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The COVID-19 pandemic originating in the Wuhan province of China in late 2019 has impacted global health, causing increased mortality among elderly patients and individuals with comorbid conditions. During the passage of the virus through affected populations, it has undergone mutations, some of which have recently been linked with increased viral load and prognostic complexities. Several of these variants are point mutations that are difficult to diagnose using the gold standard quantitative real-time PCR (qRT-PCR) method and necessitates widespread sequencing which is expensive, has long turn-around times, and requires high viral load for calling mutations accurately. Here, we repurpose the high specificity of Francisella novicida Cas9 (FnCas9) to identify mismatches in the target for developing a lateral flow assay that can be successfully adapted for the simultaneous detection of SARS-CoV-2 infection as well as for detecting point mutations in the sequence of the virus obtained from patient samples. We report the detection of the S gene mutation N501Y (present across multiple variant lineages of SARS-CoV-2) within an hour using lateral flow paper strip chemistry. The results were corroborated using deep sequencing on multiple wild-type (n = 37) and mutant (n = 22) virus infected patient samples with a sensitivity of 87% and specificity of 97%. The design principle can be rapidly adapted for other mutations (as shown also for E484K and T716I) highlighting the advantages of quick optimization and roll-out of CRISPR diagnostics (CRISPRDx) for disease surveillance even beyond COVID-19. This study was funded by Council for Scientific and Industrial Research, India. [ABSTRACT FROM AUTHOR]

After the outbreak of COVID-19 pandemic, devising an effective reverse logistics supply chain to clean up disaster medical waste is conducive to controlling and containing novel coronavirus transmission. Thus, the focus of this paper concentrates on multi-period multi-type disaster medical waste location-transportation integrated optimization problem with the concern of sustainability, which is formulated as a tri-objective mixed-integer programming model with the goals of maximizing total economic benefits, minimizing total carbon emissions and total potential social risks. Then, a real-world case from Wuhan using CPLEX solver is used to validate the developed model. Results indicate that constructing DMWTTSs with flexible capacity in different periods is encouraged to handle the sharply increasing disaster medical waste. The multi-period decision model outperforms the single-period one in disaster medical waste supply chains because the former has the capability of handling the uncertainties in the future periods. Increasingly, since the increase of budget doesn't always work well and social resources are limited, the estimation of minimum budget to obtain optimum overall performance is of great importance. [ABSTRACT FROM AUTHOR]

The onset of the COVID-19 pandemic in late 2019 triggered an unprecedented global health crisis. Originating in Wuhan, China, the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a worldwide upheaval, affecting every aspect of human life. As countries grappled with rising case counts, hospitalizations, and fatalities, the role of geospatial information and visualization in managing and understanding the pandemic became increasingly vital. This special issue of the Cartography and Geographic Information Science (CaGIS) Journal sought to explore the innovative and impactful ways in which geovisualization techniques have been employed to confront and elucidate the complexities of COVID-19. We describe significance and contribution of each paper that is part of the special issue, and avenues for new, exciting research around infectious diseases, keeping in mind that the research needs to be reproducible. [ABSTRACT FROM AUTHOR]

The outbreak of COVID-19 from Wuhan, China in 2019 has spread across the world, with more than 687 million confirmed coronavirus cases still increasing. Vaccines and medicines are one aspect of fighting the pandemic outbreak, but modern Information Technologies, web/ mobile-based technologies, blockchain, and Internet of Things (IoT) devices are being used to control the pandemic outbreak at an earlier/later stage. The IoT devices with sensors, and mobile apps/ websites having self-assessment tests can help in tracking COVID-19 infections. These people's tracking information and self-assessment tests are generating huge amounts of data. This white paper introduces an IoT and cloud-based architectural framework in the COVID-19 pandemic to predict infection risk based on citizens' self-assessments and storage of data in the cloud and the intelligent technique of hesitant Intuitionistic Fuzzy Set (IFS) has been used on the self-assessment dataset to predict the risk. [ABSTRACT FROM AUTHOR]

The 2019 novel coronavirus (SARS-CoV-2 / COVID-19), with a point of origin in Wuhan, China, has spread rapidly all over the world. It turned into a raging pandemic wrecking havoc on health care facilities, world economy and affecting everyone's life to date. With every new variant, rate of transmission, spread of infections and the number of cases continues to rise at an international level and scale. There are limited reliable researches that study microdroplets spread and transmissions from human sneeze or cough in the airborne space. In this paper, we propose an intelligent technique to visualize, detect, measure the distance of spread in a real-world settings of microdroplet transmissions in airborne space, called "COVNET45". In this paper, we investigate the microdroplet transmission and validate the measurements accuracy compared to published researches, by examining several microscopic and visual images taken to investigate the novel coronavirus (SARS-CoV-2 / COVID-19). The ultimate contribution is to calculate the spread of the microdroplets, measure it precisely and provide a graphical presentation. Additionally, the work employs machine learning and five algorithms for image optimization, detection and measurement. [ABSTRACT FROM AUTHOR]

The outbreak of COVID-19 posed a challenge to global governance, residents' happiness, and economic systems around the world. Since the crux of previous research centers on the reactions of both local and national governments, studies on how governance arrangement at the neighborhood level influences people's happiness during the crisis response remain insufficient. This paper aims to explore the relationship between neighborhood governance and residents' happiness based on first-hand data collected during Wuhan's first lockdown. This study highlights the significance of neighborhood governance in crisis response, which includes providing diverse public services, ensuring access to life's necessities, and offering prompt medical treatment. All of these factors are essential for maintaining overall satisfaction with governance and contributing to the happiness of individuals within the community. However, active governance actions do not always lead to favorable results. For example, increased group participation may lead to social conflicts among those involved, ultimately diminishing one's happiness. Furthermore, the COVID-19 pandemic has acted as a risk 'amplifier', exposing and exacerbating pre-existing hukou-based social inequalities in the governance process. The impact of the pandemic on citizen happiness is the cumulative effect of both the immediate social crisis brought on by the pandemic and long-standing structural inequalities. To improve people's happiness and establish inclusive policies, this paper advocates for a 'people-centered' urban governance that enhances public satisfaction and addresses the needs and priorities of migrant populations. [ABSTRACT FROM AUTHOR]

In December 2019, in Wuhan in China an outbreak of Coronavirus (COVID-19) was reported. In late February 2020, the first cases of the virus were recorded in Ireland. By 11th March, the World Health Organisation had declared the outbreak a pandemic and on 12th March, An Taoiseach, Leo Varadkar announced that all schools would close with effect from 6pm that day. The schools remained closed until September. This paper considers the impact of the closure of primary schools on both principals' and teachers' wellbeing. A mixed-methods, longitudinal research methodology was undertaken. There were two phases to the research. Phase one was undertaken in June and July 2020 when teachers and principals participated in a semi-structured interview and completed two questionnaires: the Emotional Regulation questionnaire and the Copenhagen Burnout Inventory. Phase 2 of data collection was completed in December/January 2021/2021 when the teachers participated in a further interview and completed the questionnaires again. The overall aim of the study was to provide an opportunity for principals and teachers to reflect on how the pandemic impacted on their wellbeing and by inference, the impact of the increased emotional labour of teaching during COVID. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic has been a global public health concern since March 11, 2020. Healthcare systems struggled to meet patients' growing needs for diagnosis, treatment, and care. As healthcare industries struggled to cope with the overwhelming demands, advanced intelligence and computing technologies have become essential. Artificial intelligence techniques have become essential for identifying and triaging patients, predicting disease severity, and detecting outcomes. The aim of the paper is to propose a gradient boosting-based model to predict the mortality of COVID-19 patients and to improve the prediction accuracy by incorporating resampling strategies. A real COVID-19 data that includes patients' travel, health, geographical, and demographic information is obtained from a public repository. The dataset used in the study has the class imbalance problem, and several approaches are applied to solve the problem. In this study, a gradient boosting-based model for predicting the mortality of COVID-19 patients is proposed. This approach incorporates resampling strategies, such as synthetic minority oversampling technique (SMOTE), random under-sampling, and clustering-based under-sampling, to address the imbalanced class distribution problem in the dataset. Then, gradient boosting machines (GBM) such as extreme gradient boosting (XGBoost), light gradient boosting machine (LightGBM), and categorical boosting (CatBoost) are analyzed in terms of accuracy and computational time. Random search method is used to find the optimal hyper-parameters for the algorithms. A stacking-based hybrid model that combines the XGBoost, LightGBM, and CatBoost algorithms was used for comparison in the experiments. In the experiments, the factors that can influence the mortality of COVID-19 patients are investigated. And, it is found that the age of the patient, whether the patient belonged to Wuhan, the difference between when they first noticed symptoms and when they visited the hospital (in days) affect the mortality. By utilizing over/under-sampling approaches, we ameliorated the concern of class imbalance. XGBoost, LightGBM, and CatBoost are effectively analyzed in terms of various performance metrics to determine the suitable GBM for the proposed system. The experimental results revealed that the stacking-based hybrid model performs well with the balanced dataset provided by SMOTE. CatBoost produces superior results for a balanced dataset with random under-sampling and clustering-based under-sampling. The main focus of the study is to propose a gradient boosting-based model for predicting the mortality of COVID-19 patients. This study also emphasizes the importance of addressing the imbalanced class distribution problem in the dataset and incorporates resampling strategies to improve the prediction accuracy. Our promising result confirms the success of the proposed system in predicting mortality of COVID-19 disease. [ABSTRACT FROM AUTHOR]

Considering the high variability of Covid-19 and unknown sequelae of rebound infections. We may be caught in a long-term struggle against the virus. The evaluation and summary of past anti-epidemic policies highlight profound practical significance for either decision makers or individuals. This paper applies both theoretical and empirical approaches to study the impact of city lockdown and air pollution on Covid-19. First, we apply an extended Susceptible-Infected-Removed (SIR) model to identify the relationship between lockdown, air pollution, and Covid-19 cases. Second, we apply the Differences-in-Differences (DID) model and Poisson Pseudo-Maximum Likelihood (PPML) model to test the impact of lockdown on Covid-19, by sorting out lockdown policies implemented by cities during the epidemic. Third, we empirically analyze the impact of air pollution on Covid-19, based on daily data from 257 cities in China. Finally, we examine the mechanism by which lockdown impacts Covid-19. Newly confirmed Covid-19 cases are reduced by 31.1% nationwide (excluding Wuhan) during the lockdown period. Regions with lower air pollution experience fewer Covid-19 cases. Air pollution aggravates Covid-19, with the pollutants PM2.5, PM10, NO2, CO, and O3 having the greatest impact. The results indicate that an increase in one unit of air quality index (AQI) concentrations is associated with 1.723 more newly confirmed cases. The effects of air pollution on the spread of Covid-19 diminish as the population size increases. Lockdown can inhibit the spread of Covid-19 by reducing air pollution and population movement. [ABSTRACT FROM AUTHOR]

The recent pandemic caused by the Coronavirus Disease (COVID-19) first surfaced in Wuhan, China in December 2019. This paper presents an expert system for the diagnosis of COVID-19 based on its symptoms to aid people in taking precautionary measures. When experts are not available, an expert system that can effectively diagnose the disease is crucial. It takes the place of one or more experts in decision-making and problem-solving. An expert system for diagnosis of COVID-19 is a system developed to recognize early COVID-19 symptoms that individuals may experience by allowing users to directly check the disease with results that can serve as a foundation for additional testing. This study's primary goal is to identify useful COVID-19 detection patterns or knowledge by examining the historical data we have obtained from the Kaggle dataset. The patterns are presented as rules, which are given to the expert system after consultation with a domain expert. A total of 1,048,575 pieces of data were used for model training and testing. To detect COVID-19 disease, we employ a PART rule-based algorithm, which performed 92.47% accurately in a 10-fold cross-validation test. We can therefore draw the conclusion that the algorithm produces a promising result and that the expert system aids in the diagnosis of the disease. The system offers a suggestion in line with the identified symptom. [ABSTRACT FROM AUTHOR]

Mortality is one of the most important epidemiological measures and a key indicator of the effectiveness of potential treatments or interventions. In this paper, a permutation test method of variance analysis is proposed to test the null hypothesis that the real-time fatality rates of multiple groups were equal during the epidemic period. In light of large-scale simulation studies, the proposed test method can accurately identify the differences between different groups and display satisfactory performance. We apply the proposed method to the real dataset of the COVID-19 epidemic in mainland China (excluding Hubei), Hubei Province (excluding Wuhan), and Wuhan from 31 January 2020 to 30 March 2020. By comparing the differences in the disease severity for differential cities, we show that the severity of the early disease of COVID-19 may be related to the effectiveness of interventions and the improvement in medical resources. [ABSTRACT FROM AUTHOR]

In this paper, we propose a fractional order Coronavirus (COVID-19) model incorporating non-pharmaceutical interventions and vaccine hesitancy. The proposed model was calibrated with data from literature and validated with reported daily cases of COVID-19 from Wuhan, China. We derived the reproduction number and demonstrated that it is an important threshold parameter for disease persistence and extinction. We examined the relationship between the reproduction number and model parameters. Our findings underscore the importance of awareness and vaccine uptake on mitigating the spread of COVID-19. [ABSTRACT FROM AUTHOR]

The new emerged infectious disease that is known the coronavirus disease (COVID-19), which is a high contagious viral infection that started in December 2019 in China city Wuhan and spread very fast to the rest of the world. This infection caused millions of infected cases globally and still poses an alarming situation for human lives. Pakistan in Asian countries is considered the third country with higher number of cases of coronavirus with more than 649824. Recently, some mathematical models have been constructed for better understanding the coronavirus infection. Mostly, these models are based on classical integer-order derivative using real numbers which cannot capture the fading memory. So at the current position it is a challenge for the world to understand and control the spreading of COVID-19. Therefore, the aim of our paper is to develop some novel techniques, namely complex Pythagorean fuzzy weighted averaging (abbreviated as CPFWA) operator, complex Pythagorean fuzzy ordered weighted averaging (abbreviated as CPFOWA) operator, complex Pythagorean fuzzy hybrid averaging (abbreviated as CPFHA) operator, induced complex Pythagorean fuzzy ordered weighted averaging (abbreviated as I-CPFOWA) operator and induced complex Pythagorean fuzzy hybrid averaging (abbreviated as I-CPFHA) operator to analysis the spreading of COVID-19. At the end of the paper, an illustrative the emergency situation of COVID-19 is given for demonstrating the effectiveness of the suggested approach along with a sensitivity analysis, showing the feasibility and reliability of its results. [ABSTRACT FROM AUTHOR]

Simple Summary: This paper proposes a modified SEIR model to study COVID-19 in Wuhan. The modified model is calibrated by the public number of COVID-19 hospitalization cases in Wuhan. The paper further uses this model to estimate the earliest date of COVID-19 infection in Wuhan, which is in agreement with some existing results. Based on SEIR (susceptible–exposed–infectious–removed) epidemic model, we propose a modified epidemic mathematical model to describe the spread of the coronavirus disease 2019 (COVID-19) epidemic in Wuhan, China. Using public data, the uncertainty parameters of the proposed model for COVID-19 in Wuhan were calibrated. The uncertainty of the control basic reproduction number was studied with the posterior probability density function of the uncertainty model parameters. The mathematical model was used to inverse deduce the earliest start date of COVID-19 infection in Wuhan with consideration of the lack of information for the initial conditions of the model. The result of the uncertainty analysis of the model is in line with the observed data for COVID-19 in Wuhan, China. The numerical results show that the modified mathematical model could model the spread of COVID-19 epidemics. [ABSTRACT FROM AUTHOR]

The objective of this paper is to investigate three new methods to regulate and analyze the spreading of coronavirus disease (COVID-19). COVID-19 started in the city of Wuhan, China at the end of 2019 and spread to the whole world in a short time. This infection caused millions of infected cases globally and still poses a disturbing situation for the people. Recently, some mathematical models have been constructed for better understanding of the coronavirus infection. Mostly, these models are based on classical integer-order derivative using real numbers which cannot capture the fading memory. So, at the current position, it is a challenge for the world to control the spreading of COVID-19. Therefore, the aim of this paper is to utilize fuzzy logic to control the transmission and spreading of COVID-19. Here, we develop three new methods such as the generalized interval-valued intuitionistic fuzzy Einstein weighted geometric (GIVIFEWG) operator, the generalized interval-valued intuitionistic fuzzy Einstein ordered weighted geometric (GIVIFEOWG) operator, and the generalized interval-valued intuitionistic fuzzy Einstein hybrid geometric (GIVIFEHG) operator. Intuitionistic fuzzy information for interval-valued is the moral and decent method to precise the fuzzy information for judgment or decision and Einstein operations are the best approximations, and the generalized aggregation operators are a generalization of most aggregation operators so, in these notes, we can spread the Einstein operations to aggregate the interval-valued intuitionistic fuzzy information based on the generalized aggregation operators. At the end of the paper, an illustration of the emergency situation of COVID-19 is given for demonstrating the effectiveness of the suggested approach, showing the feasibility and reliability of the new methods. [ABSTRACT FROM AUTHOR]

The worldwide outbreak of the coronavirus was first identified in 2019 in Wuhan, China. Since then, the disease has spread worldwide. As it is currently spreading in the United States, policy makers, public health officials and citizens are racing to understand the impact of this virus on the United States healthcare system. They fear a rapid influx of patients overwhelming the healthcare system and leading to unnecessary fatalities. Most countries and states in America have introduced mitigation strategies, such as using social distancing to decrease the rate of newly infected people. This is what is usually meant by flattening the curve. In this paper, we use queueing theoretic methods to analyze the time evolution of the number of people hospitalized due to the coronavirus. Given that the rate of new infections varies over time as the pandemic evolves, we model the number of coronavirus patients as a dynamical system based on the theory of infinite server queues with time inhomogeneous Poisson arrival rates. With this model we are able to quantify how flattening the curve affects the peak demand for hospital resources. This allows us to characterize how aggressive societal policy needs to be to avoid overwhelming the capacity of healthcare system. We also demonstrate how curve flattening impacts the elapsed lag between the times of the peak rate of hospitalizations and the peak demand for the hospital resources. Finally, we present empirical evidence from Italy and the United States that supports the insights from our model analysis. [ABSTRACT FROM AUTHOR]

This paper evaluated whether the citizens are satisfied with outcomes and performance of lockdown initiatives in defending against COVID-19. We statistical analyzed participants' characteristics and used a logit regression to analyze the factors associated with their experience and satisfaction with the lockdown initiative. According to our results, the issues of information disclosure, reasonable resource arrangements, and timely governmental responses significantly influenced the experiences of citizens during the lockdown period. The findings can guide policy makers regarding implementing more progressive initiatives to limit the spread of COVID-19 and facilitate the use of emergency measures for the sake of public health. [ABSTRACT FROM AUTHOR]

The first case of COVID‐19 in India detected on January 30, 2020, after its emergence in Wuhan, China, in December 2019. The lockdown was imposed as anemergency measure by the Indian government to prevent the spread of COVID‐19 but gradually eased out due to its vast economic consequences. Just 15 days after the relaxation of lockdown restrictions, Delhi became India's worst city in terms of COVID‐19 cases. In this paper, we propose a variable‐order fractional SIR (susceptible, infected, removed) model at state‐level scale. We introduce a algorithm that uses the differential evolution algorithm in combination with Adam–Bashforth–Moulton method to learn the parameters in a system of variable‐order fractional SIR model. The model can predict the confirm COVID‐19 cases in India considering the effects of nationwide lockdown and the possible estimate of the number of infliction inactive cases after the removal of lockdown on June 1, 2020. A new parameter p is introduced in the classical SIR model representing the fraction of infected people that get tested and are thereby quarantined. The COVID‐19 trajectory in Delhi, as per our model, predicts the slowing down of the spread between January and February 2021, touching a peak of around 5 lakh confirmed cases. [ABSTRACT FROM AUTHOR]

Novel coronavirus (COVID‐19), a global threat whose source is not correctly yet known, was firstly recognised in the city of Wuhan, China, in December 2019. Now, this disease has been spread out to many countries in all over the world. In this paper, we solved a time delay fractional COVID‐19 SEIR epidemic model via Caputo fractional derivatives using a predictor–corrector method. We provided numerical simulations to show the nature of the diseases for different classes. We derived existence of unique global solutions to the given time delay fractional differential equations (DFDEs) under a mild Lipschitz condition using properties of a weighted norm, Mittag–Leffler functions and the Banach fixed point theorem. For the graphical simulations, we used real numerical data based on a case study of Wuhan, China, to show the nature of the projected model with respect to time variable. We performed various plots for different values of time delay and fractional order. We observed that the proposed scheme is highly emphatic and easy to implementation for the system of DFDEs. [ABSTRACT FROM AUTHOR]

By establishing a simulation model of infectious disease transmission based on interpersonal relationship, this paper studied the process of infectious disease transmission and the trend of epidemic development under relevant prevention and control measures. Described the contact and interaction between individuals based on the interpersonal relationship, this paper established an agent-based simulation model. It adjusted the model parameters based on the initial data collected by the Wuhan COVID-19 epidemic platform of the Chinese Health Commission, estimated the basic reproduction number (R0), and simulated the scenarios of different epidemic prevention and control methods, explored the trend of epidemic spread under different intervention measures. The established model for the spread of infectious diseases based on interpersonal relationships first simulated the spreading process of the Wuhan epidemic in the early stage, and estimated the COVID-19 R0 before Wuhan was closed to the public. Subsequently, the model preliminarily predicted the development trend of the epidemic in Yangzhou and found that the epidemic had entered a controllable stage. By discussing the impact of different intervention measures on the development of the epidemic in densely populated places (in the case of schools), this paper put forward relevant prevention and control opinions for the current students starting in the fall. Finally, it discussed the effect of the social movement distance of individuals in social contact networks on the epidemics transmission, and it was found that an increase in the social movement distance of individuals increased the risk of transmission of infectious diseases. [ABSTRACT FROM AUTHOR]

Introduction: In December 2019, a cluster of atypical cases of pneumonia was reported in Wuhan, China, which was later designated as Coronavirus disease 2019 (COVID-19) by the World Health Organization (WHO) on Feb 11, 2020. We all are facing a global pandemic, and it is very important to be clear that there is no correct roadmap to navigate this difficult situation. It is imperative to state that this global pandemic impacted the spine care services of our institute. In the present study, we have assessed the spine surgeries performed by orthopedic surgeons in terms of volume and etiologies during the COVID-19 pandemic and compared the data with a pre-COVID period. Materials and Methods: We retrospectively collected data from all patients who underwent spinal surgeries at our institute under the department of orthopedics from August 20, 2019 to August 20, 2020 (a total of 12 months duration). The data was then divided into two groups--pre-COVID period (August 20, 2019-February 19, 2020-6 months) and during the COVID pandemic (February 20, 2020-August 20, 2021-6 months). Results: A total of 140 patients underwent surgery at our institute from August 20, 2019 to August 20, 2020. Of these, 91 patients underwent surgery during the pre-COVID period, and 49 patients underwent surgery during the COVID pandemic. In this devastating phase of the pandemic, our department's total number of surgeries significantly declined to 46.15%. The routine surgeries performed during the pandemic phase show a steep fall from 59.34% in the pre-COVID period to 10.20%. Conclusion: This paper is meant to focus attention on the exorbitant reduction in the operative workflow of the spine patients during the COVID-19 pandemic at a tertiary healthcare institute. It is the need of the hour that orthopedic surgeons maintain equilibrium while providing the best possible treatment to their patients and limiting the spread of the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]

The purpose of this paper is to ignite a conversation on the challenges of the ongoing 'novel' surrounding the coronavirus (SARS-CoV-2) pandemic in the Southern Africa region. The global COVID-19 pandemic started with the outbreak in Wuhan, China, in December 2019. It is understood that different countries, regions and territories will have different, context-specific challenges in fighting the pandemic. These will differ from country to country and therefore necessitates contextual research. By sharing African perspectives on swift action against this coronavirus, this paper is intended to appraise the nexus between the coronavirus and tourism in order to prepare tourism practitioners for the recovery strategies that will be needed to address the damages caused by the pandemic. This paper points to tourism researchers focusing on the Southern African region and possible key areas for further research as the coronavirus situation unfolds. It draws from published material and document analysis, including from academic research, media reports and social media platforms. [ABSTRACT FROM AUTHOR]

Many researchers began doing studies about pandemic COVID-19 which began to spread from Wuhan, China in 2019 to all around the world and so far, numerous researches have been done around the world to control this contagious disease. In this paper, we proposed a MSIlIhR-V mathematical model to study the spreading of pandemic COVID-19. This paper is aimed to study the vaccination effect in the control of the disease propagation rate. Another goal of this paper is to find the maximum number of susceptible people, minimum number of infected people, and the best value for number of vaccination people. The Jacobian matrix was obtained in the virus absenteeism equilibrium point for the proposed dynamical system. The spectral radius method was applied to find the analytical formula for the reproductive number. Reproductive number is one of the most benefit and important tools to study of epidemic model's stability and instability. In the following, by adding a controller to the model and also using the optimal control strategy, model performance was improved. To validate of the proposed models with controller and without controller we use the real data of COVID-19 from 4 January, 2021 up to 14 June, 2021 in Iran. Maple and MATLAB software's will be used for programming. We will use Maple software for analytical parts and MATLAB software for numerical and simulation parts. [ABSTRACT FROM AUTHOR]

The health organizations around the world are currently facing one of the greatest challenges, to overcome the current global pandemic, COVID-19. It erupted in December 2019, in Wuhan City, China. It spreads rapidly throughout the world within couple of months. In this paper, the data of the COVID-19 have been collected, organized, analyzed and interpreted using the discrete-time model of SIR epidemic model. Moreover, results for several countries from different regions of the world have been obtained. Furthermore, comparative study has been carried out for the countries under consideration. The comparison was performed for the data of different countries on same dates of each month. However, the calculations are carried out for thirteen consecutive weeks, to investigate the rate of spread and the control of the disease in these countries. This guides us to some important concepts like factors favoring the spread of virus and those resisting the spread. Different regions are studied and their data have been evaluated to know which regions are the most effected. This study helps to know the important factors about the behavior of the coronavirus in different environments, such as lockdowns, temperatures, humidity and other restrictions. The proposed concepts and equations can be used to project the upcoming behavior of the pandemic. [ABSTRACT FROM AUTHOR]

The coronavirus disease 2019 (COVID-19) was first reported in December 2019 in Wuhan, China, and then moved to almost every country showing an unprecedented outbreak. The world health organization declared COVID-19 a pandemic. Since then, millions of people were infected, and millions have lost their lives all around the globe. By the end of 2020, effective vaccines that could prevent the fast spread of the disease started to loom on the horizon. Nevertheless, isolation, social distancing, face masks, and quarantine are the best-known measures, in the time being, to fight the pandemic. On the other hand, contact tracing is an effective procedure in tracking infections and saving others' lives. In this paper, we devise a new approach using a hybrid harmony search (HHS) algorithm that casts the problem of finding strongly connected components (SCCs) to contact tracing. This new approach is named as hybrid harmony search contact tracing (HHS-CT) algorithm. The hybridization is achieved by integrating the stochastic hill climbing into the operators' design of the harmony search algorithm. The HHS-CT algorithm is compared to other existing algorithms of finding SCCs in directed graphs, where it showed its superiority over these algorithms. The devised approach provides a 77.18% enhancement in terms of run time and an exceptional average error rate of 1.7% compared to the other existing algorithms of finding SCCs. [ABSTRACT FROM AUTHOR]

Background: In December 2019, the first case of COVID-19 was described in Wuhan, China, and by July 2022, there were already 540 million confirmed cases. Due to the rapid spread of the virus, the scientific community has made efforts to develop techniques for the viral classification of SARS-CoV-2. Results: In this context, we developed a new proposal for gene sequence representation with Genomic Signal Processing techniques for the work presented in this paper. First, we applied the mapping approach to samples of six viral species of the Coronaviridae family, which belongs SARS-CoV-2 Virus. We then used the sequence downsized obtained by the method proposed in a deep learning architecture for viral classification, achieving an accuracy of 98.35%, 99.08%, and 99.69% for the 64, 128, and 256 sizes of the viral signatures, respectively, and obtaining 99.95% precision for the vectors with size 256. Conclusions: The classification results obtained, in comparison to the results produced using other state-of-the-art representation techniques, demonstrate that the proposed mapping can provide a satisfactory performance result with low computational memory and processing time costs. [ABSTRACT FROM AUTHOR]

A novel economic impact model is proposed by this paper to analyze the impact of economic downturn on the air quality in Wuhan during the epidemic period, and to explore the effective solutions to improve the urban air pollution. The Space Optimal Aggregation Model (SOAM) is used to evaluate the air quality of Wuhan from January to April in 2019 and 2020. The analysis results show that the air quality of Wuhan from January to April 2020 is better than that of the same period in 2019, and it shows a gradually better trend. This shows that although the measures of household isolation, shutdown and production stoppage adopted during the epidemic period in Wuhan caused economic downturn, it objectively improved the air quality of the city. In addition, the impact of economic factors on PM2.5, SO2 and NO2 is 19%, 12% and 49% respectively calculated by the SOMA. This shows that industrial adjustment and technology upgrading for enterprises that emit a large amount of NO2 can greatly improve the air pollution situation in Wuhan. The SOMA can be extended to any city to analyze the impact of the economy on the composition of air pollutants, and it has extremely important application value at the level of industrial adjustment and transformation policy formulation. [ABSTRACT FROM AUTHOR]

Introduction: Coronavirus disease 2019 (COVID-19) is a novel coronavirus that was frequently isolated from Wuhan, China in patients with respiratory tract infections. The most prevalent symptoms are fever and respiratory tract involvement. In this paper, seizures, an uncommon manifestation of the condition, is described. Case Discussion: A previously healthy 34-year-old female was taken to the emergency room with a widespread tonic-clonic seizure. Five days prior to admission, the patient complained of fever, cough, headache, widespread weakness, and myalgias. She experienced two episodes of convulsions around one hour ago. The MRI of the brain was normal, whereas the CT of the chest indicated localised ground-glass opacities. Using real-time PCR, the respiratory material was positive for COVID-19. The patient's symptoms improved after using anticonvulsive and antiviral drugs. Conclusions: To our knowledge, this is one of the rare case studies reporting a link between frequent seizures and COVID - 19. [ABSTRACT FROM AUTHOR]

Around the end of 2019, in Wuhan, Hubei Province, China, the first confirmed cases of COVID-19 were identified, and from then on, the world we were used to knowing changed globally. The role of population density, in relation to the spread of the pandemic, has been widely scrutinised in urban studies, believed to be the triggering variable. However, the results so far are inconclusive. This paper suggests instead to shift the focus to socio-spatial vulnerabilities, as the effects of the pandemic's spread have been more severe in urban units which feature long-standing inequalities. The paper's aim is, therefore, twofold: on the one hand it aims at contributing to the debate on population density and COVID-19 in urban areas, and, on the other hand, to analyse the pandemic's spread in relation to socio-spatial vulnerabilities. Different cities across the globe are drawn into a comparative project, where the pandemic's spread is analysed in relation to variables of Population Density (PD) and a Social Vulnerability Index (SVI), by employing correlation matrices. The results suggest that there is no significant correlation between density and the spread of COVID-19. Instead, a positive correlation is in place when analysing the pandemic's diffusion with socio-spatial inequalities. • COVID-19 spread is not associated with population density while social vulnerability is found to be positively correlated. • The study invites to undertake a more critical understanding of how density and vulnerability are intertwined. • Measures based on physical concentration should be supplemented by topological density, made up of relational factors. [ABSTRACT FROM AUTHOR]

An outbreak of a novel form of pneumonia due to a coronavirus occurred in Wuhan City, Hubei Province, China, in December 2019, and the disease was officially named coronavirus 2019 (COVID-19). COVID-19 is an infectious disease caused by the SARS-CoV-2 virus which attacks the human respiratory system. In critical cases of COVID-19, special treatment is administered in the ICU using a mechanical ventilator. However, since the results are less than optimal, additional interventions such as orienting the patient in the prone position can be employed, as this can reduce the pressure on the dorsal lung area so that alveolar recruitment can be improved. This study examines the effect of the prone position on increasing pulmonary ventilation. This study is a literature review study employing a narrative method and was conducted by tracing and analyzing articles relevant to the topic. This literature review searched three databases, namely, PubMed, Google Scholar, and ProQuest using the keywords "COVID-19 OR intubated COVID-19" AND "prone position OR mechanical ventilator" AND "Lung ventilation". From these databases, 1062 journals were found and filtered based on inclusion and exclusion criteria, resulting in the inclusion of 10 journals. Then, they were filtered again using a critical appraisal instrument called "JBI Critical Appraisal", which was conducted by two people, N.P. and A.S.; consequently, the results of 5 journals were obtained for further analysis; cumulatively, these papers represented a total population of 1789 patients. It was concluded that the prone position can improve pulmonary ventilation by up to 50% and reduce the total length of stay by up to 5 days in the hospital, as long as the patients do not possess any comorbid diseases. [ABSTRACT FROM AUTHOR]

The novel coronavirus disease 2019 (COVID-19) pandemic which emanated from Wuhan city, China and its successive spread across the globe has made a tremendous impact on virtually all spheres of human endeavors; ranging from economy, health, livelihood, and education amongst others. The widespread restrictions currently placed on movement and mass gatherings have made educational and academic activities be restructured to a pedagogical order. In recent times, the concept of learning has gradually transitioned from traditional classroom methods to online learning where students acquire knowledge through "hybrid". Most institutions of learning in Africa may encounter difficulties in migrating to this new form of learning due to the lack of information and communications technology (ICT) facilities of international standards. As of today, many students possess internet-enabled devices, yet cannot access the internet as a result of unaffordable data subscriptions, which has made most learners result in using their devices for non-educational purposes. As the COVID-19 pandemic continues to ravage the African continent returning to its former modus operandi by African schools is a herculean task. Thus, governments, authorities, and regulatory bodies in individual countries must improve their existing ICT and infrastructures for a better online learning experience. This paper serves as a wake-up call for Africa and its educational sector to establish online learning. [ABSTRACT FROM AUTHOR]

COVID-19 is a disease caused by infection with the virus 2019-nCoV, a single-stranded RNA virus. During the infection and transmission processes, the virus evolves and mutates rapidly, though the disease has been quickly controlled in Wuhan by 'Fangcang' hospitals. To model the virulence evolution, in this paper, we formulate a new age structured epidemic model. Under the tradeoff hypothesis, two special scenarios are used to study the virulence evolution by theoretical analysis and numerical simulations. Results show that, before 'Fangcang' hospitals, two scenarios are both consistent with the data. After 'Fangcang' hospitals, Scenario I rather than Scenario II is consistent with the data. It is concluded that the transmission pattern of COVID-19 in Wuhan obey Scenario I rather than Scenario II. Theoretical analysis show that, in Scenario I, shortening the value of L (diagnosis period) can result in an enormous selective pressure on the evolution of 2019-nCoV. [ABSTRACT FROM AUTHOR]

Towards the end of 2019 in Wuhan, suspicions of a new dangerous virus circulating in the air began to arise. It was the start of the world pandemic coronavirus disease 2019 (COVID-19). Since then, considerable research data and review papers about this virus have been published. Hundreds of researchers have shared their work in order to achieve a better comprehension of this disease, all with the common goal of overcoming this pandemic. The coronavirus is structurally similar to influenza A. Both are RNA viruses and normally associated with comparable infection symptoms. In this review, different case studies targeting polymeric materials were appraised to highlight them as an indispensable tool to fight these RNA viruses. In particular, the main focus was how polymeric materials, and their versatile features could be applied in different stages of viral disease, i.e., in protection, detection and treatment. [ABSTRACT FROM AUTHOR]

Since the infectious coronavirus disease (COVID-19) was first reported in Wuhan, it has become a public health problem in China and even around the world. This pandemic is having devastating effects on societies and economies around the world. The increase in the number of COVID-19 tests gives more information about the epidemic spread, which may lead to the possibility of surrounding it to prevent further infections. However, wearing a face mask that prevents the transmission of droplets in the air and maintaining an appropriate physical distance between people, and reducing close contact with each other can still be beneficial in combating this pandemic. Therefore, this research paper focuses on implementing a Face Mask and Social Distancing Detection model as an embedded vision system. The pretrained models such as the MobileNet, ResNet Classifier, and VGG are used in our context. People violating social distancing or not wearing masks were detected. After implementing and deploying the models, the selected one achieved a confidence score of 100%. This paper also provides a comparative study of different face detection and face mask classification models. The system performance is evaluated in terms of precision, recall, F1-score, support, sensitivity, specificity, and accuracy that demonstrate the practical applicability. The system performs with F1-score of 99%, sensitivity of 99%, specificity of 99%, and an accuracy of 100%. Hence, this solution tracks the people with or without masks in a real-time scenario and ensures social distancing by generating an alarm if there is a violation in the scene or in public places. This can be used with the existing embedded camera infrastructure to enable these analytics which can be applied to various verticals, as well as in an office building or at airport terminals/gates. [ABSTRACT FROM AUTHOR]

In the context of the global pandemic of COVID-19, with the epidemic epicenter located in the Wuhan City, China, patients with severe mental illness have also been deeply affected by the epidemic. In this paper, two patients with schizophrenia who recovered from COVID-19 were reported. Because of the long-term positive results of the SARS-CoV-2 serum antibody IgM test, they had to undergo medical isolation and social restrictions for a long time. After the situation was effectively identified by the medical staff and they were eliminated as a potential virus carrier and released from the medical isolation center. Since psychiatrists often lack systematic knowledge of infectious diseases, the authors hope that this paper can provide a reference to avoid unnecessary wastage of medical resources and prevent placing serious mental burden on such patients in the future. [ABSTRACT FROM AUTHOR]

Purpose: This paper analyzes Fang Fang's 2020 Wuhan Diary‐Dispatches from a Quarantined City, to show how the author communicates the coronavirus crisis in Wuhan in a global information ecosystem. The success of the diary showcases how the actual health emergency has been transformed into a communication issue. Design/methodology/approach: This study is exploratory and qualitative in nature. The authors conducted a thematic analysis (TA) of Wuhan Diary, in which we decided to focus on the aspects of sousveillance and solidarity. For the purposes of our paper, we used the English translation of the text by Dr. Michael Berry. Findings: The authors focus on two major themes in their exploration of the corona crisis as a global communication issue: sousveillance and solidarity. The authors argue that the diary's ways of seeing perform a version of "sousveillance" or "undersight" in juxtaposition to surveillance or "oversight" (Mann, 2017). Fang Fang calls for solidarity as an effective measure for individuals, communities and societies to contain the pandemic and a potential misinfodemic. Originality/value: Since Wuhan was the early epicenter of the COVID-19 pandemic, Wuhan Diary presents an unprecedented narrative account of life under quarantine that could function as a litmus test for other cities and countries. Fang Fang's diary provides a countermeasure to official accounts of the pandemic in Wuhan, which has resonated both with people in China and abroad. [ABSTRACT FROM AUTHOR]

Medical facility equality is a critical metric for determining equal access to medical care. Their spatial distribution is important for effective pandemic treatment and daily prevention in cities. This paper used the Kernel Density Two-Step Floating Catchment Area (KD2SFCA) and shortest distance methods to calculate the accessibility of designated COVID-19 Fangcang hospitals and fever clinics in the Wuhan Metropolitan Development Zone. Their equality was evaluated by the Gini coefficient and Lorentz curve. Several results were obtained: (1) The facilities' accessibility declines radial from the central to peripheral areas. (2) Most of the demand points in the study area can reach the medical facilities for COVID-19 pandemic treatment within 60 minutes. (3) For the spatial distribution of these facilities, the equality evaluated for different time thresholds differed significantly, with long time thresholds having better equality than for short time thresholds. (4) While the distances distribution of fever clinics is balanced, the equality gap in various areas remains enormous when considering population distribution. Suggestions for optimizing the spatial distribution of pandemic treatment medical facilities in Wuhan are proposed, and which will serve as references for the planning of Wuhan's pandemic medical facilities in the future. [ABSTRACT FROM AUTHOR]

CCOVID-19 was first reported in late 2019 in Wuhan, China, and spread throughout the world like a pandemic. The population all over the world used lots of medicinal plants for prevention purposes. India has been blessed with cultural wisdom. Social health practices across the country have been utilizing integrative treatments to fight against mild fever and cold flu-like infections. Herbal and Ayurveda medicines have shown their impact on treating such infections in the early stages. The impact of herbal medicines on Covid infection is quite evident and several drug tests and trials have proved its worth of it in treating mild to severe infections. The majority of these plants are used to treat respiratory diseases having the same signs and symptoms as coronavirus symptoms or other flu infections. Our body can fight infections only when immunity is strong and for that herbal drugs as immunomodulators work well. It has worked in boosting the immunity of the patients and normal people to fight against Corona. The paper analyzes such research studies on Covid-19 treatment by herbal medicines. It makes a point that herbal medicine-based treatments and social health practices will play a complementary role in managing Covid-19 and Post-Covid health emergencies. New-Normal social ethics will evolve through such an integrative social health culture. [ABSTRACT FROM AUTHOR]

Observing traffic flow is of great significance to contemporary urban management. Overhead images, as represented by remote sensing images, provide a major source of information about traffic flow. However, the spatial resolutions of most common high-resolution remote sensing images are often limited to 0.5 m and even below, which makes it unrealistic to count vehicles by means of widely used object detection methods. Therefore, to explore the potential of remote sensing data for studying global urban development and management, this paper introduces a density map-based vehicle counting method for remote sensing imagery with limited resolution. Density map-based models regard the vehicle counting task as estimating the density of vehicle targets in terms of pixel values. We propose an improved CNN-based network, called Congested Scene Recognition Network Minus (CSRNet—), that generates a density map of vehicles from the input remote sensing imagery. A new dataset, RSVC2021, which was generated from the public DOTA and ITCVD datasets, is also introduced for network training and testing. A benchmark on the RSVC2021 dataset is accordingly established and CSRNet— is selected as the baseline model for subsequent experiments. A set of GF-2 time series images with a resolution of 1 m taken before, during and after the COVID-19 epidemic lockdown covering Wuhan city are applied for real-world application testing. The testing results on both the RSVC2021 dataset and real satellite images confirm that, in terms of both the counting values and the visualized density maps, the proposed method achieves good performance and exhibits considerable application potential in this task. The generating codes of RSVC2021 dataset will be publicly available at https://github.com/YinongGuo/RSVC2021-Dataset. [ABSTRACT FROM AUTHOR]

COVID-19 is an infectious disease caused by the virus SARS-CoV-2, a coronavirus variant, which emerged on December 2019 in Wuhan, China. This paper presents an analysis and reflection of emerging research on the efficacy of Chinese medicine (CM) and acupuncture as a treatment for COVID-19. In CM, COVID-19 falls under the category of an epidemic disease. CM places COVID-19 into four stages: early, advanced, critical, and recovery. This research analysis presents the application of immunomodulatory acupuncture points and Chinese herbal prescriptions that may assist the body to defend against epidemic pathogens such as COVID-19 and future epidemic threats. Acupuncture has proven to be able to activate immune cells, at specific entry viral points, to prepare the body's immune system to fend off the viral invasion. The most common Chinese herbs to appear in research are Toujie Quwen granules, Lianhua Qingwen Capsules, Keguan-1, Xuebijing injection, and Chinese syndrome differentiation decoctions. The summary of evidence showed a benefit in the clinical cure, chest image improvement, and a reduction in clinical deterioration, acute respiratory distress syndrome, mechanical ventilation, and mortality with CM plus routine Western treatment compared to routine Western treatment alone. This critical analysis may prepare future generations for prevention, treatment, and integration of varying medical paradigms to effectively respond to a virus with global impact. Traditional Chinese medicine (TCM) is a viable adjunct in supportive care for patients with COVID-19. [ABSTRACT FROM AUTHOR]

In recent years, with the in-depth development of information technology, its role in people's production and life has become increasingly prominent, and it has played a significant role in improving work efficiency. At the beginning of the new year in 2020, the novel coronavirus pneumonia (COVID-19) outbreak broke out in Wuhan City, Hubei Province and spread rapidly across the country. The country attaches great importance to it, and the medical staff acted quickly and actively participated in this war against the virus without the smoke of gunpowder. After arduous efforts from all over the country, our country's COVID-19 epidemic prevention and control situation has been further consolidated, and the prevention and control work has changed from an emergency state to a normal state of prevention and control. Hospital informatization construction is an objective requirement for hospital modernization and the prevention and control of the COVID-19, and it is of great significance in the context of the normalization of the COVID-19 epidemic prevention and control. This paper elaborates on the four aspects of hospital information construction in the background of COVID-19, the existing problems in hospital information construction, the practice of hospital information construction and the exploration of hospital informatization construction, and is committed to exploring the overall thinking of hospital information construction in special period. [ABSTRACT FROM AUTHOR]

This paper treats the outbreak of coronavirus disease 2019 (COVID-19) as a natural experiment that can provide insights into the effects of investor sentiment on stock market reactions. Employing the event study methodology (ESM) and taking the date of the Wuhan lockdown as the event date, we find that average abnormal return (AAR) and cumulative abnormal return (CAR) are significantly negative, and average trading volume excesses far more than before within two days of the outbreak. Further, we establish a difference-in-differences (DID) model to investigate the differences between Hubei and non-Hubei listed companies. The results show that for Hubei listed companies, the change of excessive trading volume (ETV) between pre-event and post-event period is significantly higher than that of non-Hubei listed companies, while there exhibits no relationship between the change of AAR and registration place. Overall, our findings provide new evidence for the interaction of local bias and investor sentiment affecting stock market reactions. [ABSTRACT FROM AUTHOR]

Wuhan Province in China reported the first case of novel corona virus as pneumonia outbreak during December 2019. The novel coronavirus was soon declared a pandemic by the World Health Organization. On 16th of July 2021, the number of COVID-19 confirmed cases was 188,128,952 globally, out of which 4,059,339 individuals succumbed to this deadly virus. In a short span of time, eight vaccines were approval for emergency use in different nations. The selection of vaccine depends upon many criteria. Concepts from multi-criteria decision making (MCDM) are appropriate to compare and rank them. The paper proposes analytical network processing (ANP) method to rank the eight vaccines according to seven criteria. The study proposes a decision tool to select the best vaccine among the candidate vaccines. A mathematical model based on ANP approach with three clusters having interrelationships within and among the clusters is proposed. [ABSTRACT FROM AUTHOR]

In December 2019, human cases of novel coronavirus infection were detected in Wuhan, China which have been named as COVID-19 by the World Health Organization (WHO). Since COVID-19 was first detected in China, the virus has reached more than 120 countries and was declared a global pandemic on March 11, 2020 by the WHO. In this paper, we have highlighted the influence of temperature on the spread of COVID-19. For this, the dynamic transmission of COVID-19 is modeled taking into account the influence of the temperature on the persistence of coronavirus in the environment. We also took into account the impact of proportion of people who respect the barrier measures published by the WHO on the scale of the COVID-19 pandemic. Taking into account the influence of the temperature on the persistence of the virus in the environment, the dynamic transmission has been described by a system of ordinary differential equations (ODEs). First, we analyzed the solutions of system in the case where the impact of the temperature on the virus is neglected. Second, we carried out the mathematical analysis of the solutions of the system in the non-autonomous case. Mathematical analyzes have enabled us to establish that the temperature and proportion of persons who respect the barrier rules can affect the spread of COVID-19. Some numerical simulations have been proposed to illustrate the behavior of the pandemic in some countries. [ABSTRACT FROM AUTHOR]