151. Mitochondria from osteolineage cells regulate myeloid cell-mediated bone resorption.
- Author
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Ding, Peng, Gao, Chuan, Zhou, Jian, Mei, Jialun, Li, Gan, Liu, Delin, Li, Hao, Liao, Peng, Yao, Meng, Wang, Bingqi, Lu, Yafei, Peng, Xiaoyuan, Jiang, Chenyi, Yin, Jimin, Huang, Yigang, Zheng, Minghao, Gao, Youshui, Zhang, Changqing, and Gao, Junjie
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MYELOID cells ,BONE resorption ,DISEASE progression ,MITOCHONDRIA ,CELL determination ,HOMEOSTASIS ,BLOOD cells ,MITOCHONDRIAL membranes - Abstract
Interactions between osteolineage cells and myeloid cells play important roles in maintaining skeletal homeostasis. Herein, we find that osteolineage cells transfer mitochondria to myeloid cells. Impairment of the transfer of mitochondria by deleting MIRO1 in osteolineage cells leads to increased myeloid cell commitment toward osteoclastic lineage cells and promotes bone resorption. In detail, impaired mitochondrial transfer from osteolineage cells alters glutathione metabolism and protects osteoclastic lineage cells from ferroptosis, thus promoting osteoclast activities. Furthermore, mitochondrial transfer from osteolineage cells to myeloid cells is involved in the regulation of glucocorticoid-induced osteoporosis, and glutathione depletion alleviates the progression of glucocorticoid-induced osteoporosis. These findings reveal an unappreciated mechanism underlying the interaction between osteolineage cells and myeloid cells to regulate skeletal metabolic homeostasis and provide insights into glucocorticoid-induced osteoporosis progression. Bone and blood lineage cells communicate with each other to maintain skeletal homeostasis. Here, the authors show that MIRO1-mediated mitochondrial transfer from osteolineage to myeloid lineage cells regulates bone resorption by altering glutathione metabolism. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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