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Co-occurring extreme heat, drought, and moisture events are increasing under global warming and pose serious threats to ecosystem and food security. However, how to effectively link compound agrometeorological disasters (CADs) with climate change has not been well assessed. In this study, we focus on the comprehensive influence of large-scale climate factors on CADs rather than extreme meteorological elements. The results indicate that there are two main CADs of spring maize in Shenyang, Northeast China (NEC), including concurrent drought and cold damage (DC) and drought in multiple growth periods (MD). The related circulation anomalies at mid–high latitudes are identified as four patterns, namely, the Northeast Asia Low (NEAL) and Ural High (UH) patterns affecting DC, the Baikal High and Okhotsk Low (BHOL), and the Northeast Asia High (NEAH) patterns leading to MD. The vertical profile and water vapor transport anomalies further demonstrate the influence mechanism of large-scale circulation on compound heat–moisture stresses. This study highlights the role of atmospheric circulation, which can provide effective predictors for these synergistic agrometeorological disasters. [ABSTRACT FROM AUTHOR]