1. Vasostatins: new molecular targets for atherosclerosis, post-ischaemic angiogenesis, and arteriogenesis.
- Author
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Madonna, Rosalinda, Barachini, Serena, Ghelardoni, Sandra, Lu, Lin, Shen, Wei-Feng, and Caterina, Raffaele De
- Subjects
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VASCULAR cell adhesion molecule-1 , *DRUG target , *ENDOCRINE cells , *IMMOBILIZED proteins , *NEOVASCULARIZATION , *CELL adhesion - Abstract
The chromogranin–secretogranin secretory proteins—granins—are acidic proteins localized in granules of endocrine cells and neurons. The chromogranin family includes chromogranins A (CgA) and B, as well as secretogranin II (once called chromogranin C). Members of this family undergo catalytic proteolysis to produce active peptides. The CgA-derived peptides vasostatin-1 and vasostatin-2, in particular, appear to protect against atherosclerosis, suppressing the expression of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1, as well as exerting vasodilatory effects by enhancing nitric oxide bioavailability. Vasostatin-1 also suppresses vasoconstriction and abnormal angiogenesis. Vasostatin-1 and vasostatin-2 may be novel therapeutic targets for atherosclerosis and coronary heart disease, also protecting the myocardium against ischaemic damage. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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