1. RESEARCH ON THE IMMUNOMODULATORY EFFECT OF LEVAMISOLE IN SWINE.
- Author
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GÂJÂILĂ, Gabriel, GHIȚĂ, Marian, PETCU, Carmen Daniela, DOBRE, Răzvan Ionuț, BOTEZATU, Răzvan, ANDREI, Crina, MIHAI, Oana Diana, and COTOR, Gabriel
- Subjects
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LYMPHOCYTE subsets , *LEVAMISOLE , *T cells , *LYMPHOCYTE transformation , *SWINE , *AFRICAN swine fever , *SWINE breeding , *CLASSICAL swine fever - Abstract
Immunomodulation is an important alternative in combating many diseases, being considered a potential weapon in the fight against pathological entities that cause major economic losses in pig herds. Levamisole, in addition to its anthelmintic effect, has also an immunostimulatory effect, for which it has also been used as a vaccine adjuvant. The aim of the research was to evaluate the non-specific immune response in modern techniques in pigs given levamisole. The results showed significant differences in the case of the ratio of lymphocyte subpopulations, there was an increasing trend in favor of T lymphocytes (with 10.44%), and the % of T lymphocytes blastic transformation (with 56%). Also, we observed a significant increase of the LTh/LTs ratio (with 65.92%) which supports the immunomodulatory potential of the levamisole and its involvement on the coordination of immune processes. [ABSTRACT FROM AUTHOR]
- Published
- 2022