1. Posterior fossa ependymoma with preoperative cerebrospinal metastases: a case report with literature review.
- Author
-
Tang, Hanlu, Wu, Tao, Zhao, Fu, Zhang, Jing, Yang, Zhijun, Li, Peng, Wang, Xingchao, Wang, Bo, Wang, Zhenmin, and Liu, Pinan
- Subjects
- *
EPENDYMOMA , *LITERATURE reviews , *AUDITORY evoked response , *CEREBELLOPONTILE angle , *MAGNETIC resonance imaging , *METASTASIS - Abstract
Adult posterior fossa ependymomas (PF-EPN) with preoperative cerebrospinal metastases are extremely rare. Only 3 cases have been reported in previous literature. A case of a 32-year-old male patient complained of headaches for three months. Pure tone audiometry showed a slight decrease in bilateral hearing. Auditory evoked potential indicated that the hearing on the left was slightly weaker than that on the right. Magnetic resonance imaging (MRI) revealed a primary tumor arising within the fourth ventricle and metastasizing to bilateral cerebellopontine angle (CPA), the third ventricle, the left lateral ventricle, T1, L1-2 and L5. A gross total resection (GTR) was performed on the lesion located in the left CPA. The histological examination showed a papillary ependymoma (WHO grade II). Immunohistochemical staining for H3K27me3 showed that nuclear positivity in more than 80% of cells. No NF2 mutation was observed. No progression was found during a 24-month follow-up. Our data indicate that preoperative multiple metastases in adult PF-EPN are extremely rare. This kind of disease usually has a low WHO grade and a favorable prognosis. GTR should be achieved when feasible and patients need a long-term follow-up with MRI. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF