AML.

Author

Karakaslar, E. Onur, Severens, Jeppe F., Sánchez-López, Elena, van Veelen, Peter A., Zlei, Mihaela, van Dongen, Jacques J. M., Otte, Annemarie M., Halkes, Constantijn J. M., van Balen, Peter, Veelken, Hendrik, Reinders, Marcel J. T., Griffioen, Marieke, and van den Akker, Erik B.

Subjects
ACUTE myeloid leukemia, BCL-2 proteins, TRANSCRIPTOMES, CD14 antigen, VENETOCLAX
Abstract

The diagnostic spectrum for AML patients is increasingly based on genetic abnormalities due to their prognostic and predictive value. However, information on the AML blast phenotype regarding their maturational arrest has started to regain importance due to its predictive power for drug responses. Here, we deconvolute 1350 bulk RNA-seq samples from five independent AML cohorts on a single-cell healthy BM reference and demonstrate that the morphological differentiation stages (FAB) could be faithfully reconstituted using estimated cell compositions (ECCs). Moreover, we show that the ECCs reliably predict ex-vivo drug resistances as demonstrated for Venetoclax, a BCL-2 inhibitor, resistance specifically in AML with CD14+ monocyte phenotype. We validate these predictions using LUMC proteomics data by showing that BCL-2 protein abundance is split into two distinct clusters for NPM1-mutated AML at the extremes of CD14+ monocyte percentages, which could be crucial for the Venetoclax dosing patients. Our results suggest that Venetoclax resistance predictions can also be extended to AML without recurrent genetic abnormalities and possibly to MDS-related and secondary AML. Lastly, we show that CD14+ monocytic dominated Ven/Aza treated patients have significantly lower overall survival. Collectively, we propose a framework for allowing a joint mutation and maturation stage modeling that could be used as a blueprint for testing sensitivity for new agents across the various subtypes of AML. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Legionellosis after hematopoietic stem cell transplantation

Author

Mikulska, Malgorzata, Tridello, Gloria, Hoek, Jennifer, Gil, Lidia, Yañez, Lucrecia, Labussière-Wallet, Hélène, Passweg, Jakob, Xhaard, Aliénor, Pioltelli, Pietro, Caillot, Denis, Michel, Gerard, Veelken, Hendrik, Blaise, Didier, Bruno, Benedetto, Garcia, Carmen Botella, Itälä-Remes, Maija, Crawley, Charles, Bourhis, Jean Henri, Kaare, Ain, Arcese, William, Parody, Rocio, and Styczynski, Jan

Published
2021
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12. Frequent mutated B2M, EZH2, IRF8, and TNFRSF14 in primary bone diffuse large B-cell lymphoma reflect a GCB phenotype

Author

de Groen, Ruben A.L., van Eijk, Ronald, Böhringer, Stefan, van Wezel, Tom, Raghoo, Richard, Ruano, Dina, Jansen, Patty M., Briaire-de Bruijn, Inge, de Groot, Fleur A., Kleiverda, Karin, te Boome, Liane, Terpstra, Valeska, Levenga, Henriette, Nicolae, Alina, Posthuma, Eduardus F.M., Focke-Snieders, Isabelle, Hardi, Lizan, den Hartog, Wietske C.E., Bohmer, Lara H., Hogendoorn, Pancras C.W., van den Berg, Anke, Diepstra, Arjan, Nijland, Marcel, Lugtenburg, Pieternella J., Kersten, Marie José, Pals, Steven T., Veelken, Hendrik, Bovée, Judith V.M.G., Cleven, Arjen H.G., and Vermaat, Joost S.P.

Published
2021
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16. Joint models quantify associations between immune cell kinetics and allo-immunological events after allogeneic stem cell transplantation and subsequent donor lymphocyte infusion

Author

Koster, Eva A. S., primary, Bonneville, Edouard F., additional, Borne, Peter A. von dem, additional, van Balen, Peter, additional, Marijt, Erik W. A., additional, Tjon, Jennifer M. L., additional, Snijders, Tjeerd J. F., additional, van Lammeren, Daniëlle, additional, Veelken, Hendrik, additional, Putter, Hein, additional, Falkenburg, J. H. Frederik, additional, Halkes, Constantijn J. M., additional, and de Wreede, Liesbeth C., additional

Published
2023
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18. Competitive Repopulation and Allo-Immunologic Pressure Determine Chimerism Kinetics after T Cell-Depleted Allogeneic Stem Cell Transplantation and Donor Lymphocyte Infusion

Author

Koster, Eva A.S., von dem Borne, Peter A., van Balen, Peter, van Egmond, Esther H.M., Marijt, Erik W.A., Veld, Sabrina A.J., Jedema, Inge, Snijders, Tjeerd J.F., van Lammeren, Daniëlle, Veelken, Hendrik, Falkenburg, J.H. Frederik, de Wreede, Liesbeth C., and Halkes, Constantijn J.M.

Published
2023
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19. Acquisition of a Glycosylated B-Cell Receptor Drives Follicular Lymphoma Towards a Dark Zone Phenotype

Author

Van Bergen, Cornelis A.M., primary, Kloet, Susan L., additional, Quinten, Edwin, additional, Sepúlveda Yáñez, Julieta Haydee, additional, Menafra, Roberta, additional, Griffioen, Marieke, additional, Jansen, Patty M, additional, Koning, Marvyn T., additional, Knijnenburg, Jeroen, additional, Navarrete, Marcelo A, additional, Kielbasa, Szymon M., additional, and Veelken, Hendrik, additional

Published
2023
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20. Supplementary Figures 1 through 3 from PIM Kinases Are Essential for Chronic Lymphocytic Leukemia Cell Survival (PIM2/3) and CXCR4-Mediated Microenvironmental Interactions (PIM1)

Author

Decker, Sarah, primary, Finter, Johannes, primary, Forde, Aaron James, primary, Kissel, Sandra, primary, Schwaller, Juerg, primary, Mack, Thomas Sebastian, primary, Kuhn, Anabel, primary, Gray, Nathanael, primary, Follo, Marie, primary, Jumaa, Hassan, primary, Burger, Meike, primary, Zirlik, Katja, primary, Pfeifer, Dietmar, primary, Miduturu, Chandrasekhar V., primary, Eibel, Hermann, primary, Veelken, Hendrik, primary, and Dierks, Christine, primary

Published
2023
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21. Supplementary Table 1 from PIM Kinases Are Essential for Chronic Lymphocytic Leukemia Cell Survival (PIM2/3) and CXCR4-Mediated Microenvironmental Interactions (PIM1)

Author

Decker, Sarah, primary, Finter, Johannes, primary, Forde, Aaron James, primary, Kissel, Sandra, primary, Schwaller, Juerg, primary, Mack, Thomas Sebastian, primary, Kuhn, Anabel, primary, Gray, Nathanael, primary, Follo, Marie, primary, Jumaa, Hassan, primary, Burger, Meike, primary, Zirlik, Katja, primary, Pfeifer, Dietmar, primary, Miduturu, Chandrasekhar V., primary, Eibel, Hermann, primary, Veelken, Hendrik, primary, and Dierks, Christine, primary

Published
2023
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22. Data from The ITK-SYK Fusion Oncogene Induces a T-Cell Lymphoproliferative Disease in Mice Mimicking Human Disease

Author

Dierks, Christine, primary, Adrian, Francisco, primary, Fisch, Paul, primary, Ma, Hong, primary, Maurer, Helga, primary, Herchenbach, Dieter, primary, Forster, Christine Ulrike, primary, Sprissler, Clara, primary, Liu, Guoxun, primary, Rottmann, Sabine, primary, Guo, Gui-Rong, primary, Katja, Zirlik, primary, Veelken, Hendrik, primary, and Warmuth, Markus, primary

Published
2023
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23. Supplementary Table 1 from The ITK-SYK Fusion Oncogene Induces a T-Cell Lymphoproliferative Disease in Mice Mimicking Human Disease

Author

Dierks, Christine, primary, Adrian, Francisco, primary, Fisch, Paul, primary, Ma, Hong, primary, Maurer, Helga, primary, Herchenbach, Dieter, primary, Forster, Christine Ulrike, primary, Sprissler, Clara, primary, Liu, Guoxun, primary, Rottmann, Sabine, primary, Guo, Gui-Rong, primary, Katja, Zirlik, primary, Veelken, Hendrik, primary, and Warmuth, Markus, primary

Published
2023
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24. Supplementary Figures 1-16 from The ITK-SYK Fusion Oncogene Induces a T-Cell Lymphoproliferative Disease in Mice Mimicking Human Disease

Author

Dierks, Christine, primary, Adrian, Francisco, primary, Fisch, Paul, primary, Ma, Hong, primary, Maurer, Helga, primary, Herchenbach, Dieter, primary, Forster, Christine Ulrike, primary, Sprissler, Clara, primary, Liu, Guoxun, primary, Rottmann, Sabine, primary, Guo, Gui-Rong, primary, Katja, Zirlik, primary, Veelken, Hendrik, primary, and Warmuth, Markus, primary

Published
2023
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25. Mapping AML heterogeneity – multi-cohort transcriptomic analysis identifies novel clusters and divergent ex-vivo drug responses

Author

Severens, Jeppe F, primary, Karakaslar, E Onur, additional, van der Reijden, Bert A, additional, Sánchez-López, Elena, additional, van den Berg, Redmar R, additional, Halkes, Constantijn JM, additional, van Balen, Peter, additional, Veelken, Hendrik, additional, Reinders, Marcel JT, additional, Griffioen, Marieke, additional, and van den Akker, Erik B, additional

Published
2023
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26. Joint models quantify associations between immune cell kinetics and alloimmunological events after allogeneic stem cell transplantation and subsequent donor lymphocyte infusion.

Author

Koster, Eva A. S., Bonneville, Edouard F., von dem Borne, Peter A., van Balen, Peter, Marijt, Erik W. A., Tjon, Jennifer M. L., Snijders, Tjeerd J. F., van Lammeren, Daniëlle, Veelken, Hendrik, Putter, Hein, Falkenburg, J. H. Frederik, Halkes, Constantijn J. M., and de Wreede, Liesbeth C.

Subjects
STEM cell transplantation, HEMATOPOIETIC stem cell transplantation, KILLER cells, LYMPHOCYTES
Abstract

Alloreactive donor-derived T-cells play a pivotal role in alloimmune responses after allogeneic hematopoietic stem cell transplantation (alloSCT); both in the relapse-preventing Graft-versus-Leukemia (GvL) effect and the potentially lethal complication Graft-versus-Host-Disease (GvHD). The balance between GvL and GvHD can be shifted by removing T-cells via T-cell depletion (TCD) to reduce the risk of GvHD, and by introducing additional donor T-cells (donor lymphocyte infusions [DLI]) to boost the GvL effect. However, the association between T-cell kinetics and the occurrence of allo-immunological events has not been clearly demonstrated yet. Therefore, we investigated the complex associations between the T-cell kinetics and alloimmune responses in a cohort of 166 acute leukemia patients receiving alemtuzumab-based TCD alloSCT. Of these patients, 62 with an anticipated high risk of relapse were scheduled to receive a prophylactic DLI at 3 months after transplant. In this setting, we applied joint modelling which allowed us to better capture the complex interplay between DLI, T-cell kinetics, GvHD and relapse than traditional statistical methods. We demonstrate that DLI can induce detectable T-cell expansion, leading to an increase in total, CD4+ and CD8+ T-cell counts starting at 3 months after alloSCT. CD4+ T-cells showed the strongest association with the development of alloimmune responses: higher CD4 counts increased the risk of GvHD (hazard ratio 2.44, 95% confidence interval 1.45-4.12) and decreased the risk of relapse (hazard ratio 0.65, 95% confidence interval 0.45-0.92). Similar models showed that natural killer cells recovered rapidly after alloSCT and were associated with a lower risk of relapse (HR 0.62, 95%-CI 0.41-0.93). The results of this study advocate the use of joint models to further study immune cell kinetics in different settings. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Single cell guided deconvolution of bulk transcriptomics recapitulates differentiation stages of acute myeloid leukemia and predicts drug response

Author

Karakaslar, E Onur, primary, Severens, Jeppe, additional, Sánchez-López, Elena, additional, van Veelen, Peter A, additional, Zlei, Mihaela, additional, van Dongen, Jacques JM, additional, Otte, Annemarie M., additional, Halkes, Constantijn JM, additional, van Balen, Peter, additional, Veelken, Hendrik, additional, Reinders, Marcel JT, additional, Griffioen, Marieke, additional, and van den Akker, Erik B, additional

Published
2022
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28. Competitive Repopulation and Allo-Immunologic Pressure Determine Chimerism Kinetics after T Cell-Depleted Allogeneic Stem Cell Transplantation and Donor Lymphocyte Infusion

Author

Koster, Eva A.S., primary, von dem Borne, Peter A., additional, van Balen, Peter, additional, van Egmond, Esther H.M., additional, Marijt, Erik W.A., additional, Veld, Sabrina A.J., additional, Jedema, Inge, additional, Snijders, Tjeerd J.F., additional, van Lammeren, Daniëlle, additional, Veelken, Hendrik, additional, Falkenburg, J.H. Frederik, additional, de Wreede, Liesbeth C., additional, and Halkes, Constantijn J.M., additional

Published
2022
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29. Immunotherapy Targeting Mutant Nucleophosmin-1 on Acute Myeloid Leukemia

Author

Koutsoumpli, Georgia, primary, van der Lee, Dyantha I., additional, Groenland, Nina C., additional, Honders, M. Willy, additional, de Jong, Rob C.M., additional, Hagedoorn, Renate S., additional, Veelken, Hendrik, additional, van Veelen, Peter A., additional, Lock, Dominik, additional, Heemskerk, Mirjam H.M., additional, Falkenburg, J.H.Frederik, additional, Johnston, Ian, additional, and Griffioen, Marieke, additional

Published
2022
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30. Molecular Diagnostics for TP53 Is Recommended in B-Cell Lymphomas

Author

De Haan, Lorraine M., primary, De Groen, Ruben A.L., additional, de Groot, Fleur, additional, Noordenbos, Troy, additional, van Wezel, Tom, additional, van Eijk, Ronald, additional, Ruano, Dina, additional, Diepstra, Arjan, additional, Koens, Lianne, additional, Sijs-Szabo, Aniko, additional, Veelken, Hendrik, additional, Cleven, Arjen, additional, Jansen, Patty M., additional, and Vermaat, Joost S.P., additional

Published
2022
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31. Prophylactic Donor Lymphocyte Infusion in Patients after Allogeneic Stem Cell Transplantation with Post-Transplant Cyclophosphamide Is Associated with Low Relapse Risk and Excellent Survival in Patients below 65 Years with Acute Myeloid Leukemia and High-Risk Myelodysplasia

Author

Von Dem Borne, Peter A., primary, Snijders, Tjeerd J.F., additional, van Lammeren, Danielle, additional, Tijmensen, Janneke, additional, Planken, Erwin V., additional, Levenga, Henriette, additional, van den Berg, Yascha, additional, Marijt, Erik WAF, additional, van Balen, Peter, additional, Tjon, Jennifer M., additional, Vermaat, Joost S.P., additional, Nering Bögel, Theo L., additional, Oudshoorn, Mirjam A., additional, Halkes, Constantijn J.M., additional, and Veelken, Hendrik, additional

Published
2022
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32. Polyostotic DLBCL Is Characterized By a NF-Κb Pathway Affecting Molecular Profile and Superior Survival

Author

De Groen, Ruben A.L., primary, De Groot, Fleur A, additional, De Haan, Lorraine M., additional, van Wezel, Tom, additional, Noordenbos, Troy, additional, Boehringer, Stefan, additional, Van Eijk, Ronald, additional, Raghoo, Richard, additional, Ruano, Dina, additional, Sijs-Szabo, Aniko, additional, te Boome, Liane, additional, Terpstra, Valeska, additional, Levenga, Henriette, additional, Nicolae, Aline, additional, Posthuma, Ward, additional, Focke-Snieders, Isabelle, additional, Hardi, Lizan, additional, den Hartog, Wietske, additional, Böhmer, Lara H., additional, Van Den Berg, Anke, additional, Mutseaers, Pim, additional, Van Der Poel, Marjolein W.M., additional, Abdul Hamid, Myrurgia, additional, Woei-a-Jin, F.J. Sherida H., additional, Janssens, Ann, additional, Tousseyn, Thomas, additional, Bovée, Judith, additional, Veelken, Hendrik, additional, Pals, Steven T, additional, Diepstra, Arjan, additional, Nijland, Marcel, additional, Kersten, Marie José, additional, Jansen, Patty M., additional, Cleven, Arjen, additional, and Vermaat, Joost S.P., additional

Published
2022
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33. Antigen-Independent, Autonomous B-Cell Receptor Signaling in Diffuse Large B-Cell Lymphoma

Author

Eken, Janneke A., primary, Koning, Marvyn T., additional, Sepulveda Yanez, Julieta H., additional, van Bergen, Cornelis A.M., additional, Quinten, Edwin, additional, Kupcova, Kristyna, additional, Havranek, Ondrej, additional, De Groen, Ruben A.L., additional, Vermaat, Joost S.P., additional, de Jong, Daphne, additional, Kluin, Philip, additional, Cleven, Arjen, additional, Jumaa, Hassan, additional, and Veelken, Hendrik, additional

Published
2022
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34. Autonomous BCR Signaling and Genetic Aberrations in CLL-Phenotype Monoclonal B Lymphocytosis in Siblings of CLL Patients

Author

Sepulveda Yanez, Julieta H., primary, Quinten, Edwin, additional, Koning, Marvyn T., additional, Eken, Janneke A., additional, Pfeifer, Dietmar, additional, De Groen, Ruben A.L., additional, Alvarez Saravia, Diego, additional, Agathangelidis, Andreas, additional, van Bergen, Cornelis A.M., additional, Stamatopoulos, Kostas, additional, Vermaat, Joost S.P., additional, Zirlik, Katja, additional, Navarrete, Marcelo, additional, Jumaa, Hassan, additional, and Veelken, Hendrik, additional

Published
2022
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35. Consolidation Improves Survival in Primary Central Nervous System Lymphoma without Preference for Type of High-Dose Methotrexate-Based Induction Treatment Regimen

Author

De Groot, Fleur A, primary, Doorduijn, Jeanette K., additional, Brink, Mirian, additional, De Groen, Ruben A.L., additional, De Haan, Lorraine M., additional, Noordenbos, Troy, additional, Sijs-Szabo, Aniko, additional, Lam, King Hong, additional, Diepstra, Arjan, additional, te Boome, Liane, additional, Terpstra, Valeska, additional, Böhmer, Lara H., additional, Zijlstra, Josée M., additional, Koens, Lianne, additional, Durian, Marc, additional, Oudshoorn, Mirjam A., additional, Veelken, Hendrik, additional, Van Der Poel, Marjolein W.M., additional, Abdul Hamid, Myrurgia, additional, Stevens, Wendy B.C., additional, van Rooij, J L.M, additional, Oostvogels, Rimke, additional, Neelis, Karen J., additional, van den Brand, Michiel, additional, Woei-a-Jin, F.J. Sherida H., additional, Tousseyn, Thomas, additional, Dierickx, Daan, additional, Jansen, Patty M., additional, Kersten, Marie Jose, additional, Bromberg, Jacoline, additional, Nijland, Marcel, additional, and Vermaat, Joost S.P., additional

Published
2022
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36. Effects of HLA Mismatches on Cytokine Release Syndrome and Associated Non-Relapse Mortality in Allogeneic Stem Cell Transplantation with Post-Transplant Cyclophosphamide

Author

Von Dem Borne, Peter A., primary, Kemps-Mols, Berit M., additional, de Wreede, Liesbeth C., additional, van Beek, Adriaan A., additional, Snijders, Tjeerd J.F., additional, van Lammeren, Danielle, additional, Tijmensen, Janneke, additional, Sijs-Szabo, Aniko, additional, Nering Bögel, Theo L., additional, Oudshoorn, Mirjam A., additional, Halkes, Constantijn J.M., additional, van Balen, Peter, additional, Marijt, Erik W.A.F., additional, Tjon, Jennifer M.L., additional, Vermaat, Joost S.P., additional, and Veelken, Hendrik, additional

Published
2022
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38. Outcome of allogeneic haematopoietic cell transplantation in eosinophilic disorders: A retrospective study by the chronic malignancies working party of the EBMT

Author

McLornan, Donal P., primary, Gras, Luuk, additional, Martin, Ivonne, additional, Sirait, Tiarlan, additional, Schroeder, Thomas, additional, Blau, Igor Wolfgang, additional, Kuball, Jürgen, additional, Byrne, Jenny, additional, Collin, Matthew, additional, Stadler, Michael, additional, Desmier, Déborah, additional, Salmenniemi, Urpu, additional, Jindra, Pavel, additional, Mikhailova, Natalia, additional, Lenhoff, Stig, additional, Rifón, Jose, additional, Robin, Marie, additional, Rovira, Montserrat, additional, Veelken, Hendrik, additional, Sadowska‐Klasa, Alicja, additional, Zecca, Marco, additional, Hayden, Patrick J., additional, Czerw, Tomasz, additional, Hernández‐Boluda, Juan Carlos, additional, and Yakoub‐Agha, Ibrahim, additional

Published
2022
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39. Tandem Substitutions in Somatic Hypermutation

Author

Sepúlveda-Yáñez, Julieta H., primary, Alvarez Saravia, Diego, additional, Pilzecker, Bas, additional, van Schouwenburg, Pauline A., additional, van den Burg, Mirjam, additional, Veelken, Hendrik, additional, Navarrete, Marcelo A., additional, Jacobs, Heinz, additional, and Koning, Marvyn T., additional

Published
2022
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40. Synchronous diffuse large B-cell lymphoma and mantle cell lymphoma: support for low-threshold biopsies and genetic testing

Author

de Groot, Fleur A., primary, de Haan, Lorraine M., additional, de Groen, Ruben A. L., additional, Heijmen, Linda, additional, van Wezel, Tom, additional, van Eijk, Ronald, additional, Bohmer, Lara, additional, Bot, Freek, additional, ten Berge, Rosita L., additional, Diepstra, Arjan, additional, Veelken, Hendrik, additional, Cleven, Arjen H. G., additional, Jansen, Patty M., additional, and Vermaat, Joost S. P., additional

Published
2021
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41. Integration of Mutational Signature Analysis with 3D Chromatin Data Unveils Differential AID-Related Mutagenesis in Indolent Lymphomas

Author

Sepulveda-Yanez, Julieta H., primary, Alvarez-Saravia, Diego, additional, Fernandez-Goycoolea, Jose, additional, Aldridge, Jacqueline, additional, van Bergen, Cornelis A. M., additional, Posthuma, Ward, additional, Uribe-Paredes, Roberto, additional, Veelken, Hendrik, additional, and Navarrete, Marcelo A., additional

Published
2021
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42. Long-term results and GvHD after prophylactic and preemptive donor lymphocyte infusion after allogeneic stem cell transplantation for acute leukemia

Author

Schmid, Christoph, primary, Labopin, Myriam, additional, Schaap, Nicolaas, additional, Veelken, Hendrik, additional, Brecht, Arne, additional, Stadler, Michael, additional, Finke, Juergen, additional, Baron, Frederic, additional, Collin, Matthew, additional, Bug, Gesine, additional, Ljungman, Per, additional, Blaise, Didier, additional, Tischer, Johanna, additional, Bloor, Adrian, additional, Kulagin, Aleksander, additional, Giebel, Sebastian, additional, Gorin, Norbert-Claude, additional, Esteve, Jordi, additional, Ciceri, Fabio, additional, Savani, Bipin, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2021
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43. Impact of Specific Adverse Cytogenetic Features on Outcomes after Allogeneic Hematopoietic Cell Transplantation in Myelodysplastic Syndrome with Very Poor Risk Cytogenetics: A Study from the Chronic Malignancies Working Party of EBMT

Author

Poiré, Xavier, primary, Eikeman, Diderik-jan, additional, Koster, Linda, additional, Maertens, Johan A., additional, Cornelissen, Jan J., additional, Fegueux, Nathalie, additional, Byrne, Jennifer, additional, Salmenniemi, Urpu, additional, Choi, Goda, additional, Chevallier, Patrice, additional, Kinsella, Francesca A, additional, Schroeder, Thomas, additional, Beguin, Yves, additional, Blaise, Didier, additional, Bourhis, Jean-Henri, additional, Kuball, Jurgen H.E., additional, Veelken, Hendrik, additional, Passweg, Jakob R., additional, Bermudez Rodriguez, Arancha, additional, Srour, Micha, additional, Hayden, Patrick John, additional, Onida, Francesco, additional, Scheid, Christof, additional, Robin, Marie, additional, and Yakoub-Agha, Ibrahim, additional

Published
2021
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44. "Snapshotting" Somatic Hypermutation in Single Follicular Lymphoma Cells

Author

Sepulveda-Yanez, Juleta H., primary, Alvarez-Saravia, Diego, additional, Quinten, Edwin, additional, Menafra, Roberta, additional, Kloet, Susan L., additional, Monajemi, Ramin, additional, Kielbasa, Szymon M., additional, Navarrete Signorile, Marcelo, additional, van Bergen, Cornelis A.M., additional, and Veelken, Hendrik, additional

Published
2021
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45. Tandem Substitutions in Somatic Hypermutation

Author

Koning, Marvyn T., primary, Sepulveda Yanez, Julieta Haydee, additional, Alvarez-Saravia, Diego, additional, Pilzecker, Bas, additional, Van Schouwenburg, Pauline, additional, van den Burg, Mirjam, additional, Navarrete, Marcelo A., additional, Jacobs, Heinz, additional, and Veelken, Hendrik, additional

Published
2021
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46. An HLA-A*11:01-Binding Neoantigen from Mutated NPM1 as Target for TCR Gene Therapy in AML

Author

van der Lee, Dyantha, primary, Koutsoumpli, Georgia, additional, Reijmers, Rogier, additional, Honders, M., additional, de Jong, Rob, additional, Remst, Dennis, additional, Wachsmann, Tassilo, additional, Hagedoorn, Renate, additional, Franken, Kees, additional, Kester, Michel, additional, Harber, Karl, additional, Roelofsen, Lisanne, additional, Schouten, Annemiek, additional, Mulder, Arend, additional, Drijfhout, Jan, additional, Veelken, Hendrik, additional, van Veelen, Peter, additional, Heemskerk, Mirjam, additional, Falkenburg, J.H., additional, and Griffioen, Marieke, additional

Published
2021
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47. Synchronous diffuse large B-cell lymphoma and mantle cell lymphoma: support for low-threshold biopsies and genetic testing.

Author

de Groot, Fleur A., de Haan, Lorraine M., de Groen, Ruben A. L., Heijmen, Linda, van Wezel, Tom, van Eijk, Ronald, Bohmer, Lara, Bot, Freek, ten Berge, Rosita L., Diepstra, Arjan, Veelken, Hendrik, Cleven, Arjen H. G., Jansen, Patty M., and Vermaat, Joost S. P.

Subjects
MANTLE cell lymphoma, DIFFUSE large B-cell lymphomas, GENETIC testing, B cell lymphoma
Abstract

The differential intensity of FDG-avid lesions, along with acute and chronic symptoms and iron deficiency anemia caused by intestine involvement, was suspect for distinct disease entities, and consequently the axilla and colon lesions were biopsied. The intensity PET-CT projection showed multiple lesions with varying maximum standardized uptake values (SUVmax), indicating that these lesions reflect different disease entities (Figure 1(A,B)). These two lesions were biopsied and it has been assumed that these represent all other lesions with comparable FDG-avidity because taking more biopsies is not patient friendly, clinically inefficient and the chances of having a third synchronous lymphoma are negligibly small. The presented unique case demonstrated this individualized approach for both lymphoma subtypes and anatomical sites by adjuvant radiotherapy of the axillary PET avid lesions and the initiation of LR for the persistent MCL bowel lesions. [Extracted from the article]

Published
2022
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48. Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL

Author

Eken, Janneke A., Koning, Marvyn T., Kupcova, Kristyna, Sepúlveda Yáñez, Julieta H., de Groen, Ruben A.L., Quinten, Edwin, Janssen, Jurriaan, van Bergen, Cornelis A.M., Vermaat, Joost S.P., Cleven, Arjen, Navarrete, Marcelo A., Ylstra, Bauke, de Jong, Daphne, Havranek, Ondrej, Jumaa, Hassan, and Veelken, Hendrik

Abstract

Diffuse large B cell lymphoma of activated B cell type (ABC-DLBCL), a major cell-of-origin DLBCL subtype, is characterized by chronic active B cell receptor (BCR) signaling and NF-κB activation, which can be explained by activating mutations of the BCR signaling cascade in a minority of cases. We demonstrate that autonomous BCR signaling, akin to its essential pathogenetic role in chronic lymphocytic leukemia (CLL), can explain chronic active BCR signaling in ABC-DLBCL. 13 of 18 tested DLBCL-derived BCR, including 12 cases selected for expression of IgM, induced spontaneous calcium flux and increased phosphorylation of the BCR signaling cascade in murine triple knockout pre-B cells without antigenic stimulation or external BCR crosslinking. Autonomous BCR signaling was associated with IgM isotype, dependent on somatic BCR mutations and individual HCDR3 sequences, and largely restricted to non-GCB DLBCL. Autonomous BCR signaling represents a novel immunological oncogenic driver mechanism in DLBCL originating from individual BCR sequences and adds a new dimension to currently proposed genetics- and transcriptomics-based DLBCL classifications.

Published
2024
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50. Frequent mutated B2M, EZH2, IRF8, and TNFRSF14in primary bone diffuse large B-cell lymphoma reflect a GCB phenotype

Author

de Groen, Ruben A.L., van Eijk, Ronald, Böhringer, Stefan, van Wezel, Tom, Raghoo, Richard, Ruano, Dina, Jansen, Patty M., Briaire-de Bruijn, Inge, de Groot, Fleur A., Kleiverda, Karin, te Boome, Liane, Terpstra, Valeska, Levenga, Henriette, Nicolae, Alina, Posthuma, Eduardus F.M., Focke-Snieders, Isabelle, Hardi, Lizan, den Hartog, Wietske C.E., Bohmer, Lara H., Hogendoorn, Pancras C.W., van den Berg, Anke, Diepstra, Arjan, Nijland, Marcel, Lugtenburg, Pieternella J., Kersten, Marie José, Pals, Steven T., Veelken, Hendrik, Bovée, Judith V.M.G., Cleven, Arjen H.G., and Vermaat, Joost S.P.

Abstract

Primary bone diffuse large B-cell lymphoma (PB-DLBCL) is a rare extranodal lymphoma subtype. This retrospective study elucidates the currently unknown genetic background of a large clinically well-annotated cohort of DLBCL with osseous localizations (O-DLBCL), including PB-DLBCL. A total of 103 patients with O-DLBCL were included and compared with 63 (extra)nodal non-osseous (NO)-DLBCLs with germinal center B-cell phenotype (NO-DLBCL-GCB). Cell-of-origin was determined by immunohistochemistry and gene-expression profiling (GEP) using (extended)-NanoString/Lymph2Cx analysis. Mutational profiles were identified with targeted next-generation deep sequencing, including 52 B-cell lymphoma-relevant genes. O-DLBCLs, including 34 PB-DLBCLs, were predominantly classified as GCB phenotype based on immunohistochemistry (74%) and NanoString analysis (88%). Unsupervised hierarchical clustering of an extended-NanoString/Lymph2Cx revealed significantly different GEP clusters for PB-DLBCL as opposed to NO-DLBCL-GCB (P< .001). Expression levels of 23 genes of 2 different targeted GEP panels indicated a centrocyte-like phenotype for PB-DLBCL, whereas NO-DLBCL-GCB exhibited a centroblast-like constitution. PB-DLBCL had significantly more frequent mutations in four GCB-associated genes (ie, B2M, EZH2, IRF8, TNFRSF14) compared with NO-DLBCL-GCB (P= .031, P= .010, P= .047, and P= .003, respectively). PB-DLBCL, with its corresponding specific mutational profile, was significantly associated with a superior survival compared with equivalent Ann Arbor limited-stage I/II NO-DLBCL-GCB (P= .016). This study is the first to show that PB-DLBCL is characterized by a GCB phenotype, with a centrocyte-like GEP pattern and a GCB-associated mutational profile (both involved in immune surveillance) and a favorable prognosis. These novel biology-associated features provide evidence that PB-DLBCL represents a distinct extranodal DLBCL entity, and its specific mutational landscape offers potential for targeted therapies (eg, EZH2 inhibitors).

Published
2021
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