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1. Platinum-based chemotherapy inflames the ovarian carcinoma microenvironment through cellular senescence.

Author

Álvarez-Abril, Beatriz, García-Martínez, Elena, and Galluzzi, Lorenzo

Subjects
*CELLULAR aging, *OVARIAN epithelial cancer, *IMMUNE checkpoint inhibitors, *ANIMAL models for aging, *CANCER chemotherapy, *GENETIC recombination, *CARCINOMA
Abstract

Epithelial ovarian carcinoma (EOC) is virtually insensitive to immune checkpoint inhibitors (ICIs). Recent findings from an innovative mouse model of EOC demonstrate that senescence induction underlies the increased sensitivity of homologous recombination-defective EOCs to platinum-based chemotherapy as it initiates tumor infiltration by immune effector cells coupled to restored sensitivity to ICIs. [ABSTRACT FROM AUTHOR]

Published
2022
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