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Your search keyword '"Wei, Yun-Peng"' showing total 17 results
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17 results on '"Wei, Yun-Peng"'

3. Human Plasma IgG N -Glycome Profiles Reveal a Proinflammatory Phenotype in Chronic Thromboembolic Pulmonary Hypertension

Author

Zhang, Ze-Jian, primary, Wang, Hui-Fang, additional, Lian, Tian-Yu, additional, Zhou, Yu-Ping, additional, Xu, Xi-Qi, additional, Guo, Fan, additional, Wei, Yun-Peng, additional, Li, Jing-Yi, additional, Sun, Kai, additional, Liu, Chao, additional, Pan, Lu-Rong, additional, Ren, Ming, additional, Nie, Lei, additional, Dai, Hai-Long, additional, and Jing, Zhi-Cheng, additional

Published
2023
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4. Clonal Hematopoiesis of Indeterminate Potential in Patients with Chronic Thromboembolic Pulmonary Hypertension

Author

Liu, Chao, primary, Cheng, Chun-Yan, additional, Lian, Tian-Yu, additional, Zhou, Yu-Ping, additional, Yang, Yin-Jian, additional, Zhang, Si-Jin, additional, Wei, Yun-Peng, additional, Zhu, Yong-Jian, additional, Qiu, Lu-Hong, additional, Qiu, Bao-Chen, additional, Ren, Li-Yan, additional, Ma, Jing-Si, additional, Li, Ruo-Nan, additional, Wang, Jia, additional, Shen, Ying-Hui-Zi, additional, Han, Zhi-Yan, additional, Li, Jing-Hui, additional, Zhao, Qin-Hua, additional, Wang, Lan, additional, XU, XI-Qi, additional, Sun, Kai, additional, Wang, Duolao, additional, Zhang, Zejian, additional, and Jing, Zhi-Cheng, additional

Published
2023
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10. Human Plasma Immunoglobulin G N-Glycome Profiles Reveal a Pro-Inflammatory Phenotype in Chronic Thromboembolic Pulmonary Hypertension: A Cross-Sectional Study of Two Independent Cohorts

Author

Zhang, Zejian, primary, Wang, Hui-Fang, additional, Lian, Tian-Yu, additional, Zhou, Yu-Ping, additional, Xu, Xi-Qi, additional, Guo, Fan, additional, Wei, Yun-Peng, additional, Li, Jing-Yi, additional, Sun, Kai, additional, Liu, Chao, additional, Pan, Lu-Rong, additional, Ren, Ming, additional, Nie, Lei, additional, Dai, Hai-Long, additional, and Jing, Zhi-Cheng, additional

Published
2023
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12. Calcium Sensing Receptor Variants Increase Pulmonary Hypertension Susceptibility

Author

Liu, Bingxun, primary, Wei, Yun-Peng, additional, Fan, Xiaohang, additional, Hu, Xiaoyi, additional, Chen, Zeshuai, additional, Liu, Xiaoyuan, additional, Xu, Yan, additional, Wang, Lu, additional, Wang, Tao, additional, Ruiz, Matthieu, additional, Dupuis, Jocelyn, additional, Yuan, Ping, additional, Liu, Jinming, additional, Huang, Songling, additional, Zhu, Liping, additional, Jing, Zhi-Cheng, additional, and Hu, Qinghua, additional

Published
2022
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17. Identification of Noncoding Functional Regulatory Variants of STIM1 Gene in Idiopathic Pulmonary Arterial Hypertension.

Author

Liu B, Wen CJ, Zhou G, Wei YP, Wu Z, Zhang T, Zhou Y, Qiu S, Wang T, Ruiz M, Dupuis J, Yuan P, Liu J, Zhu L, Jing ZC, and Hu Q

Abstract

Background: STIM1 (stromal interaction molecule 1) regulates store-operated calcium entry and is involved in pulmonary artery vasoconstriction and pulmonary artery smooth muscle cell proliferation, leading to pulmonary arterial hypertension (PAH)., Methods: Bioinformatics analysis and a 2-stage matched case-control study were conducted to screen for noncoding variants that may potentially affect STIM1 transcriptional regulation in 242 patients with idiopathic PAH and 414 healthy controls. Luciferase reporter assay, real-time quantitative polymerase chain reaction, western blot, 5-ethynyl-2'-deoxyuridine (EdU) assay, and intracellular Ca 2+ measurement were performed to study the mechanistic roles of those STIM1 noncoding variants in PAH., Results: Five noncoding variants (rs3794050, rs7934581, rs3750996, rs1561876, and rs3750994) were identified and genotyped using Sanger sequencing. Rs3794050, rs7934581, and rs1561876 were associated with idiopathic PAH (recessive model, all P <0.05). Bioinformatics analysis showed that these 3 noncoding variants possibly affect the enhancer function of STIM1 or the microRNA (miRNA) binding to STIM1 . Functional validation performed in HEK293 and pulmonary artery smooth muscle cells demonstrated that the noncoding variant rs1561876-G ( STIM1 mutant) had significantly stronger transcriptional activity than the wild-type counterpart, rs1561876-A, by affecting the transcriptional regulatory function of both hsa-miRNA-3140-5p and hsa-miRNA-4766-5p. rs1561876-G enhanced intracellular Ca 2+ signaling in human pulmonary artery smooth muscle cells secondary to calcium-sensing receptor activation and promoted proliferation of pulmonary artery smooth muscle cells under both normoxia and hypoxia conditions, suggesting a possible contribution to PAH development., Conclusions: The potential clinical implications of the 3 noncoding variants of STIM1 , rs3794050, rs7934581, and rs1561876, are 2-fold, as they may help predict the risk and prognosis of idiopathic PAH and guide investigations on novel therapeutic pathway(s).

Published
2024
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