Search

Intracranial hemorrhage (ICH) occurs when blood leaks inside the skull as a result of trauma to the skull or due to medical conditions. ICH usually requires immediate medical and surgical attention because the disease has a high mortality rate, long-term disability potential, and other potentially life-threatening complications. There are a wide range of severity levels, sizes, and morphologies of ICHs, making accurate identification challenging. Hemorrhages that are small are more likely to be missed, particularly in healthcare systems that experience high turnover when it comes to computed tomography (CT) investigations. Although many neuroimaging modalities have been developed, CT remains the standard for diagnosing trauma and hemorrhage (including non-traumatic ones). A CT scan-based diagnosis can provide time-critical, urgent ICH surgery that could save lives because CT scan-based diagnoses can be obtained rapidly. The purpose of this study is to develop a machine-learning algorithm that can detect intracranial hemorrhage based on plain CT images taken from 75 patients. CT images were preprocessed using brain windowing, skull-stripping, and image inversion techniques. Hemorrhage segmentation was performed using multiple pre-trained models on preprocessed CT images. A U-Net model with DenseNet201 pre-trained encoder outperformed other U-Net, U-Net++, and FPN (Feature Pyramid Network) models with the highest Dice similarity coefficient (DSC) and intersection over union (IoU) scores, which were previously used in many other medical applications. We presented a three-dimensional brain model highlighting hemorrhages from ground truth and predicted masks. The volume of hemorrhage was measured volumetrically to determine the size of the hematoma. This study is essential in examining ICH for diagnostic purposes in clinical practice by comparing the predicted 3D model with the ground truth. [ABSTRACT FROM AUTHOR]

The increasing reliance on Computed Tomography Pulmonary Angiography (CTPA) for Pulmonary Embolism (PE) diagnosis presents challenges and a pressing need for improved diagnostic solutions. The primary objective of this study is to leverage deep learning techniques to enhance the Computer Assisted Diagnosis (CAD) of PE. With this aim, we propose a classifier-guided detection approach that effectively leverages the classifier's probabilistic inference to direct the detection predictions, marking a novel contribution in the domain of automated PE diagnosis. Our classification system includes an Attention-Guided Convolutional Neural Network (AG-CNN) that uses local context by employing an attention mechanism. This approach emulates a human expert's attention by looking at both global appearances and local lesion regions before making a decision. The classifier demonstrates robust performance on the FUMPE dataset, achieving an AUROC of 0.927, sensitivity of 0.862, specificity of 0.879, and an F1-score of 0.805 with the Inception-v3 backbone architecture. Moreover, AG-CNN outperforms the baseline DenseNet-121 model, achieving an 8.1% AUROC gain. While previous research has mostly focused on finding PE in the main arteries, our use of cutting-edge object detection models and ensembling techniques greatly improves the accuracy of detecting small embolisms in the peripheral arteries. Finally, our proposed classifier-guided detection approach further refines the detection metrics, contributing new state-of-the-art to the community: mAP 50 , sensitivity, and F1-score of 0.846, 0.901, and 0.779, respectively, outperforming the former benchmark with a significant 3.7% improvement in mAP 50. Our research aims to elevate PE patient care by integrating AI solutions into clinical workflows, highlighting the potential of human-AI collaboration in medical diagnostics. [ABSTRACT FROM AUTHOR]

The world is slowly recovering from the Coronavirus disease 2019 (COVID-19) pandemic; however, humanity has experienced one of its According to work by Mishra et al. (2020), the study's first phase included a cohort of 5,262 subjects, with 3,325 Fitbit users constituting the majority. However, among this large cohort of 5,262 subjects, most significant trials in modern times only to learn about its lack of preparedness in the face of a highly contagious pathogen. To better prepare the world for any new mutation of the same pathogen or the newer ones, technological development in the healthcare system is a must. Hence, in this work, PCovNet+, a deep learning framework, was proposed for smartwatches and fitness trackers to monitor the user's Resting Heart Rate (RHR) for the infection-induced anomaly. A convolutional neural network (CNN)-based variational autoencoder (VAE) architecture was used as the primary model along with a long short-term memory (LSTM) network to create latent space embeddings for the VAE. Moreover, the framework employed pre-training using normal data from healthy subjects to circumvent the data shortage problem in the personalized models. This framework was validated on a dataset of 68 COVID-19-infected subjects, resulting in anomalous RHR detection with precision, recall, F-beta, and F-1 score of 0.993, 0.534, 0.9849, and 0.6932, respectively, which is a significant improvement compared to the literature. Furthermore, the PCovNet+ framework successfully detected COVID-19 infection for 74% of the subjects (47% presymptomatic and 27% post-symptomatic detection). The results prove the usability of such a system as a secondary diagnostic tool enabling continuous health monitoring and contact tracing. • A CNN-VAE-based anomaly detection model and an LSTM network to generate temporal-aware embeddings of the latent vector of the primary model is used. • Healthy patient data is used to pretrain the base model and fine-tuned using each subject's baseline data to achieve a personalized version. • The proposed model is validated on 68 COVID-19-infected individuals' data. [ABSTRACT FROM AUTHOR]